Articles

HUMAN GENOME SCIENCE: A NEW FACE OF PHARMACEUTICAL SCIENCE: A REVIEW

ABOUT AUHTORS
Tahseen Sameena*1, Prathima Patil1, S.P.Sethy*1
1Department Of Pharmaceutics.
Azad College of Pharmacy
Moinabad-Chilkur Road , Hyderabad- India
* tahseensameena1992@gmail.com

ABSTRACT: -
The Human Genome Project (HGP) refers to the international 13‐year effort, formally begun in October 1990 and completed in 2003, to discover all the estimated 20,000–25,000 human genes and make them accessible for further biological study. Another goal of this project was to determine the complete sequence of the 3 billion DNA subunits (bases in the human genome). As part of the HGP, parallel studies were carried out on selected model organisms such as the bacterium E.coli and the mouse to help develop the technology and interpret human gene function. The DOE Human Genome Program and the U.S National institute of Health (NIH) National Human Genome Research Institute (NHGRI) together sponsored the U.S.Human Genome Project.”


DENDRIMERS: A NOVEL CARRIER FOR DRUG DELIVERY SYSTEM

ABOUT AUHTORS
Pandey Noopur*, Mahara Kamal
Department of Pharmaceutics
Global Institute of Pharmaceutical Education and Research,
Kashipur, Dehradun,
Himachal Pradesh, India
* noopurpandey56@gmail.com

ABSTRACT
Dendrimers are macromolecules having highly branched, 3 D structure, nano scale architecture with monodispersity and high functionality. These properties make it attractive candidates as unique and optimum drug carriers for controlled release or targeted delivery. Dendrimer is a smart polymer and as a result of their behavior dendrimers are suitable for a wide range of biomedical and industrial applications and in medical applications such as drug delivery, tumor therapy, diagnostics etc. The field of dendrimers has recently emerged as the most commercially viable technology of this century because of its wide ranging potential applications in many fields such as: healthcare, electronics, photonics, biotechnology, pharmaceuticals, drug delivery, catalysis and nanotechnologies. The review aims mainly on the introduction, objectives, properties, synthesis and applications, in future aspects of dendrimers. Dendrimers help in achieving increased bioavailability, sustained, controlled and targeted release of drug. Thus present review focuses on the fundamentals of dendrimers and their use as drug delivery agents in treatment of disorders.


QUALITY RISK MANAGEMENT (QRM) OF ACTIVE PHARMACEUTICAL INGREDIENTS DURING TRANSPORTATION BY USING FMEA TOOLS AND METHODOLOGY

ABOUT AUHTORS
UPENDRA KUMAR SINGH*, Mr. Sammer Rastogi, Dr. Manish Kumar Yadav
*MASTER OF PHARMACY in QUALITY ASSURANCE
School of Pharmacy, Lloyd Institute of Management and Technology
Uttar Pradesh, India
* upendra.singh81@gmail.com

ABSTRACT Quality Risk Management (QRM) is a key component for access the product quality. For any pharmaceutical product, Quality Risk Management shall be applied to aim that raising the level of protection for the patient by the reduction of the risk to which that patient is exposed at the time he /she receives a drug product. This general objective can only be achieved by implemented policy of Quality Risk Management (QRM) on the product and process design and its lifecycle. The concept of risk management was first applied in the financial and insurance sectors. This concept was systematically transferred and applied in the pharmaceutical industries in 2005 with the International Conference on Harmonization (ICH) and its publication of the ICH guideline Q9 on “Quality Risk Management”. The European Commission added this guideline as Annex 20 to the EU GMP guide in March 2008. This research was explored the risk identification, risk assessment and development scientific risk control measures during transportation of API from API manufacturing site to user site (formulation plant).


