Applications are invited from suitable candidates for Senior Research Fellowship to work fon the project entitled “Chemical Modification of Starch” sponsored by Sheekharr Starch Pvt. Ltd, under the supervision of K.S. Lacldha in the Pharmaceutical Division of this department.

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ABOUT AUTHORS
L Reddenna¹*, Dr. P. Venkatesh¹, K Siva Kumar², A Sai keshava Reddy²
1* Department of Pharmacy Practice,
Jagan’s College of Pharmacy,
Nellore, Andhra Pradesh, India
² Department of Pharmacy Practice,
Nirmala College of Pharmacy,
Kadapa, Andhra Pradesh, India
*reddennapharmd@gmail.com

ABSTRACT
Genotoxicity describes the possessions of chemical agents that damage the genetic information within a cell causing mutations, which may lead to cancer. Heritable changes can influence either somatic cells of the organism or germ cells to be passed on to future generations. As a result, many urbane techniques including Ames Assay, in vitro and in vivo Toxicology Tests, and Comet Assay have been developed to evaluate the chemicals probable to cause DNA damage that may lead to cancer. The genotoxic substances provoke damage to the genetic material in the cells through exchanges with the DNA sequence and structure. Genotoxicity testing is to resolve if a substrate will sway genetic material or may cause cancer. Genotoxic Chemotherapy is the treatment of cancer with the use of one or more genotoxic drugs. The treatment is traditionally part of standardized regime. By utilizing the destructive properties of genotoxins treatments aims to induce DNA damage into cancer cells.

Novo Nordisk is a global healthcare company with 89 years of innovation and leadership in diabetes care. The company also has leading positions within Haemophilia care, growth hormone therapy and hormone replacement therapy. Headquartered in Denmark, Novo Nordisk employs approximately 33,300 employees in 75 countries, and markets its products in more than 190 countries Novo Nordisk’s B shares are listed on NASDAQ OMX Copenhagen (Novo-B).

Post : Drug Safety Associate

Thomson Reuters is the leading source of intelligent information for the world's businesses and professionals, providing customers with competitive advantage. Intelligent information is a unique synthesis of human intelligence, industry expertise and innovative technology that provides decision-makers with the knowledge to act, enabling them to make better decisions faster. Through its more than 50,000 people across 93 countries, Thomson Reuters delivers this must-have insight to the financial, legal, tax and accounting, scientific, healthcare and media markets, and is powered by the world's most trusted news organization.

Post : Associate

Torrent Pharma, the flagship company of Torrent Group, is ranked amongst the top pharma companies of India. It is a dominant player in the therapeutic areas of cardiovascular (CV) and central nervous system (CNS) and has achieved significant presence in gastro-intestinal, diabetology, anti-infective and pain management segments. Torrent Pharma has a strong international presence spanning over 70 countries across five continents with over 1200 product registrations. Today, Torrent Pharma, with its state of the art manufacturing and research facilities and a global presence, is all poised to carve a niche foritselfintheinternationalpharmaarena.lt is well set on an exciting growth phase in all directions.

Post : Tech. Asst. / Executive / Asst. Manager

Otsuka Pharmaceutical India Private Limited (OPI) is a major player in Infusion Business in India and Emerging Markets. We primarily manufacture & market products across multiple markets and therapeutic segments. To keep pace with our growth plans, we require experienced and highly competent team members in following areas for our manufacturing facility at Ahmedabad, Gujarat.

Forretindia is fasted growing Company.

Post : Registered Nurse - UK

Pioneers in natural herbal supplements. Innovation driven by research and development. Scientifically proven components and formulations to keep healthy life.

Post : Manager - 02 posts

Applications are invited from suitably qualified and experienced candidates in the prescribed format (to be copied on a plain paper) for the temporary post(s) mentioned below in the research project titled

Post: Clinical Research Coordinator

The history of the IIT system dates back to 1946 when a committee was set up by Hon'ble Sir Jogendra Singh, Member of the Viceroy's Executive Council, Department of Education, Health and Agriculture to consider the setting up of Higher Technical Institutions for post war industrial development in India. The 22 member committee headed by Sri N.R.Sarkar, in its report, recommended the establishment of four Higher Technical Institutions in the Eastern, Western, Northern and Southern regions, possibly on the lines of the Massachusetts Institute of Technology, USA, with a number of secondary institutions affiliated to it.

