Articles

PATHOPHYSIOLOGY OF TUBERCULOSIS: AN UPDATE REVIEW

ABOUT AUHTORS
Devender Sharma*1, Deepika Sarkar1
1Hi – Tech College of Pharmacy, Chandrapur, Maharashtra (India)

ABSTRACT
Tuberculosis is a hypersensitive granulomatous infectious disease caused by Mycobacterium Tuberculosis (M.TB).In India 40% people are affected by T.B. So need of knowledge about T.B.  and pathophysiology of T.B. to people or society. Pathophysiology means, when a human being or animal being suffering from a disease this is because deranged or change in function on that organ or human body.  Infection is caused by air- borne droplets of organisms person to person. The main object of this review is how to diagnose and how it is cure or treat. It is diagnosed by PPD, IGRA, Sputum studies, X-rays and Biopsies. Mostly antibiotics are preferred for the first treatment.


EUROPEAN UNION NEW MEDICAL DEVICE REGULATIONS-2017

ABOUT AUHTORS
U.Swathi lakshmi1,  K.Revathi1 , Dr.P.Shailaja1, Prof.J.Vijaya Ratna1, Blessy A. Daniel2, Dr.Prashanth.S.2
1Andhra University College of Pharmaceutical Sciences, Visakhapatnam
2S3V Vascular technologies Pvt.Ltd, Bangalore

ABSTRACT:
The New Medical Device Regulations of European Union replace the E.U’s current Medical Device Directive (93/42/EEC) and the E.U’s Directive on Active Implantable Medical Devices (90/385/EEC) According to the draft document, NB’s would be placed under a strict regimen of super vision, although it remains unclear whether the intended sanctions could be implemented against the will of a Member State, should the need occur. The qualification requirements for auditing and reviewing NB staff are steeply increased. Greater emphasis will be placed on clinical data and the Clinical Evaluation. For implantable medical devices and Class III devices clinical investigations will be expected since equivalence will generally no longer be an acceptable approach, although some exceptions can be made. The proposed MDR attempts to make more transparent the periods for review by various parties for different activities. Implementation of Unique device identification helpful for the unambiguous identification of a specific device on the market.


MICROBIAL BIOFILMS : PATHOGENICITY AND TREATMENT STRATEGIES

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SMRUTIPRAGNYA SAMAL, PRATYUSH KUMAR DAS*
Centre for Biotechnology, Siksha ‘O’ Anusandhan University, Bhubaneswar, Odisha, India – 751003
*pratyushdas@soauniversity.ac.in

ABSTRACT
Microbial biofilms are complex structures wherein the planktonic cells change their growth mode to the sessile form. This kind of growth is assisted by the formation of a matrix of extracellular polymeric substances (EPS) which encapsulates the bacterial cells within it and thus, provides an additional protection. These biofilms are highly resistant to high concentration of antibiotics and poses a great threat towards public health. These biofilms are even beyond the access of a normal human immune system and are involved in infections of teeth, lungs and many other diseases. There lies an immediate need to replace the extensive use of antibiotics with new emerging strategies. The review intends to provide an insight on the various perspectives of microbial biofilms including their formation, composition, mechanism of communication (Quorum sensing) and pathogenicity. Recent emerging strategies have also been discussed that can be considered for successful eradication or inhibition of biofilms and related infections.


A REVIEW ON PHYTOCHEMICAL COMPOSITION AND PHARMACOLOGICAL ASPECTS OF THE GENUS ALSTONIA

ABOUT AUHTORS
RAMYA MADHIRI1, G. VIJAYALAKSHMI2
1Department of Pharmacognosy and Phytochemistry, AU college of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003.
2Department of Biotechnology, GIT,  GITAM University, Visakhapatnam -530 045
*ramyapraveen2709@gmail.com

ABSTRACT
Herbal medicines contribute a major share of officially recognized health care systems. Scientific research was trending on the isolation of active compounds of herbal origin. The present review concentrate on important species, active constituents, pharmacological aspects, identification tests for active constituents and the important research work carried out on the genus   Alstonia which may be helpful for the future research work.