A STUDY ON ROLE OF DOCTOR OF PHARMACY IN DRUG UTILIZATION EVALUATION PATTERN ANALYSIS IN INPATIENT UNITS AND REPORTING ITS COMORBIDITIES IN A TERTIARY CARE TEACHING HOSPITAL

ABOUT AUHTORS
M. Manasa Rekha1*, T.Mubeena2,
1*,2 Doctor of pharmacy,
Department of Pharmacy Practice,
Annamacharya college of Pharmacy,
Rajampet, Y.S.R kadapa district, Andhra Pradesh,  India.
* manasarekharoyal@gmail.com

ABSTRACT:
The area of the pharmacy concerned with science and practice of rational usage of the drugs. The clinical pharmacist is the one of the member in the health care team. clinical pharmacists provide care to their patients and that this practice can occur in any practice setting. Drug Utilization Reviews (DUR), also referred to as Drug Utilization Evaluations (DUE) or Medication Utilization Evaluations (MUE), are defined as an authorized, structured, ongoing review of healthcare provider prescribing, pharmacist dispensing, and patient use of medication. DURs involve a comprehensive review of patients' prescription and medication data before, during, and after dispensing to ensure appropriate medication decision making and positive patient outcomes.


PREPARATION & EVALUATION OF ANNONA MURICATA EXTRACT AGAINST CANCER CELLS WITH MODIFIED RELEASE

About Authors:
*Dilipkumar.J.P, Agliandeshwari.D
Rajiv Gandhi University of Health Sciences
Bangalore, India
*dilipkumar9447@gmail.com

INTRODUCTION
Natural products, especially those derived from plants, have been used to help mankind sustain its health since the dawn of medicine. Over the past century, the phytochemicals in plants have been a pivotal pipeline for pharmaceutical discovery. The importance of the active ingredients of plants in agriculture and medicine has stimulated significant scientific interest in the biological activities of these substances1. Despite these studies, a restricted range of plant species has experienced detailed scientific inspection, and our knowledge is comparatively insufficient concerning their potential role in nature. Hence, the attainment of a reasonable perception of natural products necessitates comprehensive investigations on the biological activities of these plants and their key phytochemicals2. In a pharmaceutical landscape, plants with a long history of use in ethno medicine are a rich source of active phytoconstituents that provide medicinal or health benefits against various ailments and diseases. One such plant with extensive traditional use is Annona muricata. In this review, we describe the botany, distribution and ethnomedicinal uses of this plant, and we summarize the phytochemistry, biological activities and possible mechanisms of A. muricata bioactivities.


ANTIDEPRESSANT ACTIVITY ON LEAVES OF POLYGONUM GLABRUM WILLD IN EXPERIMENTAL ANIMAL

About Authors:
Deepak singh1*, Arpit Dixit2, Amir khan3, Vikas singh4, Abhishek sachan4
1*Department of Clinical Research, Jamia Hamdard, Hamdard nagar, New Delhi-110062
2Business executive at Merck Pvt.ltd, Ghaziabad, India
3Business executive at Cipla Pvt.ltd, Lucknow, India
4Shri RLT Institute of Pharmaceutical Science & Technology, Etawah(UP), India
*deep_singh4u21@rediffmail.com

ABSTRACT:
The present investigations, which were primarily conducted with the aim of investigating some neuropharmacological activity of Polygonum glabrum (PG), i.e. PG has got anxiolytic activity when tested against open field exploratory behavior, where as elevated plus maze did not show any positive results. The action produced by PG was more than that of diazepam in open field exploratory behaviour. Observations confirms that PG possesses significant antidepressant activity. The observed antidepressant activity of PG was qualitatively comparable to that induced by Imipramine. Pentobarbitone induced hypnosis in mice was significant potentiated by PG.PG at 100 and 200mg/kg, reduced locomotor activity in rats.The PG seems to be little or no motor incoordination effect in mice when tested against rota-rod test.PG had significant analgesic activity which is both centrally and peripherally mediated, when tested against various analgesic models in rodents.The investigations indicates that PG has significant analgesic, anti-inflammatory, antidepressant and anxiolytic actions, some of these actions, including antidepressant and anxiolytic can be rationalized on the basis of the neurochemical data emanating from this study . The present study indicate that PG can be clinically useful not only in inflammation, pain and fever, and worm infestation but also in depression and anxiety. Clinical studies are required to confirm the above mentioned activities.


