Molecular Docking Studies of N-(2-Benzoylphenyl)-L-Tyrosine Derivatives with Anti-Diabetic Activity of Type 2 Diabetes

  • Posted on: 1 February 2015
  • By: admin

 

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PharmaTutor (February- 2015)

 

Print-ISSN: 2394 - 6679
e-ISSN: 2347 - 7881
(Volume 3, Issue 2)

 

Received On: 24/11/2014; Accepted On: 03/12/2014; Published On: 01/02/2015

 

AUTHORS: Anuradha Sharma1*, Vaibhav Walia2, Monika Gahlawat3
1Division of Pharma. Chemistry,2 Division of Pharmacology,3 Division of Pharmaceutics,
G.V.M. College of Pharmacy,
Sonepat, Haryana, India
*anusarswat@gmail.com

 

ABSTRACT: Type 2 diabetes is one of the major life threatening diseases worldwide. These cases are progressing at an incremental rate every year and number of research works is going on to control the disease by targeting its enzymes or proteins. In modern drug designing, molecular docking is routinely used for understanding drug receptor interaction. In the present study molecular docking were performed on a diverse set of N-(2-benzoylphenyl)-L-tyrosine derivatives that demonstrate antidiabetic activity by stimulating peroxisome proliferator activated receptor- γ. The docking program in Glide dock justifies the correlation between the experimental values and the values derived computationally. Therefore, the dock analysis performed in Glide dock suggests the importance of evaluating the prediction accuracy of scoring functions adopted in various docking program.

 

How to cite this article: A Sharma, V Walia, M Gahlawat; Molecular Docking Studies of N-(2-Benzoylphenyl)-L-Tyrosine Derivatives with Anti-Diabetic Activity of Type 2 Diabetes; PharmaTutor; 2015; 3(2); 58-68

 

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