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Singh Surya Pratap*, Soni Shankar Lal, Khinchi Mahaveer Prasad, Gulia Ritu, Namdev Abhisek
Department of pharmaceutics, Kota College of Pharmacy,
Ranpur, Kota, Rajasthan, India
The objective of the present study was to focus on sustained release matrix tablets of baclofen, for treatment of spastically resulting from multiple sclerosis, flexor spasm and muscular rigidity. Designing effective therapies for Spinal cord injury (SCI) has been a challenging problem because spinal cord injuries are heterogeneous in causality, severity and location of injury.
Effective drug therapy for Spinal cord injury (SCI) first became a reality in 1990 with the finding that the steroid drug methylprednisolone(MP) can significantly improve recovery. Significant advances in recent year, including an effective drug therapy for acute SCI, have improve recovery. In spinal cord injury, pain persist for longer period i.e., several months, hence the long-term treatment is necessary for maintaining the drug concentration in the therapeutic range.
Hence, there is a need of sustained release dosage form. Baclofen,4-amino-3-(4-chlorophenyl)-butyric acid is another structural analog of GABA, which is widely used now a days in the treatment of multiple sclerosis, flexor spasms, muscular rigidity. spinal cord injuries and other spinal cord diseases.
Rajesh Tiwari1*, Roshan kumar2
1Chemistry Department, Dr. Ghanshyam Singh Post Graduate College, Varanasi
2SBCBE VIT University, Vellore
In 16th century physician were of the opinion that magnet can be used for the treatment or eliminate the diseases from the body. Here the reports about the chemical synthesis, protection, functionalization and application of magnetic nanoparticles of nano structured system. Research of magnetic nanoparticles for targeted drug delivery system and function of magnetic nanoparticles on particular area are reviewed. Use of magnetic nanoparticles for cancer diagnosis has been advancing day by day. This review is related to the multifunctional use of magnetic nanoparticles probes and their use in bio imaging and nano medicine.
Duvvuru Ashok Kumar1*, Languluri Reddenna2
1Department of Pharm-D, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India
2Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India
MS is the most common inflammatory-demyelinating disease of the central nervous system (CNS). MS is estimated to affect 400,000 persons in the United States and 2 million people worldwide. Women are affected twice as frequently as men, between the ages of 20 and 40. The etiology of MS is still unknown, but according to current data the disease develops in genetically susceptible individuals and may require additional environmental triggers. In this paper, we present the insight on simple cure for multiple sclerosis.
Balay Ragini*, A.Pavani, R.Raja Reddy
Malla Reddy Pharmacy College,
Maisammaguda(via-hakimpet), Secunderabad, Telengana. india
Cefuroxime Axetil is a second generation antibacterial belongs to Cephalosporin Group. The drug undergoes rapid metabolism in intestinal mucosa due to change in pH Environment and hence has decreased oral bioavailability. The aim of present investigation is to increase the gastric residence time by preparing gastroretentive tablets here by improving bioavailability of Cefuroxime Axetil. A simple UV spectrophotometric method has been employed for the estimation of Cefuroxime Axetil at 281 nm. A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicarbonate, sodium alginate and hydrocolloids like hydroxyl propyl methyl cellulose (HPMC) and guggul. The prepared tablets were evaluated in terms of their precompression parameters, physical characteristics, In vitro release, buoyancy lag-time and swelling index. The formulations were optimized for the different grades of HPMC, and its concentrations and combinations. The results of the In vitro release studies showed that the optimized formulation F3 could sustain drug release of 92% and remain buoyant for 10h. The optimized formulation was subjected to various kinetic release investigations and it was found that the mechanism of drug release was predominately Higuhci with non fickian diffusion. Finally the tablets formulations found to be economical and may overcome the draw backs associated with the drug during its absorption.
Asha Kesari*, Pushpa Kumari Mahto, Shankheswari Kishan, Suranjeeta Singh
Department of Pharmaceutics,
Kanak Manjari Institute of Pharmaceutical Sciences,
Hypertension or high blood pressure is a chronic medical condition in which the arterial blood pressure is elevated (normal blood pressure is 120/80 mm Hg). High Blood Pressure may lead to heart failure, stroke, coronary heart disease, kidney failure etc and may affect lungs, brain and heart. It is an important global problem and a very good percentage of people all over the world are affected by blood pressure. As there is no definite cure for this condition, hence controlling it is a big challenge. The main focus on BP management is to lower the elevated blood pressure and to prevent or reduce target organ damage. Although various antihypertensive drugs are available, they are usually associated with many sides –effects. The following article deals with the alternative measures used for lowering high blood pressure giving more importance on the various herbal drugs to be used as combination therapy.
