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ABSORPTION CORRECTION SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF TORSEMIDE AND AMILORIDE HYDROCHLORIDE IN THEIR COMBINED DOSAGE FORM
Dilip G. Maheshwari, Rujuta D. Patel*
Department of Quality Assurance,
L.J. Institute of Pharmacy, Sarkhej, Ahemdabad, Gujarat, India
A new sensitive, simple, rapid and precise spectrophotometric method has been developed for simultaneous estimation of Torsemide and Amiloride HCl in pharmaceutical dosage form. This method was based on UV spectrophotometric determination of two drugs, using absorbance correction method. It involves measurement of absorbances at two wavelengths 288nm(λmax of Torsemide (TOR)) and 361nm (λmax of Amiloride HCl (AMI)) in methanol for the simultaneous quantitative determination of Torsemide and Amiloride HCl in the binary mixture without previous separation. The linearity was observed in the concentration range of 5 -25 μg/ml for Torsemide and 5-25 μg/ml for Amiloride HCl. The accuracy and precision of the method was determined and validated statically. The method showed good reproducibility and recovery with % RSD less than 2. Method was found to be rapid, specific, precise and accurate, can be successfully applied for the routine analysis of Torsemide and Amiloride HCl in combined dosage form without any interference by the excipients. The method was validated according to ICH guidelines.
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DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF BROMHEXINE HYDROCHLORIDE AND PHENYLEPHRINE HYDROCHLORIDE IN THEIR COMBINED PHARMACEUTICAL DOSAGE FORM
Dharmesh R. Mevada*, Krutika Bhalodiya, Brijesh Maniar, Ketan Dadhania, Shital Faldu
Department of Quality Assurance,
Smt. R. D. Gardi B. Pharmacy College,
Rajkot, Gujarat, India
UV Spectrophotometric method has been developed for simultaneous estimation of Bromhexine HCl (BHX) and Phenylephrine HCl (PLE) in bulk drug and in their combined Pharmaceutical dosage form by first order derivative. This method utilizes methanol as a common solvent and λmax of BHX and PLE selected for analysis was found to be at 241 nm (at ZCP of PLE) and 233 nm (at ZCP of BHX) respectively. Linearity was observed in the concentration range of 5-30 μg/ml for BHX (r2 = 0.999) and 10-60 μg/ml for PLE (r2 = 0.998). The accuracy and precision were determined and found to comply with ICH guidelines. This method showes good reproducibility and recovery with % RSD in the desired range. Developed method was applied for marketed formulation. The results were found to be within acceptance criteria according to ICH guideline. This method was simple, rapid, accurate, Precise and sensitive.
Soranus was a Greek physician from Ephesus in 1st and 2nd century. He practiced in Alexandria and subsequently in Rome, and was one of the chief representatives of the Methodic school of medicine. Several of his writings still survive most notably his four-volume treatise on gynaecology and a Latin translation of his on acute and chronic diseases. He belonged to the Methodic School and was one of the most eminent physicians of that school. Little else is known about his life, except that he passed some time in Aquitania for the purpose of treating some skin diseases which were very prevalent there at the time. His treatise Gynaecology is extant also extant are parts of treatises on Signs of Fractures and on Bandages. Of his most important work (On Acute and Chronic Diseases) only a few fragments in Greek remain, but we possess a complete Latin translation by Caelius Aurelianus (5th century). Besides these works, Soranus was the author of sever al others, of which only the titles and some fragments have been preserved. Soranus himself refers to many additional works which have not survived. Gynecology contains many remarkable contributions that might have been written today. Our Corporate Group is associated with other business like leading Broking House of India, having vast exposure to Pharmaceutical Distribution since last 25 years along with chains of Retail Medical Stores and Infrastructure. Our basic philosophy is to create care with lot of values.
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