Articles

PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY STUDY OF SYZYGIUM CUMINI (MYRTACEAE) SEED EXTRACTS

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Abdul Aziz*, Sabyasachi Banerjee
Department of Pharmaceutics, Gupta College of Technological Sciences,
Ashram More, G.T. Road, Asansol 713301, West Bengal, India

*abdulaziz_94@rediffmail.com

ABSTRACT
Syzygium cumini is commonly known as jamun, jambolan, Java plum or black plum, is an evergreen tropical tree in the flowering plant from family Myrtaceae, and is one of the most popular fruits. It is planted in various regions spontaneous. It is native of India, Bangladesh, Sri Lanka, Myanmar, Nepal, China, Australia, Thailand, Kenya, Colombia, Mexico, United States of America, Zambia, and Zimbabwe. The entire part of the plants has been widely used in the treatment of various diseases in the traditional and folk medicine. The edible part of fruits (jamun) contain vitamin C, gallic acid, tannins, anthocyanins, includes cyanidin, petunidin, malvidinglucoside and other components. The seeds of Syzygium cumini possess anti-diabetic, antipyretic, anti-inflammatory, hypolipidaemic, psychopharmacological, anti-diarrheal, antioxidant and antibacterial activities.
In this present study, the phytochemical investigation and antibacterial activity studies were carried out with using methanol, petroleum ether and ethanol extracts of the seeds of Syzygium cumini from the family Myrtaceae. Preliminary the phytochemical screening of all extracts revealed the presence of phytoconstituents like alkaloids, tannins, saponins, flavonoids, phenols, terpenoids, steroids and amino acids and absence of anthraquinone glycosides. The antibacterial activity of all three extracts was tested against some pathogenic bacteria using the Cup-Plate method. The different extracts of Syzygium cumini seeds showed inhibitory activity over Gram negative bacteria such as Salmonella typhi and Escherichia coli and Gram positive bacteria such as Bacillus subtilis and Staphylococcus aureus. The results showed that the methanolic extract was slightly more potent than the other two.

A NEW TYPES OF POLYMORPHIC FORM OF 10-PROPARGYL-10-DEAZAAMINOPTERIN, FROM SL: AS A REFRACTORY PERIPHERAL T-CELL LYMPHOMA DRUG

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J. Y MANURE *, N. S NAIKWADE, P. J SHIROTE, S.A BAGWAN AND K. M KULKARNI
Department of Pharmaceutical Chemistry,
Appasaheb Birnale College of Pharmacy,
South Shivaji Nagar, Sangli- 416416, Maharashtra, India.

*javeedmanure.98600@yahoo.com

ABSTRACT 
A new crystal form of 10-Propargyl-10-Deazaaminopterin, form SL, was discovered which is thermodynamically stable, shows long term stability and is applicable for using in final dosage forms. Form SL was characterized by several analytical methods such as thermal analysis by DSC, IR, X-ray powder diffraction, SEM (Scanning Electron Microscopy), Digital optical microscopy and solubility/dissolution measurements. Active pharmaceutical ingredients should be stable during technological processes for the preparation of a final dosage form and must also remain stable during storage. The morphology of long needle and plate shaped crystals was investigated by scanning electron microscopy (SEM) and optical microscopy. Form SL was compared to other forms of 10-Propargyl-10-Deazaaminopterin such as form A, B, C and to the amorphous form. The thermodynamic stability of form SL is supported by its long-term stability. Form SL is a pharmaceutically applicable crystal form.

EVALUTION OF IN VITRO ANTI-OXIDANT ACTIVITY AND PHYTOCHEMICAL STUDIES CARRIED OUT FOR MELIA AZEDARACH LEAF EXTRACTS

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Lagu surendra babu*, Prof. Y. Rajendra Prasad, D. Geetha mounika
Department of Pharmaceutical chemistry,
AU college of Pharmaceutical Sciences,
Andhra University, Visakhapatnam, AP, India

*ysbabu033@gmail.com

ABSTRACT:
Investigation of phytochemical and biological activities was performed by Antioxidant (DPPH, H2O2, Nitric oxide) free radical scavenging methods against three gradient polarity solvents extracts of leaves of Melia azaradach Linn with different concentraions. MA species of three different assay (DPPH, H2O2, Nitric oxide) of anti-oxidant activity were showed to be IC50 values of 20.14, 35.98, 36.43 with methanolic extract of leaves were have higher concentration possess more antioxidant potential than MALEoC IC50 42.85, 54.18, 30.56 and MALEoH IC50 values of 44.68, 52.71, 48.05 when compare to reference standard ascorbic acid IC50 values of 17.87, 18.91, 25.83. They exhibited strong antioxidant DPPH, H2O2, Nitric oxide radical scavenging activities with IC50 value reference ascorbic acid, MALoME, MALoCE and MALoHE respectively. Phytoconstituents like carbohydrates, flavonoids, proteins, saponins and tannins etc. An antioxidant activity of methanol extract could be due to the presence of flavonoids and phenols The results suggest that methanol and chloroform extracts from leaf melia azedarach tree have strong antioxidant potential.

