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Auti Snehal D.*, Jadhav S. L, Gadhave Manoj V
1Department of Quality Assurance Techniques
2,3Department of Pharmaceutics
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
The present research work discusses the development of a dissolution method for Fluconazole using UV spectrophotometer. Simple, accurate and cost efficient dissolution method has been developed for the estimation of Fluconazole in bulk and tablet dosage form. The optimum conditions for the dissolution of the drug were established. The dissolution media was found to be 0.1N HCl (pH 1.2). The apparatus was found to be USP II, Paddle and the speed was found to be 50 rpm for 30 minutes time interval.
Akash M Patel*, Viren N Sisodiya
* Faculty of Pharmacy,
Dharmsinh Desai University, Nadiad-387001, Gujarat
Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric patient can create a bad psychological effect on mind. The purpose of this research was to mask the intensely bitter taste of Linezolid using ion exchange resin and to formulate the dry syrup of the taste masked drug. When suspension is swallowed the bitter taste of the drug may not be felt as ion exchange resin does not release the drug at salivary pH. When it comes in contact with acidic environment of stomach, the complex will be broken down releasing the drug which may then absorbed. Batch method was used for formation of drug resin complex. Various ion exchange resin like different grade of kyron and indion 214 were used for masking the bitter taste. Optimization of drug loading was carried out. Indion 214 was selected as a optimized resin with 84.47 % drug loading. Dry syrup was made using suspending agent like gellan gum, guar gum and CMC and evaluated for various parameters like colour, odour, taste, viscosity, sedimentation volume, redispersibility, % drug content, drug release. By evaluating all the parameter the batch formulation contained guar gum 3 % was the best one amongst all the other formulations.
Fatema Nasrin1*, Saikat Ranjan Paul2, Sonia Zaman2, Sabiha Ferdowsy Koly2
1Senior Lecturer, Department of Pharmacy, Southeast University, Banani, Dhaka-1213
2Lecturer, Department of Pharmacy, Southeast University, Banani, Dhaka-1213
In the present study the antimicrobial & cytotoxic activity of crude methanolic extracts of leaves and stems of VignaMungoLinn. Hepper (Family-Leguminosae)were studied. Antimicrobial activity was tested against eleven important pathogenic bacteria including both gram positive and gram negative bacteria and two common fungi. The bacteria are B. megaterium, B. subtilis, Staphylococcus aureus, Sarcina lutea, Escherichia coli, Salmonella paratyphi, S. typhi, Shigella boydii, S. dysenteriae Vibrio mimicus and V. parahemolyticus. Disc diffusion technique was used for invitro antibacterial and antifungal screening. Here kanamycin disc (30mg /disc) was used as standard for antibacterial study. The extracts showed antimicrobial activity against most of the bacterial strains with an average zone of inhibition of 10-20mm. The tested fungi are Candida albicans and Aspergillus niger. The extracts showed very good antifungal activity with an average 15 -19 mm zone of inhibition. The methanolic extracts of leaves of V. mungo showed maximum activity (19 mm, zone of inhibition) against Bacillus megaterium (19mm) with Minimum inhibitory concentration (MIC) values of 64mg/ml. The maximum zone of inhibition for the methanolic extracts of stems was found 20mm against Shigellaboydii with MIC values of 64mg/ml. Cytotoxicity test was also studied by Brine Shrimp Lethality Bioassay and compare with LC50 values of standard vincristin sulphate as a positive control. The results illustrated significant cytotoxicity against A. salina, with LC50 0.67μg/ml, 4.52 μg/ml and 3.25 μg/ml for vincristine sulphate as standard, leaves and stems extracts, respectively. Further pharmacological investigations are required to understand the underlying mechanism of these pharmacological activities.
Pranita Pradip Dharmadhikari
Department of Phrmacology,
N.D.M.V.P. College of Pharmacy, Nashik
“Pharmacy is the health profession that links the health science with the chemical science and it is charged with ensuring safe and effective use of pharmaceutical drugs.” That’s how the Wikipedia defines it. For a student it is a career, an ambition and of a course a learning process.
Pharmacy education in India was initiated by Medical College; Madras in 1860, the purpose was to develop pharmaceutical skills of students of medical degree or diploma course or of that pursuing hospital assistance. From 1860 to 2014 the pharmacy profession shows a tremendous growth in India, it shows that pharmacist is one of the major fraternities of health care system around the world. As a pharmacist, I must say that pharmacy is profession which benefits to the world. But certain area in pharmacy are consistently points the pharmacist as towards negative aspects. Hence it’s a pharmacist’s duty to focus on wrong practices to make a profession as boon for world.
Amarjeet Singh*, Sudeep Bhardwaj, Ashutosh Aggarwal
Department of Pharmacology,
Seth G. L. Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research,
Sri Ganganagar, Rajasthan 335001, India
Objective: The choice of drug for the treatment of hypertension changes at short intervals. Drug utilization studiesconducted at regular intervals help to guide the physician in prescribing drugs rationally. The present study was done toanalyze the prescribing patterns of antihypertensive drugs in a NorthIndian hospital.
Material & method: A retrospective, crosssectional analysis of prescriptions of antihypertensive cases admitted in Medicine in-patient wards of civil hospital of Sri Ganganagar was conducted. All the prescription files with diagnosis ofessential hypertension were analyzed. Prescriptions for hypertension with other co-morbid conditions were also included. Frequency and proportions of utilization of antihypertensive medications were charted and figured.
Result: During the studyperiod, there were 435 prescriptions for essential hypertension. The most frequently prescribed antihypertensive medications were: monotherapy (42.06%), (57.94%) of patients were on multiple drugtherapy, the most favored fixed drug combination being diuretics with angiotensin receptor blockers (31.74%).
