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  • ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF WHOLE PLANT OF SIDA ACUTA (LINN.F.ND)

    About Authors:
    *Virendra Sharma, Pooja Sinoriya, Sunil Sharma
    Lakshmi Narain Academy of Pharmacy, Gwalior
    Kumud23@indiatimes.com

    Abstract
    To evaluate the anti-inflammatory and analgesic activity of methanolic extract of whole plant of Sida acuta in experimental animal models. Methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.) was studied for its anti-inflammatory activity using Carrageenan induced rat paw edema animal model and analgesic activity at the same dose level using acetic acid induced writhing test and Hot plate analgesia in mice. The methanolic extract of whole plant of Sida acuta (MESA) (100, 200 and 400 mg/kg p.o.). The PI with indomethacin and Sida acuta in carrageenan induced paw edema  at the dose level 400 mg/kg were 60% and 52.5% at the end of 5 hr. In the acetic acid induced writhing test, the extract at the dose level 400 mg/kg showed 83.78% inhibition of writhing. In radiant heat tail- flick method the extract  at the dose 400 mg/kg showed reaction time 4.902 ± 0.545 (p<0.001). The methanolic extract possesses anti-inflammatory and analgesic activity.

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  • DEVELOPMENT AND EVALUATION OF MUCOADHESIVE BUCCAL FILMS OF GLIBENCLAMIDE

    About Authors:
    SINGH GAURAV*, GOKULAN DR P.D., KINIKAR DHANANJAY, KUSHWAH MANOJ
    Shri Ramnath Singh Institute Of Pharmaceutical Science and Technology,
    Sitholi, Gwalior, M.P

    *gaurav.robby@gmail.com

    ABSTRACT
    Glibenclamide is an oral hypoglycemic drug with very low aqueous solubility. The drug is completely metabolized in liver, its principle metabolite being very weakly active, buccal film may be more efficacious for the treatment of diabetes. The objective of this work is to investigate the feasibility of obtaining the slow release, obtaining relatively constant levels of Glibenclamide from buccal films. The films were fabricated by solvent casting technique with different polymers HPMC, Sodium CMC and PVP and systematically evaluated for in vitro and ex vivo performance. Propylene Glycol is employed as plasticizer and penetration enhancer. Hydroxypropyl methyl cellulose is acting as film forming polymer, Sodium CMC and PVP are employed as mucoadhesive polymer.  The formulation containing HPMC and Sodium CMC (F2) showed better controlled results correlated with ex vivo permeation studies.

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    Walk - In -Interview for the following position will be held on dated 27.05.2011 at 11.00 a.m. in the Office of the Assistant Director-in-charge, National Research Institute for Ayurveda -Siddha Human Resource Development, Aamkho, Gwalior-474009 (MP.). The selection procedure will comprise of a written test followed by interview of candidates who qualify in the written test, on the same day :-

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