Articles

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ABOUT AUTHORS:
Jiguru Prasant*, Mohammad Kaleemullah Quraishi, Amer Khan
Department of Doctor of Pharmacy,
Krishna Institute of Medical Sciences and Bharat Institute of Technology (Pharmacy),
Hyderabad, Telangana, India
Prashant7792@gmail.com

ABSTRACT
A 65 yrs female patient was presented with  complaints of vomiting,  loose stools, pain,  fever, high grade chills,  giddiness, loss of appetite acute renal failure, hemolytic anemia and thrombocytopenia She was diagnosed with Escherichia coli  associated hemolytic-uremic syndrome and treated with plasmapheresis and other medications for 3 weeks. She recovered without sequelae.

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ABOUT AUTHORS:
Abdul Waheed¹*, Ankit Gupta², Parth Patel^3
1Department of Pharmacology
²Department of Pharmaceutics
³Department of Drug Regulatory Affair
Amity Institute of Pharmacy, Amity University, Noida-125, U.P. (INDIA)
abdul.waheed2050@gmail.com

ABSTRACT
In the present scenario, lung cancer is one of the most prevalent and malignant cancer especially among the smoking group of people. The targeted delivery of chemotherapeutic agents to the lungs represents a novel therapeutic approach in lung cancer. Lung is an ideal route for administration of anticancer drug as it provides larger alveolar surface area, low thickness of epithelial barrier & extensive vascularization. Nanoparticles with nanocarriers have possibility of cell-targeted drug delivery with minimal systemic side effect and toxicity. Pulmonary epithelial cell, enzymes, receptors and genes are the target of the targeted drug delivery in lung cancer. This paper reviews the till date targeted drug delivery research performed for the treatment of lung cancer.

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ABOUT AUTHORS:
Anuradha Sharma¹*, Vaibhav Walia², Monika Gahlawat^3
1Division of Pharma. Chemistry, ²Division of Pharmacology, ³Division of Pharmaceutics,
G.V.M. College of Pharmacy,
Sonepat, Haryana, India
*anusarswat@gmail.com

ABSTRACT
Plagiarism is a multifaceted and ethically a complex problemwhich simply means the stealing and publication of another author’s work as one's own original work without acknowledge the original author. Plagiarism is simply an act of fraud.Authors should acknowledge sources fully and appropriately to follow the ethics and plagiarism is failure to do so. However the students or the authors sometimes fail to acknowledge the source appropriately and properly. These failures are largely due to the lack of knowledge to use the citations properly. Therefore to maintain the ethics the plagiarism should be avoided. The aim of this paper is to define plagiarism, its type, methods of detection and the ways to avoid plagiarism.

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ABOUT AUTHORS:
Singh Divya¹, Siddhi Shrimali², Rathore KS^2*
1Department of Pharmacology, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
²Department of Pharmaceutics, BN Institute of Pharmaceutical Sciences, Udaipur, Rajasthan, India
*kamalsrathore@gmail.com

ABSTRACT
Parkinsonism disease (PD) is a progressive neurological disorder. Degeneration of dopamine producing cells in the substantia nigra (part of the basal ganglia) leads to a decreased dopamine production. The cause of the damage is unknown. The main known risk factor is age. Parkinson’s affects functional activities such as balance, walking, speech, handwriting, typing, fastening buttons, driving, and many other simple, or complex but familiar and routine activities, as they are usually controlled by the mechanisms of dopamine and the basal ganglia. This review briefly focuses on deep brain stimulation neurosurgical treatment. Levodopa was the first drug approved specifically for Parkinson’s disease. Levodopa is converted by enzymes in the brain to produce dopamine, thereby supplementing function that has been lost as dopamine-producing neurons die.Topics covered in the review includes pathogenesis, mechanism of action, side effects of medicines and neurological surgery.

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ABOUT AUTHORS:
Anuradha Sharma¹*, Vaibhav Walia², Monika Gahlawat^3
1Division of Pharma. Chemistry,² Division of Pharmacology,³ Division of Pharmaceutics,
G.V.M. College of Pharmacy,
Sonepat, Haryana, India
*anusarswat@gmail.com

ABSTRACT
Type 2 diabetes is one of the major life threatening diseases worldwide. These cases are progressing at an incremental rate every year and number of research works is going on to control the disease by targeting its enzymes or proteins. In modern drug designing, molecular docking is routinely used for understanding drug receptor interaction. In the present study molecular docking were performed on a diverse set of N-(2-benzoylphenyl)-L-tyrosine derivatives that demonstrate antidiabetic activity by stimulating peroxisome proliferator activated receptor- γ. The docking program in Glide dock justifies the correlation between the experimental values and the values derived computationally. Therefore, the dock analysis performed in Glide dock suggests the importance of evaluating the prediction accuracy of scoring functions adopted in various docking program.

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ABOUT AUTHORS:
Joshi HV*¹, Patel JK², Shah UA¹, Patel Kinjal^1
1Department of QA,
²Department of Pharmaceutics,
Nootan Pharmacy College, Visnagar, Gujarat, India
hirakjoshi@gmail.com

ABSTRACT
Simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Linezolid (LIN) and Cefixime (CEF) in tablet dosage form have been developed. The method is simultaneous equation method; in this method 257.0 nm and 288.0 nm were selected respectively for LIN and CEF to measure the absorbance of both the drugs at mentioned wavelengths. Both the drugs show linearity at 10-50 μg/mL, the range was selected by studying their ratio present in combined formulation. Recovery studies range from >99.35% for CEF and >99.23% for LIN in mentioned analytical method i.e. simultaneous equation method. The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific (no heating and no organic solvent extraction is required).

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ABOUT AUTHORS:
Jadhav Santosh*, Mali Audumbar, Pawar Seemarani, Kharat Rekha, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola-413307, Solapur, Maharashtra, India.
*jadhavsan88@gmail.com

ABSTRACT:
A simple, precise and accurate difference spectroscopic method has been developed for the estimation of Acebutolol Hydrochloride in bulk drug form by difference spectrophotometric method. Acebutolol Hydrochloride has exhibited maximum absorbance at about 233nm and 234nm in acidic and basic solution respectively. Beer’s law was obeyed in the concentration range of 2-10 µg/ml in both the cases. The regression of coefficient was found to be r²=0.9992. The LOD and LOQ value were found to be 0.2670ppm and 0.8091ppm respectively. The proposed method was successfully applied for the determination of Acebutolol Hydrochloride in bulk drug. As per ICH guidelines the result of the analysis were validated statistically and were found to be satisfactory.