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IN SILICO DESIGN AND COMPUTATIONAL STUDY OF NOVEL 1, 3, 4-THIADIAZOLE DERIVATIVES AS POTENTIAL AFFINITY WITH NA/H EXCHANGER RECEPTOR FOR ANTICONVULSANT ACTIVITY
Vinit Raj*, Amit Rai, Jitendra Kumar Rawat
Department of Pharmaceutical Sciences,
Babasaheb Bhimrao Ambedkar University (A Central University),
Vidya Vihar, Raebreli Road, Lucknow-226025 (U.P.), India
A series of novel 1, 3, 4-thiadiazole derivatives were designed keeping in view the structural requirement of pharmacophore and Quantitative structure activity relationship (QSAR) and evaluated in silico anticonvulsant activity. Docking procedures allow virtually screening a database of compounds and predict the strongest binder based on various scoring functions. In the docking study, the most active compounds of the series were, VR 2, VR 3 and VR 4 exhibited good binding properties. Result reveals that the protein-ligand interaction energy of derivatives VR 2, VR 3 and VR 4 were -7.08 kcal/mol, -6.64 kcal/mol and -7.42 kcal/mol respectively, which is slightly higher than the standard anticonvulsant phenytoin drug as -6.03 kcal/mol, so that the derivatives have satisfactory affinity with established convulsant receptor namely Na/H exchanger. A computational study was also carried out including prediction of pharmacokinetic properties, toxicity and bioactivity studies. The percentage of absorption (%ABS) was calculatedand observed that all titled compounds exhibited a better %ABS ranging 92.66, 85.81, 90.07 and 86.98, respectively and compared than standard Phenytoin drug as %ABS 88.92. Although VR 1 had slightly lesser protein affinity, its other pharmacological parameters were same like other screened compounds. The above observation suggested that these compounds would serve as better lead compound for anticonvulsant screening for future drug design perspective.
Global Institute of Regulatory Affairs provides Industry Oriented Courses in Regulatory Affairs (RA), Quality Assurance & Quality Control (QA/QC) for Life Science Graduates with Placement Assisstance in Pharma Sector
Global Institute of Regulatory Affairs (GIRA) is a change that will help you begin & grow your career in Pharma Industry. GIRA through its industrial expertise offers quality educational programs in the field of Regulatory Affairs and QA/QC. It offers Full time, Part time and Distance Learning courses; this flexibility ensures prior commitments are taken care of and at the same time skills are added to their CVs.
Certifications: GIRA is an ISO Certified Institute as per the norms of ISO 9001:2008. It is Accredited by Joint Accreditation System of Australia & New Zealand (JAS-ANZ).
Distance Learning Courses Offered by GIRA:
* Post Graduate Program in Regulatory Affairs (PGDRA- 10 months)
* Certificate Course in e-CTD (4 months)
* Certificate Course in QA/QC (6 months)
Note: Fast Track mode also available for the above given courses.
* Completely Online (From Admission to Examination)
* Industry Accepted Course Curriculum & Certificate
* Experienced and Quality Faculty
* Online Examination (Exams from Home)
* Online Interaction (Discussion Forums, GIRA Blog)
* 100 % Placement Assistance & Career Guidance
Candidates Pursuing Courses from GIRA are associated with:
Emcure Pharmaceutical Ltd, Novartis Pharma, Dr Reddys Laboratories Ltd, Wockhardt Pharma, Cipla, Glenmark Pharmaceuticals, Himalaya Company, USV Limited, Mylan Labs, Glaxo Company, Macleods Pharma, Ranbaxy Pharma, Torrent Pharmaceuticals, TCS etc.. etc.. etc..
Innovation and Technology Transfer to Industries Role of Universities (10th and 11th March, 2014) at BBAU
The Babasaheb Bhimrao Ambedkar University, Lucknow is one of the youngest central universities in the country. The jurisdiction of this residential University is over the entire state of Uttar Pradesh. The campus Vidya Vihar is located off Rae Bareli Road, about 10 kms south of the Charbagh Railway Station, Lucknow. The objects of the University IS to promote advanced knowledge by providing instructional and research facilities in such branches of learning as it may deem fit.
Carrying forth the Apeejay Stya legacy of over 45 years of excellence in education
School of Pharmaceutical Sciences
Experience the International Edge...
· Established on the academic pattern of the lvy League universities of the USA
· Trans-disciplinary and Liberal Arts approach
· Strong industry linkages to facilitate training & placement
· Truly global campus with students from over 15 countries
Awards & Accolades
· Best Innovation by Private University at World Education Summit 2012
· No.1 in Innovative Teaching Techniques & No. 3 in Most Reputed Faculty as per TOI B-School Ratings 2013 (North Region)
· Mr. Aditya Berlia, Co-Founder & Pro-Chancellor, Apeejay Stya University, received the 'Outstanding Educational Entrepreneur' award at the World Education Congress Global Awards 2013.
