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Anmol Eldose*, Hetal Patel, Pooja Patel, Vinish Sharma, Zeel Rajput, Hitesh Jain, U.M. Upadhyay
Sigma Institute of Pharmacy,
Vadodara, Gujarat, India
Ebola virus is a fatal illness in humans and non primates. Ebola virus causes Ebola hemorrhagic fever. Ebola Virus Disease (EVD) is transmitted to people from wild animals and spread to humans through human to human transmission. EVD is caused by the sudden onset of weakness, muscle pain, headache, sore throat, fever, vomiting, diarrhoea, liver dysfunction, rashes and also internal- external bleeding. As such no specific treatment foe EVD is available but a number of researches are going on. Oral rehydration therapy or intravenous fluids are some of the treating symptoms.
*S R Thorat1, S M Meshram2
1Lupin Research Park, Hinjewadi, Pune, Maharashtra
2TATA Consultancy Services, Hinjewadi, Pune, Maharashtra
Pressurized metered dose inhalers (MDIs) are widely used dosage form for treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary disease. The metered dose inhaler (MDI) contains the active pharmaceutical ingredient dispersed or solubilised in a high vapour pressure propellant and metered accurately in tens to hundreds of micrograms and administered directly to the lungs. The most dominant characteristics of MDI include their portability, convenience of use and quick effect. MDI comprises of drug formulation, propellant, metering valve, actuator, and container. This review contains overview of excipient selection, primary packaging material, propellant selection and formulation development of pMDI. Two of the most commonly used methods for the manufacturings of MDIs are cold filling method and pressure filling method.This review demonstrates different analytical techniques for characterization of pMDI’s like uniformity of delivered dose, water content, spray pattern and plume geometry were discussed. This review also presents in-vitro characterization, pharmacokinetic and pharamcodynamic study of MDI.
Syed Saida begum*, B. Sai Sushmaa, S.Vijayaraja
Department of Pharmaceutical Analysis
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A.Rangampeta, Tirupati, Chittoor (Dt), Andhra Pradesh.
The development of the bioanalytical techniques brought a progressive discipline for which the future holds many exciting opportunities to further improvement. The main impact of bionalysis in the pharmaceutical industry is to obtain a quantitative measure of the drug and its metabolites. The purpose is to perform the pharmacokinetics, toxicokinetics, bioequivalence and exposure response like pharmacokinetic/pharmacodynamic studies. Various bioanalytical techniques are performed in bioanalytical studies such as hyphenated techniques, chromatographic techniques, and ligand binding assays. This review extensively highlights the role of bioanalytical techniques and hyphenated instruments in assessing the bioanalysis of the drugs.
Rahul Kumar*, Ved Prakash Singh, Damini Maurya, Anand Kumar Pandey
Department of Biotechnology, Institute of Engineering and Technology
Bundelkhand University, Jhansi, Uttar Pradesh, India
Nanoparticle, a core of bio-nanoparticle, which is used for polymers including natural and synthetic polymer and form different types of, liposomal and polymer nanoparticle. The designing, synthesis and manipulation of structures which is smaller than 100 nm, is termed as Nanotechnology. Nanoparticles are developed as a colloidal structure, synthesized by semi-synthetic and synthetic polymers. The emerging area of nanotechnology and Nano-sciencesare the application of nanoparticles, ranges in 1 to 100 nanometre (nm). The synthesis of silver nanoparticles for their potential application, it was originate to be eco-friendly and reliable, because of their exclusive properties. Mostly synthesis of AgNPs, by physical and chemical methods are too expensive, toxic, hazardous chemicals for various biological risks.The main objective of this study preferably lies thatgreen synthesis of AgNPs by several plants and its metabolites, extracts can be much safer to handle and easily available. The synthesis of AgNPs are using several plants extract such as Oryza sativa, Zea mays, Basella alba, Helianthusannuls, Camellia sinensis ( green tea), Azadirachta indica (neem) ,Ssebania drummondii (leguminous shrub)sp. The AgNPs get attached in the cell wall of microorganism and can disturb the cellular respiration, permeability of the cell wall. Sometimes it can penetrate inside the cell wall which can interact protein, DNA, sulphur and phosphorus and causing cellular injury inside cell. It confers the antimicrobial activity. The AgNPs shows less antimicrobial activity against gram positive bacteria in comparison to gram negative bacteria because gram negative contain β-barrel proteins (i.e. Porins) and thinner peptidoglycan. The distinguishing property of silver nanoparticles it can be have higher surface area to volume ratio. When surface area increases the catalytic activity and surface energy of AgNPs corresponding to increase and biological effectiveness also increases.
It identified that amalgamation of silver nanoparticle biochemical process is very fast process as compare to using microorganism (even several hours to few days). The NPs monodispersity, size are significant part in the valuation of NPs amalgamation. Therefore, operative regulator of monodispersity and NPs size are essentially examined. On numerous readings silver nanoparticle synthesis by microbes can be decompose later withassured dated of time. Thus the constancyof nanoparticle producebiological approachesmerits supplementary learning.
Ayurvedic Pharmacy, Lovely School of Pharmaceutical Sciences,
Lovely Professional University, Phagwara, Punjab, India
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from increased hepatic glucose production, diminished insulin secretion and impaired insulin action. Though diabetes is a global problem so the present study aims to open new avenue to explore the antidiabetic activity of various medicinal plants on a firm scientific footing and different market formulation which add value as novel antidiabetic drug.
