• PharmaTutor
    30 January 2015

    DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF DICLOFENAC SODIUM BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Mali Audumbar Digambar*, Jadhav Santosh, Mane Pandurang, Tamboli Ashpak
    Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
    Sangola- 413307, Solapur, Maharashtra, India
    maliaudu442@gmail.com

    ABSTRACT
    A simple, precise, accurate and economical UV visible spectrophotometric method has  been developed for estimation of Diclofenac sodium drug by AUC method. The standard and  sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 270-282 nm. The linearity was established over the concentration range of 05,10,15,20&25µg/ml for Diclofenac sodium with correlation coefficient value of 0.9981. Precision studies showed that % relative standard  deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.38%.The proposed method has been validated as per ICH guidelines.

  • 29 January 2015
    THE USE OF EXPERIMENTAL DESIGN IN THE DEVELOPMENT AND OPTIMIZATION OF A RP-HPLC METHOD FOR THE DETERMINATION AND QUANTITATION OF NEVIRAPINE

    ABOUT AUTHORS:
    Chiluba Mwila1*, Sandile S. M. M. Khamanga2, Roderick B. Walker2
    1University of Zambia, School of Medicine, Department of Pharmacy, Lusaka, Zambia
    2Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa
    *mwilachiluba@yahoo.co.uk

    ABSTRACT
    A simple, accurate and specific reversed phase high performance liquid chromatography (RP-HPLC) method that was developed and validated for the analysis of NVP is presented. The stationary phase used was Phenomenex® Luna C18 (2), 5 µm, 250 x 4.6 mm I.D. The mobile phase comprised of acetonitrile and water in the ratio 44: 56 (v/v) and detection was accomplished using UV detector set at 284 nm. RSM using CCD was used to facilitate method optimization. Organic phase composition, flow rate and column temperature were identified as critical factors to be studied to establish the retention times of NVP and CBZ (internal standard) and the resolution factor between the two compounds. Twenty experiments including center points were performed and quadratic models were derived for the retention times of the two compounds and the resolution factor using the experimental data. The method was validated for linearity, precision, limits of quantitation and detection, and stability indicating as per ICH guidelines. The method was found to produce sharp and well resolved peaks for NVP and CBZ with retention times of 4.30 and 7.60 minutes respectively. The method was linear in the concentration range 1 – 240 µg/ml, with the calibration curve showing a good linear relationship with a regression correlation coefficient of 0.9996. The linear regression equation was y = 0.0064x – 0.0016. The limit of quantitation (LOQ) and detection (LOD) were found to be 1.0 and 0.3 µg/ml, respectively.

  • 28 January 2015
    RISK ASSESSMENT OF DEVELOPING TYPE 2 DIABETES MELLITUS IN PATIENT ON ANTIHYPERTENSIVE MEDICATION

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS
    Amarjeet Singh*, Sudeep bhardwaj, Ashutosh aggarwal
    Department of Pharmacology,
    Seth G. L. Bihani S. D. College of Technical Education,
    Institute of Pharmaceutical Sciences & Drug Research
    amarjeetsingh024@gmail.com

    ABSTRACT
    Objective:     The purpose of this study was to examine the risk assessment of developing type 2 diabetes mellitus in patient on antihypertensive medication.

    Material & Method: In the present study total 30 patient with essential hypertension of both sex with mean age (48.6±0.8313) were recruited as per the inclusion criteria. Patients were segregated on the behalf of therapy they were using. 22 patients were on Losartan+HCTZ therapy and 8 patients were on Atenolol therapy.

    Result: After six month of antihypertensive therapy Atenolol group showing a significant difference in their blood glucose (0.0014) whereas in Losartan+HCTZ group significant difference was not observed (0.1542). Patients of Atenolol group when compared with patient of Losartan+HCTZ group a significant difference was observed in the serum cholesterol level (0.0290).