INTERACTION STUDIES BETWEEN SITAGLIPTIN PHOSPHATE AND ATORVASTATIN CALCIUM IN STREPTOZOTOCIN INDUCED CHRONIC TYPE II DIABETES MELLITUS RAT MODEL

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Ms. Swati Dhande*, Mr. Parikshit Gandhi
Bharati Vidyapeeth's College of Pharmacy
Navi Mumbai, 400614, Maharashtra, India.
*dswatir@gmail.com

ABSTRACT
Diabetes Mellitus describes a metabolic disorder which is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion. Various combination therapies are used to treat metabolic syndrome and includes an antidiabetic drug to control the blood glucose levels, anti-hyperlipidemic drug to control cholesterol and lipid levels. In this study interaction between Sitagliptin phosphate, drug from antidiabetic class i.e. dipeptidyl peptidase IV inhibitor and Atorvastatin calcium other from antihyperlipidemic class i.e. HMG-COA reductase inhibitor was evaluated in Streptozotocin and High-fat diet induced type II diabetic rat model. The combination was selected since Sitagliptin phosphate and Atorvastatin Calcium share a common metabolizing enzyme, CYP3A4, there might be chances of interaction taking place due to the co-administration of the same. Bioanalytical method was developed and validated according to ICH guidelines for evaluation of pharmacokinetic parameters. Pharmacodynamic parameters such as Serum glucose, Serum cholesterol, Serum triglyceride levels and other related tests were performed to evaluate interaction at pharmacodynamic level. Results suggest that, at pharmacodynamic and pharmacokinetic level, this combination treatment can have good application in managing blood glucose level and lipid level as well. Being not affected by the CYP450 metabolisms as when correlated with plasma levels at their particular half-life, we suggest that Sitagliptin phosphate and atorvastatin calcium on simultaneous administration will not lead to cause any toxic effect.

NIOSOMES AS NOVEL DRUG DELIVERY SYSTEM : REVIEW ARTICLE

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Devender Sharma1, Aashiya Aara E. Ali2, Jayshree R. Aate1
1Hi-Tech College of pharmacy, Chandrapur, Maharashtra (India)
2Kamla Nehru College of pharmacy, Nagpur (India)
*sdevender350@gmail.com

ABSTRACT
Niosome are non-ionic surfactant vesicles obtained by hydrating mixture of cholesterol and nonionic surfactants. It can be used as carriers of amphiphilic and lipophilic drug. In niosomes drug delivery system, the medication is encapsulated in a vesicle. Niosomes are biodegradable, biocompatible non-immunogenic and exhibit flexibility in their structural characterization. The main object of this review the application of niosome technology is used to treat a number of diseases, niosome have good oppurnity in research and beneficial for researcher and pharma industries.  Niosome appears to be a well preferred drug delivery system over liposome as niosome being stable and economic. Also niosomes have great drug delivery potential for targeted delivery of anti-cancer, anti-infective agents. Drug delivery potential of niosome can enhances by using novel drug delivery concepts like proniosomes, discomes and aspasome. Niosomes also serve better aid in diagnostic imaging and as a vaccine adjuvant. Thus these areas need further exploration and research so as to bring out or to make for commercially available niosomal preparation.

EFFECT OF TERMENALIA CATAPPA LEAF EXTRACT ON CAFETERIA INDUCED OBESITY IN RATS

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Sridatha. P*, Subbareddy.P, Sowjanya.K, Sudheer. A
Department of Pharmacology
Raghavendra Institute of Pharmaceutical Education & Research (RIPER),
Anantapuramu, Andhra Pradesh, India.

*puranamdatha@gmail.com

ABSTRACT :
Obesity is a leading cause of death worldwide, with increasing rates in adults and children.  To investigate anti-obesity effect of Termenalia catappa leaf extract on cafeteria induced obesity in rats. For anti-obesity experiment, animals were divided into five groups of six animals and housed in cages. Normal control group continued to be fed a laboratory pellet chow ad libitum. Cafeteria diet-control group received cafeteria diet in addition to the normal pellet diet. The remaining three groups were fed with cafeteria diet and NPD along with T. catappa leaf extract (200 mg/kg, p.o.), Termenalia catappa leaf extract (400 mg/kg, p.o.) and orlistat (30 mg/kg, p.o.). Treatment was continued for 4 weeks. Animals and various adipose pads were weighed and serum total cholesterol, triglyceride, LDL, VLDL and HDL-C were measured after 4 weeks of treatment. At the end various adipose tissues, aorta were removed and processed for Histopathological study.  The Termenalia catappa leaf extract -treated groups showed a significant decrease in body weight, and various adipose pad weight and serum TC, TG, LDL, VLDL and increase in HDL levels after 4 weeks treatment and decrease in the adipose tissue size and adipocyte number.  At present study, Termenalia catappa leaf extract can inhibit the development of obesity and hyperlipidemia on cafeteria induced obesity in rat. It is because of various phytoconstituents of leaf extract. But further studies are still waiting for establishing mechanism and isolation of phytoconstituents. By observing above results Termenalia catappa leaf extract can act as adjuvant in obesity treatment.

