ABOUT AUTGHORS:
*Olayode, Ahmed A1; Ofusori, David A1; Ogunniyi, Titus A. B2; Saka, Olusola S1; Ajayi, Olusoji C3; Adewole, Oluwole S1
1Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
2Department of Medical Microbiology and Parasitology, College of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
3Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria
*olayodeahmed01@gmail.com
ABSTRACT
This study was carried out to assess the biochemical effects of Mangifera indica on the liver function enzymes of Plasmodium – infected albino mice. Forty-two male Swiss albino mice, weighing between 20 and 25 g, were used for this research. The mice were randomly assigned into six groupsA, B, C, D, E and F of seven mice each. Groups B, C, D, E and F were infected with Plasmodium berghei. Group A was the negative control, group B was positive control. Mice in groups C, D and E were orally administered with Mangifera indica(MI) extract (50 mg/kg, 100 mg/kg and 150 mg/kg body weight) respectively for 5 days starting from the 4th day of inoculation while mice in group F were orally administered with Artesunate for 5 days (3 mg/kg body weight on the first day and 1.5 mg/kg body weight for the next 4 days) starting from the 4th day of inoculation. The animals were left for another 14 days after treatment. Blood samples, collected through cardiac puncture, were centrifuged to obtain sera. Activities of ALT, AST and ALP as well as bilirubin concentration were measured from the sera using enzyme colorimetric methods. Dataobtained were analyzed using descriptive and inferential statistics. Mangifera indica extract has an ameliorative effect on the serum level of total bilirubin concentration but appeared to be less effective in reducing the activities of the liver function enzymes.
ABOUT AUTHORS:
ABOUT AUTHORS:
