76-125 questions are available below:
76. Mechanism of action of Ketoconazole is:
(a) Inhibits Ergosterol synthesis
(b) Inhibits DNA gyrase
(c) Inhibits dihydropteroate synthetase
(d) Induces translation misreading
77. All are adrenal gland over activity disorders EXCEPT
(a) Addison’s disease
(b) Conn’s syndrome
(c) Cushing’s syndrome
(d) Cushing’s disease
78. The oil used in a parenteral product cannot contain.......................
(a) WFI (b) Parffin oil (c) Peanut oil (d) Glycerine
79. Identity the non-absorbable sature
(a) Catgut suture (b) Chromic catgut suture (c) Silk suture (d) Polydioxanone suture
80. The relative lowering of vapour pressure is given by
(a) Raoult’s law (b) Henry’s law (c) Boyle’s law (d) Charles law
81. Identity the functional group present in meprobamate
(a) Amide (b) Ester (c) Carbamic (d) Lactam
82. Match the following
(a) P-1, Q-2, R-4, S-3
(b) P-3, Q-4, R-1, S-2
(c) P-4, Q-3, R-1, S-2
(d) P-2, Q-4, R-1, S-3
83. Tinea capitis is ringworm infection of
(a) Feet (b) Groin (c) Head (d) Nails
84. Rank the following compounds is order of increasing reactivity in electrophilic aromatic Substitution reactions
(a) Q<P<R (b) R<P<Q (c) Q<R<P (d) P<Q<R
85. Dose dumping may be a general problem in the formulation of:
(a) Soft gelatin capsules (b) Suppositories (c) Modified release drug products (d) None
86. Codeine differ in structure from morphine by:
(a) N-methyl group (b) Acetyl group at C1 and C6 (c) –OC2H5 group (d) –OCH3 group
87. Isotopes differ in:
(a) The number of protons (b) The valency number
(c) The chemical activity (d) The number of neutrons
88. Arrange the given acids in increasing order as per the number of carbons present in them
(P) Capric (Q) Caprylic (R) Caproic (D) Lauric
(a) P<Q<R<S
(b) R<Q<P<S
(c) R<Q<P<S
(d) Q<P<R<S
89. E1cb (Elimination reaction via conjugate base) which reaction intermediate will form?
(a) Carbocation (b) Carbanion (c) Free radical (d) All
90. What are the three basic steps of conventional PCR
(a) Denature, anneal, & Strand displacement (b) Denature, anneal & extension
(c) Strand displacement, synthesis & release (d) Reverse-Transcription, anneal & extend
