Articles

29 September 2014

A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM BY ETHOSOMES

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ABOUT AUTHORS:
V. Sujatha*, T. Vishnuvaravidyadhar, M.Parvathi, Suryaprakash Reddy
*Department of Pharmaceutics,
Raghavendra Institute of Pharmaceutical Education & Research,
RIPERK R Palli Cross, Near S.K University, Anantapuramu District, Andhra Pradesh, India
valmiki.sujatha@gmail.com

ABSTRACT
Transdermal drug delivery system is one type of more convenient drug delivery system. Skin acts a barrier for transdermal through drug delivery system. Drug across through stratum corneum by low diffusion process. Drug formulation with elastic vesicle or skin enhances vesicles. Etho sources are the ethanolic phospholipids vesicles and which are having higher rate of penetration through the skin. The purpose of writing this Review on ethosome drug focus on the Ethosomes including their mechanism of penetration. Transdermal drug delivery system was came into existence by more than 30 years ago. Ethosomes are the ethanolic phospholipid vesicles. These are used mainly for transdermal delivery of drugs. Ethosomes have higher penetration rate through the skin as compared to liposomes hence these can be used widely in place of liposomes. Ethosomes enhanced skin permeation, improved drug delivery, increased drug entrapment efficiency etc.
26 September 2014

A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLE

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ABOUT AUTHORS:
Monika A. Rana*, Hasumati A. Raj
Department of Quality Assurance
Shree Dhanvantary College of Pharmacy,
Kim, Gujarat, India
monika92rana@gmail.com

ABSTRACT
Levosulpiride is an atypical antipsychotic agent. Levosulpiride is the levo enantiomer of sulpiride. It is a substitute benzamide which is meant to be used for several indications: depression, psychosis, somatoform disorders, emesis anddyspepsia. It blocks the presynaptic dopaminergic D2 receptor. Chemically it is N-[[(2S)-1-Ethylpyrrolidin-2-yl] methyl]-2-methoxy-5 sulfamoylbenzamide. several method such as HPLC in human plasma, area under curve, stability by RP-HPLC is done. The parent drug is given in a dose of 400-1800 mg orally. According to literature survey study of impurity profiling of LIVOSULPIRIDE in presence of intermediate has not been reported.
22 September 2014

A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION OF PRAVASTATIN IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL FLUIDS

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ABOUT AUTHORS
Grishma Trivedi*, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Gujarat
*trivedigrishma18@gmail.com

ABSTRACT
Pravastatin is an inhibitor of HMG-CoA reductase inhibitor which is used as a hypolipidemic agent to reduce cholesterol level. Chemically, 9-Fluoro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl disodium phosphate. Pravastatin is a drug of choice for the cardiovascular disease. It reduces the coronary and cerebrovascular morbidity and mortality in middle aged individual. Elevated plasma concentration of C-reactive protein are associated with protein increased cardiovascular disease, long term therapy with pravastatin an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter. This review consist of various analytical methods for the determination of pravastatin in various marketed pharmaceutical formulation of biological fluid. Analytical methods consist of various chromatographic methods, spectrophotometer methods and electrical methods reported for determination of pravastatin.
19 September 2014

A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION BROMHEXINE HYDROCHLORIDE IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

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ABOUT AUTHORS:
Meera V. Lad¹*, Vineet Jain², Hasumati Raj¹
¹Department of Quality Assurance,
²Department of Pharmacognosy,
Shree Dhanvantary Pharmacy College, Kim, Gujarat
meeralad235@gmail.com

ABSTRACT:
Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ionselectiveelectrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.
18 September 2014

A REVIEW: ANALYTICAL METHODS FOR DETERMINATION OF CILNIDIPINE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS

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ABOUT AUTHORS:
Farhana V. Buchiya*, Vineet Jain, Hasumati Raj
Shree Dhanvantary Pharmacy College,
Kim, Surat, Gujarat
buchiyafarhana22@gmail.com

ABSTRACT:
Cilnidipine is act as a dual blocker by blocking L- type of calcium channel present in vascular smooth muscles and N- type of calcium channel present in sympathetic nerve terminal that supply blood vessels. Cilnidipine used in treatment of mostly in hypertension and various cardiovascular diseases except in Angina. Cilnidipine used alone or in combination. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of cilnidipine in various pharmaceutical dosage forms and biological matrix were reported.

