Articles

A REVEIW ON: PHYTOCHEMICAL AND PHARMACOLOGICAL STUDY OF ANNONA SQUAMOSA

ABOUT AUTHORS
Diksha A. Narwade*, Dr. A. N. Aher
Department of Pharmacognosy,
MVP samaj college of pharmacy,
Gangapur road Nashik, Maharastra, India

ABSTRACT
This paper gives the information about the Annona squamosa Linn. (Family: Annonaceae). Phytochemical and pharmacological studies of medicinal plant were performed. The plant is highly used traditionally for curing diverse diseases and disorders. It is locally known as “Sitaphal'' in Hindi. Macroscopical & microscopical studies of leaves have been studied. The phytochemical studies showed the presence of amino acids, terpenes, lipids, steroids, flavonoids, ascorbic acid, tannins, vitamins and alkaloids. The plant has various pharmacological actions such as insecticidal, purgative, laxatives, astringent, anti-inflammatory, antidiabetic, anti-ulcer, anti-oxidant, antimalarial and antibacterial. The reveiw specifically deals with the phytochemical and folkloric medicinal importance of plant.

REVIEW ON GOOD DOCUMENTATION PRACTICE IN PHARMACEUTICAL MANUFACTURING UNIT AS PER EUROPEAN UNION GMP CHAPTER-4 ON DOCUMENTATION

ABOUT AUTHORS
Suleman S. khoja * 1, Dr. L J. Patel 2, Sohil S. Khoja 3, Karim R. Panjwani 3, Jagdish Ray3
1 PhD. Research Scholar, Ganpat University, Mehesana, Gujarat, India
2 Faculty of Pharmacy, Ganpat University, Mehesana, Gujarat, India
3 Resource person, Pharmaceutical Quality Assurance, Audit and Compliance, Vapi, Gujarat, India

ABSTRACT
Good documentation constitutes an essential part of the quality assurance system and is key to operating in compliance with GMP requirements. Documentation requirements of maintaining complete, accurate, truthful and verifiable data in all cGXP documents that are needed to be maintained as per regulatory requirements and various Governmental regulations, laws, rules and statutes/acts. Documentation may exist in a variety of forms, including paper-based, electronic or photographic media. Ensure that the Document should be free from error and during any point if error identify then rectify with proper reason for correcting including sign and date. A system should be in place to indicate special observations and any changes to critical data. GMP Document must have predefined retention period and document must be stored in secure and easy to retrieve or easily available as and when required. Batch Processing and Packaging Instruction must be in place and Contemporaneous entry provision must be available. Instruction and procedure for using equipment; instrument must be clear and specific.  Specification with authorization should be available for analysis of Raw Material and Packing Material, Intermediate and Bulk Product, Finished Product.

A REVIEW ON ANALYTICAL METHOD FOR DETERMINATION OF INDAPAMIDE IN MARKETED PHARMACEUTICAL PREPARATION

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ABOUT AUTHORS
Patil N.B.*1, Patil K.B.1, Wagh M.N.1, Patil A. A.1
1. Department of Pharmacy, Ahinsa Institute of pharmacy, Dondaicha Tal-Shindakheda Dist-Dhule, Maharashtra, India

ABSTRACT
Indapamide is the Thiazide like diuretic drug used in treatment of Hypertension, as well as odema, Heart attack, stroke and heart failure in persons with high blood pressure. It is available in market single component and multicomponent formulations. The article summarizes 57 analytical method including the chromatographic method, LC-MS (Liquid Chromatography-mass spectroscopy), GC-MS (Gas chromatography-mass spectroscopy), spectriflurometric and UV Visible spectrophotometry techniques for estimation of   Indapamide in biological samples, bulk and pharmaceutical formulation.

AN A-Z OF PHARMA INDUSTRY REVIEW: BANGLADESH PERSPECTIVE

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ABOUT AUTHOR
AK MOHIUDDIN

Faculty of Pharmacy, World University of Bangladesh

ABSTRACT
After liberation, Bangladesh pharma industry was largely dominated by the import dependent MNCs. On or before 1982 ordinance, 75% of the market was dominated by the MNCs and the rest share was with the other 133 local companies. After NDP formulation and the Drug Control Ordinance, there was a dramatic change of reverse. By 1994, a few pharma companies achieved a tremendous growth and they reinvest their profit for faster return. By next decade, Bangladesh is aiming to 30 world class drug manufacturers to establish strong footstep in global pharma market. Bangladesh, as an LDC got exempted from the obligation of patent and data protection in this arena until 2033. Interestingly, Bangladesh already passed across the LDC landmark to a developing country. So, there’s window of opportunity of more than a decade to grow further from that aspect.

