Articles

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ABOUT AUTHOR
Abhishek Singhal
Department of Pharmacology,
Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk.),
Pune, Maharastra, India
*abhishekspharma@gmail.com

ABSTRACT
Aim: This review is written to describe the role of immunotherapy in cancer treatment.
Annually, 13,000 deaths result from bladder cancer. Since the first report of intravesical use of BCG in 1976, investigators try to understand the working mechanism of BCG as an antitumour modality. Arbitrarily, BCG therapy consists of a single course of six weekly intravesical instillations. Bacillus Calmette-Gue´rin, an attenuated strain of Mycobacterium bovis, was developed by Calmette and Gue´rin with the intention to generate a vaccine against tuberculosis. Extension of BCG treatment (maintenance immunotherapy) is used to increase efficacy.
Results of various experiments describe that after instillation in the bladder, BCG accumulates near the bladder wall and is internalised and processed by professional antigen-presenting cells (APCs) and (high-grade) tumour cells. Then BCG antigens are presented to CD4+ T cells. Then local synthesis of a particular set of cytokines or cell-mediated immune response. NK cells may be involve in tumour cell killing.

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ABOUT AUTHORS:
P. Devi¹, R. Meera^2*, P. Rajasoundarapandian², Madhavanmallayasamy^2
1Department of pharmacognosy, K.M.College of pharmacy,
²Researcher, Radianz, Healthcare private Limited,
Madurai, Tamil Nadu, India.
*meeraharsa23@gmail.com

ABSTRACT
Objective: Imporal, Vivati and Teerankottai Lehyams were prepared by ayurvedic formulary and were analysed.
Materials and Methods: Lehyams conjunction with ingredients such as kadukkai, tetrankottai, chebula, impural, verpatti, pacum pal, panankarkantu, catipattiri, valmilaku,catikkay, terrankottai, tipple, milakucukku, kadukkai, tanrikkay, cirrarakottai, nellikkay, cirakam, carkkarai, honey and ghee in different proportions.
Results: The Loss on drying, Total ash, Acid insoluble ash, Alcohol soluble extractive, Water soluble extractive, Saponification value and Sugar content were determined respectively. The preliminary phyto chemical investigation shows the presence of alkaloids, carbohydrates, glycosides, saponin, tannins and flavonoids.
Conclusion: Increase the medicinal properties against appetizer, cough and tuberculosis by preparing like this herbal products.

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ABOUT AUTHOR:
Madhusudan P Dabhole
Group Manager - BioProcess,
Richcore Life Sciences Ltd, Bangalore, Karnataka, India.
madhav888@rediffmail.com

ABSTRACT
The scale up of recombinant proteins involves a multi- dynamic strategic approach to achieve maximum output consistently. Various parameters during the fermentation will limit the synthesis of desired protein, which otherwise can be produced with ease in case of classical fermentation. In order to synthesis the protein, it is very important to understand the process at laboratory scale – both from scale up point of view and productivity improvement at large scale. Some of this parameters and scale up parameters are discussed below in this review.

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ABOUT AUTHORS:
Kavitha Reddy Jupally*, A.Pavani, R. Raja Reddy, Habibuddin.
Department of Pharmaceutics, Malla Reddy Pharmacy College,
Maisammaguda (via- Hakimpet), secunderabad, Telangana, India.
kavithareddy0811@gmail.com

ABSTRACT
Ramipril is a prodrug belonging to the class of angiotensin-converting enzyme (ACE) inhibitor, which undergoes extensive hepatic first pass metabolism. The aim of the present study is to develop buccoadhesive bilayered tablet of ramipril  to achieve the greater therapeutic efficacy, to increase the bioavailability, to overcome the first pass hepatic metabolism of the drug. A UV spectrophotometric method has been employed for the estimation of Ramipril at 219 nm. Buccal tablets of Ramipril were prepared by direct compression method using ethyl cellulose as a polymer. The precompression parameters like bulk density, tapped density, carr’s index and angle of repose were determined. The post compression parameters like hardness, thickness, friability, weight variation, in vitro dissolution, FTIR studies were carried out to check if any interactions had occurred, results were promising. The optimized formulation was selected based on results and percentage drug release was found to be 92.95 and followed First order, peppas model with Fickian release mechanism.

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ABOUT AUTHORS:
Rajesh Tiwari^1*, Roshan kumar^2
1Chemistry Department, Dr. Ghanshyam Singh Post Graduate College, Varanasi
²SBCBE VIT University, Vellore
*Rajesh.tiwari851@gmail.com

ABSTRACT
In 16^th century physician were of the opinion that magnet can be used for the treatment or eliminate the diseases from the body. Here the reports about the chemical synthesis, protection, functionalization and application of magnetic nanoparticles of nano structured system. Research of magnetic nanoparticles for targeted drug delivery system and function of magnetic nanoparticles on particular area are reviewed. Use of magnetic nanoparticles for cancer diagnosis has been advancing day by day. This review is related to the multifunctional use of magnetic nanoparticles probes and their use in bio imaging and nano medicine.

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ABOUT AUTHORS:
Duvvuru Ashok Kumar¹*, Languluri Reddenna^2
1Department of Pharm-D, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India
²Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India
ashok.alex11@gmail.com

ABSTRACT
MS is the most common inflammatory-demyelinating disease of the central nervous system (CNS). MS is estimated to affect 400,000 persons in the United States and 2 million people worldwide. Women are affected twice as frequently as men, between the ages of 20 and 40. The etiology of MS is still unknown, but according to current data the disease develops in genetically susceptible individuals and may require additional environmental triggers. In this paper, we present the insight on simple cure for multiple sclerosis.

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ABOUT AUTHORS
Balay Ragini*, A.Pavani, R.Raja Reddy
Malla Reddy Pharmacy College,
Maisammaguda(via-hakimpet), Secunderabad, Telengana. india
ragini.balay@gmail.com

ABSTRACT
Cefuroxime Axetil is a second generation antibacterial belongs to Cephalosporin Group. The drug undergoes rapid metabolism in intestinal mucosa due to change in pH Environment and hence has decreased oral bioavailability. The aim of present investigation is to increase the gastric residence time by preparing gastroretentive tablets here by improving bioavailability of Cefuroxime Axetil. A simple UV spectrophotometric method has been employed for the estimation of Cefuroxime Axetil at 281 nm. A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicarbonate, sodium alginate and hydrocolloids like hydroxyl propyl methyl cellulose (HPMC) and guggul. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, In vitro release, buoyancy lag-time and swelling index. The formulations were optimized for the different grades of HPMC, and its concentrations and combinations. The results of the In vitro release studies showed that the optimized formulation F3 could sustain drug release of 92% and remain buoyant for 10h. The optimized formulation was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominately Higuhci with non fickian diffusion. Finally the tablets formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.

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