Articles

ABOUT AUTHORS:
G. JYOTHI REDDY*¹, A. SRILAKSHMI¹, S.SINDHUJA², N.K. SREE¹, SK.AFSAR¹, B.PRIYANKA¹, R.E.AMRUTHA^1
1 Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
² Sri Padmavathi School Of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India

ABSTRACT
The ethanolic leaf extract of Allophylus serratus shown significant (p<0.05) antidiarrheal activity on gastrointestinal motility with  castor oil- induced diarrheal model in rats. The results obtained revealed that the leaf extract possess pharmacological activity against diarrhoea and may possibly explain the use of the plant in traditional medicine. The extract tested at 200 and 400 mg/kg like the standard drug, loperamide significantly inhibited the frequency of defecation droppings compared to untreated control rats. This result is in support of previous claims in respect of antidiarrhoeal herbs.

About Authors:
Dr. BJ Mahendra kumar^*1, Jagadish babu D², Jyothi K²,
^*1Professor, Department of Clinical pharmacy,
Sri Adichunchanagiri College of pharmacy, Mandya, Karnataka, India.
²Scholars, Department of Clinical pharmacy,
Sri Adichunchanagiri College of pharmacy, Karnataka,
Mandya, India.

Introduction:
Antibiotics are among the most widely prescribed therapeutic agents among paediatrics patients.¹ As we all know, the advantage of therapy with a cephalosporin not only lies in its rather broad spectrum but also in its low toxicity and the drug can be used safely in pregnant women and children. Such therapy can reduce the duration of hospitalization if the susceptible bacterial pathogens have been almost eradicated by a parental cephalosporin and patient’s condition has been brought under control.² Despite their widespread use in paediatrics, few antibiotics have been studied adequately to be considered safe and effective for use in children. Oral third-generation cephalosporins used commonly in paediatrics include cefixime, cefpodoxime, ceftibuten, and cefdinir.³

About Authors:
Shiv Kumar Mishra, Vinita Pawar, Archana Tiwari
M.Tech Biotech
RGPV, Bhopal (MP)

Diabetes mellitus is a very common disorder in all over the world, often simply referred to as diabetes, is a group of metabolic diseases (Also known as metabolic syndrome and a slow poison) in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. Cause classical symptoms like polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger).

About Authors:
Dolita Shah^*, Mayur Mistry^1
*M.Pharm (Q.A, Gold Medalist),
Asst. Professor, Smt. R. B. Patel Mahila Pharmacy College
¹Production officer, Intas Pharmaceutical ltd,
Ahmedabad, India

Introduction
A new molecule can cost several millions of rupees or dollars to progress and any blunder causes greater impact on company’s status. As medicines play a vital role in human’s life there must be regulations for medicines ensuring Quality, Safety and Efficacy of drugs. The regulatory affairs professional is the only one who is completely responsible for holding products in compliance and maintaining all the records. One of the vital activities of the regulatory specialist is to ensure that the all the information regarding medicines has been correctly established to the patient covering labelling also. Even a small mistake in any of the activities related to regulatory can make the product to be recall in addition to loss of several millions of the money.

About Authors:
Dhananjay S.Jadhav¹,Vinod J Mokale¹ ,Ajit P Patil¹, Sujata S.Gaikwad², 
^1.Division of Pharmaceutical Technology,University Department of Chemical Technology,NMU,Jalgaon.Maharashtra.           
^2.Swami vivekand education societys college of pharmacy chembur, Mumbai,Maharashtra.

Abstract
Stem cells are cells found in most of the multi-cellular organisms. They have ability to renew themselves through mitotic cell division and differentiating into a diverse range of specialized cell types.¹ Once the healthy stem cells are infused into the patient's blood stream, the cells move from the blood vessels to the center of the bones where they begin making new blood cells. Starting from the beginning, cells are the basic unit of all life. They contain DNA , which is all of the cell’s genetic material. They also have the ability to undergo cell division and replication.The harvesting of stem cells from surplus embryos is prepared for in-vitro fertilization procedures in fertility clinics.“The cord in placental mammals that joins the embryo and the placenta together, where the placenta provides nutrients to the embryo via the umbilical cord while at the same time transporting the waste material from the baby.Stem cells are self- renewing cells.The supply of these cells is maintained by stem cells, which replicate many times and then differentiate into the specialized cells that are needed. In this way, cells are continuously replenished as they die.  Stem cell application is a new field with lots of promises to offer. Stem cell research is a new field with unlimited scope. Stem cells hold the key to replacing cells lost in many diseases that are caused by loss of functioning cells. The unique capability of this cell to form various tissues under definite signals received from the body, makes this cell an of extensive research.

