Articles

About Authors:
Bhupender Kumar*, Prof. Sudeep Bhardwaj, Monish Sharma, Ramchandra
Seth G.L. Bihani S.D. College of Technical Education (Institute Of Pharmaceutical Sciences
And Drug Research), Sri Ganganagar, Rajasthan, 335001
*bhupendra.nimiwal@gmail.com

ABSTRACT:
In a typical crossover design, each subject takes each of the treatments under investigation on different occasions. Comparative bioavailability or bioequivalence studies, in which two or more formulations of the same drug are compared, are usually designed as crossover studies. Perhaps the greatest appeal of the crossover design is that each patient acts as his or her own control. This feature allows for the direct comparison of treatments, and is particularly efficient in the presence of large inter individual variation. However, caution should be used when considering this design in studies where carryover effects or other interactions are anticipated. Under these circumstances, a parallel design may be more appropriate.

About Author:
Kambham Venkateswarlu
Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor District, Andhra Pradesh-517132, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
This is an inherited arrhythmia that causes the bottom chambers of the heart (the ventricles) to beat so fast that they can prevent the blood from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. While this is a disease that usually affects people in their 30's, it has actually been described at all ages. So it is important to screen everybody in a family. Not everybody who has the disease will have arrhythmias. However, we cannot know yet who will be OK and who will have problems. If you have had fainting spells related to Brugada syndrome, our experience indicates that you are at very high risk of having them again.

About Author:
Kambham Venkateswarlu
Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor District, Andhra Pradesh-517132, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Many different types of laboratory fermentors and bioreactors are used worldwide. The selection of a good quality bioreactor is not easy. Some advantageous parameters found in one product are cancelled out by other draw backs in the same system. Good high quality bioreactors are very expensive. Even then ease of use is not assured. The question arises, whether it is possible to construct a bioreactor, which would satisfy most requirements. The most important are high quality and easy to use, perfect sterility, precise measurement, control and recording of all important culture parameters and lasts but not lasts, and the bioreactor shouldn’t expensive!

About Authors:
Bhupender Kumar*, Assit. Prof. Prasant Beniwal, Monish Sharma, Ramchandra
Seth G.L. Bihani S.D. College of Technical Education
(Institute Of Pharmaceutical Sciences And Drug Research),
Sri Ganganagar, Rajasthan
*bhupendra.nimiwal@gmail.com

Abstract:
Thermoanalytical methods essentially techniques that are based entirely on the concept of heating a sample followed by well-defined modified procedures, such as : gravimetric analysis, differential thermal analysis (DTA) and differential scanning calorimetry (DSC). Thermogravimetric analysis measured weight change, differential scanning calorimetry measured heats and temperature of transitions and reactions, differential thermal analysis (DTA) measured temperatures of transitions and reactions.

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About Author:
Ravindra Singh Tomar
M.Pharm (Medicinal & Pharmaceutical Chemistry),
B R Nahta College of Pharmacy, Mandsaur (M.P)
ravindratomar16@gmail.com

ABSTRACT-
Here a scheme has been designed for synthesis of 2-chloropyridine-5-trifluoromethyl derivatives. The probability of being antiamnesic agent has been checked by pass prediction. All compound shows antiamnesic activity as result of pass prediction. By Lipinski rule of five all compounds shows drug like activity. Also a method for pharmacological evaluation & Biochemical evaluation is described under. All synthetic procedure has been designed & described under-

About Author:
Aarti Narkhede
Mahakal Institute of Pharmaceutical Studies,
Ujjain, MP
narkhede_aarti@rediffmail.com

ABSTRACT
The use of natural product has increased tremendously in a western world as well as in developing countries or in all over part of world. via this artical therapeutic potential and future prospect of Psidium guajava L. are described. Psidium guajava L. belonging to family, myrtaceae. It is a commen tree and easily found in a tropical countries or area. Traditionally it is a very popular and used from long time in a various system of medicine like, unani, Siddha, homeopathy and Ayurveda. It is used for treatment of many ailments like diarrhea, dysentery, wounds, rheumatism, lungs problems, ulcers, skin infections, vaginal discharge, epilepsy, menstrual pain, sore throat, mouth swelling, cold and cough, toothache and etc. In present time study on antipoliferitive or anticancer activities are undertaken and it is found that anticancer activity of P.Guajava has a four time greater than vincristine.

About Authors:
Awan Bharti^*1, Sweta Gautam^2
1Department of Pharmacognosy,
Shri Rawatpura Sarkar Institute of Pharmacy, Datia, M.P.
²Department of Pharmacognosy, RKDF College of Pharmacy, Bhopal
*bhartiawan@gmail.com, shwetagautam85@rediffmail

ABSTRACT
Interest in alternative medicine and plant-derived medications that affect the "mind" is growing. Anxiety affects one-eighth of the total population of the world and has become a very important area of research interest in psychopharmacology during this decade. Anxiety, a state of excessive fear, is characterized by motor tension, sympathetic hyperactivity, and apprehension and vigilance syndromes. Benzodiazepines are the major class of compounds used in anxiety and they have remained the most commonly prescribed treatment for anxiety, despite the important unwanted side effects that they produce such as sedation, muscle relaxation, ataxia, amnesia, ethanol and barbiturate potentiation and tolerance. Various types of herbal medicines have been used as anxiolytic drugs in different parts of the world. Folk medicines have particular values, for example, plants that "calm down", tranquilize, and raise mood, such as Passiflora coerulea, Valeriana officinalis, Matricaria recutita, Jatropa cilliata, Salvia guaranitica, Tilia tormentosa, and Tilia europeae. Plants have long been used to treat central nervous system (CNS) disorders.

About Authors:
Sailesh Narayan*, Ankit Diwan
Sagar institute of Pharmacy and Technology,
Gandhi Nagar, Bhopal
*saileshcology@yahoo.co.in

INTRODUCTION
A tablet is a pharmaceutical dosage form. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from  a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment or to enhance the tablet's appearance. These are compressed tablets. formulated to deliver an accurate dosage to a specific site; it is usually taken orally, but can be administered sublingually, buccally, rectally or intravaginally. Medicinal tablets were originally made in the shape of a disk of whatever color their components determined, but are now made in many shapes and colors to help distinguish different medicines. Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified.

About Authors:
Nareshkumar. G¹*, A.Eashwar rao², Ch.Ganga prasad³.
¹*Center for Pharmaceutical Sciences, IST, JNTU Hyderabad, India,
²Talla Padmavathi College of Pharmacy, Warangal, India,
³National College of Pharmacy, Shimoga, Karnataka, India.
*nareshkumar62@gmail.com

ABSTRACT:
Liquisolid technique is a new and propitious method that can change the dissolution rate of poorly water soluble drugs. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit enhanced release profiles. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Successful liquisolid tablet is a determination of optimal flowable liquid retention.

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