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  • NANOPARTICLE - NOVEL DRUG DELIVERY SYSTEM: A REVIEW

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    ABOUT AUHTORS
    Hnawate R.M*., Deore P.
    Dr. Vedprakash Patil Pharmacy College,
    Aurangabad,
    Maharashtra, India
    ravi_hanwate@yahoo.co.in

    ABSTRACT
    For the past few years, there has been a considerable research on the basis of Novel drug delivery system, using particulate vesicle systems as such drug carriers for small and large molecules. Nanoparticles, Liposomes, Microspheres, Niosomes, Pronisomes, Ethosomes, Proliposomes have been used as drug carrier in vesicle drug delivery system. Nanotechnology refers to the creation and utilization of materials whose constituents exist at the nanoscale; and, by convention, be up to 100 nm in size.. Nanoparticles are being used for diverse purposes, from medical treatments, using in various branches of industry production such as solar and oxide fuel batteries for energy storage, to wide incorporation into diverse materials of everyday use such as cosmetics or clothes, optical devices, catalytic, bactericidal, electronic, sensor technology, biological labelling and treatment of some cancers. Various polymers have been used in the formation of Nanoparticles. Nanoparticles have been improving the therapeutic effect of drugs and minimize the side effects. Basically, Nanoparticles have been prepared by using various techniques as such dispersion of preformed polymers, polymerization of monomers and ionic gelation or co-acervation of hydrophilic polymer. Nanoparticles have been evaluated by using parameters of drug entrapment efficiency, particle shape, drug release study

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  • A REVIEW ON QUALITY AGREEMENT REQUIREMENT IN PHARMACEUTICALS BY REGULATORY AUTHORITY IN COMPLIANCE TO CGMP GUIDELINES

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    ABOUT AUHTORS
    Suleman S khoja*1,Sohil S khoja1, Farhad S Khoja2,Shamim S Khoja2, Narmin A Pirani2
    1 Resource person in Pharmaceutical Quality Assurance and Facility Audit,
    Vapi, Gujarat, India.
    2 Registered Pharmacist, Gujarat State Pharmacy Council, Gujarat, India
    *premukhoja@gmail.com

    ABSTRACT
    A quality agreement is a comprehensive written agreement between parties involved in the contract manufacturing of drugs that defines and establishes each party’s manufacturing activities in terms of how each will comply with CGMP. Quality agreements may be reviewed during inspections. A quality agreement describes the owner’s and the contract facility’s roles and manufacturing activities under CGMP. The quality agreement should explain how the contractor will report manufacturing deviations to the owner, as well as how deviations will be investigated, documented, and resolved in compliance with CGMP. Quality agreements should state that manufacturing services provided by contract facilities (including laboratories) will comply with CGMP. The most critical pieces are quality and change control, as described in the following sections. Manufacturing Activities Change Control Associated With Manufacturing Activities

  • NANO-PARTICLES CONTAINING ANTICANCER DRUG

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    ABOUT AUHTORS
    Debpratim Chakraborty*, Nisha Lama Yolmo
    Department of Pharmaceutical tech,
    Jadavpur University,
    Kolkata, West Bengal, India
    *debpratim008@gmail.com

    ABSTRACT:
    Now a day in medical science and researches, cancer is one of the most life threatening disease but unfortunately still now we have no medical treatment for procurement of this disease. The pathology is not totally clear but according to medical evidence if we consider genes then we must agree that oncogene and tumor suppressor genes are mainly responsible. There are some risk factor also consider which may leads to cancer. The conventional treatments are surgery, Radio-therapy and chemo therapy but the real fact is none of the above mentioned treatment is enough for procurement of cancer and that’s why now scientist and researchers are thinking about nan-technology. NCI has identified that nano-technology have the potential to make paradigm changing impacts on the detection, treatment and prevention of cancer.  There are different strategies for cancer therapy using nano-particles like targeted and non-targeted nano-particles. Different studies show that the side effect of doxorubicine (an anticancer drug) can be minimizing by nano-technology, which also reduce the multi drug resistance. Nano-sphere and Nano-capsule of anti-steroid 4-hydroxytamoxifen RU reduce estrogen dependent tumor. Dendritic nano-technology with 5-fluro Uracil decreases the drug clearance and increase the therapeutic time. Methotrixate incorporated dendritic polymer target the folic acid receptor. Camptothecin loaded nano-particles show longer plasma retention, high and longer tumor localization. Nano-particles prepared by poly-lactic-co-glycolide increase the half life of Cisplatin. Paclitaxel, a microtubule-stabilizing agent that promotes polymerization of tubulin causing cell death by disrupting the dynamics necessary for cell division, is effective against a wide spectrum of cancers. Miscellaneous agent like Arsenic trioxide, Butyric Acid, Diethylene-triamine-Acetic acid show more prominent activity. Recent development in nanoparticle-based combination therapy have shown several unique features that are untenable in traditional chemotherapy. Drug combinations can now be optimizedand cleverly delivered in a more effective way.

