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ABOUT AUTHORS
Aliyu Hamidu Ahmed¹, Yusuf Ibrahim Alkali^2
1Department of Pharmacognosy and Ethno pharmacy, Faculty of Pharmaceutical Sciences
Usmanu Danfodiyo University, Sokoto- Nigeria
²Department of Pharmacology and Toxicology, Usmanu Danfodiyo University, Sokoto- Nigeria.

ABSTRACT
Pharmacokinetics and toxicity profile along with efficacy are the major determinants for successful drug development. This study was carried out to determine the pharmacokinetic profile, potential biological activities and toxicity of diospyrin, lupeol and plumbagin using in silico approaches. The Swiss ADME tool was used to calculate the molecular properties of the ligands based on Lipinski’s rule of five (5).All ligands in the present study satisfied the rule. Using the Swiss ADME tool, the pharmacokinetic profile of the compounds was evaluated. Protox-II server was used to predict the organ toxicities and toxicological end points of the ligands and their LD50. Plumbagin is found to have both mutagenicity and carcinogenicity. Lupeol and diospyrin are reported to be immunotoxic. Lupeol has LD50 of 2000mg/kg. Diospyrin and plumbagin have 16mg/kg. Swiss target prediction server was used to identify the various potential target. The target prediction suggests that plumbagin and lupeol have high preference for Microtubule-associated protein tau (MAPT). The best target for diospyrin was Aurora kinase A. Molecular docking study was conducted using AutoDock vina in The Python Prescription (PyRx) 0.8 virtual screening tool.  Plumbagin and lupeol were docked against Microtubule associated protein tau. The dockings scores based on binding energy were; plumbagin -33.8 (kcal/mole) and lupeol -44.7 (kcal/mole). Diospyrin showed a binding energy of -10.7 (kcal/mole) against Aurora A kinase. Results in this study suggest that diospyrin may serve as an important aurora kinase inhibitor while lupeol and plumbagin may be useful in treatment of Alzheimer’s disease.

The CSIR-National Botanical Research Institute (NBRI) - is amongst one of the constituent research institutes of the Council of Scientific and Industrial Research (CSIR), New Delhi. Originally set up as the National Botanic Gardens (NBG) by the State Government of Uttar Pradesh (U.P.), it was taken over by the CSIR in 1953. Though, initially engaged in research in the classical botanical disciplines, the NBG went on laying an increasing emphasis, in keeping with the national needs and priorities in the field of plant sciences, on its applied and developmental research activities. A time came when it was felt that the name NBG no longer projected the correct nature and extent of its aims and objectives, functions and R & D activities.

Biotechnology Industry Research Assistance Council (BIRAC) is a Public Sector Section 25 ‘Not-for-Profit Company’ recently set up by the Department of Biotechnology (DBT), Ministry of Science & Technology, Government of India to promote and nurture innovation research and growth of the biotech enterprise. BIRAC as an Interface agency serves the emerging biotech industries through gap filling interventions that facilitate high risk research, innovation and product development and also facilitates industry academia interaction. BIRAC’s focus is on empowering and enabling the biotech innovation ecosystem for affordable product development.

The Centre for Cellular and Molecular Biology (CCMB) is one of the constituent national laboratories of the Council of Scientific & Industrial Research (CSIR) and a premier scientific institute that conducts high quality research in frontier and multi-disciplinary areas of modern biology.

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an 'Institute of National Importance'. It is an autonomous body set up under the aegis of Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India. The Institute is conceived to provide leadership in pharmaceutical sciences and related areas not only within the country, but also to the countries in South East Asia, South Asia and Africa. NIPER is a member of Association of Indian Universities and Association of Commonwealth Universities.

Post : Research Assistant

The PGIMER owes its inception to the vision of late Sardar Partap Singh Kairon, the then Chief Minister of Punjab and the distinguished medical educationists of the then combined state of Punjab, supported by the first Prime Minister of India Pt. Jawahar Lal Nehru who considered the institutions of scientific knowledge as temples of learning and the places of pilgrimage. The institute started in 1962 and Pt Jawahar Lal Nehru inaugurated the hospital now named “Nehru Hospital” on 7th July 1963. The Institute was originally under the Government of undivided Punjab.

Post : Junior Research Fellow (JRF)

NESGI Naigaon, Pune was established in 2010 in response to growing for quality Engineering Education for the youth of Pune. The institute is situated on lush-green, pollution free serene environment at out skirts of Pune city on Satara road.  We offer 5 Undergraduate programs in Engineering & Technology.  NESGI campus provides an ideal opportunity to students to learn and shape their career and is committed to highest standards of academic excellence inculcating learning skills, creativity, team work and leadership. The upto date world class facilities - computing, laboratory and other educational and recreational facilities aid and the process of learning. We respect merit, encourage innovation and collaboration. We invite bright students and faculty to come and be part of NESGI family.

Bemetara district is a newly constituted district of the state of Chhattisgarh, which was formed on January 1, 2012 after partition of the Durg district.It is located on the northern side of the durg district.Total area of the district is 2854.81 sq. km. and the total population of the district is approximately 795759.The boundary of the district is surrounded by 7 districts of Chhattisgarh state ie Durg, Raipur, Baloda Bazar, Bilaspur, Kawardha and Rajnandgaon.

