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GPAT 2015 | Question paper with key solutions

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76-125 questions are available below:

76. Which of the following classes of medication is the most common initial treatment of men with symptomatic benign prostatic hypertrophy (BPH)
(a) Alpha-1 agonist (b) Alpha-1 blocker (c) Beta-1 agonist (d) Beta-1 blocker

77. Which of the following reagents can be used for alkaloid detection
(P) Mayer reagent (Q) Kedde reagent
(R) Dr4agendoff reagent (S) Alcoholic solution of 2, 4 dinitrophenylhydrazine
(a) Only P and Q are correct
(b) Only P and R are correct
(c) Only P and Rare correct
(d) Only R and S are correct

78. Which schedule Drugs & Cosmetics Act include Particulars to the shown in /manufacturing Records
(a) Schedule A (b) Schedule V (c) Schedule U (d) Schedule W

79. All of the following statements about plasmodium falciparum are correct EXCEPT
(a) Trohozoites, Schizonts and gametocytes are not seen in peripheral blood smear.
(b) Is associated with recurrent relapses after initial treatment because of liver hypnozoites
(c) More than one parasite/multiple infection can be seen within single RBC
(d) Causes more severe disease in pregnancy

80. The chairman of the investigational new Drug (IND) committee in India is
(a) Drugs controller General of India, Government of India
(b) Secetary, Department of Health Reasearch, Government of India
(c) Directorate General of Health Sciences, Government of India
(d) Secretary, Department of Biotechnology, Government of India

81. In the filling of container what is the meaning of “overfill container”
(a) Container filled to its minimum capacity
(b) Container filled to its maximum capacity
(c) Empty container
(d) Cleaned container

82. What is the name of floor on which production work is done rather than administration
(a) Administration area (b) Production area (c) Quality control area (d) Quarentine Area

83. Quinoline contains two basic rings. One of the rings in quinolone. It is attached to second ring via o one carbon bridge. Which in the second ring
(a) 8-Azabicyclo [3.2.1] octane (b) 1-Azabicyclo [2.2.2] octane
(c) 1, 4-Diazabicyclo [2.2.2] octane (d) Rubane

84. Which of the first drugs are potentiated by the second
(a) Phenytoin – Ethinyloestradiol
(b) Warfarin – Phenobarbitone
(c) Lithium- Thaazide diuretics Potentiated due to reduced Lithium clearance
(d) Bromorcriptine- Metpoclopramide

85. Which of the following is a long acting β2 agonist that can be given by nebulization and as well a dry powder inhaler for the treatment of COPD
(a) Foramterol (b) Albuterol (c) Pulmicort (d) Fluticasone

86. Which anticholinergic drug mostly used as anti Parkinson drug
(a) Procyclidin (b) Methinicol (c) Tacrin (d) Atropine

87. To create successful new product, a company understands consumers, markets, and competitors and develop a/an
(a) Impressive advertising campaign (b) Strong wed site to push the product
(c) Aggressive marketing strategy (d) Product that satisties consumers’ needs

88. Which of the following method is an example of facilitated diffusion?
(a) Passive diffusion (b) Endocytosis
(c) Carrier mediated diffusion (d) Active transport

89. Which of the following causes arterial and bronchial constriction and platelet aggregation
(a) Prostaglandin E2
(b) Prostaglanding A2
(c) Prostaglandin D2
(d) Thromboxane A2

90. What is mechanism of action of carbamazepine
(a) Inhibition of GABA transaminase (b) Blockade of sodium channel
(c) Blockade of glutamate receptor (d) Blockade of GABA receptors

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91. Passive diffusion follows which order of kinetics
(a) Non selective and mixed order
(b) Selective and first order
(c) Non selective and first order
(d) Selective and mixed order 

92. Conc v/s time curve drown from single oral dose, which parameter can be calculated 
(a) Elimination constant (b) Rate constant (c) Absorption peak (d) Plasma conc.

93. If a basic drug reabsorbed significantly from kidney which of the following statement will be correct
(a) Its renal clearance increases in basic urine
(b) Its renal clearance decreases in basic urine
(c) Its renal clearance increases in acidic urine
(d) Its renal clearance decreases in acidic urine

94. o, m, p- isomers can be differentiated on the basis of:
(a) Chemical shift
(b) Coupling constant
(c) Extinction coefficient
(d) Dipole moment

95. Monitoring of plasma drug concentration is required while using:
(a) Antihypertensive drugs (b) Levodopa (c) Lithium carbonate (d) MAO inhibitors

96. Bacterial endotoxin are mainly detected by
(a) Pyrogen test (b) LAL test (c) Thermal test (d) Bacterial tes

97. The shelf life of a medicine is defined as :
(a) Time required for 10% degradation of drug
(b) Time required for 50% degradation of drug
(c) Time required for 90% degradation of drug
(d) Time required for 100% degradation of drug

