Articles

LIFE SAVING BINDI A NOVEL APPROACH TO COMBAT IODINE DEFICIENCY

ABOUT AUHTORS
D. Giri Raja Sekhar*, D. Sai Sravani, H. Thulasi , Chakka  Gopinath
Department of Pharmacy Practice, Annamacharya college of Pharmacy, Rajampet
*giriraj.pharma@gmail.com

ABSTRACT: 
The thyroid gland produces thyroid hormones. The two most important hormones are tetraiodothyronine (thyroxine or T4) and triiodothyronine (T3).Iodine deficiency is a major health problem in India. Iodine deficiency that can lead to disorders like goiter, hypothyroidism and even brain damage. Even mild iodine deficiency in pregnant women can result in children being born with cretinism and mental retardation. The most popular method of tackling the problem has been to encourage the consumption of iodised salt. An iodine patch, designed like a regular bindi, is expected to help iodine deficiency. It seems like a brilliantly simply idea The wearing of bindis form part of a cultural practice of Indian Women, which are “self-adhesive” in between their eyebrows, have been impregnated with a solution of iodine.  Production costs are minimal, wearing the iodine-infused bindi requires no behavioral change.


INFLUENCE OF GDF-11 IN AGING PROCESS : AN REVIEW

ABOUT AUHTORS
Devender Sharma*,  Dr. Satish Kosalge1, Snehal R. Dixit1
Hi – Tech college of pharmacy, Chandrapur (M.S.)
*sdevender350@gmail.com

ABSTRACT:
Aging is one of the phases of individual’s life span, which everyone wants to escape. The process of aging is much more a social phenomena than biological phenomena. Aging brings many changes such as, loss of eyesight, hearing loss, dementia, etc. Aging may give rise to diseased states such as, heart disease, cancer, cerebrovascular disease (relating to blood vessels that supply the brain), pneumonia and flu, and chronic obstructive pulmonary diseases. The key-factor behind aging is the GDF11, i.e., Growth and Differentiation factor-11. GDF11 is also known as Bone Morphogenetic Factor-11 (BMP11). It is termed as key circulating ‘anti-aging’ factor. GDF11 is expressed in wide range of tissues and has been shown to play important roles in development of olfactory system, retina and pancreas. It functions in regulating anterior-posterior patterning of the axial skeleton muscle system. Scientists theorize that aging likely results from a combination of many factors viz., Lifestyle, Diseases and Genes. GDF11 is essential for mammalian development and has been suggested to regulate aging of multiple tissues, whereas myostatin is a well-described negative regulator of postnatal skeletal and cardiac muscle mass and modulates metabolic processes .


A REVIEW ON FORENSIC ANALYTICAL CHEMISTRY

ABOUT AUHTOR
Manimala M*1, Vijay Kumar D1
Santhi ram College of Pharmacy- Kurnool-Andhra Pradesh
*manimala.mosey@gmail.com

ABSTRACT:
The word “forensic” means “pertaining to the law”; forensic science resolves legal issues by applying scientific principles to them. Forensic Analysis is the application of Analysis to law enforcement or the failure of products or processes. It is unique among chemical sciences in that its research, practice, and presentation must meet the needs of both the scientific and the legal communities.Forensic Analysis applied the basic theory and mythology of advanced analytical chemistry to rationalize various materials of crimes and provide evidence to detection.Forensic Analysis is carried out by the two types of techniques namely Organic Analytical Technique &In- Organic Analytical Technique. And this review article covers regarding how Analytical techniques are useful in forensic analysis to resolve major problems of common man.


CURCUMIN NANO DRUG DELIVERY SYSTEMS: A REVIEW ON ITS TYPE AND THERAPEUTIC APPLICATION

ABOUT AUHTOR
S. Dhivya*, DR. A. N. Rajalakshmi
Department of Pharmaceutics,
Mother Theresa Post Graduate and Research Institute of Health Sciences,
Gorimedu, Puducherry, India

*dhivyaraji310@gmail.com

ABSTRACT: Design and development of herbal nanoparticles has become a frontier research in the nanoformulation arena. Curcumin, a hydrophobic polyphenol (diferuloyl methane) is a potent phytomolecule obtained from turmeric (Curcuma longa, Family-Zingiberaceae) has a wide range of biological activities in chronic diseases and has wide therapeutic efficacy. But the clinical application of curcumin was limited due to its poor water solubility, rapid metabolism and rapid elimination which ultimately results in poor bioavailability upon oral administration. Therefore introduction of nanotechnology provides a solution towards increased bioavailability of curcumin. In this review, an overview of curcumin nanoparticles is discussed.


A STUDY ON ROLE OF DOCTOR OF PHARMACY IN IDENTIFYING AND REPORTING OF DRUG RELATED PROBLEMS AND ITS COMORBIDITIES IN INPATIENT UNITS OF A TERITARY CARE TEACHING HOSPITAL

ABOUT AUHTORS
M. Manasa Rekha*,
Department of Pharmacy Practice,
Annamacharya college of Pharmacy,
Rajampet, Andhra Pradesh,  India.
*manasarekharoyal@gmail.com

ABSTRACT: AIM: The study aims to assess the role of DOCTOR OF PHARMACY in identifying drug related problems in inpatient units in a tertiary care teaching hospital. OBJECTIVES: The main objective of the present study includes identification and reporting of drug related problems like Drug-drug interaction, Adverse drug reactions, Drug use without indication, Therapeutic duplication, Allergy/intolerance/poisoning, Improper drug, dose, route, regimen, Awareness/adherence problems.


