Articles

ANTIMICROBIAL ACTIVITY OF GREEN TEA: A COMPARATIVE STUDY WITH DIFFERENT GREEN TEA EXTRACT

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Nabadoy Roy*, Suprodip Mandal, Beduin Mahanti, Sandipan Dasgupta*
Division of Pharmacology, Department of Pharmacy,
Bharat Technology, Uluberia, Howrah 711316,
*n.roy.santoshpur@gmail.com

ABSTRACT
Objective:  The aim of this present study is to evaluate the activity of green tea extracted in different solvents on different microorganism such as on Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8739, Salmonella abony NCTC 6017, Pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 10231, Esteritia coli mutant NCIM 2567, Bacillus subtilis ATCC 6633 &Lactobacillus lichmani ATCC 7830.
Method:  Zone of inhibition of aqueous, methanolic and ethanolic extracts were measured and compared by using cup plate method. 5µg, 10µg, 15µg & 20µg concentration of the extract were used. MIC (Minimum inhibitory concentration)& MBC (Minimum bactericidal concentration ) were observed with the concentrations of 100µg, 75µg, 50µg & 25µg.

Result: Result of zone of inhibition shows that aquous extract at the concentration of 20µg/ml is most effective to inhibit Escherichia coli growth compare to standard.Also minimum inhibitory concentration (MIC) & minimum bactericidal concentration (MBC) result suggest that aquous extract is more effective than ethanolic and methanolic extract to inhibit the growth of both Escherichia coli &Escherichia coli mutant.
Conclusion: Significant antimicrobial activity has been shown by all extracts against Escherichia coli but other microorganism inhibition is not so significant compare to Escherichia coli. Methanolic and ethanolic extract has shown little antimicrobial activity against all microorganisms as compared to the aqueous extract.

OPTIMIZATION AND EVALUATION OF IBUPROFEN TABLETS BY MADG METHOD

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Devender Sharma1*, Ameya Lanjewar2
1Department of Pharmaceutics, Hi-Tech College of Pharmacy, Chandrapur India
2Department of Pharmaceutics, Kamala Nehru College of Pharmacy, Butibori Nagpur India

*sdevender350@gmail.com

ABSTRACT
Ibuprofen largely used in various disorders  treatment likely to be  rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders, especially where pain is more prominent than inflammation. Ibuprofen is used as a simple analgesic, antipyretic and it is particularly effective in dysmenorrheal. By the process of Moisture activated dry granulation, Ibuprofen tablets prepared but these method prepared tablets do not give better drug content, drug release. So formulation optimize by full factorial i.e. change in various polymer concentration like SSG and Povidone at three different levels. Ibuprofen tablets manufactured by moisture activated dry granulation method with optimization show better drug release, drug stability in comparison of marketed preparation. Due to optimization, Ibuprofen tablets which manufactured by moisture activated dry granulation method have very low cost in comparison of marketed preparation. The main objective of this research work water poorly soluble drug like ibuprofen tablet manufactured by moisture activated dry granulation by optimize process gives better drug release, manufacture cost also less other than marketed tablets.

AN UPDATED OVERVIEW ON PHARMACOGNOSTICAL AND PHARMACOLOGICAL SCREENING OF TECOMA STANS

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
K.GOPALASATHEESKUMAR1*, T.BOOPATHI1
1KMCH college of Pharmacy, Kovai Estate,
Kalapatti Road, Coimbatore-641048, Tamil Nadu, India
gskpungai@gmail.com

ABSTRACT
The using of natural plants in treatment purposes are the nowadays most familiar than synthetic products because synthetic drugs can cause many of the side effects and the adverse effect. The Tecoma stansare one of the plants which are available in most of the tropical countries. In this plant is already used in the traditional medicine in some of the countries like India, Pakistan, etc., this plant belongs to the family of Bignoniaceae. This plant is having the many of the active chemical constituents and pharmacological effects. Many of the researchers are studied the pharmacological screening and the current research is going in that plant. The aim of this review was the updated research collections of this plant for its pharmacological screening. The review the  on various researchers like pharmacognostical study and the in vitro and in vivo screening of various parts of Tecoma stans.In this review was concluded that the various parts of the plants are having various pharmacological actions like anti-inflammatory, analgesic, anticancer cardio-protective effect, genotoxic, cytotoxicity, wound healing, anti‐hyperglycemic, protect CNS, gastric ulcer healing, antiproliferative, antioxidant, anti-microbial, hemolytic activity, anti-lipoxygenase and acetyl-cholinesterase inhibitory activities. And this review was used to develop the future research on this plant.