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91. Rabies bodies are
(a) Negri bodies
(b) Cowdry type B inclusion bodies
(c) Cowdry type A inclusion bodies
(d) Bollinge bodies
92. When glucose reacts with bromine water, the main product is
(a) Glucaric acid (b) Glucoronic acid (c) Sorbitols (d) Gluconic acid
93. Increase in melting temperature of DNA is due to high content of
(a) A+T (b) G+C (c) A+G (d) T+G
94. What will be the primary product of the following reaction
95. The mass spectrum of a compound with an approximate MW 137 shows tow equally intense. peaks at
m/z 136 and 138. What does the suggest
(a) The compound is alkyl iodide
(b) The compound is alkyl bromide
(c) The compound is alkyl chloride
(d) The compound is aryl fluoride
96. Capping in tablets mainly due to:
(a) Less upper punch pressure
(b) Poor flowability of granules
(c) Proper formulation design
(d) Entrapment of air in tablet during compression
97. How can we detect the rhizome from the root of the Rauwolfia?
(a) By the presence of small central pith
(b) By the absence of small central pith
(c) By the presence of vascular bundle
(d) None
98. Drug of choice to treat H1N1 influenza is
(a) Adefovir (b) Cidofovir (c) Oseltamivir (d) Tenofovir
99. Identify the correct statement
(P) Condensed tannins are polymers flavans
(Q) Condensed tannins do not contain sugar redidues
(R) Hydrolyzabletannis are polymers of gallic acid or ellagic acids
(S) Gallic acid and catechin are psedotannins
(a) Only Q (b) P and Q (c) P, Q and R (d) P, Q, R and S
100. Quick breaking aerosols are applicable:
(a) Orally (b) Parenterally (c) Topically (d) Ophthalmically
101. In the Reimer-Tiemann reaction............ Reacts with phenol to give the ortho-formylated product
(a) Carbene (b) Carbocation (c) Carbanion (d) Free redical
102. Which of the following in not added to chewing tablet
(a) Gildant (b) Disintegrant (c) Lubricant (d) Anitadhesive
103. Range of C=O stretching in enol is
(a) 1800 cm-1 (b) 1710 cm-1 (c) 1685 cm-1 (d) 1655 cm-1
104. Match the following phytochemicals with their source and use
(P) Shatavrin (1) Buckwheat and citrus fruits, strengthens capillary walls
(Q) Resvertatrol (2) Broccoli and cabbage, protects against bladder cancer
(R) Glucosinolates (3) Purple grape, anti inflammatory, anticancer
(S) Rutin (4) Asparagus, galactogogue
(a) P-4, Q-3, R-2, S-1 (b) P-4, Q-2, R-3, S-1 (c) P-3, Q-1, R-4, S-2 (d) P-2, Q-3, R-4, S-1
105. Which RNA polymerase is the only whose product are capped
(a) RNA polymerase I (b) RNA polymerase II
(c) RNA polymerase III (d) RNA pimase
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106. Match the scientist awarded with Nobel prize with their contributions
(P) Alexander Fleming (1) GPCR
(Q) Kobilka (2) β-blocker
(R) Banting (3) Penicillin
(S) Black (4) Insulin
(a) P-4, Q-3, R-2, S-1 (b) P-4, Q-2, R-3, S-1 (c) P-3, Q-1, R-4, S-2 (d) P-2, Q-3, R-4, S-1
107. Mean arterial pressure is
(a) Systolic pressure – Diastolic Pressure
(b) (Diastolic pressure + Diastolic Prssure )/2
(c) Diastotic alcohol + (1/3) X pulse pressure
(d) Stroke valume X heart rate
108. Eugenol is
(a) Monoterpene alcohol
(b) Sesquiterpene alcohol
(c) Aliphatic alcohol
(d) Phenylpropene
109. The Vitamin required for carboxylation of pyruvate to form oxaloacetate is
(a) Thiamine (b) Biotin (c) Pyridoxine (d) Niacin
110. Which of the following circled hydrogen is most acidic
111. The drug formulated as suspension follows .............. order reaction
(a) Zero (b) Pseudo Zero (c) First (d) Pseudo first
112. Which diuretic causes decrease in release of insulin
(a) Chlorothiazide (b) Ethacynic zero (c) Triamterene (d) Acetazolamide
113. Match the following drugs with their mode of action
(P) Methotrexate (1) Mitotic inhibitor
(Q) Cyclophosphamide (2) Antimetabolite
(R) Vincristine (3) Alkylating agent
(S) Dactinomycin (4) Intercalating agent
(a) P-4, Q-3, R-2, S-1 (b) P-2, Q-4, R-1, S-3 (c) P-3, Q-1, R-4, S-2 (d) P-2, Q-3, R-1, S-4
114. Which compound would be expected to show intense IR absorption at 3300 cm-1
(a) CH3CH2CH2CH3 (b) CH3CH2C=CH (c) CH3C=CCH3 (d) CH2CHCH2CH3
115. In the carbon NMR, in what region of the spectrum does one typically observe carbons which are part of the aromatic ring
(a) -10-0 ppm (b) 40-60 ppm (c) 80-100 ppm (d) 120-150 ppm
116. Meclofenamate belongs to which class of drug
(a) Slicylates (b) Oxicams (c) Aryl antaranillic acid (d) p-Amino phenols
117. Match the following crude with their chemical constituents
(P) Aloe (1) Hesperidine
(Q) Ginger (2) Palmitin
(R) Lemon peel (3) Barbaloin
(S) Olive oil (4) Allin
(a) P-4, Q-3, R-2, S-1 (b) P-3, Q-4, R-2, S-1 (c) P-3, Q-4, R-1, S-2 (d) P-3, Q-1, R-1, S-4
118. Dopamine agonists with tetralene function
(a) Ropinorole (b) Pirebidil (c) Pramipixole (d) Rotigotine
119. The IUPAC name of the compound-(CH3
(a) 2-methyl-3-chloropropane
(b) 1-chloro-3-mehtyl butane
(c) 1-chloropentane
(d) 2-mehtyl-4-chlorobutane
120. A powerful inhibitor of stomatal opening is
(a) Auxin (b) Bytokinin (c) Gibberellin (d) Abscisic acid
121. What is the renal clearance of a substance, if its concentration in plasma is 10mg, concentration in urine is 100 mg and urine flow is 2 ml/min
(a) 0.02 ml/min
(b) 0.2 ml/min
(c) 2ml/min
(d) 20 ml/min
122. Aim of pharmacovigilance is
(a) To monitor drug toxicity
(b) To monitor unauthorized drug manufacture
(c) To monitor rational use of drugs
(d) To check and control drug costs
123. Phase zero studies is a/an
(P) Exploratory investigational new drug study
(Q) Human microdosingstudies
(R) Step to speed up drug discovery/ development process
(S) Mandatory by FDA
(a) P and Q (b) Q and R (c) P, Q and R (d) P, Q, R and S
124. Parenteral product must be:
(a) Packed in bottle (b) Sterilized (c) Free from viable/living organism (d) Pyrogenic
125. Quinine present in highest amount in:
(a) C. calisaya (b) C. officinalis (c) C. ledgeriana (d) C. succirubra
ANSWERS AND KEY SOLUTIONS of GPAT 2014
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