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  • AN UPDATED REVIEW ON: LIPOSOMES AS DRUG DELIVERY SYSTEM

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    ABOUT AUTHORS
    Devender  Sharma*1, Aashiya Aara E. Ali 2, Leena R. Trivedi2
    1Hi – Tech College of pharmacy, Chandrapur Maharashtra (India)
    2Kamla Nehru College of pharmacy, Nagpur, Maharashtra (India)

    *sdevender350@gmail.com
     

    ABSTRACT
    Liposomes are most placed acquiring in pharma industries and very useful in the various drug delivery system used to target the drug to particular tissue. Because of structural similarity between lipid bilayer (two layer) and cell membrane, liposome can easily penetrate effectively deliver drug to such that a free drug would not easily penetrate. Liposomes can be also encapsulate in both hydrophilic and hydrophobic materials, and are utilized as drug carriers in drug delivery. This technology is very useful for the treatment of certain diseases. Now a day’s most of the researcher attraction and interest will increase for that technology i.e. Liposomes. Main object of this review this technology i.e. Liposomes very useful in certain disease and easily prepare and also give various advantages other than. Liposomes are highly biocompatible, with applications ranging from delivering enzymes, antibacterial, antiviral drugs, antiparasite drugs, transdermal transporters, fungicides, diagnostic tools and adjuvant for vaccines. This paper mainly focus on exclusively scalable techniques and also focus on strength, respectively, limitations in respect to industrial applicability and regulatory requirements concerning liposomal drug formulations based on FDA and EMEA documents.

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  • A REVIEW ON: PLANTS AS ANTICANCER

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    ABOUT AUTHOR
    JY Manure, NS Naikwade
    Department Of Pharmaceutical Chemistry
    Appasaheb Birnale College of Pharmacy,
    Sangli, Maharashtra, India
    Javeedmanure.98600@yahoo.com

    ABSTRACT 
    Cancer is a diseases characterized by out-of-control cell growth. There are various types of cancer, and is classified by the type of cell that is affected. Cancer harms the body when altered cells divide uncontrollably to form lumps or masses of tissue called tumors. The recent treatments include chemotherapy, radiotherapy and Surgery. But this treatment accomplished by several side effect like the destruction of bone marrow cell, alopecia etc. So there is a need for the new drug for treatment of cancer. Plant-derived chemical may act as anticancer in many studies. The Plant produces secondary metabolites which are being evaluated for the anticancer activities leading to the development of new drugs. So in this review we have study different plants which act as anticancer. And this will encourage further scientific study of traditionally used plants.

  • PATHOPHYSIOLOGY OF TUBERCULOSIS: AN UPDATE REVIEW

    ABOUT AUTHORS
    Devender Sharma*1, Deepika Sarkar1
    1Hi – Tech College of Pharmacy, Chandrapur, Maharashtra (India)

    *sdevender350@gmail.com
    { DOWNLOAD AS PDF }

    ABSTRACT
    Tuberculosis is a hypersensitive granulomatous infectious disease caused by Mycobacterium Tuberculosis (M.TB).In India 40% people are affected by T.B. So need of knowledge about T.B.  and pathophysiology of T.B. to people or society. Pathophysiology means, when a human being or animal being suffering from a disease this is because deranged or change in function on that organ or human body.  Infection is caused by air- borne droplets of organisms person to person. The main object of this review is how to diagnose and how it is cure or treat. It is diagnosed by PPD, IGRA, Sputum studies, X-rays and Biopsies. Mostly antibiotics are preferred for the first treatment.

  • A REVIEW ON PHYTOCHEMICAL COMPOSITION AND PHARMACOLOGICAL ASPECTS OF THE GENUS ALSTONIA

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    ABOUT AUTHORS
    RAMYA MADHIRI1, G. VIJAYALAKSHMI2
    1Department of Pharmacognosy and Phytochemistry, AU college of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003.
    2Department of Biotechnology, GIT,  GITAM University, Visakhapatnam -530 045
    *ramyapraveen2709@gmail.com

    ABSTRACT
    Herbal medicines contribute a major share of officially recognized health care systems. Scientific research was trending on the isolation of active compounds of herbal origin. The present review concentrate on important species, active constituents, pharmacological aspects, identification tests for active constituents and the important research work carried out on the genus   Alstonia which may be helpful for the future research work.

