{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Akash M Patel*, Viren N Sisodiya
* Faculty of Pharmacy,
Dharmsinh Desai University, Nadiad-387001, Gujarat
aku.pharmacy@gmail.com

ABSTRACT
Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric patient can create a bad psychological effect on mind. The purpose of this research was to mask the intensely bitter taste of Linezolid using ion exchange resin and to formulate the dry syrup of the taste masked drug. When suspension is swallowed the bitter taste of the drug may not be felt as ion exchange resin does not release the drug at salivary pH. When it comes in contact with acidic environment of stomach, the complex will be broken down releasing the drug which may then absorbed. Batch method was used for formation of drug resin complex. Various ion exchange resin like different grade of kyron and indion 214 were used for masking the bitter taste. Optimization of drug loading was carried out. Indion 214 was selected as a optimized resin with 84.47 % drug loading. Dry syrup was made using suspending agent like gellan gum, guar gum and CMC and evaluated for various parameters like colour, odour, taste, viscosity, sedimentation volume, redispersibility, % drug content, drug release. By evaluating all the parameter the batch formulation contained guar gum 3 % was the best one amongst all the other formulations.

{ DOWNLOAD AS PDF }

ABOUT AUTHORS:
Akash M Patel*, Nirav N Patel, Prakash A Sathwara
*Faculty of Pharmacy, Dharmsinh Desai University,
Nadiad, Gujarat
Aku.pharmacy@gmail.com

ABSTRACT
Quantitative analysis of any drug is an important tool in an industry. It is important to determine that the raw material, intermediate products as well as final products meet its specifications and are of required quality. The number of drugs and drug formulations introduced into the market has been increasing at an alarming rate. These drugs or formulations may be either new entities or partial structural modification of the existing ones or novel dosage forms.

Spectrophotometry and HPLC methods are considered to be most suitable for estimation of the drugs present in pharmaceutical dosage forms.

· Literature review reveals that several spectroscopic and Chromatographic method have been reported for estimation of TOL and DIC alone as well as with other drugs.
· Simultaneous equation, dual wavelength difference UV spectrophotometry and First derivative spectroscopic method is available for this combination.
· The aim of work is to develop and validate cost effective First derivative method in water and RP-HPLC method for simultaneous estimation of TOL and DIC in bulk and Tablet dosage form.
· Development of UV spectrophotometric method.

[adsense:336x280:8701650588]