REVIEW ON ZIKA VIRUS

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Nayan Jain*, Ashutosh biswas
16, jageshwar nath ki gali neem chowk, mandsaur
Mandsaur Institute of pharmacy, Mandsaur
*nayanofficial499@gmail.com

ABSTRACT
Today the world has suffered to the Zika virus is a flavivirous related to yellow fever, dengue, West Nile and Japanese encephalis virus. Zika virus causes acute, serious illness which is often fatal if it is not treated. Its name comes from the Zika forest of Uganda. Zika is a mosquito born disease. Zika virus disease is caused by a virus transmitted primarily by Aedes mosquitoes. People with Zika virus disease can have symptoms including mild fever, skin rash, conjunctivitis, muscle and joint pain, malaise or headache. These symptoms normally last for 2-7 days. There is scientific consensus that Zika virus is a cause of microcephaly and Guillain-Barré syndrome. Links to other neurological complications are also being investigated. Neither an effective treatment nor a vaccine is available for Zika virus; therefore, the public health response primarily focuses on preventing infection, particularly in pregnant women. These article also covers from where the zika was firstly introduced or its history, its transmissions, causes, diagnosis, treatment and some current affairs.


A STUDY ON IDENTIFICATION OF RISK FACTORS IN DEVELOPING POLY CYSTIC OVARIAN SYNDROME AMONG TEENAGERS AND MINIMIZING THEM BY LIFE STYLE MODIFICATIONS THROUGH ADVANCED PATIENT COUNSELLING BY DOCTOR OF PHARMACY

ABOUT AUHTORS
Dr. M. Manasa Rekha1*, Dr.M.Manasa2, C.Reddy Kumari2
1*,2 Doctor of pharmacy, Department of Pharmacy Practice,
Annamacharya college of Pharmacy,
Rajampet, Kadapa, Andhra Pradesh, India.

*manasarekharoyal@gmail.com

ABSTRACT:
Poly-Cystic Ovary Syndrome (PCOS) is characterized by multiple small ovarian cysts, obesity, hypertension, diabetes, insulin resistance, and Hirsutism. The Study Aims to assess the role of Doctor Of Pharmacy in identification of risk factors in developing poly cystic ovarian syndrome among teenagers and minimizing them by life style modifications through advanced Patient counseling.The Main Objective of the present study is to prevent the following: To prevent the complications of PCOS who are suffering with PCOS in early of their age. To prevent the occurrence of PCOS to early females who are nearer for its occurrence. To minimize the symptoms and to improve the quality of life of females suffering with PCOS. Study Design: It is a observational and interventional study. Study Period: The Present study was conducted for a period of 6 months from January 2nd  2017 to July 31st 2017.Study site : The Present study was conducted in BAHUDHA WOMENS HOSTEL affiliated to Annamacharya college of Pharmacy, Rajampet, Kadapa, Andhra Pradesh, India. In The Present Study Out of total 600 women   530 enrolled to participate in the present study. After the collection of information by PCOS  self assessment forms the scoring is given as 271 with scoring >5 with percentile 51.1320 are with Chance for getting PCOS, 159 with scoring > 10with percentile 30.01 are with high Chance for getting PCOS, 100 with scoring  <5with percentile 18.8679 are Unpredictable to PCOS. The present study concludes that Doctor Of Pharmacy is very helpful in assessing the risk factors responsible in developing PCOS and also minimizing them by life style modifications through advanced patient counseling.


ANTIMICROBIAL ACTIVITY OF GREEN TEA: A COMPARATIVE STUDY WITH DIFFERENT GREEN TEA EXTRACT

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Nabadoy Roy*, Suprodip Mandal, Beduin Mahanti, Sandipan Dasgupta*
Division of Pharmacology, Department of Pharmacy,
Bharat Technology, Uluberia, Howrah 711316,
*n.roy.santoshpur@gmail.com

ABSTRACT
The aim of this present study is to evaluate the activity of green tea extracted in different solvents on different microorganism such as on Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8739, Salmonella abonyNCTC 6017, Pseudomonas aeruginosa ATCC 9027, Candida albicansATCC 10231, Esteritia coli mutant NCIM 2567, Bacillus subtilis ATCC 6633 & Lactobacillus lichmani ATCC 7830.