IS THE CHEMOTHERAPY REALLY NECESSARY FOR SOLID TUMORS?

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
Dr. Vishwas B. Chavan
Aditya Jyot Hospital & Foundation
vishwaschavan2003@yahoo.co.in

Cancer is a leading cause of morbidity and mortality in the world today. According to one study, there were 14.1 million new cases of cancer and 8.2 million cancer-related deaths worldwide in 2012. The most commonly diagnosed cancers were lung (1.82 million), breast (1.67 million), and colorectal (1.36 million). The most common cancer deaths are due to lung cancer (1.6 million deaths), liver cancer (745,000 deaths), and stomach cancer (723,000 deaths) (Ferlay, J. et al, 2015).

MICRONEEDLES: AN APPROACH IN TRANSDERMAL DRUG DELIVERY: A REVIEW

{ DOWNLOAD AS PDF }

ABOUT AUTHOR
Devender Sharma*
Hi – Tech college of pharmacy, Chandrapur, Maharashtra (India)

*sdevender350@gmail.com

ABSTRACT
Transdermal drug delivery carried out a promising carrier in the transport of drugs to get direct access across the skin deep into the systemic circulation. Transdermal drug delivery have a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. It gives attraction to many researchers due to various biomedical advantages. Due to the limitation of oral drug delivery system and the pain related with the use of needles in case of injections, drug delivery research has tremendously oriented towards the transdermal route. Delivery of drugs via transdermal route has proved to be the convenient route for various clinical implications. The objective of the present review is to focus on newly innovations in transdermal drug delivery systems which can create a platform for the research and development of pharmaceutical drug dosage form for efficient transdermal delivery. In this review, we tell about different types of microneedles are described and their methods of fabrication. Microneedles can be fabricated in different forms like hollow, solid, and dissolving. There are also hydrogel-forming microneedles.  In relation to hydrogel-forming microneedles, special attention, these are innovative microneedles which does not contain drugs but imbibe interstitial fluid to form continuous conduits between dermal microcirculation and an attached patch-type reservoir. Regulatory authorities approved several microneedles for clinical uses are also examined. The last part of this review discusses concerns and challenges regarding microneedles use.

REVIEW ON MOISTURE ACTIVATED DRY GRANULATION PROCESS

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
Devender M. Sharma*1, Satish B. Kosalge1, Swati N. Lade1
Hi – Tech college of pharmacy, Chandrapur (M.S.)

*sdevender350@gmail.com

ABSTRACT
Tablets are unit solid dosage form of medicament which largely used to compare other dosage form of medicaments. In tablet manufacturing, wet granulation and dry granulation methods largely used as compare to MADG process. In wet granulation and dry granulation methods various steps has been carried out like dispensing and shifting, dry mixing, granulation, pre-drying, shifting, premixing, lubrication and compression. But in MADG process, escape various steps like slugging, pre- drying, shifting, and drying. Hereby in MADG process save energy, cost of product and time also. The main object of review is hereby moisture activated dry granulation process very beneficial in case of water insoluble drug and water poorly soluble drug other than granulation method like wet granulation. Another objective of review how moisture activated dry granulation process carried out and given various advantages over the other granulation method. In water insoluble drug case MADG process largely used and very useful method for pharmaceutical industries.

PHYTOFABRICATION FOR THE SYNTHESIS OF NANOPARTICLES - REVIEW

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
*R.Karthikeyan, E.Meghana, N.Gowthami, MD.Shajiya sultana, B.Mahesh reddy, SK.Magbul Johny, P.Srinivasa Babu
Department of Pharmacognosy, Vignan Pharmacy College, Vadlamudi – 522213.A.P
*rkcognosy@gmail.com

ABSTRACT
The synthesis of nanostructure substances, specifically metal nanoparticles, has accrued utmost concern over the last decade owing to their particular properties that cause them to applicable in distinctive fields of technology era. The biological technique of nanoparticle synthesis is a relatively easy, reasonably-priced, and environmental friendly approaches than the conventional chemical technique of synthesis and accordingly profits a top hand. The bio mineralization of nanoparticles in protein cages is one among such biological approaches used inside the era of nanoparticles. In this review we attempted to explore different techniques of synthesis of nanoparticles and its characterization. Further this review extended the usage of such nanoparticle in different fields.