THE PHYTOCONSTITUENTS AND PHARMACOLOGICAL ACTIONS OF FICUS RACEMOSA LINN. FAMILY: MORACEAE AN UPDATED REVIEW

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ABOUT AUTHORS
Kajal V. Kosankar*, Dr. A.N. Aher
MVP samaj college of pharmacy, Gangapur road Nashik, Maharashtra, India

ABSTRACT
Ficus racemosa it belongs to family Moraceae syn. Ficus glomerata Roxb. is the major group of angiosperm (flowering plant). They are widely distributed throughout Asia, Africa, America, Australia, Himalayan ranges, Punjab, Khasia Mountain, Bihar, Orissa, Rajasthan, Deccan, China, Indonesia and Malaysia. Udumber is used from ancient time for treating the many diseases. This tree is used traditionally for public health. It is also called yajnodumbara and grows all over the India at different areas. The common name is ‘Audumbar’ and ‘Umbar’ and used in Unani, Ayurveda and Homeopathy. The leaves tender are used in kalasha prokshana it is sprinkle water to different places from a scared copper mug and the bark is used in Homa. In review macroscopically studies, microscopically studies and chemical constituents are studied on different parts of the plant. Traditional uses and pharmacological uses are described, the extraction of leaves, fruit, stem, bark and latex are done due to this the important constituents are isolated in respective solvent like ethanol, methanol, acetone, petroleum ether, ethyl acetate and water. The more information is described below and the people are moving towards ayurvedic preparations.

ASPARAGUS RACEMOSUS, A CLIMBING AYURVEDIC MEDICINAL PLANT: REVIEW ON ITS CULTIVATION, MORPHOLOGY AND MEDICINAL SIGNIFICANCE

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ABOUT AUTHORS
Mir Sahidul Ali1, Souvik Mukherjee2, Debayan Roy2, Gargi Pal3, Subhajit Makar*2
1Department of Chemical & Polymer Engineering, Tripura University (A Central   University), Suryamaninagar, Tripura 799022, India.
2School of Basic & Applied Sciences, Central University of Punjab,Bathinda-155110, Punjab, India.
3 Department of Pharmaceutical Sciences and Technology, NSHM Knowledge Campus, Kolkata- 700053, India.

ABSTRACT: Asparagus racemosus (A. racemosus) is a well-known medicinal plant due its various application in Ayurveda. It contains various type of secondary metabolite active natural products (or ingredients) such as steroids, alkaloids, flavonoids, furan derivatives and essential oils. In the present scenario due to growing catastrophic effect of diseases in human life, researchers are trying to stop synthetic drugs by replacing with herbal drugs. Herbal drug treatments are in general used to provide first-line and public health provider, both to persons abode in faraway areas the place it is the only on hand wellness service, and to people residing in bad areas the place it offers the one cheap relief. In this point of view A. racemosus can show a new path of herbal treatment.

DETERMINATION OF SUN PROTECTION FACTOR (SPF) NUMBER OF SOME HYDROALCOHOLIC VEGETABLE EXTRACTS

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ABOUT AUTHORS
MUSLEK UDDIN MAZUMDER1*, KISHALAYA DAS2, ABHIJIT DEB CHOUDHURY1, P KHAZEO1
1department of pharmacy, regional institute of paramedical and nursing sciences, zemabawk 796017, aizawl, mizoram, india.
2department of pharmaceutical sciences, assam university, dargakona 788011, silchar, assam, india.

ABSTRACT
Exposure to sunlight can trigger various biological responses ranging from sun-burn, erythema to skin cancer. Synthetic sunscreen formulations available in market pose variety of adverse effects. Therefore formulation of the herbal sunscreen formulation and evaluation of its sun protection activity is an important aspect in the cosmetic industry. The various herbal agents contain significant sun screen properties which might be useful for formulating herbal creams and lotions. Therefore evaluation of its sun protection activity is an important aspect in the cosmetic industry. The comparative values of the calculated sun protection factor of twelve commonly used vegetables were evaluated using Mansur equation. Hydroalcoholic herbal extracts were obtained and absorbances were recorded between 290-320 nm using UV-Vis spectrophotometer. It was observed that all of the tested herbal extracts showed some UV protection capabilities with hydroalcoholic extract. Hydroalcoholic extract of beet root showed highest SPF i.e. 39.48 while capsicum extract showed lowest i.e. 2.45. These plant herbals can be formulated in the form of cosmetics formulation because of their better acceptability, less irritant nature and also these are less expensive
.