OPTIMIZATION AND EVALUATION OF IBUPROFEN TABLETS BY MADG METHOD

ABOUT AUHTORS
Devender Sharma1*, Ameya Lanjewar2
1Department of Pharmaceutics, Hi-Tech College of Pharmacy, Chandrapur India
2Department of Pharmaceutics, Kamala Nehru College of Pharmacy, Butibori Nagpur India

*sdevender350@gmail.com

ABSTRACT
Ibuprofen largely used in various disorders  treatment likely to be  rheumatoid arthritis, osteoarthritis and other musculoskeletal disorders, especially where pain is more prominent than inflammation. Ibuprofen is used as a simple analgesic, antipyretic and it is particularly effective in dysmenorrheal. By the process of Moisture activated dry granulation, Ibuprofen tablets prepared but these method prepared tablets do not give better drug content, drug release. So formulation optimize by full factorial i.e. change in various polymer concentration like SSG and Povidone at three different levels. Ibuprofen tablets manufactured by moisture activated dry granulation method with optimization show better drug release, drug stability in comparison of marketed preparation. Due to optimization, Ibuprofen tablets which manufactured by moisture activated dry granulation method have very low cost in comparison of marketed preparation. The main objective of this research work water poorly soluble drug like ibuprofen tablet manufactured by moisture activated dry granulation by optimize process gives better drug release, manufacture cost also less other than marketed tablets.


AN UPDATED OVERVIEW ON PHARMACOGNOSTICAL AND PHARMACOLOGICAL SCREENING OF TECOMA STANS

ABOUT AUHTOR
K.GOPALASATHEESKUMAR1*, T.BOOPATHI1
1KMCH college of Pharmacy, Kovai Estate,
Kalapatti Road, Coimbatore-641048, Tamil Nadu, India
gskpungai@gmail.com

ABSTRACT
The using of natural plants in treatment purposes are the nowadays most familiar than synthetic products because synthetic drugs can cause many of the side effects and the adverse effect. The Tecoma stansare one of the plants which are available in most of the tropical countries. In this plant is already used in the traditional medicine in some of the countries like India, Pakistan, etc., this plant belongs to the family of Bignoniaceae. This plant is having the many of the active chemical constituents and pharmacological effects. Many of the researchers are studied the pharmacological screening and the current research is going in that plant. The aim of this review was the updated research collections of this plant for its pharmacological screening. The review the  on various researchers like pharmacognostical study and the in vitro and in vivo screening of various parts of Tecoma stans.In this review was concluded that the various parts of the plants are having various pharmacological actions like anti-inflammatory, analgesic, anticancer cardio-protective effect, genotoxic, cytotoxicity, wound healing, anti‐hyperglycemic, protect CNS, gastric ulcer healing, antiproliferative, antioxidant, anti-microbial, hemolytic activity, anti-lipoxygenase and acetyl-cholinesterase inhibitory activities. And this review was used to develop the future research on this plant.


IS THE CHEMOTHERAPY REALLY NECESSARY FOR SOLID TUMORS?

ABOUT AUHTOR
Dr. Vishwas B. Chavan
Aditya Jyot Hospital & Foundation
vishwaschavan2003@yahoo.co.in

Cancer is a leading cause of morbidity and mortality in the world today. According to one study, there were 14.1 million new cases of cancer and 8.2 million cancer-related deaths worldwide in 2012. The most commonly diagnosed cancers were lung (1.82 million), breast (1.67 million), and colorectal (1.36 million). The most common cancer deaths are due to lung cancer (1.6 million deaths), liver cancer (745,000 deaths), and stomach cancer (723,000 deaths) (Ferlay, J. et al, 2015).


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