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  • REVIEW ON ZIKA VIRUS

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    ABOUT AUTHORS
    Nayan Jain*, Ashutosh Biswas, Kratika Vivek Daniel
    Mandsaur Institute of pharmacy,

    Mandsaur, MP, India
    *nayanofficial499@gmail.com

    ABSTRACT
    Today the world has suffered to the Zika virus is a flavivirous related to yellow fever, dengue, West Nile and Japanese encephalis virus. Zika virus causes acute, serious illness which is often fatal if it is not treated. Its name comes from the Zika forest of Uganda. Zika is a mosquito born disease. Zika virus disease is caused by a virus transmitted primarily by Aedes mosquitoes. People with Zika virus disease can have symptoms including mild fever, skin rash, conjunctivitis, muscle and joint pain, malaise or headache. These symptoms normally last for 2-7 days. There is scientific consensus that Zika virus is a cause of microcephaly and Guillain-Barré syndrome. Links to other neurological complications are also being investigated. Neither an effective treatment nor a vaccine is available for Zika virus; therefore, the public health response primarily focuses on preventing infection, particularly in pregnant women. These article also covers from where the zika was firstly introduced or its history, its transmissions, causes, diagnosis, treatment and some current affairs.

  • MICRONEEDLES: AN APPROACH IN TRANSDERMAL DRUG DELIVERY: A REVIEW

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    ABOUT AUTHOR
    Devender Sharma*
    Hi – Tech college of pharmacy, Chandrapur, Maharashtra (India)

    *sdevender350@gmail.com

    ABSTRACT
    Transdermal drug delivery carried out a promising carrier in the transport of drugs to get direct access across the skin deep into the systemic circulation. Transdermal drug delivery have a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. It gives attraction to many researchers due to various biomedical advantages. Due to the limitation of oral drug delivery system and the pain related with the use of needles in case of injections, drug delivery research has tremendously oriented towards the transdermal route. Delivery of drugs via transdermal route has proved to be the convenient route for various clinical implications. The objective of the present review is to focus on newly innovations in transdermal drug delivery systems which can create a platform for the research and development of pharmaceutical drug dosage form for efficient transdermal delivery. In this review, we tell about different types of microneedles are described and their methods of fabrication. Microneedles can be fabricated in different forms like hollow, solid, and dissolving. There are also hydrogel-forming microneedles.  In relation to hydrogel-forming microneedles, special attention, these are innovative microneedles which does not contain drugs but imbibe interstitial fluid to form continuous conduits between dermal microcirculation and an attached patch-type reservoir. Regulatory authorities approved several microneedles for clinical uses are also examined. The last part of this review discusses concerns and challenges regarding microneedles use.

  • REVIEW ON MOISTURE ACTIVATED DRY GRANULATION PROCESS

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    ABOUT AUTHORS
    Devender M. Sharma*1, Satish B. Kosalge1, Swati N. Lade1
    Hi – Tech college of pharmacy, Chandrapur (M.S.)

    *sdevender350@gmail.com

    ABSTRACT
    Tablets are unit solid dosage form of medicament which largely used to compare other dosage form of medicaments. In tablet manufacturing, wet granulation and dry granulation methods largely used as compare to MADG process. In wet granulation and dry granulation methods various steps has been carried out like dispensing and shifting, dry mixing, granulation, pre-drying, shifting, premixing, lubrication and compression. But in MADG process, escape various steps like slugging, pre- drying, shifting, and drying. Hereby in MADG process save energy, cost of product and time also. The main object of review is hereby moisture activated dry granulation process very beneficial in case of water insoluble drug and water poorly soluble drug other than granulation method like wet granulation. Another objective of review how moisture activated dry granulation process carried out and given various advantages over the other granulation method. In water insoluble drug case MADG process largely used and very useful method for pharmaceutical industries.

