Articles

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ABOUT AUTHORS
Goundla Uday Bhasker Goud¹*, Jakkampudi Sri Venu Prakash¹, Avadhanam Pranav Kumar², Gangi Reddy Sreenivas Reddy², Manikanta Sai Krishna².
¹Department of Industrial Pharmacy
²Department of Pharmaceutics
Bharat Institute Of Technology, Mangalpally, Hyd, Telangana, India.
gouds.uday04@gmail.com

ABSTRACT
Aim: The current paper was an attempt to design a extended release dosage form of Metformin hydrochloride using various grades of hydrophilic polymers, hydroxy propyl methyl cellulose (HPMC K4M, HPMC K15M, HPMC K100M and HPMC K200M) and MCC.
Materials and Methods: Laboratory scale batches of 4 tablet formulations were prepared by wet granulation technique. Precompression parameters of the granules were evaluated prior to compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, drug content or assay and evaluated for in-vitro release pattern for 12 hr using Phosphate buffer of pH 6.8 at 37 ± 0.5°C.
Results and Discussion: The results obtained revealed that HPMC K100M in formulation (F3) was able to sustain the drug release for 12 h and followed the Higuchi pattern quasi-Fickian diffusion. and charged for stability testing, parameters were within the limit of acceptance. There was no chemical interaction found between the drug and excipients during Fourier Transform Infrared Spectroscopy (FTIR).
Conclusion: Hence it can be concluded that formulation F3 containing HPMC K100M is suitable for development of extended release tablets of Metformin Hydrochloride.

ABOUT AUTHOR
Prakash Chanda Gupta
Quality Control Executive,
National Healthcare Pvt. Ltd, Nepal
p_c_gupta@yahoo.com
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ABSTRACT
The science of physics is understood to be very away from the Pharmaceutical Science. But in the real context, Physics is found to be most densely involved in the Pharmaceutical Science than any other field of science. Physics can be considered as a backbone that supports Pharmaceutical Science. The advance technology that describes that formation and its mode of action to the biological organ is Physics. The structure, action and result of Pharmaceutical material are explained by the theories of Physics.

ABOUT AUTHOR
Madhusudan P Dabhole
Group Manager – BioProcess,
Richcore Life Sciences Ltd, Bangalore, Karnataka, India
madhav888@rediffmail.com

ABSTRACT
The manufacturing of recombinant products by fermentation and purification in stainless steel vessels has seen the transition from small scale to large scale and further to single use disposable technology. The requirement to develop and modulate the process has arisen from the cost and manufacturers need to move the facility on mobile platforms. The review describes the strategies and considerations for Single Use Disposable Technology. Recombinant proteins are widely used for treatment of various diseases and disorders. Single Use Disposable Technology makes it promising to produce and formulate these proteins from bench scale to commercial level in a shorter span of time so that it can reach the physician and patients.