AN OVERVIEW ON POLYMERIC NANOPARTICLESUSED IN THE TREATMENT OF DIABETES MELLITUS

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
K.GOPALASATHEESKUMAR1*, S.KOMALA2 AND M.MAHALAKSHMI2
1KMCH college of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India.
2Jaya College of Paramedical sciences, College of Pharmacy, Thiruninravur, Chennai – 602024, Tamil Nadu, India.
*gskpungai@gmail.com

ABSTRACT 
The review was carried out to discuss in detail about the polymeric nanoparticles for diabetic treatment. The diabetes is the chronic metabolic disorder characterized by the deficiency of insulin production. The various treatments are available for the diabetes and the nanoparticles are having the several advantages. The various types of nanoparticles are available for the anti-diabetic drugs; the polymeric nanoparticles are the one of the most commonly used nanoparticles. The polymeric nanoparticles are commonly 10-1000nm in size. The polymeric nanoparticles are formulated by drug with the polymers. The main advantages of the polymeric nanoparticles are the simplest preparation method, targeted delivery, the minimizing of the dose and high therapeutic efficiency. In this review was mainly can be focused on advantages, disadvantages of polymeric nanoparticles, various polymers, various formulation techniques, diabetes disease profile, insulin production, various anti-diabetic drugs and the polymeric nanoparticle formulation of anti-diabetic drugs.

FORMULATION, EVALUATION AND VALIDATION OF ORALLY DISINTEGRATING RIZATRIPTAN BENZOATE TABLET

ABOUT AUTHOR
Ms. Sapna
Department of Pharmaceutical Sciences
Himalayan Institute of Pharmacy and Research Rajawala, Dehradun, Uttarakhand, India
*bhandarisapna747@gmail.com

ABSTRACT: The present investigation deals with development of orally disintegrating tablets of Rizatriptan Benzoate to produce the intended benefits. Orally disintegrating tablets of Rizatriptan Benzoate were prepared by wet granulation method to provide faster relief from pain to migraine sufferers. Formulation research is oriented towards safety, efficacy and quick onset of action of existing drug molecule through novel concept of drug delivery. About four formulations for the present study were carried out full factorial design. Kyron 314 was used as super disintegrants, while microcrystalline cellulose and mannitol was used as diluents. Starch was used as binder. The prepared batches of tablets were evaluated for weight variation, hardness, friability, wetting time, drug content and in-vitro dissolution studies. The optimized formulation dispersed in within 15 seconds. It also showed a higher water absorption ratio and 99.67% of drug is released within a minute.

LIFE SAVING BINDI A NOVEL APPROACH TO COMBAT IODINE DEFICIENCY

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
D. Giri Raja Sekhar*, D. Sai Sravani, H. Thulasi , Chakka  Gopinath
Department of Pharmacy Practice, Annamacharya college of Pharmacy, Rajampet
*giriraj.pharma@gmail.com

ABSTRACT: 
The thyroid gland produces thyroid hormones. The two most important hormones are tetraiodothyronine (thyroxine or T4) and triiodothyronine (T3).Iodine deficiency is a major health problem in India. Iodine deficiency that can lead to disorders like goiter, hypothyroidism and even brain damage. Even mild iodine deficiency in pregnant women can result in children being born with cretinism and mental retardation. The most popular method of tackling the problem has been to encourage the consumption of iodised salt. An iodine patch, designed like a regular bindi, is expected to help iodine deficiency. It seems like a brilliantly simply idea The wearing of bindis form part of a cultural practice of Indian Women, which are “self-adhesive” in between their eyebrows, have been impregnated with a solution of iodine.  Production costs are minimal, wearing the iodine-infused bindi requires no behavioral change.

Pages