Conclusion: The present study revealed that Angiotensin receptor blockers arethe drugs of choice as monotherapy and as combination therapy for hypertensives. This pattern of prescription is also supported by the current JNC VIII guidelines for the treatment of hypertension.
MOLECULAR MODELING STUDIED FOR INHIBITION OF CALCIUM CHANNEL RECEPTOR: A STRATEGY FOR THE DEVELOPMENT OF NEW ANTIEPILEPTIC DRUG
Vinit Raj*, Amit Rai, Deepak Kumar and Vinod Kumar
Department of Pharmaceutical Sciences,
Babasaheb Bhimrao Ambedkar University (A Central University),
VidyaVihar, Raebreli Road, Lucknow, Uttar Pradesh, 226025, India
Epilepsy is a common brain disease that is characterized by recurrent and spontaneous seizures that result from abnormal and excessive synchronization of neuronal activity. Whereas, accumulation of Ca++ in presynaptic terminals, leading to improved neurotransmitter release. In additional, depolarization-induced inauguration of the NMDA subtype of the excitatory amino acid receptor, which causes more Ca++ influx and neuronal activation. The main aim of this study to focus on the deactivation of Ca++ influx and prevent the augmentation of neuron activation. However, we performed molecular modeling of novel 1,3,4-thiadiazole derivatives keeping in view structural requirement of pharmacophore and Quantitative structure activity relationship (QSAR) and evaluated in silico anticonvulsant activity. Docking procedures allow virtually screening a database of compounds and predict the strongest binder based on various scoring functions. In the docking study, targeted ligand produced significantly affinity with the calcium channel receptor which is slightly higher than the phenytoin drug. A computational study was also carried out including prediction of pharmacokinetic properties, toxicity and bioactivity studies. All above parameter was calculated which exhibited slightly excellent compared than standard Phenytoin drug. The above observation suggested that these compounds would serve as better lead for anticonvulsant screening for future drug design perspective.
EVALUATION OF ADAPTOGENIC ACTIVITY OF VARIOUS EXTRACTS OF BREYNIA VITIS-IDAEA (BURM.F) C. FISHER LEAVES BY USING SWIM ENDURENCE TEST
Manju Gowda M R*, Gnanasekaran D, Ashik navas T, Antony george
Department of Pharmacology, Bharathi College of Pharmacy,
Bharathinagara, Mandya, Karnataka-571422
The present study was under taken to study the Adaptogenic activity of ethanol, aqueous and ethyl acetate extracts of Breynia vitis-idaea (burm.f) c. fisher. (Euphorbiaceae) leaves. Adaptogenic activity of these extracts were studied using in-vivo Swim Endurance test and compared with the standard Fluoxetin. All the extracts showed significant increase in the swimming time. Adaptogenic nature of the extracts may be attributed to the presence of constituents such as alkaloids, glycosides, flavonoids and saponins in plant extracts. This study proven that the potential adaptogenic nature of the extract of Breynia vitis-idaea leaves.
Jadhav Santosh1*, Mali Audumbar1, Tamboli Ashpak2
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India1.
Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India2.
Since the current Ebola Virus Disease (also referred to as Ebola Haemorrhagic Fever) outbreak began in Guinea in December of 2013, the outbreak now involves trans-mission in Guinea, Liberia, Nigeria, and Sierra Leone. Ebola haemorrhagic fever (EHF) is a zoonosis affecting both human and non-human primates (NHP). Ebola virus (formerly officially designated Zaire Ebolavirus, or EBOV) was first seen infecting humans in African continent; especially Sudan, Democratic Republican of Congo, Zaire and nearby countries. Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. The World Health Organization (WHO) reports that this is the largest Ebola Virus Disease (EVD) outbreak ever recorded. EVD outbreaks have a case fatality rate ofup to 90%. The research is on-going on development of making vaccine to curb this virus yet licensed success or specific treatment is not achieved.
PLANT SPECIES USED BY LOCALS AS ETHANO - MEDICINE IN GOHAR TEHSIL, DISTT. MANDI REGION OF NORTH WESTERN HIMALAYA
Monika Rana*1, Atul Kabra1, Ruchika Kabra1, Meenakshi Rana2, Vinay Dhatwalia3
1 Department of Pharmacy, Abhilashi university, Chailchowk, Mandi (H.P)
2 HIPER college of Pharmacy, Nadaun, (H.P)
3 Abhilashi College of Pharmacy, Mandi (H.P)
Objective: An exhaustive ethno medicinal investigation of plants was carried out in Gohar Tehsil of Distt. Mandi.
Methods: The paper encompasses 38 medicinal plants, collected from forest of Chailchowk and its adjoining areas, and authenticated. The information was collected from local people. This study reveals the status of ethno-medicinal plants and their importance preserved by locals of Gohar Tehsil of Distt. Mandi.
Results: Total 38 medicinal plants were studied in the forest of Chailchowk Village and its adjoining areas of Gohar Tehsil are very valuable medicinal plants which are already known for their numerous medicinal values.
Conclusion: This study will assist the forest, pharmaceutical firm, medicos and wild life manager in their efforts for improving the public health service and medicinal plant wealth of the area.
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF DICLOFENAC SODIUM BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD
Mali Audumbar Digambar*, Jadhav Santosh, Mane Pandurang, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola- 413307, Solapur, Maharashtra, India
A simple, precise, accurate and economical UV visible spectrophotometric method has been developed for estimation of Diclofenac sodium drug by AUC method. The standard and sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 270-282 nm. The linearity was established over the concentration range of 05,10,15,20&25µg/ml for Diclofenac sodium with correlation coefficient value of 0.9981. Precision studies showed that % relative standard deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.38%.The proposed method has been validated as per ICH guidelines.