    Conclusion: We found that the use of β-blocker was independently associated with increased risk of type 2 diabetes. So increase in blood glucose in the Atenolol group patient revealed a significant association between use of Atenolol therapy and metabolic dysfunction whereas in Losartan+HCTZ group significant increase in blood glucose was not observed and from these we can conclude therapy with Losartan+HCTZ therapy not associated with metabolic dysfunction.

  • 15 January 2015
    WONDERS OF IMMUNE SYSTEM: SPONTANEOUS REGRESSION OF CANCERS

    { DOWNLOAD AS PDF }

    About Author
    Vishwas B. Chavan
    Consultant, Sunflower laboratory and diagnostic Center and Clinical Diagnostic Center
    Mumbai, Maharashtra.
    vishwaschavan2003@yahoo.co.in

    Cancer incidence is increasing worldwide [1]. It can affect any part of the body, showing symptoms often in late stages. Diagnosis of cancer has a huge impact on patient and his/her family. Cancer treatments are costly and toxic, many times giving rise to secondary cancers. Even after successful treatment, risk of recurrence of cancer is significant sometimes.

  • 9 January 2015
    A REVIEW ON DYSLEXIA

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    S.Ramyasilpa
    Department of pharmacology,
    Nargund college of pharmacy, Bengaluru
    shilpasankarapu@gmail.com

    ABSTRACT
    Dyslexia is a specific reading disorder. It is common childhood disorder affecting around 5% of school aged children. The main deficits of dyslexia include inability to process sensory input (i.e., acoustic information) that comes into the nervous system rapidly, and an impaired reading ability. Secondary consequences may include problems in reading comprehension and reduced reading experience that can impede growth of vocabulary and background knowledge. The dyslexia is associated with alteration of several biological levels like genetic, biochemical, physiological, cognitive levels.

    [adsense:336x280:8701650588]

  • 5 January 2015
    CLINICAL PHARMACY IN INDIA: RECENT ADVANCES AND PERSPECTIVE

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Mazhar M1, Ansari. A2, Rajput SK1*
    1Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh-201313.
    2Department of Social Work, University Road, University of Delhi, Delhi-110007.
    *skrajput95@amity.edu

    ABSTRACT
    In lieu of the fact that without adequate supervision, the assurance of quality of any system is not possible; clinical pharmacy has emerged as one of the latest and unmapped discipline of pharmacy in the 21st century. The existence of clinical pharmacists in medical rounds could support physicians in optimizing pharmacotherapy. This novel profession in India extends its diversions to good manufacturing practices, procurement/preparation/distribution of medication, reporting ADRs/ ADEs and on the whole to a very promising aspect of patient healthcare service. The state of clinical pharmacy in India is in the transformational state showing serious positive promising changes in the past couple of years. Even hospitals have started distinguishing the importance of clinical pharmacy and have taken initiatives for making it possible although at a budding stage. The clinical pharmacy branch of pharmacy is surely attaining new heights in regard to patient care services which have certainly increased the services and satisfaction to the patients.

  • 23 December 2014
    CHILDHOOD OBESITY: REASON BEHIND THIS HEALTH CRISIS

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Abhinav Sawhney*, Nidha Amir, Mohd Mazhar, Sumeet Gullaiya, Satyendra K Rajput
    Department of Pharmacology,
    Amity institute of Pharmacy, Amity University,
    Noida, Uttar Pradesh
    abhinavsawhney@live.com

    ABSTRACT:
    Obesity has emerged as a major health issues for pediatric population as well as in adults in the present global scenario. In children, numerous studies have reveiled a relationship between the breast feeding and obesity in children. Apart from these, Family economic and education level, child meal pattern, duration of sleep and birth weight are also responsible for obesity. Some genetic problems including environmental and socio-economic factors are also responsible for the child obesity. Several studies have shown an evidence of protective effect of breast feeding against obesity while some shows a time dependent effect of breast feeding on childhood obesity. As per WHO recommendations, a child should be exclusively breast fed upto 6 months and breast fed along with the complementary food of good quality.  Introduction of the complementary food has a relationship bound with adipose rebound, which goes upto the age of 14. The intake of complementary food reduces the intake of breast milk and also induces the allergic reactions in the child. Apart from these leptin level and energy regulation in the body also plays and important role in pediatric obesity.