ASSESS THE CLINICAL USAGE OF NEBULIZATION THERAPY AND ANTIBIOTICS IN IN-PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A RANDOMIZED PROSPECTIVE STUDY AT A TERTIARY CARE TEACHING HOSPITAL

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ABOUT AUTHORS
SPANDANA. M*, VAISHNAVI. M, PRAVALIKA. P, SUSMITHA. S, AMATUL ALI SAMEERA
Dept. of Pharmacy Practice
Sree Dattha Institute of Pharmacy,
Sheriguda (V), Ibrahimpatnam (M), Ranga Reddy, Telangana, India

ABSTRACT
AIMS AND OBJECTIVES: Our aim is to assess the clinical usage of Nebulization and Antibiotic therapy in COPD.
METHOD: An Observational, Prospective, Cohort study was conducted at a tertiary care teaching hospital, Telangana State, India. A total of 102 patients from the In-patient department of Pulmonology in Gleneagles Global Hospital, who were prescribed Nebulizers and Antibiotics and those who fulfilled the exclusion and inclusion criteria were selected for the study which was conducted for 6 months. All information significant to the study was collected from the case records and discussion conducted with the In-patients and bystanders during ward rounds with the support of a physician which were analyzed by SPSS software. Moreover daily follow-ups were conducted to assemble data on amendment in therapy, add on therapy, and clinical improvement.
RESULTS: The Mean age was 66 years and Standard Deviation was 13 years of the population. 41% were smokers and 27% were alcoholics. The most commonly used Bronchodilator is Duolin with a percentage of 96%. The most commonly used antibiotic is Magnex Forte with a percentage of 41.1%. The most commonly used formulation is Orals with a percentage of 53%. 92% of individuals responded in a positive way after the Nebulization therapy with Oxygen therapy provided to them, as their SpO 2 levels with oxygen therapy changed to normal range.
CONCLUSION: Nebulization therapy had more clinical improvement when compared to Inhalational therapy. The addition of corticosteroids had decreased the patient stay in hospital. Antibiotics added to the treatment decreased the frequency of exacerbations. Antibiotics added to the treatment decreased the frequency of exacerbations. The patient should be educated about the rational use of the drugs and decrease the risk and exacerbations of COPD.

GASTRO ESOPHAGEAL REFLUX DISEASE

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ABOUT AUTHORS
T.vijayalaxmi1, N.mounika2,Nagavamsidhar3 Qadrie ZL*,4.
1, 2,3 Research Scholar, Department of Pharmacy Practice, Pratishta Institute of Pharmaceutical     Sciences, Suryapet, Hyderabad, Telangana
*, 4 Professor and Head, Department of Pharmacy Practice, Pratishta Institute of Pharmaceutical Sciences, Suryapet, Hyderabad, Telangana

ABSTRACT
Gastro esophageal reflux disease is also known as GERD. It is a long term condition where stomach contents come back up into the esophagus. Resulting in either symptoms or complications. Symptoms include the taste of acid in the back of the mouth, heartburn, bad breath, chest pain, vomiting, breathing problems and wearing away of the teeth complications includes oesophagitis, esophageal strictures and Barrett’s esophagus. Recent studies have demonstrated that peripheral and central factors are pivotal for the emergence of symptoms after gastroesphageal reflux had occurs supporting the view the GERD is a sensory -motor disorder rather than motor disorder alone. The primary pathophysiologic event in GERD is the movement of acid, pepsin and other injurious substance from the stomach in to the esophagus. GERD is a common problem world-wide, the frequency and severity of GERD and severity of GERD and its complications such as burette’s esophagus and geographic variations. most studies from India suggests that these might be less in the Indian population on the other hand studies in a multiethnic population showed that people of Indian origin are at higher risk of GERD than ethnic Malay of Chinese.

A REVIEW ON ANALYTICAL METHODS FOR THE ESTIMATION OF RIZATRIPTAN, AN ANTIMIGRAINE DRUG

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ABOUT AUTHORS
Pushpa latha E*1, Sailaja B2
1,2 Dept. of Pharm. Analysis & Quality Assurance, Institute of Pharmaceutical Technology, Sri Padmavathi Mahila Visvavidyalayam, Tirupati, Andra Pradesh, India-517502

ABSTRACT
Rizatriptan is a selective serotonin receptor agonist of the 1B and 1D sub types used in the acute treatment of migraine attacks. Effective analytical procedures are required for qualitative and quantitative determination of a drug. An extensive literature survey has been conducted in various analytical and pharmaceutical journals and the analytical methods which were developed and used for estimation of Rizatriptan in single or in combination with other drugs in bulk drugs, pharmaceutical formulations, biological fluids, stability indicating and impurity profiling methods have been reviewed. Various analytical methods used for the estimation of Rizatriptan reviewed in this paper includes Ultraviolet spectrometry, Visible spectrometry, High performance thin layer chromatography, High performance liquid chromatography, Liquid chromatography- mass spectrometry.

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