· ASU has been conferred the 'CSR Excellence in Education Award 2013' by Competition Success Review (CSR) magazine in recognition of exceptional contribution made by institutions in their respective areas like education, scientific research, etc.
· E-Gov. Campus of Gurgaon District, Haryana (India) by the Ministry of Communications & Information Technology, in collaboration with the United Nations
· Best Engineering Institute in North India at National Education Awards 2013 by ET Now
PharmaTutor is mainly intended to promote rapid publication (original research articles, review articles, and Short communication) in all fields of Pharmaceutical, Health and allied biosciences. PharmaTutor will primarily publish the manuscripts on original work; either experimental or theoretical that adheres to scientific excellence pertaining to Pharmaceutical, Health and allied biosciences.
Publication of Vol 2 Issue 03 is scheduled in March 2014. We call upon the authors, researchers and colleagues to contribute the articles for upcoming issues (March 2014 & next issues).
You can read past issues online at any point of time on:
NOW YOU CAN ALSO PUBLISH YOUR ARTICLE ONLINE AND YOU WILL GET CERTIFICATE FOR SUBMISSION.
SUBMIT YOUR ARTICLE/PROJECT/SHORT COMMUNICATION ALONG WITH YOUR SCAN PHOTOGRAPH AND COPYRIGHT FORM AT email@example.com
NATIONAL WORKSHOP ON NANOMEDICINE Organised by- Integral University (Department of Biosciences), GBIOFIN & SERE India 7th-9th March, 2014
About Department of BioScience @ Integral University
Bioscience is the branch of the sciences concerned with living organisms, from microorganisms to towering trees and gigantic whales. Bioscience technology is a growing and dynamic field that applies life processes to practical uses, such as the manufacturing of medical devices and the development of new bioscience procedures. From pharmaceutical drugs to pacemakers, genetically engineered plants to gene therapy, bioscience technology is at work all around us.
AWARD OF DBT-JUNIOR RESEARCH FELLOWSHIP (DBT-JRF) IN BIOTECHNOLOGY at National Centre for Cell Science
Applications are invited from Indian nationals for the award of “DBT-Junior Research Fellowship” (DBT-JRF) for pursuing research in frontier areas of Biotechnology and Applied Biology. JRFs will be selected according to merit under two categories: Category I & II. Category I fellowship (Top 275 in number) are tenable in any University/Institute in India where the students can register for Ph.D. Category II students (100 in number) will be eligible to join any DBT sponsored Project and avail fellowship equivalent to NET/GATE qualifications as per DST Guidelines, subject to selection through institutional selection process. Fellowship will be co-terminus with the duration of project and institutional rules will be applicable. There will be no binding on PIs of DBT sponsored projects to select JRF/SRF for their projects from category II list. Selection in Category II will not entitle student for any fellowship from DBT-JRF programme.
Post: Junior Research Fellowship
The bill for the establishment of Jawaharlal Nehru University was placed in the Rajya Sabha on September 1, 1965 by the then Education Minister, Mr M.C. Chagla. During the discussion that followed, Hon. M.P. Mr. Bhushan Gupta voiced the opinion that this should not be yet another university. New faculties should be created, including scientific socialism, and one thing that this university should ensure was to keep noble ideas in mind and provide accessibility to students from weaker sections of society.
The CSIR and UGC provide CSIR/UGC Research Fellowship to bright young men and women for training in methods of research under expert guidance of faculty members/scientists working in University Departments/ National Laboratories and Institutions in various fields of Science & Technology. The CSIR/UGC fellowships are tenable in Universities/IITs/Post Graduate Colleges/Govt. Research Establishments including those of the CSIR, Academy of Scientific & Innovative Research (AcSIR), Research & Development establishments of recognized public or private sector industrial firms and other recognized institutions. However, CSIR reserves right to determine the place best suited to provide necessary facilities in the area of science and technology in which the awardees are to specialize. The CSIR/UGC Fellowship is tenable in India. Only bonafide Indian citizen residing in India are eligible for the award of Junior Research fellowships. The program is aimed at National Science & Technology Human Resource Development.
Post: Junior Research Fellowship And Eligibility for Lectureship
Central Institute of Medicinal and Aromatic Plants, popularly known as CIMAP, is a frontier plant research laboratory of Council of Scientific and Industrial Research (CSIR).