Pharmaceutics Articles

A REVIEW ON THE PREPARATION METHODS OF CURCUMIN NANOPARTICLES

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ABOUT AUTHORS
S. Dhivya*, DR. A. N. Rajalakshmi
Department of Pharmaceutics, Mother Theresa Post Graduate and Research Institute of Health Sciences,  Gorimedu, Puducherry-605006, India.

ABSTRACT:
Design and development of herbal nanoparticles has become a frontier research in the nanoformulation arena. Curcumin is the main bioactive component contained in Curcuma longa, largely employed in traditional medicine. Recently, beneficial properties, useful for prevention and treatment of several disorders, have been discovered for this compound. Although curcumin has shown therapeutic efficacy against many human ailments, one of the major problems with curcumin is its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid systemic elimination. Therefore introduction of nanotechnology provides a solution towards increased bioavailability of curcumin. In this review, the various methods of preparation of curcumin nanoparticles are briefly discussed.

FORMULATION AND EVALUATION OF MICROENCAPSULATED GLIMEPIRIDE PRODUCED BY THE EMULSION - SOLVENT EVAPORATION METHOD

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P. S. Bhandare 1, V.G Gharge 2.
1*Department of Pharmacology,
GIPER, Satara, Maharashtra, India.
2 Department of Pharmaceutics,
GIPER, Satara
, Maharashtra, India.

ABSTRACT
"The objective of the present investigation was to formulate and evaluate microencapsulated  Glimepiride produced by the emulsion - solvent evaporation method. Microparticles were prepared using Eudragit RLPO by emulsion solvent evaporation and characterized for their micromeritic properties, encapsulation efficiency, particle size, In vitro release studies were performed in phosphate buffer (pH 7.4). The resulting microparticles obtained by solvent evaporation method were free flowinging nature. The mean particle size of microparticles ranges from 140.40 - 173.90 μm and encapsulation efficiency ranges from 90.46 – 93.09%. Eudragit RLPO microparticles containing Glimepiride could be prepared successfully by using an emulsion solvent evaporation technique, which will not only sustain the release of drug but also manage complicacy of the diabetes in a better manner.

GREEN TEA –AN ANTIOXIDANT MYSTIC HERB

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SUNIL JAIN*, HARVINDER POPLI, GEETA AGGARWAL, MADHU GUPTA
Dept. of Pharmaceutics, School of Pharmaceutical Sciences
Delhi Pharmaceutical Sciences and Research University,
New Delhi -110017

ABSTRACT
It is worldwide accepted that green tea have supernatural property to fight against chronic diseases such as cancer and many more. The presence of polyphenols in green tea is having such property to protect against severe disease and have antioxidant potential. The purpose of this review to explore the beneficial antioxidant potential of green tea with compilation of previously published literature. Green tea is produced from the leaves of the Camellia sinensis plant has provided to be the most popular beverages worldwide. Now people from 160 countries in the world are accustomed to tea drinking although the amount of green tea consumption in worldwide is less than other tea and coffee. Generally, green tea has been found to be superior to black tea in terms of health benefits due to their greater health benefits their demands and popularities are enhanced. The processes used in the manufacture of black tea are known to decrease levels of the monometric catechins to a much greater extent than the less severe conditions applied to other teas. Green tea is accounted for to contain a large number of bioactive fixings which are nearly contributed by polyphenols which assumes a key part of counteractive action and treatment of numerous infections and diseases. The major polyphenols in green tea are catechins, epicatechin (EC), epigallocatechin (EGC), epicatechin gallate (ECG) and epigallocatechin gallate (EGCG). Epigallocatechin gallate is viewed as the most significant active component. This review highlights chapter will highlight the antioxidant activities of green tea that is connected with the high cell reinforcement parts of green tea. This article shows the advantages of green tea for its calming, cancer prevention agent potential and oral human services. Despite the fact that the human clinical information is as yet constrained, this article demonstrates that green tea has its place in both the traditional and elective medicinal groups.

A REVIEW ON NOVEL APPROACHES FOR COLON TARGETED DRUG DELIVERY SYSTEMS

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Sumedha Saxena, Chandan Kumar Singh*, MukeshYadav, Alex Laurel Samson.
Department of Pharmacy, Dr. M.C. Saxena College of pharmacy, Lucknow, (U.P.)

