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  • Synthesis and evaluation of carbodithioic acid esters of naphthylmethylamine, a novel class of spermicides

    About Authors
    M. M. Singhal, Monica Gupta
    Department of chemistry,
    Delhi Institute of Pharmaceutical science & Research,
    New Delhi, India

    Affiliation Affiliated from Govt. of NCT Delhi

    Abstract :
    Carbodithioic acid esters of naphthylmethylamine prepared by replacing the amino function in amino methyl side chain with carbodithioic acid ester group and by adding various S-2-hydroxy propyl ester of dialkyl carbodithioic acid at amino group. Some of these compounds showed better spermicidal activity. The study revealed that incorporation of carbodithioic acid residue directly into naphthylmethylamine leads to compounds with better spermicidal activity and naphathalene-1-yl-methyl-carbodithioic acid-3-dialkyl amino-2-hydroxy-propyl ester has shown better profile than nonoxynol-9. Further, lead optimization may yield a potent spermicide.

  • MOBILE PHONE & BRAIN TUMOUR

    About Authors:
    Ankit Kumar Jhangta,
    M.Pharm
    Kumaun Univ. Nainital

    ABSTRACT
    Mobile telecommunication technology became commercially available about 20-30 year ago in different countries around the world commencing with europian countries. Telecommunication Industry has grown by leaps and bound over the last decade. Thus any health hazard from these devices promises  to have large
    epidemiological impact as more than half of the population are mobile users.The key aim of this paper is to scientifically and objectively review data suggesting or refuting a relationship between mobile phone usage and brain tumours.

  • Eclipta alba (L.) A review on its phytochemical and pharmacological profile

    About Authors:
    Mithun NM*, Dr.Shashidhara S1

    Dept. of Pharmacognosy,
    Government college of pharmacy,
    Bangalore

    Abstract: Eclipta alba (L.) is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical regions. The herb has been known for its curative properties and has been utilized as antimytotoxic, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic, antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. Recent studies showed an antivenom property & corrosion pickling inhibitor action on mild steel in hydrochloric acid. A wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts and metabolites from this plant have been known to possess pharmacological properties. This contribution provides an comprehensive review on ethnomedicinal uses, chemical composition, and the pharmacological profile as medicinal plant. Particular attention is given to antihepatotoxic, analgesic, antioxidant , antihyperglycemic, antiaggresive, wound healing properties and insecticidal effects presented in this review such that the potential use of this plant either in pharmaceutics or as an agricultural resource can be evaluated.

  • Drug Latentation,

                                      Drug latentation

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