About Authors: Sahil Sharma
Reference ID: PHARMATUTOR-ART-1083
One hundred years ago Scottish chemist Andrew Norman Meldrum synthesized a substance  that later obtained his name. To date Meldrum’s acid is one of the most useful reagents in the synthesis of heterocycles. In contrast to the great popularity of Meldrum’s acid, its discoverer remains almost unknown for the majority of chemists.
Andrew Norman Meldrum  was born on 19th March, 1876, in a small burgh, Alloa, Scotland. In 1899 he received his B.Sc. with ?rst-class honors (chemistry) from the University of Aberdeen, where he worked as a research assistant with Francis Robert Japp .
In his ?rst independent publication , he studied the reaction between acetone and malonic acid and, following the suggestion of Prof. Japp, employed a mixture of acetic anhydride and sulfuric acid as condensing agent. From elemental analysis data, in conjunction with previous results and the acidic properties of the ?nal compound, he formulated the structure of the product to be β-lactone of β-hydroxyisopropylmalonic acid 1 (Scheme 1).