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DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR SIMULTANEOUS ESTIMATION OF LAMOTRIGINE AND CLOZAPINE IN SYNTHETIC MIXTURE BY ABSORPTION CORRECTION METHOD
Priyanka P. Atodariya*, Hasumati A. Raj, Vineet C. Jain
*Shree Dhanvantary Pharmacy Collage, Kim,
Surat, Gujarat, India
The simple spectroscopic method has been developed for simultaneous estimation of Lamotrigine and Clozapine in synthetic mixture. Absorption Correction Method involves the measurement of absorption at two wavelengths 307 nm (lmaxfor Lamotrigine) and 360 nm (lmax for Clozapine). The method was found linear between the range of 1-5 µg/ml for Lamotrigine and 6-30 µg/ml for Clozapine for method .The accuracy and precision was determined and validated statistically. Both the method showed good reproducibility and recovery with %RSD less than 1. The method was found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis for Lamotrigine and Clozapine in bulk and combined dosage form.
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SIMULTANEOUS DETERMINATION OF ITOPRIDE HYDROCHLORIDE AND LANSOPRAZOLE IN SYNTHETIC MIXTURE USING SPECTROPHOTOMETRIC TECHNIQUE (FIRST ORDER DERIVATIVE METHOD
*Ashif I. Bhim1, Farhana V. Buchiy1, Hasumati A. Raj1, Vineet C. Jain2
1Department of Qaulity Assurane, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
2Department of Pharmacognocy, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India.
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Itopride Hydrochloride and Lansoprazole in synthetic mixture using first order derivative zero-crossing method. Itopride Hydrochlorideshowed zero crossing point at 278.12nmwhile Lansoprazole showed zero crossing point at 244.58nm. The dA/dλ was measured at 244.12 nm for Itopride Hydrochloride and 278.12nmfor Lansoprazole and calibration curves were plotted as dA/dλ versus concentration, respectively. The method was found to be linear (r2>0.999) in the range of 5-25μg/ml for Itopride Hydrochloride at 244.58nm. The linear correlation was obtained (r2>0.996) in the range of 5-25 μg/ml for Lansoprazole at 278.12 nm. The limit of determination was 0.155μg/ml and 0.059μg/ml forItopride Hydrochloride and Lansoprazole, respectively. The limit of quantification was 0.472μg/ml and 0.179μg/ml for Itopride Hydrochloride and Lansoprazolerespectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99% shows first order derivation zero crossing. The method was successfully applied for simultaneous determination of Itopride Hydrochloride and Lansoprazolein binary mixture.
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Post: Quality Assurance / Regulatory Affairs
DEVELOPMENT AND VALIDATION OF ANALYTICAL METHODS FOR SIMULTANEOUS ESTIMATION OF AMITRIPTYLINE HYDROCHLORIDE AND METHYLCOBALAMIN IN THEIR TABLET DOSAGE FORM BY UV SPECTROPHOTOMETRIC METHOD
Chetna V. Karchaliya*, Parula B. Patel
Department of Quality Assurance,
S. J. Thakkar Pharmacy College,
Rajkot, Gujarat, India
The simple, accurate and precise Absorption Correction Method has been developed for the simultaneous estimation of Amitriptyline hydrochloride and Methylcobalamin in combined tablet dosage form. The method utilizes distilled water as solvent and λmax of Amitriptyline hydrochloride and Methylcobalamin selected for analysis were found to be 239 nm and 351 nm respectively. The method was validated as per International Conference on Harmonization (ICH) guidelines. The Linearity range lies between 20-60 µg/ml (R2 0.9998) for Amitrityline hydrochloride and 3-9 µg/ml (R2 0.9990) for methylcobalamin. The accuracy and precision were determined and found to comply with ICH guidelines. The method showed good reproducibility and recovery with %RSD in desired range. The proposed method can be applied for routine analysis of both drugs.
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A Walk in Interview to fill up the various posts on Adhoc Contractual basis in different SFIs of Gujarat Ayurved University, Jamnagar has been fixed on 31.03.2015 at the above stated address.
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ABSORBANCE CORRECTION METHOD FOR SIMULTANEOUS ESTIMATION OF AMLODIPINE BESYLATE AND SIMVASTATIN IN SYNTHETIC MIXTURE
Vandana M Patel*, Hasumati A Raj, Vineet C Jain
*Shree Dhanvantary College of Pharmacy,
Kim, Surat, Gujarat, India.
A simple, accurate and precise spectroscopic method was developed for simultaneous estimation of Amlodipine besylate and Simvastatin in synthetic mixture using Absorbance correction method. At 360.80 nm (λmax of Amlodipine besylate) Simvastatin has zero absorbance so Amlodipine besylate is directly estimate at 360.80 nm. At 237.60 nm (λmax of Simvastatin) both drugs have some absorbance so Simvastatin is estimate at 237.60 nm using absorbance correction method. The method was found to be linear (r2>0.999) in the range of 5-10 μg/ml for Amlodipine besylate at 360.80 nm. The linear correlation was obtained (r2>0.999) in the range of 5-10 μg/ml for Simvastatin at 237.60 nm. The limit of determination was 0.17 μg/ml and 0.10μg/ml for Amlodipine besylate and Simvastatin, respectively. The limit of quantification was 0. 54μg/ml and 0. 32μg/ml for Amlodipine besylate and Simvastatin, respectively. The accuracy of these method were evaluated by recovery studies and good recovery result were obtained greater than 99%. The method was successfully applied for simultaneous determination of Amlodipine besylate and Simvastatin in binary mixture.
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Anand Pharmacy College is one of the leading institute of Gujarat, established in 1998 by Shri Ramkrishna Seva Mandal. The institute is con-ducting All India Council for Technical Education (AICTE), New Delhi approved courses since 1998. The institute is accredited by NAAC-UGC with CGPA 2.68 and National Board of Accreditation (B.Pharm). Anand Pharmacy College offers B.Pharm, M.Pharm in Pharmaceutics, Pharmacology, Quality Assurance, Industrial Pharmacy, Pharmaceutical Technology & Pharmaceutical Quality Assurance and Ph.D. courses.