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Kambham Venkateswarlu1*, N.Devanna2, C.Vanajakshi3, Kottamasi Vijaya Bhaskar4
1M.Pharm Scholar, Department Of Pharmaceutics,
2Director Of Jntua-Otri,
3M.Pharm Scholar, Department Of Pharmaceutics,
4M.Pharm Scholar, Department Of Pharmacology,
JNTUA-Oil Technological Research Institute,
Beside Collector Office, Anantapur, Anantapur District, Andhra Pradesh, India. Pin Code: 515001
This review gives the information about what are the causes, symptoms and treatment of atherosclerosis. Atherosclerosis or arteriosclerosis is a slow and progressive building up of plaque, fatty substances, cholesterol, cellular waste products, calcium and fibrin in the inner lining of an artery. This building up of plaque may lead to thickening of the arteries, subsequently blocking the blood flow either partially of totally in an artery.
Kambham Venkateswarlu*, Kutagulla Ashna, Nandamuri Manideepika, Shaik Shaheena Parveen, M.G.Vasantharekha
M.Pharm Scholar, Department Of Pharmaceutics,
JNTUA-Oil Technological Research Institute,
Beside Collector Office, Anantapur, Anantapur District, Andhra Pradesh, India
A tablet is a pharmaceutical dosage form. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tableting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavors to enhance taste; pigments to make the tablets visually attractive. A polymer coating is often is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredients, to make it more resistant to the environment or to enhance the tablet’s appearance.
These FDTs will give the better merits when compared to existing conventional dosage forms. This system has a better compliance in the case of geriatrics and pediatrics.
Vishwanadham Yerragunta*1, Duggi.Suman1, Kumara swamy1, V.Anusha1, Pratima Patil1, M. Naresh2
Department of Pharmaceutical Chemistry,
1Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad-500014, A.P.
2Bharath Institute of Technology Pharmacy-Ibrahimpatnam, AP.
The aim of this review is to provide an overview of diverse pharmacological activities of pyrazole moiety. Pyrazole are well known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. Pyrazole chemically known as 1, 2-diazole has become a popular topic due to its manifold uses. Numerous pyrazole derivatives have been found to possess a broad spectrum of biological activities, which stimulated the research activity in this field. Pyrazoles and its derivatives represent one of the most active classes of compounds, which possess wide range of biological activities like anti-bacterial, anti-convulsant, analgesic, anti-microbial, anti-inflammatory, ant diabetic, sedative anti-rheumatic, anticancer, and anti-tubercular activities. The purpose of this review was to collate literature work reported by researchers on pyrazole for their various pharmacological activities and also reported recent efforts made on this moiety.
Kanak Manjari Institute of pharmaceutical Sciences.
Reactive arthritis, formerly referred to as Reiter's syndrome, is a form of arthritis that affects the joints, eyes, urethra and skin. The disease is recognized by various symptoms in different organs of the body that may or may not appear at the same time. Also one form of reactive arthritis is characterized by a triad of arthritis, nongonococcal urethritis, and conjunctivitis, and by lesions of the skin and mucosal surfaces.
Umakant Sahu1,2, Nrusingha Charan Panda2, B.V.V Ravikumar2, Anjan Kumar2
1Drugs testing laboratory avam anusandhan Kendra, First Floor, Govt. Ayurvedic College Hospital Building, Ayurvedic College Campus, G.E. Road Raipur, Chhattisgarh- 492010
2Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa-760010, India
Chalcones considered as the precursor of flavonoids and isoflavonoids abundantly found in plants, and have also been shown to display a diverse array of pharmacological activities. This review is complementary to earlier reviews and covers more recent report of antimicrobial activity of chalcones as well as its important role as an intermediate for the synthesis of different synthetic molecules. The enone linkage presents in basic structure play crucial role for the activity of chalcone and chalcone derivatives. The members of the chalcone and flavonoid family have attracted a great deal of interest due to it has showed diffent activity as antibacterial, antifungal, anti-inflammatory, antihyperglycemic anti HIV and anticancer pharmacological activity. Recently a molecule of chalcone has been reported as a novel class of HIV-1 integrase inhibitors. The purpose of this review is to focus on some important pharmacological activity of the chalcone and its derivatives.