  • A REVIEW ON PREVENTION AND MANAGEMENT OF DIABETIC NEUROPATHY

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    ABOUT AUHTOR
    *A. Bharath kumar, T. Mubeena, Y. Charitha

    Annamacharya college of Pharmacy
    Rajampet, Andhra pradesh, India
    *abharatpharma@gmail.com

     

    ABSTRACT:
    Diabetic neuropathy is a debilitating disorder that occurs in of Patients with diabetes. The primary types of diabetic neuropathy are sensorimotor and autonomic. Patients may present with one type of diabetic neuropathy or may develop combinations of neuropathies when its severity was more. Diabetes is metabolic disorder which causes the abnormal elevations of blood glucose levels in the body. The diabetic neuropathy was neurological affecting disorder. Diabetic neuropathies are a family of nerve disorders caused by diabetes. People with diabetes can, over time, develop nerve damage throughout the body. The symptoms such as pain, tingling, or numbness and loss of feeling in the hands, arms, feet, and legs. About 60 to 70 percent of people with diabetes have some form of neuropathy.The diabetes people develop nerve problems at any time, but risk rises with age and longer duration of diabetes. Regular monitoring blood sugar levels normal levels and foot care practices we can Prevent the diabetic neuropathy complications in the community.

  • Protein-protein surface interactions: Constrains of homologous versus heterogeneous domains

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    ABOUT AUHTOR
    Nitisha Bhandari*, Akanksha Bhandari
    Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar,
    Dehradun 2Graphic Era University, Dehradun, India
    *nitishabhandari89@gmail.com

    ABSTRACT
    Interactions of proteins could be resulted from homodimerisation or heterodimerisation. But these are quite specific and always selective in nature and act onlyon particular set of class of proteins, which provide substantial target behaviour to a drug designer. Here in this paper, provided a commentary based review compiling the short notes information provided on protein proteins interactions, by “Catherine Royer”

  • A REVIEW ON CHEMISTRY AND PHARMACOLOGICAL ACTIVITY OF METFORMIN HYDROCHLORIDE AND TENELIGLIPTIN HYDROBROMIDE HYDRATE IN COMBINED DOSAGE FORM

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    ABOUT AUHTOR
    Manish Patil*1, Harsha D Jani1, Suleman S Khoja2, Narmin A Pirani3, Shamim S Khoja3
    1Department of Quality Assurance,
    Shivam Pharmaceutical Studies and Research Centre, Anand
    Gujarat, India.

    2Resource person in pharmaceutical quality assurance and Audit Compliance, Vapi
    3Registered Pharmacist, Gujarat, India

    *manishpatil3194@gmail.com

    ABSTRACT
    This review article presents the pharmacology of combined Metformin hydrochloride and Teneligliptin hydrobromide hydrate is effective on type 2 Diabetes Mellitus. Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Teneligliptin, a third generation Dipeptidyl Peptidase-4 (DPP-4) inhibitor exhibits unique “J shaped” structure with “anchor-lock domain” mechanism which provides potent & long duration of action. The addition of teneligliptin once daily to Metformin was effective and generally well tolerated in Korean patients with type 2 diabetes. The mechanism of Metformin hydrochloride and teneligliptin hydrobromide hydrate is quite different. The main objective of this review article is to provide pharmacological and Analytical information of combination of Metformin hydrochloride and Teneligliptin hydrobromide hydrate to researcher in development of combined dosage form.