PHYTOCHEMICAL SCREENING AND ALBUMIN INDUCED ANTI-INFLAMMATORY ACTIVITY OF PENTAS LANCEOLATA LEAVES.

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Priyanka. Kura, Ashwini. Patlolla, Alluri. Ramesh, Vishwanadham. Y*
Department of Medicinal Chemistry Research Division,
Vishnu Institute of Pharmaceutical Education and Research (VIPER),
Narsapur, Medak, Telangana, India

*vishwanadham.y@gmail.com

ABSTRACT
The anti-inflammatory drug activity of petroleum ether (Pet.ether) extract of leaves pentas lanceolata was investigated in rats exploitation egg albumen induced paw oedema model. Experimental animals received 20-25 gms (orally) of the extracts five groups divided., control group (saline), test group 50, 100, 200 mg/ kg the standard group received 15 mg/ kg of diclofenac. The results show that the extracts considerably (p <0.05) reduced paw oedema within the albumen induced anti-inflammatory drug activity.

The leaf extract of pentas lanceolata reduced inflamed hind paw diameter of mice by between 0.98%- 3.99% The diclofenac reduced inflamed hind paw diameter by between 1.12%-4.02%. The qualitative phytochemical screening indicated the presence of saponins, flavonoid, alkaloids, terpenoids and cardiac glycosides. The current study establishes potent antiinflammatory activities of pet ether extracts of pentas lanceolata leaves.

GREEN TEA IN GREEN WORLD AN UPDATED REVIEW

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Devender Sharma*1, Kajal V. Kosankar2,
1Hi – Tech College of Pharmacy, Chandrapur, Maharashtra (India)
2Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra (India).
*sdevender350@gmail.com

ABSTRACT
“Green tea in green world” it means that healthy green tea in healthy world. As we know when leaves are in green color they are considered as they are fresh and healthy to use. Tea, it is present in two forms that is green or black tea, it is consumed most widely in the world. Extracts of tea leaves it is supplied in the dietary supplements which will maintain the health. However, this review shows an interest in the health care properties of green tea which will help in treatment of cancer which is more dangerous cannot be cure easily. The comparison between black and green tea is given which will help to make a choice. Green tea contains catechins which is an important chemical constituents it shows biological activity like antioxidant, anti-angiogenesis, and anti-proliferative effects and also in treatment of various forms of cancer. This review has much more focus on the biological properties like catechin, epigallocatechingallate (EGCg) show effects on antitumor properties and other health benefits. The antioxidant properties of green are responsible to improvement in cardiac health, atherosclerosis and it has powerful effects on the body. Catechins may reduce cholesterol levels in blood and also improve brain function. The studies show that when caffeine and L-theanine have synergistic effects. Green tea shows fat oxidation about increased by 17%. Green tea contains approximately 20-40% polyphenols and 60-80% catechins such as EGCG by weight. Synergistic properties of polyphenolicconstituents are increasing now a day that are important in medicinal benefits. Tea is now finding its way into topical preparations like patches. The uses of green tea are clinically proved.

PHYTOSOMES IS A NOVEL DRUG DELIVERY SYSTEM BASED HERBAL FORMULATION: AN REVIEW

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Devender Sharma1*, Ankita A. Bhujbale2
1Hi – Tech College of pharmacy, 

Chandrapur, Maharashtra, India
2Sinhgad College of Pharmacy, 
Vadgaon, Pune Maharashtra, India
*sdevender350@gmail.com

ABSTRACT

Phytosomes is a novel drug delivery dosage form. Phytosomes is a patented technology. It is used for development of formulation for improved bioavability of medicaments of phytoconstituents present in herbal extract or herbal preparation. Phytosomes is prepared by using the phospholipids and forming the complex between phytoconstituent and phospholipids. Phytosomes now a day’s most valuable space in pharma-industries and good research space for industry scholar, students for future. The main object of this review giving various useful advantages of phytosomes and how it is prepare formulate. Phospholipids are employed as natural digestive aids and carriers for water soluble and lipid soluble nutrients.

A REVIEW ON CHALCONES SYNTHESIS AND THEIR BIOLOGICAL ACTIVITY

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Shipra Vermaa, Alok Kumar Srivastava*1, O.P. Pandeyb
1Department of Chemistry, Mahatma Gandhi P. G. College, Gorakhpur, U.P., India
2Department of Chemistry, D.D.U. Gorakhpur University, Gorakhpur, U.P., India

*sdevender350@gmail.com

ABSTRACT
Chalcones are a valuable molecule of medicinal importance due to presence of reactive ketoethylenic group –CO–CH=CH–, belonging to the flavonoid family. These reactive α,β-unsatutated keto function in chalcones are  responsible for their biological activity. Chalcone can be synthesized by several methods using aldehydes and ketones as starting material. This review is focused about different methods of synthesis and versatile biological activity of chalcones including antimicrobial, anticancer, antioxidant, antimalarial, antituberculosis etc.

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