*chandansingh.skic@gmail.com

ABSTRACT
This review mainly focus on targeted drug delivery to the colon is extremely desirable for local treatment of inflammatory bowel disease such as ulcerative colitis, crohn's disease, amoebiasis, colonic cancer as well as for systemic delivery of protein and peptide drugs. The colon is a site where local delivery allows topical treatment of inflammatory bowel disease and systemic delivery of drug can take place. Treatment of colon can be made effective if the drug can be targeted directly into the colon because drug release and absorption should not be take in abdomen and the small intestine and bioactive agents should not be degraded and to allow drug release into the colon. Drug targeting to the colonic area is not only associated with the treatment of colonic ailment locally but also delivering drugs such as protein and peptide for their systemic effects which are degraded and bioavailability is very depressed due to the instability in the GI Tract.

ORODISPERSIBLE LIQUISOLID COMPACTS: A NOVEL APPROACH TO ENHANCE SOLUBILITY AND BIOAVAILABILITY

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ABOUT AUTHORS
VINOTH KUMAR P 1,
*RAJALAKSHMI A.N.1, STEPHEN P2
1Department of Pharmaceutics, College Oof Pharmacy, Mother Theresa Postgraduate And Research Institute of Health Sciences, Puducherry-6, India
1 Department of Pharmaceutics, College of Pharmacy, Mother Theresa Postgraduate And Research Institute of Health Sciences, Puducherry-6
, India
2 Formulation Research and Development, Sai Mirra Innopharm Pvt Ltd., Chennai, India

*ocusertraji@gmail.com

ABSTRACT:
Orodispersible liquisolid system is the combination of liquisolid technique and orodispersible system. The poor dissolution rate of water insoluble drug is a major drawback for the development of pharmaceutical dosage forms. The oral absorption of drug is most often controlled by dissolution in the gastrointestinal tract. Liquisolid system has been used to enhance dissolution rate of poorly water-soluble drugs. Orodispersible tablets are given in order to provide fast action by disperse in the mouth, without the need of water and make them compliance for paediatric and geriatric patients and to bypass the liver metabolism.

FORMULATION AND EVALUATION OF FLUCONAZOLE GEL BY USING SYNTHETIC POLYMER

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Sachin G. Dhandore*1,
Kalyani B.Wagh2
1 Department of Pharmaceutics,
Shivnagar Vidya Prasarak Mandal’s College of Pharmacy,
Malegaon(Bk), Baramati, Pune Maharashtra, India
2 Jalna Education Society’s Institute of Pharmacy,
J.E.S. College Campus, Jalna Maharashtra, India

*sachindhandore5@gmail.com

ABSTRACT
Fluconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Fluconazole is not much recomanded as it has many side effects. Thus these formulations are made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by using the synthetic polymer like carbapol 934 and HPMC by changing the polymer ratio. Gel formulations were characterized for drug content, pH determination, viscosity measurement, in-vitro diffusion. Among the six formulations F2 was selected as the best formulation as its %CDR after four and half hour was 99.01%. The viscosity of the F2 formulation was within the limit. Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin and reduced side effects associated with conventional treatment.

FORMULATION AND EVALUATION OF PHARMACEUTICAL AQUEOUS GEL OF POWDERED GUAVA LEAVES FOR MOUTH ULCER TREATMENT

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ABOUT AUTHORS
Sabir Shaikh*1, Amol Shete2, Rajendra Doijad3
1S. Kant Health care R&D Centre, 
Turbhe, Navi Mumbai, Maharashtra-400705.
2Department of pharmaceutics,
Krishna institute of Pharmacy
Krishna institute medical sciences Deemed university, Karad. MS, India
3Department of Pharmaceutics and Quality Assurance,
Shree Santkrupa College of Pharmacy Ghogaon, Karad, MS, India

*sabirmshaikh17@gmail.com

ABSTRACT:
The objectives of present investigation were to formulate and evaluate herbal gel for mouth ulcer treatment of dried powdered guava leaves.
Herbal gel was prepared by using different concentration of powdered guava leaves and Carbopol 934, Propylene glycol as a gel base. Formulations were evaluated for various parameters
Infrared spectroscopy revealed that there was no interaction between powdered Guava leaves and Polymer. The formulated gel was transparent, homogeneous and pH ranges from 7 to 7.5. Formulation showed acceptable rheological behaviour with applicable Spreadability and Extrudability properties. Anti-fungal studies of formulations showed excellent efficacy against Aspargiliousaureus, Candida albicans.
From the experimental evidence of invitro studies it was observed that powdered guava leaves contain flavonoids so it showed significant antioxidant effect.
Developed herbal formulation was stable, safe and effective over to synthetic formulations for the treatment of mouth ulcer.

