• 4 November 2014

    BIOSIMILARS: SCALE UP FROM R&D TO COMMERCIAL STAGE

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    ABOUT AUTHOR:
    Madhusudan P Dabhole
    Group Manager - BioProcess,
    Richcore Life Sciences Ltd, Bangalore, Karnataka, India.
    madhav888@rediffmail.com

    ABSTRACT
    The scale up of recombinant proteins involves a multi- dynamic strategic approach to achieve maximum output consistently. Various parameters during the fermentation will limit the synthesis of desired protein, which otherwise can be produced with ease in case of classical fermentation. In order to synthesis the protein, it is very important to understand the process at laboratory scale – both from scale up point of view and productivity improvement at large scale. Some of this parameters and scale up parameters are discussed below in this review.

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  • 2 November 2014
    DEVELOPMENT, CHARACTERISATION AND INVITRO EVALUATION OF BUCCOADHESIVE BILAYERED TABLETS FOR THE TREATMENT OF HYPERTENSION

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    ABOUT AUTHORS:
    Kavitha Reddy Jupally*, A.Pavani, R. Raja Reddy, Habibuddin.
    Department of Pharmaceutics, Malla Reddy Pharmacy College,
    Maisammaguda (via- Hakimpet), secunderabad, Telangana, India.
    kavithareddy0811@gmail.com

    ABSTRACT
    Ramipril is a prodrug belonging to the class of angiotensin-converting enzyme (ACE) inhibitor, which undergoes extensive hepatic first pass metabolism. The aim of the present study is to develop buccoadhesive bilayered tablet of ramipril  to achieve the greater therapeutic efficacy, to increase the bioavailability, to overcome the first pass hepatic metabolism of the drug. A UV spectrophotometric method has been employed for the estimation of Ramipril at 219 nm. Buccal tablets of Ramipril were prepared by direct compression method using ethyl cellulose as a polymer. The precompression parameters like bulk density, tapped density, carr’s index and angle of repose were determined. The post compression parameters like hardness, thickness, friability, weight variation, in vitro dissolution, FTIR studies were carried out to check if any interactions had occurred, results were promising. The optimized formulation was selected based on results and percentage drug release was found to be 92.95 and followed First order, peppas model with Fickian release mechanism.

  • 28 October 2014
    A BRIEF REVIEW ON SUSTAINED RELEASE MATRIX TABLETS OF BACLOFEN

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    ABOUT AUTHORS:
    Singh Surya Pratap*, Soni Shankar Lal, Khinchi Mahaveer Prasad, Gulia Ritu, Namdev Abhisek
    Department of pharmaceutics, Kota College of  Pharmacy,
    Ranpur, Kota, Rajasthan, India
    sp.kota91@gmail.com

    ABSTRACT
    The objective of the present study was to focus on sustained release matrix tablets of baclofen, for treatment of spastically resulting from multiple sclerosis, flexor spasm and muscular rigidity. Designing effective therapies for Spinal cord injury (SCI) has been a challenging problem because spinal cord injuries are heterogeneous in causality, severity and location of injury.
    Effective drug therapy for Spinal cord injury (SCI) first became a reality in 1990 with the finding that the steroid drug methylprednisolone(MP) can significantly improve recovery. Significant advances in recent year, including an effective drug therapy for acute SCI, have improve recovery. In spinal cord injury, pain persist for longer period i.e., several months, hence the long-term treatment is necessary for maintaining the drug concentration in the therapeutic range.
    Hence, there is a need of sustained release dosage form. Baclofen,4-amino-3-(4-chlorophenyl)-butyric acid is another structural analog of GABA, which is widely used now a days in the treatment of multiple sclerosis, flexor spasms, muscular rigidity. spinal cord injuries and other spinal cord diseases.

  • 27 October 2014
    EFFECT OF MAGNETIC FIELD ON CANCER CELLS

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    ABOUT AUTHORS:
    Rajesh Tiwari1*, Roshan kumar2
    1Chemistry Department, Dr. Ghanshyam Singh Post Graduate College, Varanasi
    2SBCBE VIT University, Vellore
    *Rajesh.tiwari851@gmail.com

    ABSTRACT
    In 16th century physician were of the opinion that magnet can be used for the treatment or eliminate the diseases from the body. Here the reports about the chemical synthesis, protection, functionalization and application of magnetic nanoparticles of nano structured system. Research of magnetic nanoparticles for targeted drug delivery system and function of magnetic nanoparticles on particular area are reviewed. Use of magnetic nanoparticles for cancer diagnosis has been advancing day by day. This review is related to the multifunctional use of magnetic nanoparticles probes and their use in bio imaging and nano medicine.

  • 26 October 2014
    MULTIPLE SCLEROSIS: OVERVIEW ON SIMPLE CURE

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    ABOUT AUTHORS:
    Duvvuru Ashok Kumar1*, Languluri Reddenna2
    1Department of Pharm-D, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India
    2Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India
    ashok.alex11@gmail.com

    ABSTRACT
    MS is the most common inflammatory-demyelinating disease of the central nervous system (CNS). MS is estimated to affect 400,000 persons in the United States and 2 million people worldwide. Women are affected twice as frequently as men, between the ages of 20 and 40. The etiology of MS is still unknown, but according to current data the disease develops in genetically susceptible individuals and may require additional environmental triggers. In this paper, we present the insight on simple cure for multiple sclerosis.

  • 24 October 2014
    FORMULATION AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF CEFUROXIME AXETIL

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    ABOUT AUTHORS
    Balay Ragini*, A.Pavani, R.Raja Reddy
    Malla Reddy Pharmacy College,
    Maisammaguda(via-hakimpet), Secunderabad, Telengana. india
    ragini.balay@gmail.com

    ABSTRACT
    Cefuroxime Axetil is a second generation antibacterial belongs to Cephalosporin Group. The drug undergoes rapid metabolism in intestinal mucosa due to change in pH Environment and hence has decreased oral bioavailability. The aim of present investigation is to increase the gastric residence time by preparing gastroretentive tablets here by improving bioavailability of Cefuroxime Axetil. A simple UV spectrophotometric method has been employed for the estimation of Cefuroxime Axetil at 281 nm. A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicarbonate, sodium alginate and hydrocolloids like hydroxyl propyl methyl cellulose (HPMC) and guggul. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, In vitro release, buoyancy lag-time and swelling index. The formulations were optimized for the different grades of HPMC, and its concentrations and combinations. The results of the In vitro release studies showed that the optimized formulation F3 could sustain drug release of 92% and remain buoyant for 10h. The optimized formulation was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominately Higuhci with non fickian diffusion. Finally the tablets formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.

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  • 22 October 2014
    HERBAL ANTI HYPERTENSION DRUGS

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    ABOUT AUTHORS:
    Asha Kesari*, Pushpa Kumari Mahto, Shankheswari Kishan, Suranjeeta Singh
    Department of Pharmaceutics,
    Kanak Manjari Institute of Pharmaceutical Sciences,
    Rourkela, Odisha
    ashakeshri@yahoo.co.in

    ABSTRACT
    Hypertension or high blood pressure is a chronic medical condition in which the arterial blood pressure is elevated (normal blood pressure is 120/80 mm Hg). High Blood Pressure may lead to heart failure, stroke, coronary heart disease, kidney failure etc and may affect lungs, brain and heart. It is an important global problem and a very good percentage of people all over the world are affected by blood pressure. As there is no definite cure for this condition, hence controlling it is a big challenge. The main focus on BP management is to lower the elevated blood pressure and to prevent or reduce target organ damage. Although various antihypertensive drugs are available, they are usually associated with many sides –effects. The following article deals with the alternative measures used for lowering high blood pressure giving more importance on the various herbal drugs to be used as combination therapy.

  • 20 October 2014
    ROLE OF PRODRUGS IN SOLUBILITY ENHANCEMENT OF DRUGS

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    ABOUT AUTHORS:
    Anitha Sriram*, Kalyana Chakravarthi G, Vijayaraj S, Venugopal A, Naresh Ch, Saritha B
    Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy,
    Tirupati, A.P., India.
    *anithasagar8@gmail.com

    ABSTRACT
    Solubility is one of the essential parameters to achieve bioavailability of drug in systemic circulation to produce expected therapeutic response.  Nearly 40% of new drug molecules face solubility challenge. Though several techniques like micronization, crystal engineering, hydrotrophy, solid dispersion and so forth were available for solubility enhancement of poorly soluble drugs based on physical and chemical modification, prodrug approach is a vital technique amongst the other. Prodrugs are biologically inactive compound which can be metabolized in the body to produce active drug. It is estimated that currently about 10% of all world-wide approved drugs are prodrugs. This review extensively confers the role of prodrugs and the kind of promoieties used for solubility enhancement.

  • 16 October 2014
    PHYTOCHEMICAL STUDIES OF VERTICILLIUM TENERU AND ACREMONIUM

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  • 13 October 2014
    AN OVERVIEW ON MANGIFERA INDICA: IMPORTANCE AND ITS VARIOUS PHARMACOLOGICAL ACTION

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    About Author:
    Pallab Kalita
    Assam Down Town University,
    Institute of Pharmacy, Guwahati, Assam, India
    kalitapallab@gmail.com

    Abstract
    Majority of crude drugs from plant origin are used in  Indian system of medicine. Medicinal  plants are using as herbal remedies to prevent and cure several ailments differs from community to community. Most studies on the exploitation of mango have been dealing with mango peels, juices and stem bark and mango leaves. Mangifera indica (Anacardiaceae), reported to contain active substances like mangiferin. In ayurveda, one of its uses is clearing digestion and acidity. Mangiferin is a pharmacologically active flavonoids, which having the anti bacterial, antioxidant, anticancer, antidiabetes, hepatoprotective, anti inflammatory activities.

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