GPAT Paper, 2011 | Find out GPAT question Paper

Q.46    Larger values of Ky in the Heckel Plot indicate formation of what quality of tablets?
(A)   Harder tablets    (B)   Softer tablets
(C)   Fluffy tablets    (D)   Brittle tablets

Q.47    Which is NOT applicable to protein binding?
(A)   Klotz reciprocal plot    (B)   Sandberg modified equation
(C)   Blanchard equation    (D)   Detli plot

Q.48 According to USP, the speed regulating device of the dissolution apparatus should be capable of maintaining the speed within limits of what % of the selected speed?
(A)   1%    (B)   2%    (C)   4%    (D)   5%

Q.49    Which statement is NOT true for steam distillation?
(A)    It is also called differential distillation
(B)    It can be used for separation of immiscible liquids -
(C)    It can be applied for volatile substances
CD)   It can be used for separation of miscible liquids

Q.50    What is Primogel?
(A)    Substituted HPMC for direct compression
(B)    Modified microcrystalline cellulose for direct compression
(C)    Hydro gelling polymer for gel formation
(D)    Modified starch for disintegration

Q.51    Statement [P] : Soft gelatin capsules contain 12-15 % moisture.
Statement [QJ : Hard gelatin capsule shells contain 6-10 % moisture.
Choose the correct statement?
(A)    Both of the above statements P & Q are true
(B)    Both of the above statements P & Q are false
(C)    Statement P is true and Q is false
(D)    Statement P is false and Q is true

Q.52 A drug whose solubility is 1 g/L in water, when given orally at a dose of 500 mg is absorbed upto 95% of the administered dose. The drug belongs to which class according to the BCS classification?
(A)   Class I    (B)   Class II    (C)   Class III    (D)   Class IV

Q.53 The area of clear opening of any two successive sieves according to Tyler standard is in the ratio of,
(A)   1 : 4    (B)   1 : 6    (G)   1: √2    (D)   1: √3

Q.54 Iodine-131 as sodium iodide solution is used as a radiopharmaceutical for diagnostic and therapeutic purposes. Its usage is dependent on the release of the following emissions:
[P] Alpha particles       [Q] Positrons    [R] Beta emission        [S] Gamma radiation
Choose the correct combination of statements?
(A)   R&S    (B)   Q&S    (C)   P&R    (D)   P&S

Q.55 Alkenes show typical electrophilic addition reactions. If an electron withdrawing group is attached to one of the carbons bearing the double bond, what will happen to the mechanism of the addition reaction?
(A)   It remains electrophilic    (B)   It becomes free radical addition
(C)   It becomes pericyclic reaction    (D)   It becomes nucleophilic

Q.56 Five-membered heteroaromatic compounds show a much higher rate of electrophilic aromatic substitution reactions than the six-membered ones. This is due to which one of the following reasons?
(A)    Five-membered heteroaromatic compounds have higher circulating electron density in the ring than the six-membered ones
(B)    Five-membered heteroaromatic compounds have lower circulating electron density in the ring than the six-membered ones
(C)    Five-membered rings are smaller in size than the six membered ones which affects their reaction rates
(D)    Six membered heteroaromatic rings are flat while the five-membered ones are puckered

Q.57 Arrange the following Lowry-Bronsted acids into their decreasing order of acidity (highest to lowest)?
[P] C2H5OH    [Q] H3C-CsCH    [R] H20    [S] CH3NH2
(A)   R>P>Q>S    (B)   P>R>Q>S       (C)   P>Q>R>S    (D)   R>Q>P>S

Q.58 Aprotic polar solvents increase the rate of SN2 reactions manifold. Enhancement in the rate of such reactions is due to which one of the following effects?
(A)    Solvation of the anion by the solvent leaving the cation unaffected
(B)    Solvation of both of the ionic species
(C)    Desolvation of the cation and solvation of the anion
(D)    Solvation of the cation by the solvent leaving the anion unaffected

Q.59 In context of complexometry (complexometric titrations), the two terms labile and inert complexes, are used frequently. Choose the correct statement about them?
(A)    Labile complexes are formed instantly while inert complexes take hours or days in their formation
(B)    Labile complexes take much longer tine in formation than inert complexes
(C)    Labile complexes get hydrolyzed in water immediately while inert complexes are      stable in water
(D)    Labile complexes get decomposed on mild heating in aqueous solutions while inert complexes do not decompose

Q.60 In colorimetric estimation of a drug, the following sequence of reactions is carried out: treatment of the aqueous solution of the drug with sodium nitrite solution in acidic medium followed by addition of sulphamic acid and then treatment with N-(l-naphthyl)ethylene- diamine in slightly basic medium to obtain a pink colour; which is measured at a fixed wavelength to correlate the quantity of the drug with the optical density. Identify the drug under estimation?
(A)    Streptomycin sulphate    B    Thiamine hydrochloride
(C)    Dexamethasone    (D)   Sulphamethoxazole