Post : Post doctoral fellow

Applications are invited from deserving and suitable candidates for the post of Project Technical Assistant for IBSD, Sikkim Centre, Gangtok on contractual basis for the project entitled “Establishment of Culture Collection Centre in North East Region of India” under Department of Biotechnology (DBT), Govt. of India.

Post : Project Technical Assistant

Bliss GVS is a fast-growing Pharmaceutical Company with a proven track record of developing, manufacturing and marketing high quality pharmaceutical formulations at affordable prices for the global market. We are a public limited company listed on India’s National Stock Exchange and Bombay Stock Exchange with more than three decades of industry expertise.

Post : Strategy & Project Management

Piramal Life Sciences Limited (PLSL) is an independent research-driven drug company that was recently demerged from Piramal Healthcare Limited (Formerly known as Nicholas Piramal India Limited). PLSL was formerly the NCE R&D division of NPIL. PLSL has state-of-the-art R&D laboratories built over 200,000 square-feet of space in Mumbai, India and over 300 scientists engaged in drug discovery and development.

Post : Junior Research Scientist

Micro Labs Limited is a multi-faceted healthcare organization with a proficient marketing team, state-of-the-art manufacturing facilities and R&D centres that are at par with international standards. All this, robustly backed by a strong distribution network and path-breaking research work has placed us amongst India’s fast growing transnational healthcare organizations.

Post : Officer / Executive for QC and Validation

National Institute of Biologicals an autonomous Institution under the Ministry of Health & Family Welfare (MOHFW)-Government of India is a premier Scientific Organization and a Centre of Excellence to ensure quality of biologicals and vaccines in the country. The institute responsibly assures and reviews the quality of number of  Biological products available through domestic manufacturers or imports. The operations are carried out in the state of the art Facility of the Institute and in close coordination with Government of India regulatory authorities as Office of Drug Controller of India, Indian Pharmacopeia's Commission.

Post : Consultant

Newcastle University, we have always focused on academic excellence and the impact of our academic work. Today, these long-held ideals are more relevant than ever. They define our vision for the University – the kind of university we wish to be.

Covidien and Medtronic are committed to improving the lives of patients through ground-breaking medical technologies. By bringing our companies together, we are able to expedite our ability to create the meaningful innovations and therapies that fuel our mission to improve patients’ lives. This partnership will create new opportunities for skilled, ambitious people to change the way we work, and ultimately deliver better health for more people.

Post : Regional Sales Manager/ District Manager, Reg/Ctry

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ABOUT AUTHOR
Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry,
Shri Sarvajanik Pharmacy College,
Mehsana, Gujarat, India
dhrubosen69@yahoo.com

ABSTRACT: Our goal is to perform in-vitro biotransformation of Prodrugs of ibuprofen+paracetamol, diclofenac sodium+paracetamol and ibuprofen+diclofenac sodium by acidic and alkaline hydrolysis of both ester (–COO–) and amide (–CONH–) linkages into free drugs and chromatographically separation of their Rt in HPLC. Since both ester (–COO–) and amide (–CONH–) linkages are susceptible for hydrolysis in both acidic pH (gastric pH) and basic pH (intestinal pH) to produce parent drug ibuprofen, diclofenac and paracetamol by biotransformation in in-vivo; so it will be implemented as a Prodrug which can show prolong action on pain and fever after getting release into free parent drug by biotransformation. The HPLC (High Performance Liquid Chromatography) study reports the retention time (Rt) and release kinetics of three Prodrugs by taking HPLC degradation datas of three samples of Prodrugs and individual HPLC datas of parent drugs separately to compare the Rt value of release of three drugs from Prodrugs in both acidic and alkaline pH. Prodrug–A (logP=4.56) releases Ibuprofen & Paracetamol, Prodrug–B (logP=4.90) releases Diclofenac & Paracetamol and Prodrug–C (logP=6.13) releases Ibuprofen & Diclofenac. This is a comparison study of drug release in in-vitro gastric as well as intestinal pH focusing on in-vivo biotransformation.  Keywords: Prodrug-A/Prodrug-B/Prodrug-C, Ibuprofen, Paracetamol, Diclofenac sodium, Molecular weight, logP, UV λmax, IR, Mobile phase, TLC-Rf value, HPLC-Rt value, LOD, LOC

We want you to understand the medicines that you take and that you give your loved ones. Buying medicines may require you to try 5 medical stores which are miles apart. We want you to be able to do it with a click. Medicines can be expensive. We want you to know about medicines which have the same composition as prescribed by your doctor but can be considerably cheaper. We want you to be in charge of your medical care.

Post: Pharmacist / Sr. Pharmacist (10 posts)