Post : Pharmacist

The Advanced Centre for Treatment, Research and Education in Cancer (ACTREC) is the state-of-the-art R&D satellite of the Tata Memorial Centre (TMC), which also includes under its umbrella the Tata Memorial Hospital (TMH), the largest cancer hospital in Asia. ACTREC has the mandate to function as a national centre for treatment, research and education in cancer. TMC is an autonomous grant-in-aid institution of the Department of Atomic Energy (DAE), Government of India. It is registered under the Societies Registration Act (1860) and the Bombay Public Trust Act (1950). Its Governing Council is headed by the Chairman, Atomic Energy Commission, Government of India.

Post: SENIOR RESEARCH FELLOW

Real Placement Group is the largest FREE job placement provider in India. Real Placement Group was established in 10/10/2010. Real Placement Group leading recruitment firm flourished under the umbrella of Mr. Pankaj Mangawa.  Real Placement Group is one of the leading recruitment group to provide a complete range of services in field of human Resources. We are in the field of management providing Services from Since 2010 to Automobile , Engineering ,FMCG Beverage, Rubber & Plastic , Electronics & Telecom, Oil and Gas, Power Infrastructure & Energy , Ceramics , Sanitary ware, Steel & Glass , Pharmaceutical, Chemicals, Power Plant , Construction. Currently we are providing our services in 55+ Companies.

Post : Biotechnology

Novartis has one of the most exciting product pipelines in the industry today. A pipeline of innovative medicines brought to life by diverse, talented and performance driven people. All of which makes them one of the most rewarding employers in their field.

Post : Manager - Medical Affairs

SEACOM SKILLS UNIVERSITY is the latest venture of a well known Trust in Kolkata involved in multifarious activities for more than a decade now. The Group has taken a new approach in offering Engineering and Technical Education with maximum industry orientation and more stress on practical skills, aiming at building greater confidence in students. To keep abreast with emerging technological and industrial needs, experts will be inducted from time to time and as when necessary. The institute aims also to provide quality technical education along with development of intellectual qualities and corporate ethics – creating potential manpower for industries as well as research and development. The charitable educational Trust is ably managed by the Chairman, Mr. Anish Chakraborty.

Post : Assistant Professor

SRISTI is a developmental voluntary organization aiming to  strengthen the creativity of/at/for grassroots communities ,including individual innovators. It supports eco-friendly solutions to local problems being scouted, spawned and spread by the Honey Bee Network for over 26 years. It also nurtures ecopreneurs engaged in conserving biodiversity, common property resources, cultural diversity and educational innovators.

SRISTI, an Ahmedabad based developmental voluntary organization in the space of grassroots innovations invites applications from young Copy Editor and Research Fellow committed to work with social purpose

Apollo Pharmacy is a leading retail chain of Pharmacy and is a unit of - Apollo Hospitals Enterprise Ltd. - Asia's largest healthcare group.   Our growing Retail Pharmacy network touches lives across the length and breadth of India. Accredited with - International Quality Certification, with over 30 years of retailing experience, customer-focused service and brand value our network spans out to over 3300 plus retail pharmacies through which we have been serving our customers for their healthcare needs 24x7.

Post : Sr. Manager – Training & Development

Applications are invited for the following posts on full time basis in SLSS’S DHANVANTRI COLLEGE OF PHARMACY, ALAND.

Prasad Institute of Technology was established in the year 2004 by Prasad education Trust, having an impressive campus is dedicated to develop and nurture pharmaceutical education and research. The campus gives an aesthetic and pleasant look where it will be our endeavour to produce the best graduates in learner focused environment. The institute has well stocked library, modern laboratories, offering latest technology equipment and classrooms for materializing the dream of PIT to contribute more in the area of Pharmaceutical Sciences & Research.

Post : Assistant Professor

National Institute of Mental Health and Neuro Sciences is a multidisciplinary Institute for patient care and academic pursuit in the frontier area of Mental Health and Neuro Sciences. The Lunatic Asylum which came into being in the latter part of the 19th Century was renamed as Mental Hospital in 1925 by the erstwhile Government of Mysore. This hospital and All India Institute of Mental Health established in 1954 by Government of India were amalgamated on 27th December 1974, and thus was formed the autonomous National Institute of Mental Health and Neuro Sciences (NIMHANS).

Post : Technical Officer

Indian Institute of Integrative Medicine (IIIM) is a national Institute of the Council of Scientific & Industrial Research (CSIR) of India, with primary focus of research on drug discovery from natural products (medicinal plants and microbial species).

Eligible & interested candidates are invited for WALK-IN-INTERVIEW for the following purely temporary positions of PROJECT ASSISTANT–I, II & III under the sponsored projects (GAP-2181, HCP-0007 & HCP-0008) tenable at CSIRIIIM, JAMMU.

The year was 1993 when T. John College with its premises in Campbell Road, Austin Town, Bangalore – 47 begun. The college started by Dr. Thomas P John, offered a 3 year BHM (Hotel Management) Degree course to 24 students to start with.  The college also offered the BBM and BSc (CMS) courses. Since a humble beginning in 1993, there has been no looking back and every year the college crosses new milestones. Two decades later the college premises has expanded to include new departments and blocks and spread over an area of 20 acres of land. Cosmopolitan and secular in ethos and philosophy. T. John Group of Institutions attracts students from all over India and the neighboring countries.