Articles

FORMULATION AND EVALUATION OF FLUCONAZOLE GEL BY USING SYNTHETIC POLYMER

ABOUT AUHTORS
Mr. Sachin G. Dhandore*1,
Miss. Kalyani B.Wagh2
1 Department of Pharmaceutics, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon(Bk), Baramati, Dist. Pune Maharashtra, India 413115.
2 Jalna Education Society’s Institute of Pharmacy, Jalna, J.E.S. College Campus, Durgamata road, Jalna Maharashtra, India 431203

*sachindhandore5@gmail.com

ABSTRACT
Fluconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Fluconazole is not much recomanded as it has many side effects. Thus these formulations are made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by using the synthetic polymer like carbapol 934 and HPMC by changing the polymer ratio. Gel formulations were characterized for drug content, pH determination, viscosity measurement, in-vitro diffusion. Among the six formulations F2 was selected as the best formulation as its %CDR after four and half hour was 99.01%. The viscosity of the F2 formulation was within the limit. Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin and reduced side effects associated with conventional treatment.


FORMULATION AND EVALUATION PHARMACEUTICAL AQUEOUS GEL OF POWDERED GUAVA LEAVES FOR MOUTH ULCER TREATMENT

ABOUT AUHTORS
Sabir Shaikh*1, Amol Shete2, Rajendra Doijad3
1S. Kant Health care R&D Centre, 
Turbhe, Navi Mumbai, Maharashtra-400705.
2Department of pharmaceutics,
Krishna institute of Pharmacy
Krishna institute medical sciences Deemed university, Karad. MS, India
3Department of Pharmaceutics and Quality Assurance,
Shree Santkrupa College of Pharmacy Ghogaon, Karad, MS, India

*sabirmshaikh17@gmail.com

ABSTRACT:
The objectives of present investigation were to formulate and evaluate herbal gel for mouth ulcer treatment of dried powdered guava leaves.
Herbal gel was prepared by using different concentration of powdered guava leaves and Carbopol 934, Propylene glycol as a gel base. Formulations were evaluated for various parameters
Infrared spectroscopy revealed that there was no interaction between powdered Guava leaves and Polymer. The formulated gel was transparent, homogeneous and pH ranges from 7 to 7.5. Formulation showed acceptable rheological behaviour with applicable Spreadability and Extrudability properties. Anti-fungal studies of formulations showed excellent efficacy against Aspargiliousaureus, Candida albicans.
From the experimental evidence of invitro studies it was observed that powdered guava leaves contain flavonoids so it showed significant antioxidant effect.
Developed herbal formulation was stable, safe and effective over to synthetic formulations for the treatment of mouth ulcer.


PREPARATION AND EVALUATION OF ISONIAZID MICROBEADS BY USING DIFFERENT MEMBRANE

ABOUT AUHTORS
Narinder Singh*, Raminder kaur
Department of Pharmaceutics
CT institute of Pharmaceutical Sciences,
Jalandhar, Punjab, India

*Pharmacist.narinder@gmail.com

ABSTRACT
Current experimental investigation is dedicated to formulated alginate floating microbeads of Isoniazid as a model drug by ion cross-linking method or ion gelation technique using calcium chloride as cross-linking agent. Drug effectiveness might be influenced by blood plasma protein binding. The less bound drug is more viable it can cross cell membrane and diffuse. Protein binding can impact the drug’s biological half-life in the body. Isoniazid was first generation antibiotic which are used for the resistance is an obstacle to the treatment of tuberculosis disease and latent tuberculosis infection. The permeability of Isoniazid study using different membrane (Egg membrane and cellophane membrane). The IN VITRO drug release studies showed the optimized formulation of drug release 91 % in cellophane membrane and 88 % in egg membrane at 60 mins. The percentage buoyancy and swelling index of microbeads F1-F4 respectively 53-72% and 56-76%. The drug entrapment efficiency of the microbeads prepared from sodium alginate alone were found to be in the range of 52-71%.Experimental report revealed that Isoniazid loaded microbeads may act as ideal nano formulation with elaborated studies.


NEXUS BETWEEN MEDICAL HEALTHCARE PROFESSIONALS AND PHARMACEUTICAL COMPANIES : BOON OR BANE FOR PATIENTS

ABOUT AUHTORS
BALVINDER SINGH*1, PAWAN JALWAL 1, VIKASH KUMAR RUHIL 2
1Shri Baba Mastnath Institute of Pharmaceutical Sciences & Research,
Baba Mastnath University, Asthal Bohar, Rohtak, Haryana, India
2P.D.M. College of Pharmacy, P.D.M. University, Bahadurgarh, Haryana, India

