GPAT Paper, 2012 | Find out GPAT 2012 question Paper with key answers

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Q.1.Which of the following respective Phase-I and Phase-II reactions are the most common drug biotransformation reactions?
(A)    Oxidation and Glucuronidation
(B)    Reduction and Acetylation
(C)    Hydrolysis and Glucuronidation
(D)    Oxidation and Glutathion conjugation

Q.2 Which one of the following drugs has positive inotropic and negative chronotropic action?
(A)   Dopamine    (B)   Epinephrine    (C)   Digoxin    (D)   Isoprenaline

Q.3 Which one of the following therapeutic classes has been proved clinically as a first line therapy for heart failure and has shown decreased hospitalization, improved symptoms and delayed disease progression?
(A) Cardiac glycosides                 (C) Renin Antagonists
(B) ACE Inhibitors (ACEIs)            (D)   Nitrites

Q.4 Which one of the following glucose transporters is the new drug target for the management of Type-2 diabetes mellitus?
(A)    Sodium glucose linked transporter-2 (SGLT2)
(B)    Glucose transporter-1 (GLUT1)
(C)    Sodium glucose linked transporter-1 (SGLT1)
(D)    Glucose transporter-2 (GLUT2)

Q.5 Which one of the following modes of HIV transmission carries highest relative risk of infection with single exposure?
(A)    Transfusion of blood and blood products
(B)    Perinatal - from mother to child
(C)    Sexual contacts with infected partners
(D)    Syringe sharing with drug addicts

Q.6 Which of the followings are the critical neurotransmitters playing major role in depression?
(A)    Acetylcholine, Norepinephrine and Dopamine
(B)    Dopamine, Norepinephrine and Serotonin
(C)    Serotonin, Dopamine and y-Amino butyric acid
(D)    Acetylcholine, Serotonin and y-Amino butyric acid

Q.7 A 55 years old man is under DOTS treatment for pulmonary tuberculosis for the last four months. Now, he has developed symptoms of peripheral neuritis. Which one of the followings is the right addition to his therapy to manage peripheral neuritis?
(A)   Cyanocobalamin    (B)  
α-Lipoic acid
(C)   Pyridoxine            (D)   Prednisolone

Q.8 What is the primary mechanism of action of local anesthetics?
(A)    Activation of ligand-gated potassium channels
(B)    Blockade of voltage-gated sodium channels
(C)    Stimulation of voltage-gated N-type calcium channels
(D)    Blockade of GABA-gated chloride channels

Q.9      Which one of the following anti-asthmatic drugs can cause convulsions and arrhythmia?
(A)   Prednisolone  (B)   Salmeterol (C)   Zafirlukast   (D)   Theophylline

Q.10 Which one of the following anti-arrhythmic drugs acts by inhibiting potassium, sodium and calcium channels?
(A)   Quinidine    (B)   Lignocaine    (C)   Amiodarone      (D)   Flecainide

Q.11 A 48 years old woman is having the symptoms of weight gain, cold intolerance, constipation, bradycardia, puffy face, lethargy and dry skin. These symptoms are suggestive of which of the followings?
(A)   Over use of corticosteroid    (B)   Hypothyroidism
(C)   Estrogen deficiency            (D)   Over use of thyroxin sodium

Q.12 Increased risk of hypoglycemia and weight gain is the common side effect of drugs used in the management of Type-2 diabetes mellitus. Followings are some commonly used drugs, alone or in combination, for the management of Type-2 diabetes mellitus:
[P] : Metformin    [Q]: Pioglitazone
[R]: Glipizide        [S] : Sitagliptin
Choose the correct combination which is weight neutral and without risk of hypoglycemia.
(A)   P and Q    (B)   Q and R    (C)   R and S    (D)   P and S

Q.13    Which one of the following receptors is NOT a ligand-gated ion channel receptor?
(A)   Nicotinic Receptor    (B)   5HT3 - Receptor
(C)   GABAA - Receptor    (D)   H2 - Receptor

Q.14 Which one of the following classes of drugs causes side effects like dryness of mouth, tachycardia, urinary retention, constipation, blurring of vision, precipitation of glaucoma, drowsiness and impairment of cognition?
(A)    Anti-adrenergic       (B)   Anti-cholinergic
(C)   An ti-serotonergic    (D)   Anti-dopaminergic

Q.15 Which of the following cytokines are the most important regulators in inflammation and are the targets for anti-inflammatory agents used in rheumatoid arthritis?
(A)   Tumor necrosis factor-a and Interleukin-1
(B)    Acetylcholine esterase and Eicosanoids
(C)    Leukotrienes and Isoprostanes
(D)    Adhesion factor and Monoamine oxidase A

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