A STUDY OF PROCEDURES FOR DOSSIER PREPARATION AND THEIR MARKETING AUTHORISATION IN DIFFERENT COUNTRIES OF SELECTED DRUG(S)

ABOUT AUHTORS
1Veerendra Kr. Gautam*, 2Mohamad. Irfan
1Executive in Drug Regulatory Affairs Department; East African (India) Overseas
1 120 Suncity Business Tower,Sector-54, Gurgaon-122002 (Haryana).
2Research Associate; Jubilant Chemsys Ltd.
2D-12, Sector 59, Noida , Uttar Pradesh, India
1dra.veerendra.gautam@gmail.com;
1viren.gautam.dra@gmail.com 2mohd.irfan.ivar@gmail.com

Abstract : Dossier is a collection of documents on the particular subjects. Any preparation of pharmaceutical product for human use go through the process of reviewing and assessing the dossier of pharmaceutical product which contains details information about administrative, quality, non-clinical and clinical data. This process is governed and permitted by Drug Regulatory Authority of a particular country and process is called as NDA in USA, MAA in EU and other countries as simply Registration Dossier. There are basically two formats for dossier preparation i.e. ICH-CTD and ACTD. ICH-CTD followed by ICH countries as well as low economical or developing countries where as ACTD is followed by ASEAN countries. ACTD act as bridge between regulatory requirements of developed and developing countries. Also if both guidelines of CTD and ACTD can be harmonized then differences and variation between both guidelines can be minimized.


BIO-REMEDIATION OF HEAVY METALS DERIVED FROM DELTAMETHRIN PESTICIDES USING POTENTIAL MICROBES: A REVIEW

ABOUT AUHTORS
*Avinash Jyoti, Anupam Kumar
School of Bioengineering and Biosciences,
Lovely Professional University, Phagwara,
Punjab, India
*aashi.avinash25@gmail.com

ABSTRACT
The adage that “everything in excess is opposed to nature” fits perfectly when subjected to the usage of pesticides & heavy metals derived from them, which are required for various metabolic activities but possess adverse effects beyond their recommended EPA limits. Contamination due to heavy metals presents a major global concern in the environment as a result of their non-biodegradability, persistence in the environment and accumulation in the biological systems. Heavy metal pollutants could be prevailed by any one of the anthropogenic activities, one of them is agricultural deposition that is reported to be caused as a result of prolonged & widespread applications of pyrethroids & their affiliated heavy metals. They tend to possess serious intimidation to non-target species including humans as well as the ecosystem. Among various methods, bio remediation has been reported as the ideal way out of the abatement of pollution for these non-biodegradable metals, which is the microbe-mediated process for the clearance of pollutants. Bioremediation is a promising technology as a result of its possible cost effectiveness and environmental compatibility. The present review shed lights on possible hazards of pyrethroids on non-target organisms & summarizes the potential of microbes (bacteria and fungi) used as biosorbent for various heavy metals.


A REVIEW ON INTERNATIONAL REGULATORY CONCERN ON ROLE AND RESPONSIBILITY OF PHARMACEUTICAL HIGHER MANAGEMENT

ABOUT AUHTORS
Suleman S. khoja * 1, Sohil S. khoja 1, Karim R. Panjwani1,
Jagdish Ray 1 , Parthkumar H. chauhan 2

1 Resource person in Pharmaceutical Quality Assurance,
Audit and Compliance, Vapi .
2 Resource person in Quality Assurance,
Navsari
*premukhoja@gmail.com

ABSTRACT:
It has been always International Regulatory concern on Role and Responsibility of Pharmaceutical Higher Management in  this review article we have taken some of the concern and how responsible  leadership should ensure the support and commitment of staff at all levels and sites within the organization to the Pharmaceutical Quality System ,management review , Quality committee and to make a platform for leadership engagement, awareness and decision making around quality and process performance. Implement new controls as per GMP Guidelines to check impact and management tool for identification and reduction of human Errors in pharmaceuticals Industry.


A PROSPECTIVE STUDY ON ROLE OF DOCTOR OF PHARMACY IN IMPROVING QUALITY OF LIFE OF HIV PATIENTS BY PATIENT COUNSELLING IN AN ANTIRETROVIRAL THERAPY WARD OF A TERTIARY CARE TEACHING HOSPITAL

ABOUT AUHTORS
M. Manasa Rekha*,
Department of Pharmacy Practice,
Annamacharya college of Pharmacy,
Rajampet, Andhra Pradesh,  India.
*manasarekharoyal@gmail.com

ABSTRACT:
The study aims to assess the role of clinical pharmacist in Improving the quality of life of HIV patients in an antiretroviral therapy wards of a teritary care teaching hospital


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