Articles

STEM CELL THERAPY FOR PARKINSON’S DISEASE: A REVIEW

ABOUT AUTHORS
Vipul Gandhi*, Sushil Burle, Satish Kosalge
Hi-Tech College of Pharmacy Chandrapur
Padoli Phata,  Nagpur Highway, Morwa, Chandrapur-442406.
*vipul96gandhi@gmail.com

ABSTRACT
Some of the problems with Un productive relaxing treatments and insufficient repair aptitude in the central nervous system are most troubling problems for few neurological diseases. Providentially, the development of clinically relevant populations of stem cells has provided an opportunity to overcome the failure of endogenous repair systems and substitute new cells into the injured brain. However, there are still several existing difficulties in interpreting into clinical application. In this review, we mainly focus on the stem cell based therapies for Parkinson’s disease and discuss the possible advantages and drawbacks. We hope this review may provide suggestions for viable policies to overcome the current technical and biological issues relatedto the application of stem cells in Parkinson’s disease (Fu et al., 2015).


APICOPLAST: A BRILLIANT FOCUS FOR ANTIMALARIAL DRUG DEVELOPMENT

ABOUT AUTHORS
Souvik Mukherjee*1, Deepronil Roy2 and Suman Das3
1Department of Pharmaceutical Sciences & Natural Products, Central University of Punjab, Bathinda, Punjab, India
2Department of Animal Sciences, Central University of Punjab, Bathinda, Punjab, India  3Department of Human Genetics & Molecular Medicine, Central University of Punjab, Bathinda, Punjab, India
mukherjees388@gmail.com

ABSTRACT
Malaria is a lifestyle-threatening tropical disorder, due to the intracellular parasite Plasmodium falciparum. The sector health employer counts malaria as one of the pinnacle ten reasons of worldwide demise. The unavailability of a successful malaria vaccine and the ever-increasing times of drug resistance in the malaria parasite call for the invention of new targets inside P. falciparum for the development of next generation antimalarial drug. Fortuitously, all apicomplexan parasites, along with P. falciparum harbor a relict, non-photosynthetic plastid referred to as the apicoplast. The apicoplast is a semi-self-sustaining organelle within P. falciparum, containing a 35 kb circular genome. Notwithstanding a genome of its own, majority of the apicoplast proteins are encoded by means of the parasite nucleus and imported into the apicoplast. The organelle has been proven to be vital to P. falciparum survival and the loss the apicoplast manifests as a ‘not on time loss of life’ response in the parasite. The apicoplast has advanced out of cyanobacteria in a complicated, two step endosymbiotic event. As a result, the architecture and the gene expression machinery of the apicoplast is pretty bacteria-like and is at risk of a wide variety of antibiotics consisting of fosmidomycin, tetracycline, azithromycin, clindamycin and triclosan. The biosynthetic pathways for isoprenoids, fatty acids and heme function within the malaria apicoplast, making the organelle a top notch goal for drug development. This review specializes in the evolution, biology and the essentiality of the apicoplast inside the malaria parasite and discusses a number of the current achievements toward the layout and discovery of apicoplast focused antimalarial drug.


ISATIN SCHIFF BASE -AN OVERVIEW

ABOUT AUTHORS
D.Visagaperumal*, Justin Ebuka Ezekwem, Hemaprasad Munji, Vineeth Chandy
Department of Pharmaceutical Chemistry,
T. John College of Pharmacy, Bangalore, Karnataka, India
*vishak_dr@yahoo.co.in

ABSTRACT
The review article is focused on studies of Isatin-based Schciff Bases and their biological and pharmacological activities. Isatin-based Schiff base are generally synthesized by condensation of the keto group of Isatin with different aromatic primary amines carrying imine or azomethine (–C=N–) functional group. Isatin Schciff Base possesses numerous biological properties like antitumor, antimicrobial, anti-inflammatory, anticonvulsant, antiviral, anti HIV, antioxidant, CNS depressant activities


REVIEW ON ISCHEMIC HEART DISEASES AND ITS MEDICATION

ABOUT AUTHORS
Salman S. Dhankwala*, Ajinkya N. Gavsane, Prithvirj M. Ghuli, Sagar A. Jadhav
Department of Pharmaceutical Chemistry,
Appasaheb Birnale College of Pharmacy,
Sangli, Maharashtra, India
*salman.2.dhankwala@gmail.com

ABSTRACT
Ischemic heart   diseases are a major public health problem, it includes disorders of the heart and blood vessel. Ischemia is a condition in which the blood flow (and thus oxygen) is restricted or reduced in a part of the body.Cardiac ischemia is the name for decreased blood flow and oxygen to the heart muscle It's the term given to heart problems caused by narrowed heart arteries. When arteries are narrowed, less blood and oxygen reaches the heart muscle. This is also called coronary artery disease and coronary heart disease. This can ultimately lead to attack. Ischemia often causes chest pain or discomfort known as angina pectoris. Disease is diagnosed according to medical parameters; following diagnosis of the disease the treatment is started. The treatment is includes in medicines of Heart diseases and is as well as lifestyle.


