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RNA INTERFERENCE-WEAPON AGAINST CANCER

ABOUT AUTHORS:
Shalja Verma, Anand Kumar Pandey*
Department of Biotechnology, Institute of Engineering & Technology,
Bundelkhand University, Jhansi, Uttar Pradesh, India
vnsanand_9@rediffmail.com

ABSTRACT
Cancer is the second principal death cause, in the recent scenario 1 out of every 4 people die out of cancer. Not more than 50% advanced cancer subjects live a year ahead. RNA interference (RNAi) a phenomenon which serves for shutting off the expression of a specific sequence has proved itself a finest weapon against cancer. This mechanism involves silencing of the expression of desired mRNA sequence by degrading it using a dsRNA (double stranded RNA) molecule having complementarity to the desired mRNA. However a major challenge in proficient implementation of this therapy against cancer is lack of efficient delivery methods for the dsRNA to the target tissue. Various delivery methods had already been developed for efficient and effective delivery of the dsRNA and many are under trial. This review is going to present the great efficacy of RNAi against cancer and the various delivery methods performing capable work in accurate application of this therapy.


BIOLOGICAL FUNCTIONS OF VITAMIN B COMPLEX AND EFFECTS ON HUMAN HEALTH IN BOTH EXCESS AND DEFICIENCY LEVELS

ABOUT AUTHORS:
Amarjeet Kaur
Department of Pharmacy,
Guru Ram Das (PG) Institute of Management & Technology,
Dehradun, Uttarakhand, 248009, India.
amarjeetkaur069@gmail.com

ABSTRACT:
Vitamins are micronutrients and play vital role in healthy life. Body needs them in relatively small amounts, in comparison with other nutrients. Vitamins are two types on bases of their solubility viz. lipid soluble and water soluble. B vitamins or vitamin B complex are a group of water-soluble vitamins that play important roles in cell metabolism. These vitamins are chemically distinct vitamins that often coexist in the same foods. Individual B vitamin supplements are referred to by the specific name of each vitamin (e.g., B1, B2, B3, B5, B6, B7, B8, B9, B12 etc.). In general, supplements containing all eight vitamins are referred to as a vitamin B complex. B vitamins are found in whole unprocessed foods. Processed carbohydrates such as sugar and white flour tend to have a lower B vitamin than their unprocessed counterparts. Good sources for B vitamins include legumes (pulses or beans), whole grains, potatoes, banana, chilli peppers, tempeh, nutritional yeast, brewer’s yeast, and molasses. The vitamin B12 is of note because it is not available from plant products, making B12 deficiency a legitimate concern for vegetarians. Deficiency of B vitamins causes various diseases. Their deficiency may cause diseases viz.Vit. B1-Beriberi; Vit B2-Ariboflavinosis; Vit B3-Pellagra; Vit B5-acne; Vit B6-microcytic anaemia; Vit B7-CNS disorders; Vit B9–leucopaenia, macrocytic anaemia; Vit. B12­-Macrocytic anaemia, memory loss.


MBA Pharmaceutical Management- Opening New Frontiers for a Vibrant Career in Pharmaceutical Industry

ABOUT AUTHORS:
Saurabh Kumar Banerjee
Assistant Professor, School of Pharmaceutical Management,
The IIHMR University, Jaipur, Rajasthan, India
saurabh@iihmr.edu.in

Pablo Picasso the famous Spanish painter, poet and playwright once quoted-
“Our goals can only be reached through a vehicle of a plan, In which we must fervently believe, and upon which we must vigorously act.
There is no other route to success”

In our journey for achieving excellence in professional career, meticulous planning and correct decision making, plays the most vital role in transforming our dreams and aspirations into reality. This piece of writing is an effort to give the reader an insight into the world of Pharmaceutical Management and help them to take a rational decision on the basis of facts and evidence, so that they can pursue a successful professional career in the area of Pharmaceutical Management.