PREPARATION AND EVALUATION OF ISONIAZID MICROBEADS BY USING DIFFERENT MEMBRANE

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Narinder Singh*, Raminder kaur
Department of Pharmaceutics
CT institute of Pharmaceutical Sciences,
Jalandhar, Punjab, India

*Pharmacist.narinder@gmail.com

ABSTRACT
Current experimental investigation is dedicated to formulated alginate floating microbeads of Isoniazid as a model drug by ion cross-linking method or ion gelation technique using calcium chloride as cross-linking agent. Drug effectiveness might be influenced by blood plasma protein binding. The less bound drug is more viable it can cross cell membrane and diffuse. Protein binding can impact the drug’s biological half-life in the body. Isoniazid was first generation antibiotic which are used for the resistance is an obstacle to the treatment of tuberculosis disease and latent tuberculosis infection. The permeability of Isoniazid study using different membrane (Egg membrane and cellophane membrane). The IN VITRO drug release studies showed the optimized formulation of drug release 91 % in cellophane membrane and 88 % in egg membrane at 60 mins. The percentage buoyancy and swelling index of microbeads F1-F4 respectively 53-72% and 56-76%. The drug entrapment efficiency of the microbeads prepared from sodium alginate alone were found to be in the range of 52-71%.Experimental report revealed that Isoniazid loaded microbeads may act as ideal nano formulation with elaborated studies.

PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY STUDY OF SYZYGIUM CUMINI (MYRTACEAE) SEED EXTRACTS

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Abdul Aziz*, Sabyasachi Banerjee
Department of Pharmaceutics, Gupta College of Technological Sciences,
Ashram More, G.T. Road, Asansol 713301, West Bengal, India

*abdulaziz_94@rediffmail.com

ABSTRACT
Syzygium cumini is commonly known as jamun, jambolan, Java plum or black plum, is an evergreen tropical tree in the flowering plant from family Myrtaceae, and is one of the most popular fruits. It is planted in various regions spontaneous. It is native of India, Bangladesh, Sri Lanka, Myanmar, Nepal, China, Australia, Thailand, Kenya, Colombia, Mexico, United States of America, Zambia, and Zimbabwe. The entire part of the plants has been widely used in the treatment of various diseases in the traditional and folk medicine. The edible part of fruits (jamun) contain vitamin C, gallic acid, tannins, anthocyanins, includes cyanidin, petunidin, malvidinglucoside and other components. The seeds of Syzygium cumini possess anti-diabetic, antipyretic, anti-inflammatory, hypolipidaemic, psychopharmacological, anti-diarrheal, antioxidant and antibacterial activities.
In this present study, the phytochemical investigation and antibacterial activity studies were carried out with using methanol, petroleum ether and ethanol extracts of the seeds of Syzygium cumini from the family Myrtaceae. Preliminary the phytochemical screening of all extracts revealed the presence of phytoconstituents like alkaloids, tannins, saponins, flavonoids, phenols, terpenoids, steroids and amino acids and absence of anthraquinone glycosides. The antibacterial activity of all three extracts was tested against some pathogenic bacteria using the Cup-Plate method. The different extracts of Syzygium cumini seeds showed inhibitory activity over Gram negative bacteria such as Salmonella typhi and Escherichia coli and Gram positive bacteria such as Bacillus subtilis and Staphylococcus aureus. The results showed that the methanolic extract was slightly more potent than the other two.

FORMULATION, EVALUATION AND VALIDATION OF ORALLY DISINTEGRATING RIZATRIPTAN BENZOATE TABLET

ABOUT AUTHOR
Ms. Sapna
Department of Pharmaceutical Sciences
Himalayan Institute of Pharmacy and Research Rajawala, Dehradun, Uttarakhand, India
*bhandarisapna747@gmail.com

ABSTRACT: The present investigation deals with development of orally disintegrating tablets of Rizatriptan Benzoate to produce the intended benefits. Orally disintegrating tablets of Rizatriptan Benzoate were prepared by wet granulation method to provide faster relief from pain to migraine sufferers. Formulation research is oriented towards safety, efficacy and quick onset of action of existing drug molecule through novel concept of drug delivery. About four formulations for the present study were carried out full factorial design. Kyron 314 was used as super disintegrants, while microcrystalline cellulose and mannitol was used as diluents. Starch was used as binder. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, drug content and in-vitro dissolution studies. The optimized formulation dispersed in within 15 seconds. It also showed a higher water absorption ratio and 99.67% of drug is released within a minute.

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