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  • ANALYTICAL TECHNIQUES FOR ANALYSIS OF INORGANIC ELEMENTS – A REVIEW

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    ABOUT AUHTOR
    G.Swapna
    Department of pharmaceutical Analysis & Quality Assurance,
    Nirmala college of pharmacy, Guntur,
    AP, India
    swapna.goday.gs@gmail.com

    ABSTRACT
    To make drugs serve their purpose various chemical and instrumental methods were developed and regular intervals which are involved in the estimation of drugs. A photoelectric flame photometer is a device used in inorganic chemical analysis to determine the concentration of certain metal ions, among them sodium, potassium, lithium, and calcium. Group 1 and Group 2 metals are quite sensitive to Flame Photometry due to their low excitation energies [1].These pharmaceuticals would serve their intent only if they are free from impurities and are administered at appropriate amounts [2] . These pharmaceuticals develop  impurities at various stages of their development, transportation and storage which makes the pharmaceuticals risky to be administered thus they may be detected and quantified. For this analytical instrumentation and methods play important role. This review highlights a variety of analytical techniques for analysis of inorganic elements. Analytical techniques for analysis of inorganic elements. The most commonly used techniques for the determination of inorganic elements is atomic spectroscopy the different branches of atomic absorption spectroscopy are(1) flame photometry or flame atomic emission spectrometry. (2) atomic absorption spectrophotometer, (aas). (3) inductively coupled plasma-atomic emission spectrometry (icp-aes).(4)  uv - visible    spectrophotometer.

  • A BRIEF REVIEW ON ION EXCHANGE CHROMATOGRAPHY

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    ABOUT AUHTORS
    Jaha Sultana Mohammed
    Pelcat Formulation PVT ltd
    sohnivya786@gmail.com

    ABSTRACT:
    Ion exchange chromatography is probably the most powerful and classic type of liquid chromatography. The popularity of ion exchange chromatography has been increased in recent years because this technique allows analysis of wide range of molecules in pharmaceutical, biotechnology, environmental, agricultural and other industries for water purification to separation of various antibiotics from fermentation broths which will enhance the yields and reduce the production time for industrial process. The main objective of this particular study is to develop some understanding for the process of ion exchange and helps to determine whether or not ion exchange will be useful for a particular application. This topic includes background, theory, instrumentation, application which covers both the production of the ion exchange substance, a resin and its operation depending on the condition of matrix during use.

  • IMPACT AND MANAGEMENT TOOL FOR IDENTIFICATION AND REDUCTION OF HUMAN ERRORS IN PHARMACEUTICALS INDUSTRY

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    ABOUT AUHTORS
    Suleman S. khoja 1 , Sohil S. khoja 1,
    Farhad S. Khoja 2,Shamim Khoja2,Narmin Pirani2

    1)Resource person in pharmaceutical quality assurance and Audit Compliance,VAPI 2) Registered Pharmacist , Gujarat
    Suleman salim khoja
    Email: premukhoja@gmail.com

    Scope 
    Human Error is commonly defined as “a failure of a planned action to achieve a desired outcome”. GMPs clearly state in CFR 211.22 that “[the quality control unit has]…the authority to review Production records to assure that no errors have occurred or, if errors have occurred, that they have been fully investigated.” Let’s analyze this statement. If the FDA expects that errors be fully investigated, it is safe to assume that the term error is NOT a root cause. That’s why it needs to be fully investigated, hence determine the root cause of the human error.  In order to successfully achieve this goal, we have to understand how to improve the way we deal with these types of situations. review article accurately how to accurately identify human errors, determine when a deviation or nonconformance requires CAPA, and get started using human performance improvement tools and processes in your organization.

  • BASICS OF AGING THEORIES AND DISEASE RELATED AGING - AN OVERVIEW

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    ABOUT AUHTORS
    Abhijit De*, Chandan Ghosh
    Department of Pharmaceutical Science,
    Bengal School of Technology, Sugandha,
    Hooghly, West Bengal, India
    * abhi8981@gmail.com

    ABSTRACT
    Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. In this review, several theories and mechanisms have been put to explain the molecular basis of aging. For example, random damage of the DNA of somatic cell is believed to accumulate with increasing age. Free radicals produced during oxidation of metabolites for energy production also damage DNA and proteins.

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