GPAT Paper, 2015 | Find out GPAT 2015 question Paper with key answers

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46. Tamoxifen is nonsteroidal drug acting at steroid receptor(s) It produces which type of effects
(P) Androgen (Q) Antiestrogen (R) Antiprogestogen (S) Estrogen
(a) P and Q
(b) Q and S
(c) Q and R
(d) R and S

47. Which enzymes is used by the HIV to form DNA in the host cell
(a) Restriction endonuclease (b) DNA-directed polymerase only
(c) Reverse transcriptate only (d) Both (b)and (c)

48. ‘Sparging’ is the process where
(a) Silanol groups react with trimethylsilyl group
(b) An inert has is bubbled through the solvent reservoir to remove dissolved gases
(c) Solvents are mixed together in a fixed ratio
(d) Column is washed with solvents from nonpolar to polar and reverse

49. Morphine does not cause:
(a) Constriction of pupil (b) CNS depression (c) Respiratory depression (d) Diarrhoea

50. Which of the following is not recommended in patients with renal insufficiency or cardiac dysfunction
(a) Aloe (b) Bisacodyl (c) Isapghol (d) Magnesium hydroxide

51. Higuchi model is applicable to drug that is............. In the formulation
(a) Dissolved in formulation
(b) Dispersed in formulation
(c) Chemically bound to carrier in formulation
(d) Osmotically controlled in the formulation

52. Which of the following in correct about parenteral nutrition
(a) Parentral nutrition solutions are hypertonic solutionsand IV fluids are isotonic
(b) Parentralnutribtionsolutions and IV preparations are isotonic solutions
(c) Parentrtal nutrition solutions are hypertonic solutions and IV fluids are isotonic
(d) Parentral nutrition solutions can be supplemented with mediacations

53. Cyclic AMP (cAMP) is an important second messenger in signal transduction pathway(s)Which enzyme
catalyzes the generation/accumulation of cAMP after a receptor – ligand interaction
(a) Protein kinase A
(b) cAMP phosphodiesterase
(c) Guanylyl cyclase
(d) Adenylate cyclase

54. Which of the following in not include in immunization programme as per WHO recommendations for all children
(a) BCG (b) Oral polio (c) Measels (d) Typhoid

55. Match the given condition with appropriate drug used for its treatment
(1) Pernicious anemia (P) Erythropetin
(2) Meagaloblastic anemia (Q) Oprelvekin
(3) Anemia associated with chronic renal failure (R) Ratenteral Vitamin B12
(4) Thrombocypeniadue to cancer chemotherapy (S) Folic acid
(a) 1-P, 2-Q, 3-R, 4-S (b) 1-R, 2-S, 3-P, 4-Q (c) 1-R, 2-Q, 3-S, 4-P (d) 1-R, 2-P, 3-S, 4-Q

56. In mammals, The major fat in adipose tissue is:
(a) Triglyceride (b) Cholesterol (c) Sphingophospholipids (d) Phospholipids

57. Plarographic method of analysis to obtain individual amounts of Cu2+ and Cd2+ in a given mixture of the two ions (Cu2+ and Cd2+) is achieved by measuring their
(a) Half-wave potentials
(b) Migration currents
(c) Decomposition potentials
(d) Diffusion currents

58. What is the objective of trademark
(a) To claim exclusive properties of products or services
(b) To claim innovation of products or services
(c) To deal with market place of expressive ideas
(d) To protect consumers from being misled

59. Turbulent flow is exhibited by fluids whose
(a) Re<40’ (b) Re>40’ (c) Re=40 (d) All of the above

60. Characteristics of drug-protein binding
(P) Often parallels drug lipid solubility
(Q) Drug-plasma albumin binding tends to be relatively nonselective
(R) Acidic drugs bind to albumin while basic drug bind to glycoproteins
(S) In rheumatoid arthritis patients, increased alpha1- acidic glycoprotein tends to promote increased lidocaine protein binding
(a) P and Q (b) P, Q and R (c) P, Q, R and S (d) P and R


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