Articles

About Authors:
Narasimha Murthy Yedulapurapu*, Babu Rao. Chandu
Donbosco P.G. College of Pharmacy, 5th mile,
Pulladigunta, Kornepadu (V), vatticherukuru (M),
Guntur, Pin code: 522017, Andhra Pradesh.
*Murthyvedulapurapu@gmail.com

ABSTRACT:
Cefixime Trihydrate is an orally active third generation cephalosporin. It has plasma half-life of 3-4hrs; it is active against Gram+ve as well as Gram-ve bacteria. The present investigation involves the enhancement of dissolution rate of cefixime by using various solid dispersion techniques with a view to prolong the drug release in the gastrointestinal tract and consequently into the plasma. The solid dispersions were formulated by using the Croscarmelose sodium as a disintegrant. The solid dispersions were prepared by solvent evaporation, kneading, Physical mixing, Co-grinding techniques. In solvent evaporation technique, Dichloromethane is used as a solvent and in kneading technique water is used as solvent. The prepared solid dispersions were evaluated for in-vitro dissolution studies. Among the 5 formulations F5 sows the good results.

About Author:
Kambham Venkateswarlu
Final Year Graduate student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor-517132, Andhra Pradesh, India
k.v.reddy9441701016@gmail.com

ABSTRACT:
Electrophoresis is also called as cataphoresis. It is the motion of dispersed particles relative to a fluid under the influence of spatially uniform electric field. This electro kinetic phenomenon was observed for the first time in 1807 by Reuss (Moscow State University), who noticed that the application of a constant electric field caused clay particles dispersed in water to migrate. It is ultimately caused by the presence of a charged interface between the particle surface and the surrounding fluid. Electrophoresis is a rapid separation technique.Factors governing the migration of ions are Charge of ions, Size of the ions, Viscosity of the medium, Voltage applied, pH of buffer and ionic strength. Factors affecting electrophoresis are Molecular characteristics (size, shape), Buffer Properties, Electric Field Characteristics, Temperature.

About Author:
Kambham Venkateswarlu
1-Final Year Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chottoor-517132, Andhra Pradesh, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Hepatitis is a general term meaning inflammation of the liver and can be caused by a variety of different viruses such as hepatitis-A, B, C, D, and E. Since the development of jaundice is a characteristic of liver disease, a correct diagnosis can only be made by testing patient’s sera for the presence of specific anti-viral antibiotics. Transmission of HAV is typically by the faecal, oral route. Hepatitis A was formerly called infectious hepatitis, Epidemic hepatitis, Epidemic jaundice, Catarrhal jaundice, type A hepatitis, HA.

About Author:
Kambham venkateswarlu
graduate student
Sri lakshmi narasimha college of pharmacy,
palluru, chittor-517132, andhra pradesh, india
k.v.reddy9441701016@gmail.com

ABSTRACT:
Nanotechnology is the technology of nanoparticles which are made of polymers of synthetic or natural origin. Nanoparticle is a collective name for nanospheres and nanocapsules of size from 10-1000nm. Nanocapsules are vesicular systems in which drug is confined to a cavity surrounded by a unique polymer membrane. Nanospheres are matrix systems in the drug are physically and uniformly dispersed. Nanotechnology is the design, characterization, production on and application of structures, devices and systems by controlling shape and size on the nanoscale. Nanotechnology in medicine is referred to as nanomedicine and involves the implementation of technologies that exist or function at the cellular and levels medical use.

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About Authors:
Bharathi.V*, SwarnaLatha.D, M.Sreenivasulu
Annamcharya college of pharmacy, newboyana pally, rajampet(M),
kadapa(dt). Andhara Pradesh, India.
*bharu.v.net@gmail.com

ABSTRACT:
Medicinal plants have played an essential role in the development of human culture. Many of the modern medicines are produced indirectly from medicinal plants, for example aspirin. The present study was concentrated on past work reported on the some mussaenda species and study of different activities and phyto constitutions reported on mussaenda species. The genus Mussaenda (rubiaceae) is an important source of medicinal natural products, steroids, flavonoids, glycosides and only a few number of species reported positive for alkaloids and tannins. Many Mussaenda species were reported to possess anti-oxidant, anti-inflammatory in different models, analgesic, antimicrobial, diuretic, antiphlogistic and antipyretic, acute gastroenteritis and dysentery, anti- fertility activity, antiviral property , antibacterial effect rarely for hepato protective activity and wound healing activity.

About Authors:
Khayyam Shaikh*, Patwekar Shailesh, Santosh Payghan, John Disouza
Department of Pharmaceutics,
Tatyasaheb Kore College of Pharmacy,
Warananagar, Kolhapur, Maharashtra, India 416113.
*ramzanshek0587@gmail.com

ABSTRACT
During the last two decades there has been a remarkable increase in interest in sustained release drug delivery system. This has been due to various factors viz. the extensive cost of developing new drug entities, expiration of existing international patents, discovery of new polymeric materials suitable for prolonging the drug release, and improvement in therapeutic efficacy and safety achieved by this delivery system. A number of design options are available for the preparation of controlled release formulations to modify oral absorption. Formulation approaches are being explored to enhance bioavailability of poorly water-soluble drugs. One such approach that has been shown significantly enhanced absorption of such drugs is to formulate solid dispersionand then formulate its tablets. Solid dispersion technology can be used to improve the in- vitro and in- vivo dissolution properties of slightly water soluble drugs and to control their dissolution rate. In this current study attempts have been made to formulate sustained release tablets of solid dispersions.

About Authors:
Sofiya Verma*, Dipak V, Ashok A, Neha C, Jagruti R, Ashutosh. M
Shri ram institute of pharmacy
Jabalpur M.P
*sofiyavermamph@gmail.com

ABSTRACT:
The purpose of this research was to prepare and characterize theophylline microsphere of guar gum polymer for the application of nocturnal asthma. The microsphere were prepared by using emulsification method using sodium borate as a cross linking agent and coating was done by solvent evaporation method with the pH sensitive eudragit S-100 polymers. The prepared microsphere were white, free flowing and spherical in shape. The drug-loaded microsphere showed entrapment efficiency and   drug release was extended upto 6 to 8 h. The infrared spectra, differential scanning calorimetry thermographs and XRD spectra all showed the stable character of both the drugs in the drug-loaded microspheres and revealed the absence of drug-polymer interactions. Scanning electron microscopy study revealed that the microspheres were spherical and porous in nature. The prepared theopylline microsphere has the potential for delaying the release of drug.

About Authors:
Dhanya V C
Kasturba medical college, Manipal University
Indian Veterinary Research Institute
dhanya285@gmail.com

INTRODUCTION:
A biosensor is a device that uses specific biochemical reactions mediated by isolated enzymes, immunosystems, tissues, organelles or whole cells to detect chemical compounds usually by electrical, thermal or optical signals (1). Or in other words, Sensor that integrates a biological element with a physiochemical transducer to produce an electronic signal proportional to a single analyte which is then conveyed to a detector.

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