  • 22 December 2014
    SYSTEMATIC APPROACH FOR COMPLAINT HANDLING IN PHARMACEUTICAL INDUSTRIES- AN UPDATED REVIEW

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Jadhav Santosh*, Mali Audumbar, Bathe Ritesh, Tamboli Ashpak, Sawale Jyotiram
    Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
    Sangola, Solapur, Maharashtra, India.
    *jadhavsan88@gmail.com

    ABSTRACT:
    This article covers fundamental basics of quality complaint.Complaints show customer dissatisfaction about the quality of a pharmaceutical Product. Complaints may be about: Services, delivery, quality of product, communication, response time, documentation, billing, follow up etc. a good complaint handling system gives the company an opportunity to improve the quality of their products, being a good tool for the maintenance of Good Manufacturing Practices. A systematic procedure must be developed and implemented in order to register and investigate each complaint received and not only the Quality Assurance area must be involved. Systematic handling of complaints maintains a good relationship between customer and company. Thus the aim of this article is to discuss the main steps of a good complaint handling procedure that can be readily implemented in pharmaceutical companies.

  • 21 December 2014
    CHRONOPHARMACOTHERAPY OF HYPERTENSION: TIME-DEPENDENT EFFECTS OF TREATMENT ON BLOOD PRESSURE

    { DOWNLOAD AS PDF }

    ABOUT AUHTORS:
    Suresh Rewar1*, Bansal BK1, Singh CJ2, Sharma AK2
    1Department of pharmaceutics, Arya College of Pharmacy, Jaipur, Rajasthan India
    2Department Of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan India
    sureshrewar1990@gmail.com

    ABSTRACT
    Chronopharmaceutical drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, right time and right amount, as per the pathophysiological needs of the diseases. These systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, GIT motility, etc. These systems are designed for chronopharmacotherapy which is based on the circadian rhythm of the body. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 hr. rhythms of biochemical, physiological and behavioral processes under the control of circadian clock. The chronobiology of the various common 24-hour BP profiles seen in hypertensive patients in relation to cardiovascular risk and end-organ injury and ultimately the control and normalization of abnormal BP throughout daytime activity and night time sleep. Chronopharmacotherapy provides a means of individualizing the treatment of hypertension according to the circadian BP profile of each patient, and constitutes a new option to optimize BP control and to reduce the risk of cardiovascular disease. Various latest and upcoming marketed technologies of Chronopharmaceutical drug delivery used in treatment of hypertension diseases like OROS®, CODAS®, CEFORM®, DIFFUCAPS®, PULSINCAP® etc.

  • 19 December 2014
    A CASE STUDY ON HEMOLYTIC UREMIC SYNDROME- LEADING TO ACUTE RENAL FAILURE

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Jiguru Prasant*, Mohammad Kaleemullah Quraishi, Amer Khan
    Department of Doctor of Pharmacy,
    Krishna Institute of Medical Sciences and Bharat Institute of Technology (Pharmacy),
    Hyderabad, Telangana, India
    Prashant7792@gmail.com

    ABSTRACT
    A 65 yrs female patient was presented with  complaints of vomiting,  loose stools, pain,  fever, high grade chills,  giddiness, loss of appetite acute renal failure, hemolytic anemia and thrombocytopenia She was diagnosed with Escherichia coli  associated hemolytic-uremic syndrome and treated with plasmapheresis and other medications for 3 weeks. She recovered without sequelae.

    [adsense:336x280:8701650588]

Subscribe to Articles