*balvindersinghpharmaco@gmail.com

ABSTRACT
What started as imparting education to medical healthcare professionals, regarding pharmaceutical products by various pharmaceutical companies, has now become a grave, giant problem in the category of bribery and to be more precise, corruption in this 21st century. Now detailing of pharmaceutical company product has included giving free physician’s sample packs, prescription pads, pen and includes an entire range of latest electronic gazettes of mobile phones, laptops, tablets, AC, Refrigerator, LED TV, sponsoring a conference, refreshment to all expenses like return air ticket with free boarding and lodging in national or international tourist spot or hilly area. The real problem is that nothing comes free; all these expenses will add to cost of medicines and medical fraternity will heed least to quality of medicine. Now the market is flooded with abundant, spurious, sub-standard medicines; as pharmaceutical companies have the confidence of selling these products by shelling huge, attractive offers/gifts to some of greedy doctors, who fall prey to their lucrative offers. In this article, the aim is to probe this association or rather; we can call nexus between the medical healthcare professionals and various pharmaceutical companies. Various aspects are covered in this article, like….How this association works? What is the modus operandi and rationale of this association? Various angles of this association; from medical healthcare professionals, medical councils, pharmaceutical companies and society point of views are covered.


PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY STUDY OF SYZYGIUM CUMINI (MYRTACEAE) SEED EXTRACTS

ABOUT AUHTORS
Abdul Aziz*, Sabyasachi Banerjee
Department of Pharmaceutics, Gupta College of Technological Sciences,
Ashram More, G.T. Road, Asansol 713301, West Bengal, India

*abdulaziz_94@rediffmail.com

ABSTRACT
Syzygium cumini is commonly known as jamun, jambolan, Java plum or black plum, is an evergreen tropical tree in the flowering plant from family Myrtaceae, and is one of the most popular fruits. It is planted in various regions spontaneous. It is native of India, Bangladesh, Sri Lanka, Myanmar, Nepal, China, Australia, Thailand, Kenya, Colombia, Mexico, United States of America, Zambia, and Zimbabwe. The entire part of the plants has been widely used in the treatment of various diseases in the traditional and folk medicine. The edible part of fruits (jamun) contain vitamin C, gallic acid, tannins, anthocyanins, includes cyanidin, petunidin, malvidinglucoside and other components. The seeds of Syzygium cumini possess anti-diabetic, antipyretic, anti-inflammatory, hypolipidaemic, psychopharmacological, anti-diarrheal, antioxidant and antibacterial activities.


A NEW TYPES OF POLYMORPHIC FORM OF 10-PROPARGYL-10-DEAZAAMINOPTERIN, FROM SL: AS A REFRACTORY PERIPHERAL T-CELL LYMPHOMA DRUG

ABOUT AUHTORS
J. Y MANURE *, N. S NAIKWADE, P. J SHIROTE, S.A BAGWAN AND K. M KULKARNI
Department of Pharmaceutical Chemistry,
Appasaheb Birnale College of Pharmacy,
South Shivaji Nagar, Sangli- 416416, Maharashtra, India.

*javeedmanure.98600@yahoo.com

ABSTRACT 
A new crystal form of 10-Propargyl-10-Deazaaminopterin, form SL, was discovered which is thermodynamically stable, shows long term stability and is applicable for using in final dosage forms. Form SL was characterized by several analytical methods such as thermal analysis by DSC, IR, X-ray powder diffraction, SEM (Scanning Electron Microscopy), Digital optical microscopy and solubility/dissolution measurements. Active pharmaceutical ingredients should be stable during technological processes for the preparation of a final dosage form and must also remain stable during storage. The morphology of long needle and plate shaped crystals was investigated by scanning electron microscopy (SEM) and optical microscopy. Form SL was compared to other forms of 10-Propargyl-10-Deazaaminopterin such as form A, B, C and to the amorphous form. The thermodynamic stability of form SL is supported by its long-term stability. Form SL is a pharmaceutically applicable crystal form.


EVALUTION OF IN VITRO ANTI-OXIDANT ACTIVITY AND PHYTOCHEMICAL STUDIES CARRIED OUT FOR MELIA AZEDARACH LEAF EXTRACTS

ABOUT AUHTORS
Lagu surendra babu*, Prof. Y. Rajendra Prasad, D. Geetha mounika
Department of Pharmaceutical chemistry,
AU college of Pharmaceutical Sciences,
Andhra University, Visakhapatnam, AP, India

*ysbabu033@gmail.com

ABSTRACT:
Investigation of phytochemical and biological activities was performed by Antioxidant (DPPH, H2O2, Nitric oxide) free radical scavenging methods against three gradient polarity solvents extracts of leaves of Melia azaradach Linn with different concentraions. MA species of three different assay (DPPH, H2O2, Nitric oxide) of anti-oxidant activity were showed to be IC50 values of 20.14, 35.98, 36.43 with methanolic extract of leaves were have higher concentration possess more antioxidant potential than MALEoC IC50 42.85, 54.18, 30.56 and MALEoH IC50 values of 44.68, 52.71, 48.05 when compare to reference standard ascorbic acid IC50 values of 17.87, 18.91, 25.83. They exhibited strong antioxidant DPPH, H2O2, Nitric oxide radical scavenging activities with IC50 value reference ascorbic acid, MALoME, MALoCE and MALoHE respectively. Phytoconstituents like carbohydrates, flavonoids, proteins, saponins and tannins etc. An antioxidant activity of methanol extract could be due to the presence of flavonoids and phenols The results suggest that methanol and chloroform extracts from leaf melia azedarach tree have strong antioxidant potential.