M. Jambulingam*, S. Ananda Thangathurai1, D. Kamalakannan1, S. Punitha1, Rincy T.R1, S. Santhi1, G. Surya1, M. Vasanthi.1, S. Josephine Subarla.1
Department of Pharmaceutical Analysis, Swamy Vivekanandha College of Pharmacy,
Elayampalayam-637205, TN, India
A simple spectrometric method has been developed for the estimation of the ceftriaxone sodium in powder for injection dosage form by derivatization with p-dimethyl amino benzaldehyde. The measurement of absorbance and derivatized ceftriaxone sodium at 490.4nm. The both methods obeys Beer’s and Lambert’s law in the range of 5-25µg/ml with the correlation co-efficient of r²0.998. The colour reaction was highly stable and didn’t show any changes in absorbance up to 48hrs. The % RSD associated with all the validation parameter was less than 2, showing the accuracy of the method developed. The compliance of acceptance criteria of Q2 (R1), (R2) international conference on harmonization (2005 guidelines).
Suresh Rewar1*, Dashrath Mirdha2, Prahlad Rewar3
1Department of pharmaceutics, Rajasthan University of Health Sciences, Jaipur, Rajasthan,
2Dr. Sarvepali Radhakrishnan Rajasthan Ayurved University, Jodhpur, Rajasthan, India
3Jawaharlal Nehru Medical College, Ajmer, Rajasthan, India
A severe viral illness caused by a newly discovered coronavirus was first reported in the Middle East in 2012. The virus has since been named the Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV cases have been reported in several countries around the world in travelers from the Middle East., A substantial number of Indians live and work in Gulf countries. People from India also travel to Saudi Arabia as Pilgrims to Hajj. The illness has a high mortality rate. Limited human-to-human transmission has occurred including transmission to health care workers. The source of the virus remains unclear, but camels are a possible source. Since April 2012 and as of 20 February 2015, 1042 cases (including 419 deaths) of Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported by local health authorities worldwide. Laboratory confirmation of MERS-CoV infections to date has largely been by real-time reverse transcription polymerase chain reaction (rRT-PCR) of lower respiratory tract specimens. Neither a vaccine nor effective therapy against the virus is available. Treatment consists of limited to supportive care, including mechanical ventilation for respiratory failure and/or hemodialysis in the setting of renal failure. Therapeutic modalities based on monoclonal antibodies (mAbs) have shown clinical success in the treatment of many diseases.
Mohammad Akbar Dar, Mubashir Hussain Masoodi*, Saeema Farooq
Dept. of Pharmaceutical Sciences,
Faculty of Applied Sciences, University of Kashmir, Srinagar, J&K, India
A radiopharmaceutical is a preparation intended for in-vivo use that contains a radionuclide in the form of a simple salt or a complex. It may exist as a solid, liquid, gas or a pseudo gas. The chemical and physical identity and a form of a radiopharmaceutical are very important because in each case, once administered the radiopharmaceutical is intended to target certain tissues, binding sites, biochemical pathways. A radiopharmaceutical can be used for either diagnostic or therapeutic purposes depending on its specific physicochemical and radiation properties. The characteristic of radioactive decay is what makes radioisotopes useful in their medical applications; however, different applications will take advantage of radioactive emissions in different ways. Radioactive materials are regularly used to treat medical conditions, diagnosis pathology, visualize and measure physiological functions, and localize structures and pathways. This review describes both the therapeutic as well as diagnostic uses of radiopharmaceuticals.
Bikash Debnath*, Md. JashimUddin, Debasish Maiti
State Biotech Hub, Department of Human Physiology,
Tripura University, Suryamaninagar.
Central nervous system (CNS) drug development will be biology driven. Due to absence of functional platform for CNS drug targeting since, the large molecules pharmaceuticals cannot be delivered to brain. About 1.5 billion people worldwide are suffering from various type of central nervous system (CNS) disorders. Overcome to this problem modern pharmaceutical technology manufacturing the nonaparticles. Properly use of nonamedicines (nanoparticles) is one of the ways to control the CNS disorder in all over world. Nanoparticles are particles between 1 to 100 nm in size. Using nanotechnology it is possible to deliver the drug to the specific site of the tissue across the Blood -Brain Barrier (BBB).Various types of nanoparticle are available for treatment of CNS disorders. These are lipid based nanoparticles, solid lipid nanoparticles, polymer-based nanoparticles etc.
ESTIMATION OF ONDANSETRON HYDROCHLORIDE IN BULK AND FORMULATION BY SECOND ORDER DERIVATIVE AREA UNDER CURVE UV-SPECTROPHOTOMETRIC METHODS
Jadhav Santosh1*, Kharat Rekha1, Ansari Afaque2, Tamboli Ashpak3
1Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
2Department of Pharmaceutic’s, D. S. T. S Mandal’s College Of Pharmacy Solapur, Maharashtra India.
3Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade,
Sangola-413307, Solapur, Maharashtra, India.
Simple, fast and reliable spectrophotometric methods were developed for determination of Ondansetron Hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Distilled Water. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 248-254nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Ondansetron Hydrochloride using 2-10μg/ml (r²=0.9986) for second order Derivative Area under Curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Ondansetron Hydrochloride in pharmaceutical formulations.