THIN LAYER CHROMATOGRAPHIC STUDY OF THREE DIFFERENT EXTRACT OF Calendula officinalis LEAVES

ABOUT AUTHORS:
Kuntal Pal1, Sampat Kumar Kundu2*, Manas Kumar Mandal3
1Manufacturing Chemist at Paharpur Ousadhalay, Kolkata, West Bengal, India.
2Research Scholar at Gurunanak Institute of Pharmaceutical Science & Technology, Sodepur, West Bengal, India.
3Consultant Urologist at AMRI Hospital, Kolkata
*sampatkundu001@gmail.com

ABSTRACT
Calendula officinalis
is a plant that possess many pharmacological actions like Stomach upset, Ulcer, Menstrual Period Problems, Eye Infections, Inflammation, Wound Healing, Anti-Septic etc. most widely it is used as wound healing purposes. If the leaf of that plant can be applied after crunching at the affected area, blood will be clot within a few time. But while this leaf can perform this action, it means it possess some active compound in it. To find out what the actual component it is, first we have to perform the Thin Layer Chromatographic study. In our present study we are going study the TLC profile of that Calendula officinalis leaf.


A REVIEW ON ACRIDONE DERIVATIVES AND ITS IMPORTANCE

ABOUT AUTHORS:
Vishwanadham Yerragunta*, E.Sathish Reddy, M.Kishore, Hari Om Prakash rao, Ayesha Sadia, Ayesha Saba, Syeda Kausar Fatima
Department of Pharmaceutical Chemistry, Prathap Narendar Reddy College of Pharmacy,
Pedda shapur, Shamshabad, Hyderabad, Telangana.
vishwanadham.y@gmail.com

ABSTRACT:
Acridoneis an organic compound containing a carbonyl group attached to the 9 position. It may be synthesized by the self-condensation of N-phenylanthranilic acidAcridone and its derivatives can be synthesized by a number of methods such as Ullmann condensation, by benzyne mechanism, by radical reaction of quinines etc. acridone nucleus due to its variety of pharmacological activities. These pharmacological activities include anticancer, antimicrobial, antiviral, antimalarial and anti-inflammatory activities. This review article literature survey summerizes the synthesis and pharmacological activities of acridone and its derivatives.


MEDICINAL EFFICACY OF ROSE PLANT: A MINI REVIEW

ABOUT AUTHORS:
Sonali Nanda, Pratyush Kumar Das*
Centre of Biotechnology, Siksha O Anusandhan University,
Bhubaneswar, Odisha, India
*das.pratyushkumar@yahoo.co.in

ABSTRACT
A rose is a woody perennial plant belonging to the genus Rosa in the family Rosaceae. Known for its sweet smell and beauty, generally is used as a decorative in household and public gardens. Besides being used as a decorative, very few know its use as a medicinal herb. The petals, stems, leaves and roots of a rose plant contain various secondary metabolites and nutrients in the form of vitamins and minerals. Extracts from different parts of rose plant have also been reported to show substantial anti-bacterial and anti-fungal activity. The parts of the plant especially the petals have high antioxidant property that helps in curing many health ailments. In this review the various vital constituents and medicinal properties of different parts of the plant have been highlighted. The information were collected online from various research papers and websites using search engines and assembled in a sequential manner to provide a complete knowledge guide for the readers.


A REVIEW ON: EBOLA VIRUS DISEASE (EVD)

ABOUT AUTHORS:
Anmol Eldose*, Hetal Patel, Pooja Patel, Vinish Sharma, Zeel Rajput, Hitesh Jain, U.M. Upadhyay
Sigma Institute of Pharmacy,
Vadodara, Gujarat, India
*anmoleldose38@gmail.com

ABSTRACT
Ebola virus is a fatal illness in humans and non primates. Ebola virus causes Ebola hemorrhagic fever. Ebola Virus Disease (EVD) is transmitted to people from wild animals and spread to humans through human to human transmission. EVD is caused by the sudden onset of weakness, muscle pain, headache, sore throat, fever, vomiting, diarrhoea, liver dysfunction, rashes and also internal- external bleeding. As such no specific treatment foe EVD is available but a number of researches are going on. Oral rehydration therapy or intravenous fluids are some of the treating symptoms.


