Articles

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ABOUT AUTHORS:
Abhinav Sawhney*, Nidha Amir, Mohd Mazhar, Sumeet Gullaiya, Satyendra K Rajput
Department of Pharmacology,
Amity institute of Pharmacy, Amity University,
Noida, Uttar Pradesh
abhinavsawhney@live.com

ABSTRACT:
Obesity has emerged as a major health issues for pediatric population as well as in adults in the present global scenario. In children, numerous studies have reveiled a relationship between the breast feeding and obesity in children. Apart from these, Family economic and education level, child meal pattern, duration of sleep and birth weight are also responsible for obesity. Some genetic problems including environmental and socio-economic factors are also responsible for the child obesity. Several studies have shown an evidence of protective effect of breast feeding against obesity while some shows a time dependent effect of breast feeding on childhood obesity. As per WHO recommendations, a child should be exclusively breast fed upto 6 months and breast fed along with the complementary food of good quality.  Introduction of the complementary food has a relationship bound with adipose rebound, which goes upto the age of 14. The intake of complementary food reduces the intake of breast milk and also induces the allergic reactions in the child. Apart from these leptin level and energy regulation in the body also plays and important role in pediatric obesity.

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ABOUT AUTHORS:
Jadhav Santosh*, Mali Audumbar, Bathe Ritesh, Tamboli Ashpak, Sawale Jyotiram
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola, Solapur, Maharashtra, India.
*jadhavsan88@gmail.com

ABSTRACT:
This article covers fundamental basics of quality complaint.Complaints show customer dissatisfaction about the quality of a pharmaceutical Product. Complaints may be about: Services, delivery, quality of product, communication, response time, documentation, billing, follow up etc. a good complaint handling system gives the company an opportunity to improve the quality of their products, being a good tool for the maintenance of Good Manufacturing Practices. A systematic procedure must be developed and implemented in order to register and investigate each complaint received and not only the Quality Assurance area must be involved. Systematic handling of complaints maintains a good relationship between customer and company. Thus the aim of this article is to discuss the main steps of a good complaint handling procedure that can be readily implemented in pharmaceutical companies.

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ABOUT AUHTORS:
Suresh Rewar¹*, Bansal BK¹, Singh CJ², Sharma AK^2
1Department of pharmaceutics, Arya College of Pharmacy, Jaipur, Rajasthan India
²Department Of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan India
sureshrewar1990@gmail.com

ABSTRACT
Chronopharmaceutical drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, right time and right amount, as per the pathophysiological needs of the diseases. These systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, GIT motility, etc. These systems are designed for chronopharmacotherapy which is based on the circadian rhythm of the body. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 hr. rhythms of biochemical, physiological and behavioral processes under the control of circadian clock. The chronobiology of the various common 24-hour BP profiles seen in hypertensive patients in relation to cardiovascular risk and end-organ injury and ultimately the control and normalization of abnormal BP throughout daytime activity and night time sleep. Chronopharmacotherapy provides a means of individualizing the treatment of hypertension according to the circadian BP profile of each patient, and constitutes a new option to optimize BP control and to reduce the risk of cardiovascular disease. Various latest and upcoming marketed technologies of Chronopharmaceutical drug delivery used in treatment of hypertension diseases like OROS^®, CODAS^®, CEFORM^®, DIFFUCAPS^®, PULSINCAP^® etc.

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ABOUT AUTHORS:
Jiguru Prasant*, Mohammad Kaleemullah Quraishi, Amer Khan
Department of Doctor of Pharmacy,
Krishna Institute of Medical Sciences and Bharat Institute of Technology (Pharmacy),
Hyderabad, Telangana, India
Prashant7792@gmail.com

ABSTRACT
A 65 yrs female patient was presented with  complaints of vomiting,  loose stools, pain,  fever, high grade chills,  giddiness, loss of appetite acute renal failure, hemolytic anemia and thrombocytopenia She was diagnosed with Escherichia coli  associated hemolytic-uremic syndrome and treated with plasmapheresis and other medications for 3 weeks. She recovered without sequelae.

