Articles

About Authors:
Kambham Venkateswarlu
Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Clinical trials are the set of procedures in medical research and drug development that are conducted to allow safety and efficacy data to be collected for place only interventions. These trials can take place only after satisfactory information has been gathered on the quality of the country where the trial is taking place.

Depending on the type of product and the stage of its development, investigators enrol healthy volunteers and patients into small pilot studies, followed by larger scale studies in patients that often compare the new product with the currently prescribed treatment. As positive safety and efficacy data are gathered, the number of patients is typically increased. Clinical trials can vary in size from a single centre in one country to multicenter trials in multiple countries.

About Author:
Kambham Venkateswarlu
Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
The diet is selection of food eaten by an individual. A balanced diet is essential for health. It provides the appropriate amounts of all nutrients in the correct proportions to meet body requirements.
An essential nutrient is substances that cannot be made by the body and must be supplied through the diet. Foods are described as carbohydrate or protein because they contain a higher proportion of one or the other. A balanced diet contains all nutrients required for health in appropriate proportions and is normally achieved by eating a variety of foods.

About Authors:
^*1Krishna Das Gupta, ²Dileep Bharti
¹M.Pharm(P'cology), NRI Institute of Pharmaceutical Sciences(NIPS), Bhopal
²Asst professor, NIPS, Bhopal(MP)
*krishna.gupta384@gmail.com

About Authors:
Neethu.R.R
Uthradam
Kannayamkodu
Chenkikunnu
Kilimanoor.P.O, Trivandrum dist, Kerala 695601
neethalekshmi87@gmail.com

Abstract:
Budesonide is a corticosteroid, used in the treatment of inflammatory conditions such as asthma and COPD. The present study was undertaken with the aim to formulate and evaluate dry powder inhalers of Budesonide for pulmonary delivery. Dry powder inhalers of Budesonide were prepared using different concentrations of fine lactose and magnesium stearate by Geometric dilution method. The drug-carrrier compatibility study was carried out by FT-IR studies. A total of eleven batches were formulated and evaluated for physical appearance, average fill weight, flow properties, particle size analysis, content uniformity, moisture content and assay. In-vitro drug deposition studies were carried out by using Modified Twin Stage Impinger (TSI) apparatus. Of all eleven batches, the formulation F4, comprising of fine lactose 30% was found to be the best having comparatively higher fine particle fraction (FPF) of 25.32%. The result indicated that the amount of drug that reaches in the lung was higher for formulation F4. Further invivo safety and deposition studies on suitable animal models and human volunteers will give better insight for clinical applications of the Budesonide DPI.