*1Mr. Ronak Patel, 2Mr. Ripal Mistry
1M.Pharm, Bhupal Nobels’ College Of Pharmacy, Udaipur 313001
2M.pharm, Indubhai Patel College Of Phaarmacy And Research Center, Dharmaj
Ocular administration of the drug is primarily associated with the need to treat ophthalmic diseases and is not regarded as a means for gaining systemic drug action. Major classes of drugs used are miotics, mydriatics/cyclopegics, anti-inflammatory, anti- infectives surgical adjutants and diagnostics, which are all meant for local therapy. Systemic action by using eye as a portal is generally avoided in order to prevent the risk of eye damage from high blood concentrations of drug not intended for eye. The unique anatomy, physiology and biochemistry of eye renders this organ exquisitely impervious to for gain substances thus presenting a constant challenge to the formulator to circumvent the protective barriers of the eye without causing any permanent tissue damage. Currently, the knowledge in this field is rapidly expanding, and many concept and drug delivery strategies are emerging out.
Clinical Research Coordinator(CRC)
Tech Observer India Pvt Ltd
The Global CRO, N.Delhi
The Clinical trial design is the formulation of trials and experiments in Medical and epidemiological research. Clinical trials are research studies that involve patient or healthy people. They are designed to test new treatments such as drugs, vaccines, new approaches to preventing disease, surgery, radiotherapy, physical and psychological therapies and methods of diagnosing disease. The choice of trial design is always a critical decision in designing a clinical trial: That choice affects the inferences that can be drawn from the trial, the ethical acceptability of the trial, the degree to which bias in conducting and analyzing the study can be minimized, the type of subjects that can be recruited and the pace of recruitment, the kind of endpoint that can be studied, the acceptability of the results by the regulatory authorities, and many other features of the study, it conduct and its interpretation.
Tapan Behl*, Monika Sharma, Dr. Heena Goel
Assistant Professor, Department of Pharmacology,
Doaba Group of Colleges, Kharar, Mohali
Neurofibromatosis is genetic disease characterized by lesions mainly in brain region with a broad array of complications associated with it. The prime role of treatment is to obtain a relief from the symptoms associated this disease.
Prof. (Dr.) N.V.Satheesh madhav, Rohit Singh Negi, *Vikash kumar
DIT-Faculty of Pharmacy,
Dehradun Institute of Technology,
Mussoorie Diversion Road,
Makkawala, P.O. Bhagwantpur,
The aim of research work was to isolate novel biopolymer from the seeds of Tagetes erecta and to characterize its physicochemical properties along with the acute toxicity. The isolated polymer was subjected for screening its retard ability by using as a bio nano carrier for formulating Doxycycline (model drug) loaded floating films. Tagetes is a genus of 56 species of annual and perennial mostly herbaceous plants in the sunflower family. The genus is native to North and South America, but some species have become naturalized around the world. Tagetes species vary in size from 0.01 to 2.2m tall. They have pinnate green leaves blooms are naturally in golden, orange, yellow and white colors, often with maroon highlights. Tagetes grow well in almost any sort of soil. It contains essentials oils, fatty acids, carotenoids and lutein. Tagetes erecta has long been known for its medicinal use, especially for strengthening the heart, and for treating ailments like headaches, swellings and tooth aches. Tagetes erecta seeds were soaked in water and then washed with chloroform and ethyl acetate. Obtained 100 gm of fine powder was soaked in 100ml boiled water for 24 hours. The mixture was filtered and methanol was added in double. The solution was refrigerated for 24 hours and then centrifuged. Precipitate was collected as biopolymer and was dried. The separated biopolymer was subjected for various physicochemical parameters like color, texture, particle size, solubility, colour changing point. Spectral analysis such as IRspectroscopy was done to check the polymeric nature of biopolymers. Drug–polymer interaction and skin irritancy studies are also done to check the polymer safety.
Vishwanadham Yerragunta*, Prathima Patil, V.Anusha, T.Kumara Swamy, D.Suman, T.Samhitha.
Department of Pharmaceutical Chemistry,
Malla Reddy College of Pharmacy,
Maisammaguda, secunderabad-14. A.P.
Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six- member ring shows wide range of biological activities. Pyrimidine posses wide spectrum of biological activities like including anti-tubercular, anti-bacterial, anti-fungal, anti-viral, anti-inflammatory, Anti-malarial activity, anti-cancer and anti-neoplastic activity, anti-hiv activity. The present reviews attempted to gather the various biological activities of pyrimidine derivatives and is marketed drugs.