Drug Inspector Question Paper 2009 -TNPSC

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1. Which of the following trademarked sustained release systems are based on encapsulated drug particles that will dissolve at various rates ?  
I.   Sequels
II.   Spansules
III.  Extentabs.
Of these
A)  I only
B)  III Only
C) I and II
D) I, II, and III

2. Compartmental models are often used to illustrate the various principles of pharmacokinetics. A compartment is best defined as
A)    any anatomic entity that is capable of absorbing drug
B)    a kinetically distinguishable pool of drug
C)    specific body organs in tissues that can be assayed for drug
D)    any body fluid such as blood in urine that may contain drug.

3. Dimethyl sulphoxide is commonly used as an excipient in transdermal patches as
AJ adhesive
B)    permeation enhancer of lipophilic drugs
C)    permeation enhancer of hydrophilic drugs
D)    release liner.

4. Ideal conditions for effective transdermal drug delivery would include molecular
weight of...........and pH of.............for the saturated aqueous solution
of the drug.
A)    < 500 Da,    1  -  5  
 B)    > 500 Da.    1 - 5
C)    < 500 Da,    5  - 9    
D)    > 500 Da,    5-9.

5.  All of the following drugs are believed to undergo significant first-pass hepatic biotransformation, except
A)    phenytoin    B)    lidocaine
C)    morphine    D)    nitroglycerine.

6.    Agglomeration In aerosols can be reduced by including
A)    anionic surfactants with HLB greater than 10
B)    cationic surfactants with HLB less than 10
C)    non-ionic surfactants with HLB greater than 10
D)    non-ionic surfactants with HLB less than 10.

7.    In a suspension, open network aggregate or floccule tends to
A)    settle quickly and cannot be easily redispersed
BJ settle slowly and can be easily redispersed
C)    settle quickly and can be easily redispersed
D)    settle slowly and cannot be easily redispersed.

8.    The particle size range of nano-    -particles is    
A)    1 nm — 1 pm    
B)    1 nm — 1000 nm
C)    Inm — 100 nm    
D)    0-5 pm — 1 nm.

9. Transdermal drug delivery systems contain drugs meant for
A)    local action    
B)    systemic action
C)    both (A) and (B)  
D)    none of these.

10.Which one of the following per oral dosage forms is likely to exhibit the longest lag time ?
A)    Delayed release tablet    
B)    Elixir
C)    Enteric coated tablet  
D)    Sustained release capsule.

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