  • PHYTOFABRICATION FOR THE SYNTHESIS OF NANOPARTICLES - REVIEW

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    ABOUT AUTHORS
    *R.Karthikeyan, E.Meghana, N.Gowthami, MD.Shajiya sultana, B.Mahesh reddy, SK.Magbul Johny, P.Srinivasa Babu
    Department of Pharmacognosy, Vignan Pharmacy College, Vadlamudi – 522213.A.P
    *rkcognosy@gmail.com

    ABSTRACT
    The synthesis of nanostructure substances, specifically metal nanoparticles, has accrued utmost concern over the last decade owing to their particular properties that cause them to applicable in distinctive fields of technology era. The biological technique of nanoparticle synthesis is a relatively easy, reasonably-priced, and environmental friendly approaches than the conventional chemical technique of synthesis and accordingly profits a top hand. The bio mineralization of nanoparticles in protein cages is one among such biological approaches used inside the era of nanoparticles. In this review we attempted to explore different techniques of synthesis of nanoparticles and its characterization. Further this review extended the usage of such nanoparticle in different fields.

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  • AN OVERVIEW ON POLYMERIC NANOPARTICLESUSED IN THE TREATMENT OF DIABETES MELLITUS

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    ABOUT AUTHORS
    K.GOPALASATHEESKUMAR1*, S.KOMALA2 AND M.MAHALAKSHMI2
    1KMCH college of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore-641048, Tamil Nadu, India.
    2Jaya College of Paramedical sciences, College of Pharmacy, Thiruninravur, Chennai – 602024, Tamil Nadu, India.
    *gskpungai@gmail.com

    ABSTRACT 
    The review was carried out to discuss in detail about the polymeric nanoparticles for diabetic treatment. The diabetes is the chronic metabolic disorder characterized by the deficiency of insulin production. The various treatments are available for the diabetes and the nanoparticles are having the several advantages. The various types of nanoparticles are available for the anti-diabetic drugs; the polymeric nanoparticles are the one of the most commonly used nanoparticles. The polymeric nanoparticles are commonly 10-1000nm in size. The polymeric nanoparticles are formulated by drug with the polymers. The main advantages of the polymeric nanoparticles are the simplest preparation method, targeted delivery, the minimizing of the dose and high therapeutic efficiency. In this review was mainly can be focused on advantages, disadvantages of polymeric nanoparticles, various polymers, various formulation techniques, diabetes disease profile, insulin production, various anti-diabetic drugs and the polymeric nanoparticle formulation of anti-diabetic drugs.

  • INFLUENCE OF GDF-11 IN AGING PROCESS : AN REVIEW

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    ABOUT AUTHORS
    Devender Sharma*,  Dr. Satish Kosalge1, Snehal R. Dixit1
    Hi – Tech college of pharmacy, Chandrapur (M.S.)
    *sdevender350@gmail.com

    ABSTRACT
    Aging is one of the phases of individual’s life span, which everyone wants to escape. The process of aging is much more a social phenomena than biological phenomena. Aging brings many changes such as, loss of eyesight, hearing loss, dementia, etc. Aging may give rise to diseased states such as, heart disease, cancer, cerebrovascular disease (relating to blood vessels that supply the brain), pneumonia and flu, and chronic obstructive pulmonary diseases. The key-factor behind aging is the GDF11, i.e., Growth and Differentiation factor-11. GDF11 is also known as Bone Morphogenetic Factor-11 (BMP11). It is termed as key circulating ‘anti-aging’ factor. GDF11 is expressed in wide range of tissues and has been shown to play important roles in development of olfactory system, retina and pancreas. It functions in regulating anterior-posterior patterning of the axial skeleton muscle system. Scientists theorize that aging likely results from a combination of many factors viz., Lifestyle, Diseases and Genes. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues, whereas myostatin is a well-described negative regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes .

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