About Authors:
Bhawana Kapoor^*1, Vishnukant Rai², Sonu Sharma^3
1Seth G.L. Bihani S.D. College of Technical Education, Sriganganagar, Rajasthan, India
²Shri Ramnath Singh College of Pharmacy, Gormi, Bhind, M.P., India
³NIMS Institute of Pharmacy, Jaipur, Rajasthan, India

ABSTRACT
Chromatography, although primarily a separation technique, is mostly employed in chemical analysis in which High-performance liquid chromatography (HPLC) is an extremely versatile technique where analytes are separated by passage through a column packed with micrometer-sized particles. Now a day reversed-phase chromatography is the most commonly used separation technique in HPLC. The reasons for this include the simplicity, versatility, and scope of the reversed-phase method as it is able to handle compounds of a diverse polarity and molecular mass. This review covers the importance of RP-HPLC in analytical method development and their strategies along with brief knowledge of critical chromatographic parameters need to be optimized for an efficient method development.

About Author:
Nitish Chhabra
Arbro Phamaceuticals Ltd.(Analytical Divison), New Delhi
Seth G.L. Bihani S.D. College of Technical Education,
Sriganganagar, Rajasthan, INDIA

INTRODUCTION
The pharma packaging industry in India is still n a nascent stage. “First impression is the last impression; packaging plays a very important role in creation that impression for any product. But when it comes to pharmaceuticals, it has to go beyond looks”.
The term “compatibility” encompasses three different consequences of chemical interaction between the package and any of the components of a drug product formulation.
(1)The first results in actual reduction in drug availability or potency through sorption- the removal of the drug by the package.
(2) The second result in contamination as the formulation extracts substances from the package.
(3)The third cause’s breakdown of the package by deterioration of its strength, stiffness or barrier properties as the formulation chemically attacks the package

About Authors: 
Shakya Pragati*, Khwaja Sadiya,
Asst. Professor, Integral University,
Lucknow,
U.P, India

1.ABSTRACT
Transdermal delivery of medications was foreshadowed in earlier eras by the use of certain plasters and ointments. The mustard plaster, applied as a home remedy for severe chest congestion, may be considered an example. (This author remembers his mother making mustard plasters for members of the family.) Powdered mustard seed (Brassica nigra) was mixed with warm water, and the resulting paste was spread on a strip of flannel, which was applied to the patient’s chest with a cloth binding wrapped around the body to hold the plaster in place. The moisture and body warmth activated an enzyme (myrosin) in the mustard that hydrolyzed a glycoside (sinigrin), causing the release of the pungent active ingredient allyl isothio-cyanate (CH2=CHCH2NCS) (7). This substance possesses the qualifications listed above for transdermal absorption. A transdermal patch or skin patch is a medicated adhesive patch that is placed on the skin to deliver a specific dose of medication through the skin and into the bloodstream.

About Authors:
A. Srilakshmi, SK. Afsar, B. Priyanka, G. Jyothi Reddy, R.E.Amrutha, B.Jagadeesh babu, C. Raja ram
1. Department of Pharmacology,
P. Rami Reddy Memorial College of Pharmacy,
Kadapa, Andhra Pradesh, India.

ABSTRACT
ALLOPHYLUS SERRATUS is a medicinal plant used for the treatment of various risk factors like analgesia, inflammation, ulcers, and wounds. The aqueous extract of the leaf was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 100, 200 and 400mg/kg body weight reduced significantly the formation of oedema induced by formalin. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 0.05ml of 10% formalin. These results were also comparable to those of ibuprofen, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations.