Simultaneous Estimation of Linezolid and Cefixime in their Combined Dosage Form

  • Posted on: 1 February 2015
  • By: admin

 

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PharmaTutor (February- 2015)

 

Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 2)

 

Received On: 21/11/2014; Accepted On: 02/12/2014; Published On: 01/02/2015

 

AUTHORS: Joshi HV*, Patel JK, Shah UA, Patel Kinjal
Nootan Pharmacy College,
Visnagar, Gujarat, India
hirakjoshi@gmail.com

 

ABSTRACT: Simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Linezolid (LIN) and Cefixime (CEF) in tablet dosage form have been developed. The method is simultaneous equation method; in this method 257.0 nm and 288.0 nm were selected respectively for LIN and CEF to measure the absorbance of both the drugs at mentioned wavelengths. Both the drugs show linearity at 10-50 μg/mL, the range was selected by studying their ratio present in combined formulation. Recovery studies range from >99.35% for CEF and >99.23% for LIN in mentioned analytical method i.e. simultaneous equation method. The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific (no heating and no organic solvent extraction is required).

 

How to cite this article: HV Joshi, JK Patel, UA Shah, K Patel; Simultaneous Estimation of Linezolid and Cefixime in their Combined Dosage Form; PharmaTutor; 2015; 3(2); 48-52

 

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