FORMULATION AND PRODUCT DEVLOPMENT OF PRESSURISED METERED DOSE INHALER: AN OVERVIEW

ABOUT AUTHORS:
*S R Thorat1, S M Meshram2
1Lupin Research Park, Hinjewadi, Pune, Maharashtra
2TATA Consultancy Services, Hinjewadi, Pune, Maharashtra
santoshthorat345@gmail.com

ABSTRACT
Pressurized metered dose inhalers (MDIs) are widely used dosage form for treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary disease. The metered dose inhaler (MDI) contains the active pharmaceutical ingredient dispersed or solubilised in a high vapour pressure propellant and metered accurately in tens to hundreds of micrograms and administered directly to the lungs. The most dominant characteristics of MDI include their portability, convenience of use and quick effect. MDI comprises of drug formulation, propellant, metering valve, actuator, and container. This review contains overview of excipient selection, primary packaging material, propellant selection and formulation development of pMDI. Two of the most commonly used methods for the manufacturings of MDIs are cold filling method and pressure filling method.This review demonstrates different analytical techniques for characterization of pMDI’s like uniformity of delivered dose, water content, spray pattern and plume geometry were discussed. This review also presents in-vitro characterization, pharmacokinetic and pharamcodynamic study of MDI.


BIOANALYTICAL TECHNIQUES – AN OVERVIEW

ABOUT AUTHORS:
Syed Saida begum*, B. Sai Sushmaa, S.Vijayaraja
Department of Pharmaceutical Analysis
Sree Vidyanikethan College of Pharmacy, Sree Sainath Nagar, A.Rangampeta, Tirupati, Chittoor (Dt), Andhra Pradesh.
msg2saida@gmail.com

ABSTRACT
The development of the bioanalytical techniques brought a progressive discipline for which the future holds many exciting opportunities to further improvement. The main impact of bionalysis in the pharmaceutical industry is to obtain a quantitative measure of the drug and its metabolites. The purpose is to perform the pharmacokinetics, toxicokinetics, bioequivalence and exposure response like pharmacokinetic/pharmacodynamic studies. Various bioanalytical techniques are performed in bioanalytical studies such as hyphenated techniques, chromatographic techniques, and ligand binding assays. This review extensively highlights the role of bioanalytical techniques and hyphenated instruments in assessing the bioanalysis of the drugs.


BIONANOPARTICLES: A GREEN NANOCHEMICAL APPROACH

ABOUT AUTHORS:
Rahul Kumar*, Ved Prakash Singh, Damini Maurya, Anand Kumar Pandey
Department of Biotechnology, Institute of Engineering and Technology
Bundelkhand University, Jhansi, Uttar Pradesh, India
vnsanand_9@rediffmail.com

ABSTRACT
Nanoparticle, a core of bio-nanoparticle, which is used for polymers including natural and synthetic polymer and form different types of, liposomal and polymer nanoparticle. The designing, synthesis and manipulation of structures which is smaller than 100 nm, is termed as Nanotechnology. Nanoparticles are developed as a colloidal structure, synthesized by semi-synthetic and synthetic polymers. The emerging area of nanotechnology and Nano-sciencesare the application of nanoparticles, ranges in 1 to 100 nanometre (nm). The synthesis of silver nanoparticles for their potential application, it was originate to be eco-friendly and reliable, because of their exclusive properties. Mostly synthesis of AgNPs, by physical and chemical methods are too expensive, toxic, hazardous chemicals for various biological risks.The main objective of this study preferably lies thatgreen synthesis of AgNPs by several plants and its metabolites, extracts can be much safer to handle and easily available. The synthesis of AgNPs  are using several plants extract such as Oryza sativa, Zea mays, Basella alba, Helianthusannuls, Camellia sinensis ( green tea), Azadirachta indica (neem) ,Ssebania drummondii (leguminous shrub)sp. The AgNPs get attached in the cell wall of microorganism and can disturb the cellular respiration, permeability of the cell wall. Sometimes it can penetrate inside the cell wall which can interact protein, DNA, sulphur and phosphorus and causing cellular injury inside cell. It confers the antimicrobial activity. The AgNPs shows less antimicrobial activity against gram positive bacteria in comparison to gram negative bacteria because gram negative contain β-barrel proteins (i.e. Porins) and thinner peptidoglycan. The distinguishing property of silver nanoparticles it can be have higher surface area to volume ratio. When surface area increases the catalytic activity and surface energy of AgNPs corresponding to increase and biological effectiveness also increases. 

It identified that amalgamation of silver nanoparticle biochemical process is very fast process as compare to using microorganism (even several hours to few days). The NPs monodispersity, size are significant part in the valuation of NPs amalgamation. Therefore, operative regulator of monodispersity and NPs size are essentially examined. On numerous readings silver nanoparticle synthesis by microbes can be decompose later withassured dated of time. Thus the constancyof nanoparticle producebiological approachesmerits supplementary learning.