Kalyana Chakravarthi G*, Vijayaraj S, Venugopal A, Naresh Ch, Saritha B
Department of Pharmaceutical Analysis, Sree Vidyanikethan College of Pharmacy,
Tirupati, A.P., India.
Solubility is one of the essential parameters to achieve bioavailability of drug in systemic circulation to produce expected therapeutic response. Nearly 40% of new drug molecules face solubility challenge. Though several techniques like micronization, crystal engineering, hydrotrophy, solid dispersion and so forth were available for solubility enhancement of poorly soluble drugs based on physical and chemical modification, prodrug approach is a vital technique amongst the other. Prodrugs are biologically inactive compound which can be metabolized in the body to produce active drug. It is estimated that currently about 10% of all world-wide approved drugs are prodrugs. This review extensively confers the role of prodrugs and the kind of promoieties used for solubility enhancement.
Somaia El-saedi1, Jamal S Mezogi1, Abdulrhman A. Akasha2*
1Department of Pharmacognacy
2Department of Pharmaceutics
Faculty of Pharmacy, Tripoli University, Libya,
Development of new drugs, especially in the area of oncological and infectious disease represents today one of the most important research fields. The marine environment is a tremendous source of natural products. Many new compounds isolated from marine micro- and macroorganisms showed prominent biological effects, mostly antibiotic and cytotoxic activities. The current study aimed to investigate pure compounds which were isolated from marine-derived fungi. The study was preformed with fractions from two marine derived fungal strains, i.e. Verticillium teneru and Acremonium sp. The isolation of the desired secondary metabolites was carried out using different chromatographic separation techniques (TLC, VLC and mainly HPLC). Chemical and spectroscopic methods (1D NMR, 2D NMR, MS, IR and UV) were applied for structural elucidation of the separation compounds. Extracts of two algal-derived fungus strains with high cytotoxic properties, were investigated chemically. This investigation resulted in the isolation and structure elucidation of three pure compounds representing different structural sub-classes, one of them 1 proved to be new natural products and two were known compounds2 & 3.
Assam Down Town University,
Institute of Pharmacy, Guwahati, Assam, India
Majority of crude drugs from plant origin are used in Indian system of medicine. Medicinal plants are using as herbal remedies to prevent and cure several ailments differs from community to community. Most studies on the exploitation of mango have been dealing with mango peels, juices and stem bark and mango leaves. Mangifera indica (Anacardiaceae), reported to contain active substances like mangiferin. In ayurveda, one of its uses is clearing digestion and acidity. Mangiferin is a pharmacologically active flavonoids, which having the anti bacterial, antioxidant, anticancer, antidiabetes, hepatoprotective, anti inflammatory activities.
ANGIOTENSIN CONVERTING ENZYME INHIBITORY POTENTIAL OF ECHINOSYSTIC ACID RELEVANCE TO CARDIOVASCULAR DISEASES: AN IN SILICO STUDY
Monjur Ahmed Laskar*, Manabendra Dutta Choudhury
Bioinformatics Centre, Assam University,
Silchar, Assam, India
Plants have been used in treating cardiovascular diseases (CVD) and are recognized for their ability to produce secondary metabolites. Secondary metabolites obtained from different plants have been the starting material for designing different drugs. Echinosystic acid, a pentacyclic triterpene was isolated and identified from the fruits of Gleditsia sinensis Lam. Echinosystic acid has significant cardioprotective effects. Different phytochemicals have been found to be cardioprotective and paved the path towards development of cardioprotective formulations. In the present study we have analyzed the inhibitory potential of Echinosystic acid, on the Angiotensin Converting Enzyme (ACE) - the enzyme responsible for various cardiovascular diseases.
The study revealed that Echinosystic acidhave high ACE inhibiting potential as compared to other known ACE inhibitors.
Department of Pharmacy, GRD(PG) Institute of Management and Technology,
Dehradun, Uttarakhand, India
Different heterocyclic analogues were evaluated for their diverse biological activities. The triazole moiety seems to be very small but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. Triazole analogues have a wide range of biological applications including antimicrobial, antimalarial, antitubercular, anti-inflammatory, analgesic, antiepileptic, antiviral, antihypertensive, antianxiety, antidepressant, antihistaminic activities etc. This review provides a brief response of the medicinal chemistry of triazole analogues particulary as analgesic and anti-inflammatory activities.