HEALTH RISK ASSESSMENT TO ZINC IN DRINKING WATER OF RURAL RESIDENTS LIVING IN BHUSAWAL CITY, MAHARASHTRA (INDIA)

PhotoABOUT AUTHORS
Sanjay A. Nagdev*1, Mayur R. Bhurat1 and Krishna R. Gupta2
1 K.Y.D.S.C.T’s College of Pharmacy, Sakegaon-Bhusawal, Maharashtra
2 Smt. Kishoritai Bhoyar college of Pharmacy, Kamptee, Maharashtra
*snsanjurocks@gmail.com

ABSTARCT
The Present study was designed for the estimation of essential trace element Zinc in drinking water from natural sources like well, bore-well and river of Bhusawal (Maharashtra) (21.0455° N, 75.8011° E).Samples were evaluated as per Bureau of Indian standards 10500 for Zinc, Concentration of Zinc in water samples of River, well and Bore well was found within the safe limits of World Health Organization guidelines for zinc and also study finding suggest that bore well is the better and rich source of Zinc as compared to Well and river and population residing in the region and consuming water from bore well would be less prone to Zinc deficiency as compared to Population consuming water from other sources like well and river.


VISUALIZING CHALLENGES OF GST ON DIFFERENT CORNERS OF PHARMACEUTICAL INDUSTRY

ABOUT AUTHORS
ABDUL KHALID QUADRI*, MD. BARKATH ALI SHAMS
Department of Pharmacy practice, Deccan School of Pharmacy, Hyderabad-500001, Telangana, India
*a.k.quadri4all@gmail.com

ABSTRACT
The Indian pharmaceutical industry is amongst the largest producer of pharmaceutical products in the world (by volume). The pharmaceutical sector is witnessing high growth rate over the past 8-10 years, it has been burdened with diminishing margins. The Indian pharmaceutical industry is facing pressures of increasing span control on account of changing regulations. GST which embodies the principle of one nation, one tax, one market is aimed at unifying the country’s INRs 124.9 trillion economy and 1.3 billion people into a common market. For corporates, the elimination of multiple taxes will improve the ease of doing business. And for consumers the biggest advantage would be in terms of reduction in overall tax burden on goods. In other words GST would make doing business in the country tax-neutral, irrespective of the choice of place of doing business, the important roll-out of GST is to provide a method for companies to simplify their operations, and achieve better efficiencies enabling them to serve customers better. It is also expected that supply chain and other operational planning opportunities and efficiencies may be available, depending on a company’s facts. However, in short–term/transitional phase, pharmaceutical industry, are likely to face a number of challenges, including possibly negative financial impacts, the need to assess existing supply chain structures, the need for reconfiguration of  IT systems and more. The warehouse cost can be reduced and rationalized the supply cahin, it has a negative effect on ayurvedic products as its rate will increase from the present rate because of increase in tax slab. GST is expected to fetch a good revenue through increase in medical tourism, GST is surely going to benefit the pharmaceutical industries. It will create a level playing field for generic drug makers, boost medical tourism and simplify the tax structure.


A REVIEW ON HERBAL NANOPARTICLES

ABOUT AUTHORS
Arulanandraj. N*, Dhivya. S, DR. V. Gopal
Department of Pharmaceutical Analysis,
Mother Theresa Post Graduate and Research Institute of Health Sciences,
Gorimedu, Puducherry-605006, India
*dhivyaraji310@gmail.com

ABSTRACT
Herbal medicines have been used for several years throughout the world. Especially in India, herbal medicines are in high demand. Utilization of herbal medicines has increased because of their ability to treat various diseases with lesser side effects. The development of novel herbal formulations are reported to have remarkable advantages over respective crude drugs preparations or extracts which includes enhancement of solubility, bioavailability, protection from toxicity, enhancement of pharmacological activity, reduction in dose, enhancement of stability, improved tissue distribution, sustained delivery and protection from physical and chemical degradation. The herbal nanoparticles are colloidal system with herbal particles varying in size from 1 to 1000 nm. The objective of this review article is to summarize the drawbacks of some conventional herbal formulations and the advantages of novel herbal formulations.


