GPAT Paper, 2015 | Find out GPAT 2015 question Paper with key answers

Pharma Admission

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31. A Pharmaceutical company plans to market a generic version of a drug produce whose patent has expired has expire (d) Which type of documentation must be submitted to the FDA
(a) IND (b) NDA (c) ANDA (d) SNDA & Letter of intent

32. Which of the following does not produce azeotropic mixture with water
(a) Methanol (b) Ethanol (c) Propanol (d) Isopropanol

33. For a particular durg, the rate of absorption but not the extent of the absorption of GIT, is affected by presence of food in GIT then taking the drug with food will result in
(a) Smaller area under the plasma drug concentration time curve
(b) Smaller maximal plasma drug concentration
(c) Smaller time at which the maximal plasma drug concentration occurs
(d) Smaller fractional bioavailability and total clearance

34. According to USP Alcohol contains
(a) 94.9 to 96% Ethanol (b) 94.9 to 96% Methanol (c) 50% Ethanol (d) 50% Methanol

35. What does in mean that a cell is polyploid
(a) That is contains more than 2 copies of one or a few of its of chromosomes
(b) That is contains more than 2 copies of a full set of homologous chromosomes
(c) That is contains more than 2 copies of its sex chromosome
(d) That is contains more than 2 copies of its autosomal chromosomes

36. Amount of dextrose in large volume infusion fluids
(a) 5% w/v (b) 10% w/v (c) 25% w/v (d) 50% w/v

37. ______________, Anthelmintics having Immunosuppressant activity.
(a) Piperazine (b) Levamisole (c) Ivermectin (d) Niclosamide

38. Choose correct statement for PEGylation:
(A) Used to enhance In-vivo half-life of smaller Peptides and proteins
(B) Avoidance of Reticulo-endothelial (RES) clearance
(C) Reduce clearance rate through kidney
(D) All

39. Characteristics feature if hemorrhagic dengue fever is
(a) Reduction in platelet count
(b) Reduction in RBC count
(c) Reduction in coagulation factors
(d) Increased RBC

40. The carbonyl starching frequency for simple aldehydes, ketones, and carboxylic acids is about 1710 cm-1 ,  where as the carbonyl stretching frequency for esters is about ..................... cm-1
(a) 1650 (b) 1700 (c) 1750 (d) 1850

41. Plarographic method of analysis to obtain individual amounts of Cu2+ and Cd2+ in a given mixture of the two ions (Cu2+ and Cd2+) is achieved by measuring their
(a) Half-wave potentials
(b) Migration currents
(c) Decomposition potentials
(d) Diffusion currents

42. Consider the reaction: A+B ≤≥ C
The unit of the thermodynamic equilibrium constant for the reaction is
(a) mol L-1 (b) L mol-1 (c) mol2 L-2 (d) Dimensionless

43. ______________, system does not have orifice to release the drug.
(a) Elementary Osmotic Pump
(b) L-OROS
(c) Sandwich Osmotic Pump Tablet
(d) Controlled Porosity Osmotic Pump Tablet

44. Sanguinarine belongs to the subgroup of:
(a) Morphinans
(b) Benzyl isoquinolines
(c) Phthalide isoquinolines
(d) Benzophenanthrenes

45. Identify the IUPAC of dexamethasone
(a) 2-Chloro-6α, 9α-difluoro-11α, 17, 21-trihydroxy-16α-methylpregna-1,4-dien-3, 20-dione
(b) 9α-Fluoro-11β, 17α, 21-trihydroxy-16β-methylpregna-1, 4-diene-3, 20-dione
(c) 9α-Fluoro-11β, 17α, 21-trihydroxy-16β-methylpregna-1, 4-diene-3, 20-dione
(d) 6α-Fluoro-11α, 21-dihydroxy-16α-methylpregna-1, 4-diene-3. 20-dione

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