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Formulation and Evaluation of Fluconazole Gel by using Synthetic Polymer


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April 2018 ARTICLE LIST >>

PharmaTutor (April - 2018)


ISSN: 2347 - 7881
(Volume 6, Issue 4)


Received On: 30/01/2018; Accepted On: 19/02/2018; Published On: 01/04/2018


Sachin G. Dhandore*1 , Kalyani B.Wagh2
1Department of Pharmaceutics,
Shivnagar Vidya Prasarak Mandal’s College of Pharmacy,
Malegaon(Bk), Pune, Maharashtra, India
2 Jalna Education Society’s Institute of Pharmacy,
J.E.S. College Campus, Jalna, Maharashtra, India



Fluconazole is an imidazole derivative and used for the treatment of local and systemic fungal infection. The oral use of Fluconazole is not much recommended as it has many side effects. Thus these formulations are made for better patient compliance and to reduce the dose of drug and to avoid the side effects like liver damage and kidney damage. The gel was formulated by using the synthetic polymer like carbapol 934 and HPMC by changing the polymer ratio. Gel formulations were characterized for drug content, pH determination, viscosity measurement, in-vitro diffusion. Among the six formulations F2 was selected as the best formulation as its %CDR after four and half hour was 99.01%. The viscosity of the F2 formulation was within the limit. Efficient delivery of drug to skin application was found to be highly beneficial in localizing the drug to desired site in the skin and reduced side effects associated with conventional treatment.



How to cite this article: Dhandore SG, Wagh KB; Formulation and Evaluation of Fluconazole Gel by using Synthetic Polymer; PharmaTutor; 2018; 6(4); 27-31;