MIGRAINE & MIGRAINE MANAGEMENT: A REVIEW

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ABOUT AUTHORS
Muthyala Nagavamsidhar*1, Qadrie ZL.2, Suman A.1
*1 Department of Pharmacy Practice,
Pratishta Institute of Pharmaceutical Sciences,
Suryapet, Hyderabad, Telangana, India

nagavamsi.muthyala@gmail.com

ABSTRACT:  Pain is defined as an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage. The WHO has rated migraine amongst the top 20 most disabling life time conditions. Migraine is a pervasive and debilitating, chronic neurological painful disorder, affecting from 15% to 29% of the general population. It is the second most common cause of headache characterized by recurrent episodes of headache and associated symptoms i.e. nausea, sensitivity to light and noise that typically last from 4 to 72 hours which is divided into four phases. Migraine is well explained with three hypothesis i.e., vascular, platelet, central nervous system. It affects people of all groups, sexes, races and social classes around the globe. Migraine can occur due to various trigger factors and can be managed with both pharmacological and non-pharmacological treatment.


RESISTANCE OF SERRATIA MARCESCENS (SPKD15) TO VARIOUS ENVIRONMENTAL STRESS CONDITIONS: EFFECT ON CELL VIABILITY AND PRODIOGISIN PRODUCTION

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ABOUT AUTHORS
1PRATYUSH KUMAR DAS*, 2SMRUTIPRAGNYA SAMAL, 3RATIKANTA SAHOO, 4PRASANT KUMAR SABAT
1,2,3Centre for Biotechnology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India – 751003
4School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India – 751003
*pratyushdas@soa.ac.in

ABSTRACT
Serratia marcescens, a gram negative bacillus is generally related to hospital acquired infections. Production of red pigment (Prodiogisin) by the bacterium is an important characteristic feature and has been reported to exhibit certain antimicrobial property. The resistance of the bacteria towards several classes of antibiotics makes it one of the most notorious pathogen. The work aimed to evaluate the resistance of Serratia marcescens (SPKD15) under various environmental stress conditions (temperature, pH, Salt concentration and UV). Effect of these stress conditions on the cell viability and production of prodiogisin was analysed. The strain was able to sustain up to temperature of 40°C, Salt (NaCl) concentration of 7%, pH up to 10 and could withstand UV radiations up to 2 minutes. However, the prodiogisin production was negatively affected and finally inhibited at all the conditions of environmental stress(Temperature = 35°C, pH = 4 and 9, Nacl concentration = 4% and UV exposure of 15 seconds). This indicates that prodiogisin may act as a protective mechanism for the bacterium under stress. Further, intracellular antimicrobial was obtained from the UV exposed culture and compared with the antimicrobial obtained from the normal culture. The antimicrobial obtained from UV exposed culture showed decreased antimicrobial effect with inhibition diameter ranging between 2 mm to 13 mm (± S.D) as compared to the antimicrobial obtained from the normal culture. An inhibition diameter ranging between 4 mm to 22 mm (± S.D) was obtained in case of the normal culture which may be attributed to the loss of pigmentation. The study highlights the resistance of the bacterium to various environmental stresses. Keeping the degree of pathogenicity of the bacterium in mind, eradication of the same is quite difficult and must be looked upon seriously.


FORMULATION AND EVALUATION OF FLUCONAZOLE GEL BY USING SYNTHETIC POLYMER

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ABOUT AUTHORS
Sachin G. Dhandore*1,
Kalyani B.Wagh2
1 Department of Pharmaceutics,
Shivnagar Vidya Prasarak Mandal’s College of Pharmacy,
Malegaon(Bk), Baramati, Pune Maharashtra, India
2 Jalna Education Society’s Institute of Pharmacy,
J.E.S. College Campus, Jalna Maharashtra, India

*sachindhandore5@gmail.com

ABSTRACT
Fluconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Fluconazole is not much recomanded as it has many side effects. Thus these formulations are made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by using the synthetic polymer like carbapol 934 and HPMC by changing the polymer ratio. Gel formulations were characterized for drug content, pH determination, viscosity measurement, in-vitro diffusion. Among the six formulations F2 was selected as the best formulation as its %CDR after four and half hour was 99.01%. The viscosity of the F2 formulation was within the limit. Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin and reduced side effects associated with conventional treatment.


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