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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF SIMVASTATIN BY TERNARY SOLID DISPERSION TECHNIQUE

ABOUT AUTHORS:
Shete Reshma S.1*, Gadhave Manoj V.2, Gaikwad D. D.3
1Department of Quality Assurance Techniques,
2Department of Pharmaceutics,
3Department of Pharmaceutics,
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
*reshma.s.shete@gmail.com

ABSTRCT
Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin, PEG 6000 & Poloxamer 407 solid dispersions were prepared with a view to study the influence of polymer on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of PEG 6000 & Poloxamer 407 as carrier by, solvent evaporation method. They were evaluated for percentage yield, drug content, FTIR spectral studies, DSC, XRD, solubility, and in-vitro dissolution. The solubility profile indicated that there is increase in solubility of Simvastatin when polymer concentration is increased. The solid dispersion complex of drug (1:5:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions. This in turn can improve the bioavailability. FT-IR, DSC shows the compatibility of drug and carrier.


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The IIHMR University, Jaipur formerly known as Institute of Health Management Research (IIHMR), Jaipur the premier University in Hospital, Health, Pharmaceutical and Rural Management, has made a phenomenal contribution in the career of its alumni. Provides excellent opportunities in education, training, research and consultancy in healthcare and hospital Services.

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A Unique Research and Postgraduate University in Health Sector Established Under IIHMR Private University Act 2014, Government of Rajasthan
Formerly known as Institute of Health Management Research (IIHMR), Jaipur A WHO Collaborating Centre for District Health Systems based on Primary Health Care

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· Recognized Bachelor's Degree in Medicine/Pharmacy/ Biotechnology/Science/Management with at least 50% marks in aggregate.
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DISSOLUTION METHOD DEVOLOPMENT OF FLUCONAZOLE IN FLUCONAZOLE TABLETS DOSSAGE FORM

ABOUT AUTHORS:
Auti Snehal D.*, Jadhav S. L, Gadhave Manoj V
1Department of Quality Assurance Techniques
2,3Department of Pharmaceutics
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
snehal.d.auti@gmail.com

ABSTRACT:
The present research work discusses the development of a dissolution method for Fluconazole using UV spectrophotometer. Simple, accurate and cost efficient dissolution method has been developed for the estimation of Fluconazole in bulk and tablet dosage form. The optimum conditions for the dissolution of the drug were established. The dissolution media was found to be 0.1N HCl (pH 1.2). The apparatus was found to be USP II, Paddle and the speed was found to be 50 rpm for 30 minutes time interval.


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In business profit earnings and overall growth of business get the highest priority and are certainly creditable, but ultimate credibility of business enterprise, particularly of larger ones is in the utilisation of profit, be it for best possible upliftment of its workforce and for espousing Social, National Development causes or for rendering services to mankind as a whole. Fulfilling the Qualitative aspect of utilisation of profit, the world's largest family ‘Sahara India Pariwar' is proud to have reached today new horizons of growth and development.

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Invitation for the post of Pharmacist in Medybiz Pharma- Pune

Medybizpharma is incorporated since 2009 focussed on distribution of Super Specialty products cross PAN India with delivery capabalities at 17 locations.

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