PHYTOSOMES IS A NOVEL DRUG DELIVERY SYSTEM BASED HERBAL FORMULATION: AN REVIEW

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ABOUT AUTHORS
Devender Sharma1*, Ankita A. Bhujbale2
1Hi – Tech College of pharmacy, 

Chandrapur, Maharashtra, India
2Sinhgad College of Pharmacy, 
Vadgaon, Pune Maharashtra, India
*sdevender350@gmail.com

ABSTRACT

Phytosomes is a novel drug delivery dosage form. Phytosomes is a patented technology. It is used for development of formulation for improved bioavability of medicaments of phytoconstituents present in herbal extract or herbal preparation. Phytosomes is prepared by using the phospholipids and forming the complex between phytoconstituent and phospholipids. Phytosomes now a day’s most valuable space in pharma-industries and good research space for industry scholar, students for future. The main object of this review giving various useful advantages of phytosomes and how it is prepare formulate. Phospholipids are employed as natural digestive aids and carriers for water soluble and lipid soluble nutrients.

Reference Id: PHARMATUTOR-ART-2567

PharmaTutor (Print-ISSN: 2394 - 6679; e-ISSN: 2347 - 7881)

Volume 6, Issue 3

Received On: 23/10/2017; Accepted On: 25/12/2017; Published On: 01/03/2018

How to cite this article: Sharma D, Bhujbale AA; Phytosomes is a Novel Drug Delivery System based herbal formulation: An Review; PharmaTutor; 2018; 6(3); 23-26; http://dx.doi.org/10.29161/PT.v6.i3.2018.23

INTRODUCTION:
Phytosomes is a novel approach of drug delivery system and it is advantageous in delivering the herbal drug at predetermined rate, delivery of drug at the site of action, Minimizes the toxic effects, Increase in bioavailability of drugs, Control of the distribution of drug is achieved by incorporate the drug in carrier system or in changing the structure of the drug at molecular level, Herbal drug are becoming more popular in the modern world for their applications and safety aspects. (Awasthi et al., 2011) Phytosomes is newly introduced patented technologies by Indian to developed and incorporate the standardized plant extracts. (Awasthi et al., 2011) The phytosomes process produces a little cell because of that the valuable components of the herbal extract are protected from destruction by digestive secretions and gut bacteria. Phytosomes are better able to transition from a hydrophilic environment into the lipid-friendly environment of the enterocyte cell membrane and from there into the cell finally reaching the blood. Phytosomes have improved pharmacokinetic and pharmacological parameter. Phytosomes are more bioavailability as compared to herbal extract owing to their enhanced capacity to cross the lipid rich biomembranes and finally reaching the blood. Phosphatidylcholine is phospholipids. It is a key component of phytosomes process. Phospholipids are employed as natural digestive aids and carriers for water soluble and lipid soluble nutrients. (Karimi et al., 2015)

 

Commercial formulations of phytosomes available in market (Sundaraganapathy et al., 2016)

Product

Daily dose

Indication

Grape Seed Phytosomes

50 to 100 mg

Specific for the eyes, lungs, diabetes, varicose veins, and protection against heart disease.

Green Tea Phytosomes

50 to 100 mg

Best choice for protection against cancer. Also protects against damage to cholesterol

Ginkgo Biloba Phytosomes

120 mg

Best choice for geriatric patient. Protects brain and vascular lining

SILIPHOS™

120 mg

Best choice if the liver or skin needs additional antioxidant protection

Milk Thistle Phytosomes

150 mg

Good choice when the liver or skin only needs minor support

Method of preparations of phytosomes: (Singh et al., 2015)

Antisolvent precipitation technique
The specific amount of drug and soya lecithin were taken into a 100 ml round bottom flask and refluxed with 20 ml of dichloromethane at a temperature not exceeding 60oC for 2 h. The mixture is concentrated to 5-10 ml. Hexane (20 ml) was added carefully with continuous stirring to get the precipitate which was filtered and collected and stored in vacuum desiccators overnight. The dried precipitate is crushed in mortar and sieved through #100 meshes. Powdered complex was placed in amber colored glass bottle and stored at room temperature. (Jan et al., 2013)

Rotary evaporation technique
The specific amount of drug and soya lecithin were dissolved in 30 ml of tetrahydrofuran in a rotary round bottom flask followed by stirring for 3 hours at a temperature not exceeding 40oC. (Awasthi et al., 2011) Thin film of the sample was obtained to which n-hexane was added and continuously stirred using a magnetic stirrer. The precipitate obtained was collected, placed in amber colored glass bottle and stored at room temperature. (Fei et al., 2016)

 

Solvent evaporation method
The specific amount of drug and soya lecithin were taken into a 100 ml round bottom flask and refluxed with 20 ml of acetone at a temperature 50 - 60oC for 2 h. The mixture is concentrated to 5-10 ml to obtain the precipitate which was filtered and collected. (Mazumder et al., 2016) The dried precipitate phytosomes complexes was placed in amber colored glass bottle and stored at room temperature.

General method for preparations of phytosomes: (Sabzichi et al., 2014)

Different additives used in the formulations of Phytosomes: (Naik et al., 2008)

Phospholipids: Soya phosphatidyl choline, Egg phosphatidyl choline , Dipalmityl phosphatidyl choline, Distearyl phosphatidyl choline .

Aprotic solvent: Dioxane, acetone, methylene chloride

Non solvent:  n-hexane and non solvent i.e. aliphatic hydrocarbon

Alcohol: Ethanol, Methanol

List of equipment used for the preparation of phytosomes:
1.UV-Visible spectrophotometer
2.FT-IR Spectrometer
3.HPLC
4.Different Scanning Calorimeter
5.Single pan electronic balance
6.Digital PH meter
7.Melting point apparatus
8.Scanning electron microscopy(SEM)
9.Transmission electron microscopy (TEM)

Advantages of phytosomes: (Raju et al., 2011)
1.They enhance the absorption of lipid insoluble polar botanical extract through oral as well as topical route showing better bioavailability, hence significantly greater therapeutic benefit.
2.As the absorption of active constituent(s) is improved, its small dose can produce desired results.
3.Phosphatidylcholine used in preparation of phytosomes, besides acting as a carrier also acts as a hepatoprotective, hence giving the synergistic effect when hepatoprotective substances are employed.
4.Phytosomes show better stability profile due to formation of chemical bonds between phosphatidylcholine molecule and botanical extract.
5.Phytosomes are better able to transition from a hydrophilic environment into the lipid‐friendly environment of the enterocyte cell membrane and from there into the cell, and thus can be used for systemic targeting.
6.Phytosomes are widely used in cosmetics due to there more skin penetration and have a high lipid profile.
7.By enhancing the solubility of bile to herbal constituent, phytosomes facilitates the liver targeting.

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