Articles

About Authors:
AMRUTHA R.E.*, G.RAJESHWARI, A.SRILAKSHMI, C.RAJARAM
Department of Pharmacology
P. Rami Reddy Memorial College of Pharmacy,
Andhra Pradesh, India.

ABSTRACT
Objective - The objective of the present work was to study the antipyretic activity of rhizome Curcuma amada Linn. belonging to family Zingiberaceae, known as “Amargandha” in Sanskrit & “Mamidiallam” in Telugu Materials & Methods: The ethanolic extract was taken for the study and evaluated for antipyretic activity using Brewer’s yeast induced pyrexia in Wister strain albino rats. The ethanolic extract at a dose of 100mg/kg & 200mg/kg were evaluated for antipyretic activity. Result - The extract of Curcuma amada plant showed a significant (P < 0.01) dose dependent antipyretic effect in yeast induced elevation of body temperature in experimental rats. Conclusion - The ethanolic extract of Curcuma amada Linn. plant have significant antipyretic activity when compared with the standard drug. So. It can be recommended for further studies.

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ABOUT AUTHOR:
Devesh Sharma
M.Pharm-DRA
School of Pharmaceutical Sciences, JNU, Rajasthan
Trainee, Chemist, Ind-swift labs ltd, Mohali, (punjab)
devesh.m.pharmdra@gmail.com

ABSTRACT:
Corrective and Preventive Action (CAPA)is a concept within Good Manufacturing Practice (GMP). CAPA focuses on the systematic investigation of discrepancies (failures and/or deviations) in an attempt to prevent their recurrence. To ensure that corrective and preventive actions are effective, the systematic investigation of the failure incidence is pivotal in identifying the corrective and preventive actions undertaken. CAPA is part of the overall quality management system.CAPA is of paramount importance to the FDA. According to FDA documents CAPA accounts for 30-50% of FDA-483 forms issued for non compliance.

ABOUT AUTHORS:
AMRUTHA R.E.*, G.RAJESHWARI,  A.SRILAKSHMI,  G. JYOTHI REDDY, N.KRISHNA SREE,  SK. AFSAR.
Department of Pharmacology
P. Rami Reddy Memorial College of Pharmacy,
Andhra Pradesh ,India.

ABSTRACT
Ethanolic extract of the roots of Zizyphus oenoplia were screened for its anthelmintic activity against Pheretima posthuma. The parameters like the time of paralysis and the time of death were determined by using the extract at the concentrations of 10, 20and 50 mg/ml. The extract exhibited significant anthelmintic activity at highest concentration of 50 mg/ml. Albendazole (20mg/ml) was used as standard reference and distilled water as control.

ABOUT AUTHORS:
Sudha Talasila^*1, Yamini Pendyala², Deepthi Madhu³, Dr.K.L.Senthil kumar.
^1,2 Department of Pharmaceutics,
Padmavathi College of Pharmacy and Reserch institute,
periyanahalli, Tamilnadu, India.
³ Department of Pharmaceutics, Gitams university,
Visakhapatnam, India.

ABSTRACT
Aim of our present study was to formulate the Gelatin Microspheres Loaded with Lisinopril Dihydrate by using Co-acervation phase separation technique for control prolonged release of drug. Micro-particulate drug delivery of Lisinopril Dihydrate was prepared by using a blend of gelatin-carbopol 934P NF and Gelatin-Sodium alginate as release retardant.Lisinopril Dihydrate Microspheres were formulated by using different drug, gelatin-carbopol and gelatin-sodiumalginate in 6 batches was F1, F2, F3, F4, F5 & F6. All the formulations were investigated for various evaluation parameters like particle size, Bulk density, flow behavior, Entrapment efficiency, percentage yield and in vitro drug release etc. All the formulations showed good flow behavior. SEM study revealed that the spheres were almost spherical in shape with smooth surface. In-vitro drug release study showed that by increasing the polymer concentration the drug release of all the formulations were gradually decreased and the optimized formulation (F6) was able to sustain the drug release for 24 hours. So, it was concluded that gelatin microspheres loaded with Lisinopril Dihydrate can be prepared by Coacervation phase seperation  technique and used for sustaining the drug release for prolonged period of time.

About Authors:
Kapil Sharma^*, Priyanka Sharma^**
*M.Pharm, Yaresun Pharmaceutical Pvt Ltd, India
^**M.Sc, Yaresun Pharmaceutical Pvt Ltd,
Rajasthan, India.

1.PELLETS
Pellets are spheres of varying diameter depending on the application and the wish of the producer. Applications are found not only in the pharmaceutical industry but also in the agribusiness (e.g., fertilizer, fish food) and in the polymer industry.
In the pharmaceutical industry, Pellets can be defined as small, free-flowing, spherical particulates manufactured by the agglomeration of fine powders or granules of drug substances and excipients using appropriate processing equipment. The term also has been used to describe small rods with aspect ratios of close to unity.

ABOUT AUTHORS:
Arshad Hala
Seth G. L. Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research,
Gaganpath, Sri Ganganagar, Rajasthan -335001, India

ABSTRACT:
HPTLC is one type of planar chromatography and most advanced form of instrumental TLC. Now a day, HPTLC is more useful than TLC and HPLC. Because HPTLC is independent of sample application, chromatogram development, detection, etc. it is not only instrumental TLC but entire concept that include widely standardize methodology based on validated method. It is instrument controlled by software. In this review article, we discussed about which type of instrument used in HPTLC, complete HPTLC methodology, How HPTLC better than TLC.

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About Authors:
Kapil Sharma^*, Priyanka Sharma^**
*M.Pharm, Yaresun Pharmaceutical Pvt Ltd, India
^**M.sc, Yaresun Pharmaceutical Pvt Ltd,
Rajasthan, India.

Aim: - To search Pharmaceutical medicine (New, Safe & Effective) to enhance health and benefits of patients & community.

Trends:-Usually search a pharmaceutical medicine is starting from “Drug Discovery and Drug Development” (D4) or Pharmaceutical R&D.
D4 is very long, very costly and very complex process, so mostly companies put together D4 plan. Drug Discovery and Drug Development is the treds of searching a Pharmaceutical medicine

About Authors:
Nilesh Sovasia, Prof.Sanjeev Thacker, Tarun Patel
Seth G.L.Bihani S.D.College Of Technical Education,
Institute Of Pharmaceutical Science & Drug Research,
Sri Ganganagar,
Rajasthan, India

ABSTRACT
Despite a company's best efforts to design, manufacture and sell safe and reliable products, the possibility still exists that dangerously defective products may reach the customers. These products may cause accidents,leading to adverse verdicts in product liability litigations.There for Quality management of Complaints and Product recalls are essential to ensure the safety of customer.

About Authors:
Amit A. Patel , Dr.Vipin Kukkar, Sanjeev Thacker
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA.

ABSTRACT:
Food additives have been much important in food product manufacturing. Additive” became almost synonymous with “adulteration. Food additives are used in the food product toprovide nutrition,to maintain product quality and freshness, to look good. There are many type of food additives are available in the market like anti-oxidants, preservatives,Emulsifier and stabilizers,Sweetener, etc.The “E” number system, intended to assist as a short code for some of the lengthier chemical names and to indicate common European safety approval.