BROMELAIN: APPLICATIONS AND PURIFICATION STRATEGIES

ABOUT AUHTORS
RATIKANTA SAHOO, PRATYUSH KUMAR DAS*
Centre for Biotechnology,
Siksha ‘O’ Anusandhan University,
Bhubaneswar, Odisha, India
pratyushdas@soauniversity.ac.in

ABSTRACT
Bromelain is a plant protease present in different parts of the pineapple [AnanasComosus (Linn.) Merr.]plant. It is an enzyme of high commercial interest which can be attributed to the wide therapeutic and industrial applications it possesses. As such efficient purification and recovery of the enzyme is utmost necessary on a large scale basis. The review highlights the numerous applications of the protease enzyme and further discusses the various purification techniques beginning from simpler ultrafiltration to the more complex and specific column chromatography that are being commonly employed nowadays. Effort has been made to compare the purification strategies extensively and suggest the best among the techniques which is cost-effective, has high output and can be used on a large scale production basis
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A REVIEW APPROACH OF ALZHEIMER DISEASE AND PHARMACOLOGICAL MANAGEMENT

ABOUT AUHTOR
Senthamil Selvan T *
Pharmaceutical Technical service department,
Mylan Laboratories Limited, Tamilnadu, India
Pharmtamil@gmail.com

ABSTRACT
Dementia is a chronic progressive disorder mainly causes the memory loss and cognitive dysfunction due to neurodegeneration. It is popularly known as Alzheimer disease. It is the fifth disorder leads to death. Those who are the people have crossed age 60 years risk chance of cause. Dementia the disorder is widely known as Alzheimer’s disease, senile dementia, vascular Dementia, Dementia with levy bodies, Parkinson’s disease, Frontotemporal dementia. By neurological examination like CT, MRI, and Spinal fluid analysis can occasionally be justified to confirm the dementia syndrome. For the AD the treatment are broadly takes place as two types, one is cognitive symptoms treatment, another Non- cognitive symptoms treatment. In that case for cognitive sign treatment cholinesterase inhibitors (such as Donepezil, rivastigmine), NMDA receptor inhibitors (Memantine) are used. Anti-psychotics’, Anti-depressant category drugs are used for Non-cognitive symptoms treatment.


GATEWAYS TO DRUG ABUSE: A BRIEF REPORT ON PUNJAB & HARYANA

ABOUT AUHTORS
Piyush Tripathi*,  Abhishek Arora
GMSCL,
GUJARAT(INDIA)
*piyushtripathi1992@rediffmail.com

Drug addiction is a serious problem in one country that is known for its culture, traditions & social values all over the world. The country where people commit suicide either because of love affairs or due to drug addiction related issues. Undoubtedly, this writing is talking about India.


CRITICAL AND COMPARATIVE ANALYSIS OF ANDA FILLING OF TABLETS IN INDIA, EUROPE AND US

ABOUT AUHTORS
Ms. NEETU*, Dr. ANUPAMA SETIA, Mr. MUNISH THAKUR
*JCDM COLLEGE OF PHARMACY,
SIRSA-HARYANA (INDIA)
*neetu.kaushal11@gmail.com

ABSTRACT
Abbreviated New Drug Application (ANDA) is an application used for regulatory submission for the authorization of generics drugs and its entry into a brand drug market. Generic drugs are pharmaceutical equivalent to the brand name drugs and distributed without patent protection. Different countries have different requirements for the registration of generic drugs and its own regulatory authority, which are responsible to enforce the rules and regulations, issue the guidelines to regulate the marketing of drugs. Various government agencies in regulating drugs are CDSCO- India, EDQM-Europe, and USFDA-US. Aim of title was to review the generic drug filing and different aspect of obtaining regulatory approval in order to get the marketing authorization in India, Europe & US. Involvement of regulatory in the generic drug development expedites the approval process and they review the queries carefully raised by the regulatory authorities and minimize them. To harmonize the different requirements, CTD format is used for filing the ANDA in respective countries. In this an attempt was made to highlight the difference between the registration requirements for generics drugs in India, Europe & US. The comparison parameters in the generic drug approval among different regions, which gives clear illustration where India lies in its generic drug approval process.


VIROSOMES AS NOVEL DRUG DELIVERY SYSTEM: AN OVERVIEW

ABOUT AUHTORS
Narinder Singh*, Surya Prakash Gautam, NeelamKumari,Rupinder Kaur,Manpreetkaur
CT Institute of Pharmaceutical Sciences, Shahpur, Jalandhar, Punjab
*pharmacist.narinder@gmail.com

ABSTRACT
Virosomes are reconstituted viral envelopes that can fill in as vaccines and as vehicles for cell conveyance of different macromolecules. The prospect of drug delivery and targeting systems utilizing virosomes is an intriguing innovative work field. Since virosomes are biocompatible, biodegradable, non-poisonous and non-autoimmunogenuic; endeavors have been made to use them as antibodies or adjuvants and also conveyance frameworks for drugs and organic for remedial purposes. The achievement of virosomal medicate conveyance relies on upon strategy used to set up the typified bioactive materials and fuse them into the virosomes. Virosome innovation could conceivably be utilized to convey peptides, nucleic acids or, then again qualities and medications like anti-toxins, anticancer agents, and steroids.


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