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ABOUT AUTHORS:
Abdul Waheed¹*, Ankit Gupta², Parth Patel^3
1Department of Pharmacology
²Department of Pharmaceutics
³Department of Drug Regulatory Affair
Amity Institute of Pharmacy, Amity University, Noida-125, U.P. (INDIA)
abdul.waheed2050@gmail.com

ABSTRACT
In the present scenario, lung cancer is one of the most prevalent and malignant cancer especially among the smoking group of people. The targeted delivery of chemotherapeutic agents to the lungs represents a novel therapeutic approach in lung cancer. Lung is an ideal route for administration of anticancer drug as it provides larger alveolar surface area, low thickness of epithelial barrier & extensive vascularization. Nanoparticles with nanocarriers have possibility of cell-targeted drug delivery with minimal systemic side effect and toxicity. Pulmonary epithelial cell, enzymes, receptors and genes are the target of the targeted drug delivery in lung cancer. This paper reviews the till date targeted drug delivery research performed for the treatment of lung cancer.

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ABOUT AUTHORS:
Anuradha Sharma¹*, Vaibhav Walia², Monika Gahlawat^3
1Division of Pharma. Chemistry, ²Division of Pharmacology, ³Division of Pharmaceutics,
G.V.M. College of Pharmacy,
Sonepat, Haryana, India
*anusarswat@gmail.com

ABSTRACT
Plagiarism is a multifaceted and ethically a complex problemwhich simply means the stealing and publication of another author’s work as one's own original work without acknowledge the original author. Plagiarism is simply an act of fraud.Authors should acknowledge sources fully and appropriately to follow the ethics and plagiarism is failure to do so. However the students or the authors sometimes fail to acknowledge the source appropriately and properly. These failures are largely due to the lack of knowledge to use the citations properly. Therefore to maintain the ethics the plagiarism should be avoided. The aim of this paper is to define plagiarism, its type, methods of detection and the ways to avoid plagiarism.

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ABOUT AUTHORS:
Singh Divya¹, Siddhi Shrimali², Rathore KS^2*
1Department of Pharmacology, Jaipur College of Pharmacy, Jaipur, Rajasthan, India
²Department of Pharmaceutics, BN Institute of Pharmaceutical Sciences, Udaipur, Rajasthan, India
*kamalsrathore@gmail.com

ABSTRACT
Parkinsonism disease (PD) is a progressive neurological disorder. Degeneration of dopamine producing cells in the substantia nigra (part of the basal ganglia) leads to a decreased dopamine production. The cause of the damage is unknown. The main known risk factor is age. Parkinson’s affects functional activities such as balance, walking, speech, handwriting, typing, fastening buttons, driving, and many other simple, or complex but familiar and routine activities, as they are usually controlled by the mechanisms of dopamine and the basal ganglia. This review briefly focuses on deep brain stimulation neurosurgical treatment. Levodopa was the first drug approved specifically for Parkinson’s disease. Levodopa is converted by enzymes in the brain to produce dopamine, thereby supplementing function that has been lost as dopamine-producing neurons die.Topics covered in the review includes pathogenesis, mechanism of action, side effects of medicines and neurological surgery.

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ABOUT AUTHORS:
Anuradha Sharma¹*, Vaibhav Walia², Monika Gahlawat^3
1Division of Pharma. Chemistry,² Division of Pharmacology,³ Division of Pharmaceutics,
G.V.M. College of Pharmacy,
Sonepat, Haryana, India
*anusarswat@gmail.com

ABSTRACT
Type 2 diabetes is one of the major life threatening diseases worldwide. These cases are progressing at an incremental rate every year and number of research works is going on to control the disease by targeting its enzymes or proteins. In modern drug designing, molecular docking is routinely used for understanding drug receptor interaction. In the present study molecular docking were performed on a diverse set of N-(2-benzoylphenyl)-L-tyrosine derivatives that demonstrate antidiabetic activity by stimulating peroxisome proliferator activated receptor- γ. The docking program in Glide dock justifies the correlation between the experimental values and the values derived computationally. Therefore, the dock analysis performed in Glide dock suggests the importance of evaluating the prediction accuracy of scoring functions adopted in various docking program.

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