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15 September 2014

MITOMYCIN C: A USEFUL ANTICANCER DRUG

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ABOUT AUTHOR:
Amitava Sinha Ray
Ranbaxy Laboratories Ltd
West Bengal, India
a.amitava.s@gmail.com
14 September 2014

DEVELOPMENT OF HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY METHOD FOR THE DETERMINATION OF SCOPOLIN IN CONVOLVULUS PLURICAULIS CHOIS

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ABOUT AUTHOR
Babu Lal
Department of Pharmacognosy,
Indo-Soviet Friendship College of Pharmacy, Moga, Punjab, India.
Babulalgughria@gmail.com

ABSTRACT
A simple, selective, precise and robust high performance thin layer chromatography (HPTLC) method was developed and validated for the determination of scopolin, in Convolvulus pluricaulis, commonly known as shankhpushpi. Aluminium backed pre-coated TLC plates (Silica gel 60F-254) of 0.2 mm thickness, were utilized to perform chromatography. The plates were developed up to 90 mm distance in twin trough glass chamber, saturated for 10 min with mobile phase system (Chloroform: methanol, 8.5:1.5, v/v). The system produces a sharp and well-defined peak for scopolin (R_f value; 0.30 ± 0.02). Scopolin was quantified in various test samples (extracts and marketed formulation) at absorbance maxima of 340 nm with the help of CAMAG TLC scanner III. The linear regression analysis data for the calibration plots (concentration Vs peak area) showed good linearity (r² = 0.9992 ± 0.0002) in the concentration range of 20-160 ng spot⁻¹. The method was validated in accordance with International Conference on Harmonization (ICH) guidelines. The statistical analysis of the results, indicate that the proposed method is specific, accurate and precise. Further, this method can be used for the standardization of shankhpushpi and its formulations.
10 September 2014

FORMULATION AND DESIGN OF METFORMIN HYDROCHLORIDE EXTENDED RELEASE TABLETS

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ABOUT AUTHORS
Goundla Uday Bhasker Goud¹*, Jakkampudi Sri Venu Prakash¹, Avadhanam Pranav Kumar², Gangi Reddy Sreenivas Reddy², Manikanta Sai Krishna².
¹Department of Industrial Pharmacy
²Department of Pharmaceutics
Bharat Institute Of Technology, Mangalpally, Hyd, Telangana, India.
gouds.uday04@gmail.com

ABSTRACT
Aim: The current paper was an attempt to design a extended release dosage form of Metformin hydrochloride using various grades of hydrophilic polymers, hydroxy propyl methyl cellulose (HPMC K4M, HPMC K15M, HPMC K100M and HPMC K200M) and MCC.
Materials and Methods: Laboratory scale batches of 4 tablet formulations were prepared by wet granulation technique. Precompression parameters of the granules were evaluated prior to compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, drug content or assay and evaluated for in-vitro release pattern for 12 hr using Phosphate buffer of pH 6.8 at 37 ± 0.5°C.
Results and Discussion: The results obtained revealed that HPMC K100M in formulation (F3) was able to sustain the drug release for 12 h and followed the Higuchi pattern quasi-Fickian diffusion. and charged for stability testing, parameters were within the limit of acceptance. There was no chemical interaction found between the drug and excipients during Fourier Transform Infrared Spectroscopy (FTIR).
Conclusion: Hence it can be concluded that formulation F3 containing HPMC K100M is suitable for development of extended release tablets of Metformin Hydrochloride.
9 September 2014

DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF SILDENAFIL CITRATE AND DAPOXETINE HYDROCHLORIDE IN THEIR COMBINED DOSAGE FORMULATION

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8 September 2014

PHYSICISTS IN PHARMACEUTICAL INDUSTRY

ABOUT AUTHOR
Prakash Chanda Gupta
Quality Control Executive,
National Healthcare Pvt. Ltd, Nepal
p_c_gupta@yahoo.com
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ABSTRACT
The science of physics is understood to be very away from the Pharmaceutical Science. But in the real context, Physics is found to be most densely involved in the Pharmaceutical Science than any other field of science. Physics can be considered as a backbone that supports Pharmaceutical Science. The advance technology that describes that formation and its mode of action to the biological organ is Physics. The structure, action and result of Pharmaceutical material are explained by the theories of Physics.