98. In which rearrangement reaction, Isocyanate is formed?
(a) Curtious (b) Lossen (c) Both A & B (d) None

99. Chitin gets converted in to Chitosan upon:
(a) Acetylation
(b) Deacetylation
(c) Oxidation
(d) Reduction

100. Efficiency of drug is checked in modest population in
(a) Clinical trail-phase1
(b) Clinical trail-phase2
(c) Clinical trail-phase3
(d) Clinical trail-phase4

101. The mixed gland of our body which secrets both hormones and digestive enzyme, so pancreatic enzyme digest which substances
(a) Lipids, Protein, Carbohydrate but not Nucleic acid
(b) Protein, Carbohydrate, Nucleic acid but not Lipids,
(c) Carbohydrate, Lipids, nucleic acid but not Protein
(d) Lipids, Protein, Nucleic acid but not Carbohydrate

102. In which type of bacteria the cell wall is thicker
(a) Gram +ve (b) Gram –ve (c) Both (d) None

103. Out of the following anti cancer drug cardio toxicity is seen in
(a) Mitomycin-C (b) Doxorubicin (c) Methotraxate (d) Cyclophosphamide

104. Which of the following free radical is most dangerous free radical
(a) O- (b) H+ (c) H2O2 (d) Superoxide

105. The phosphate of a metal has the formula MHPO4. The formula of its Bromide would be:
(a) MBr (b) MBr2 (c) MBr3 (d) MBr4

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106. Silicone based adhesive used in TDDS possess following properties:
(a) Chemical and biological inertness
(b) Low toxicity
(c) Low sensitization and irritation
(d) All

107. Schleuniger tester is used for the tablets to measure:
(a) Roughness (b) Hardness (c) Dissolution (d) Friability

108. Creatinine clearance is used as a measurement of:
(a) Passive renal absorption
(b) Glomerular filtration rate
(c) Renal excretion rate
(d) All

109. 1-[2-[(2-chloro thienly)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1Iimidazole is:
(a) Oxiconazole
(b) Sulconazole
(c) Tioconazole
(d) Miconazole

110. The drug of choice in prolonged febrile convulsions is:
(a) Carbamazepine (b) Diazepam (c) Phenytoin (d) Paracetamol

111. Geometrical isomerism is possible in case of:
(a) 2-Pentene (b) Pentane (c) Propene (d) Ethene

112. The loading dose (DL) of a drug is usually based on the:
(a) Total body clearance of the drug
(b) Percentage of drug bound to plasma proteins
(c) Fraction of drug excreted unchanged in the urine
(d) Apparent volume of distribution & desired drug concentration in plasma

113. Biologically active arachidonic acid is
(a) All transeicosatetraenoic acid
(b) All cis eicosatetraenoic acid
(c) All transeicosatrienoic acid
(d) All cis eicosatrienoic acid

114. Antidiabetic action of gliburidestart at molecular level by which mechanism
(a) Phosphorylation of receptor
(b) Binding to potassium ions
(c) Decrease in potassium effiux
(d) Increase in potassium effiux

115. Momordica charantia having blood sugar lowering activity due to:
(a) Momordicin (b) Charantin (c) Momortin (d) Charantiamarin

116. Insulin stimulates glucose transport by promoting the translocation of:
(a) GLUT 4 (b) GLUT 2 & GLUT 4 (c) GLUT 1 & GLUT 4 (d) GLUT 2

117. Oral rehydration salt contains ionic electrolytes in concentration mmlo/L
(a) Na+ 20, K+ 10 (b) Na+ 40, K+ 20 (c) Na+ 53, K+ 40 (d) Na+ 60, K+ 20

118. In pinacol – pinacolone rearrangement, the final product is ketone. What is the starting compound for the rearrangement
(a) 1, 1-diol (b) 1, 2-diol (c) 1, 3-diol (d) Geminal diol

119. Which of the following method is useful for measuring the number of viable cells in a culture
(a) Plate count technique
(b) Dry weight method
(c) Petroff-Hauser counter
(d) Light scattering in a spectrophotometer

120. Seeding involves the spread of cancer cells to
(a) Blood vessels
(b) Serious membranes of body cavities
(c) Fascia surrounding muscles and bones
(d) Dermis and subcutamneum of the skin

121. Barbiturates are being replaced by hypnotic benzodiazepines because of
(a) Low therapeutic index
(b) Suppression in REM sleep
(c) High potential of physical dependence, abuse
(d) All of the above

122. Adverse drug Event reporting in the responsibility of all of the following EXCEPT
(a) Pharmacist and physician (b) Manufacturer (c) Consumer (d) Regulatory authorities

123. Time dependent dilatant behavior is knows as
(a) Thixotrophy (b) Rheopexy (c) Rheomalaxis (d) Plastic

124. Chairman of DTAB is:
(a) Health minister of India
(b) Director general of Health services
(c) Drug controller of India
(d) President of AICTE

125. Plasmodesmata is:
(a) Lignified element (b) Vascular element (c) Very fine protoplasmic thread (d) None

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