NIOSOMES AS NOVEL DRUG DELIVERY SYSTEM : REVIEW ARTICLE

  • Posted on: 11 January 2018
  • By: admin

ABOUT AUHTORS
Devender Sharma1, Aashiya Aara E. Ali2, Jayshree R. Aate1
1Hi-Tech College of pharmacy, Chandrapur, Maharashtra (India)
2Kamla Nehru College of pharmacy, Nagpur (India)
*sdevender350@gmail.com

ABSTRACT
Niosome are non-ionic surfactant vesicles obtained by hydrating mixture of cholesterol and nonionic surfactants. It can be used as carriers of amphiphilic and lipophilic drug. In niosomes drug delivery system, the medication is encapsulated in a vesicle. Niosomes are biodegradable, biocompatible non-immunogenic and exhibit flexibility in their structural characterization. The main object of this review the application of niosome technology is used to treat a number of diseases, niosome have good oppurnity in research and beneficial for researcher and pharma industries.  Niosome appears to be a well preferred drug delivery system over liposome as niosome being stable and economic. Also niosomes have great drug delivery potential for targeted delivery of anti-cancer, anti-infective agents. Drug delivery potential of niosome can enhances by using novel drug delivery concepts like proniosomes, discomes and aspasome. Niosomes also serve better aid in diagnostic imaging and as a vaccine adjuvant. Thus these areas need further exploration and research so as to bring out or to make for commercially available niosomal preparation.


EFFECT OF TERMENALIA CATAPPA LEAF EXTRACT ON CAFETERIA INDUCED OBESITY IN RATS

ABOUT AUHTORS
Sridatha. P*, Subbareddy.P, Sowjanya.K, Sudheer. A
Department of Pharmacology
Raghavendra Institute of Pharmaceutical Education & Research (RIPER),
Anantapuramu, Andhra Pradesh, India.

*puranamdatha@gmail.com

ABSTRACT :
Obesity is a leading cause of death worldwide, with increasing rates in adults and children.  To investigate anti-obesity effect of Termenalia catappa leaf extract on cafeteria induced obesity in rats. For anti-obesity experiment, animals were divided into five groups of six animals and housed in cages. Normal control group continued to be fed a laboratory pellet chow ad libitum. Cafeteria diet-control group received cafeteria diet in addition to the normal pellet diet. The remaining three groups were fed with cafeteria diet and NPD along with T. catappa leaf extract (200 mg/kg, p.o.), Termenalia catappa leaf extract (400 mg/kg, p.o.) and orlistat (30 mg/kg, p.o.). Treatment was continued for 4 weeks. Animals and various adipose pads were weighed and serum total cholesterol, triglyceride, LDL, VLDL and HDL-C were measured after 4 weeks of treatment. At the end various adipose tissues, aorta were removed and processed for Histopathological study.  The Termenalia catappa leaf extract -treated groups showed a significant decrease in body weight, and various adipose pad weight and serum TC, TG, LDL, VLDL and increase in HDL levels after 4 weeks treatment and decrease in the adipose tissue size and adipocyte number.  At present study, Termenalia catappa leaf extract can inhibit the development of obesity and hyperlipidemia on cafeteria induced obesity in rat. It is because of various phytoconstituents of leaf extract. But further studies are still waiting for establishing mechanism and isolation of phytoconstituents. By observing above results Termenalia catappa leaf extract can act as adjuvant in obesity treatment.


PHYTOCHEMICAL SCREENING AND ALBUMIN INDUCED ANTI-INFLAMMATORY ACTIVITY OF PENTAS LANCEOLATA LEAVES.

ABOUT AUHTORS
Priyanka. Kura, Ashwini. Patlolla, Alluri. Ramesh, Vishwanadham. Y*
Department of Medicinal Chemistry Research Division,
Vishnu Institute of Pharmaceutical Education and Research (VIPER),
Narsapur, Medak, Telangana, India

*vishwanadham.y@gmail.com

ABSTRACT:
The anti-inflammatory drug activity of petroleum ether (Pet.ether) extract of leaves pentas lanceolata was investigated in rats exploitation egg albumen induced paw oedema model. Experimental animals received 20-25 gms (orally) of the extracts five groups divided., control group (saline), test group 50, 100, 200 mg/ kg the standard group received 15 mg/ kg of diclofenac. The results show that the extracts considerably (p <0.05) reduced paw oedema within the albumen induced anti-inflammatory drug activity.

The leaf extract of pentas lanceolata reduced inflamed hind paw diameter of mice by between 0.98%- 3.99% The diclofenac reduced inflamed hind paw diameter by between 1.12%-4.02%. The qualitative phytochemical screening indicated the presence of saponins, flavonoid, alkaloids, terpenoids and cardiac glycosides. The current study establishes potent antiinflammatory activities of pet ether extracts of pentas lanceolata leaves.


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