Articles

About Authors:
Richa Sood
CTIPS,Jalandhar,
India.

Abstract:
The renin-angiotensin system (RAS) plays an important role in the pathogenesis and worsening of heart failure(HF). Recently developed class of drug, angiotensin receptor blockers (ARBs) block the RAS at the receptor level, and may therefore provide more complete blockade. Angiotensin II Receptor type 1 antagonists have been widely used in treatment of diseases like hypertension, heart failure, myocardial infarction and diabetic nephropathy. Their beneficial effects are related to inhibition of Angiotensin II by blockade of AT1 receptor. Valsartan is an orally active Angiotensin II receptor type 1 antagonist which causes reduction in blood pressure and is used in treatment of hypertension. It was first developed by Novartis and has wide market in the developed and the developing countries.

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About Authors:
Tarun Patel , Prof. Dr. Vipin Kukkar, Nilesh Sovasia
Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA

INTRODUCTION
When we speak of a molecule as being raised to a higher electronic level we mean that an electron has been changed from one orbital to another orbital of higher energy. This electron can be of any kinds we have encountered –a σelectron, a π electron or an n electron. In Ultraviolet region we are confined only to the excitation of the comparatively loosely held n and πelectrons.²

About Author:
Tarun Patel, Prof. Dr. Vipin Kukkar, Amit Patel
Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA

ABSTRACT:
It is a product which is used for improvement of appearance of human body by applying it externally on human body. For better results and minimizing risk of adverse reaction of cosmetic products on human body we have to check out and maintain quality of cosmetic products during its manufacturing.  And  also required some safety parameters for manufacturing of cosmetic products. In this review article we discussed briefly about quality and safety parameters during manufacturing of cosmetic products.

About Authors:
Sreedhar Reddy C
M.Pharm, Department of Pharmaceutics,
Vasavi Insitute of Pharmaceutical Sciences,
Vasavi Nagar, Peddapalli (V), Kadapa (dist),
A.P, India

Abstract:
In this study, transdermal patches containing Itraconazole were prepared using different ratios of polyvinylpyrrolidone (PVP) and Hydroxy propyl methyl cellulose (HPMC) by solvent evaporation technique using 10%w/w of dibutyl phthalate incorporated as plasticizer. The drug matrix film of PVP and HPMC was casted on a polyvinylalcohol backing membrane that was previously dried at 60⁰C for 6 hrs. All the prepared formulations were subjected to physical studies (moisture content, moisture uptake, Tensile strength, flatness and Drug content determination), in vitro release studies and in vitro skin permeation studies. The physiochemical compatibility of the drug and the polymers studied by IR spectroscopy have absence of any incompatibility. In vitro permeation studies were performed across  skin using a Franz diffusion cell. Variations in drug release profiles among the formulations studied were observed. Based on a physicochemical and in vitro skin permeation study, formulation F1 (PVP/HPMC, 5:1) and F5 (PVP/HPMC, 1:5) were chosen for further in vivo experiments. The anti inflammatory effect and a sustaining action of Itraconazole from the two transdermal patches selected were studied by inducing paw edema in rats with 1% w/v carrageenan solution. Hence, it can be reasonably concluded that Itraconazole can be formulated into the transdermal matrix type patches to sustain its release characteristics.

About Authors:
Mr. Davender. S. Bhandari
Department Of Pharmaceutical Science
Kumarhatti, Solan (H.P)

TECHNOLOGY TRANSFER
“Technology Transfer involves transferring technique & responsibility from  development phase to regular production group .Whether transfer takes place between two sites, two companies, a company & third party manufacturer, or from R&D to a pilot plant or commercial facility.”

ABOUT AUTHORS:
S Hamza*, Dr D. K. Suresh, R. Hasan, Md S. Khalid, R. Mistry
Department of Pharmacology,
Luqman College of Pharmacy,
Gulbarga - 585 102,
Karnataka, India.

ABSTRACT:
The study was to assess the antidiabetic activity ofa polyherbal formulation in alloxan induced diabetic rats. The antidiabetic activity of a polyherbal formulation in alloxan induced diabetic rats was assessed using Alloxan β-cytotoxin induced chemical diabetes in a wide variety of wistar albinorats. The polyherbal formulation contains thefollowing plants leaves of Gymnema sylvestre, Ginkgo biloba and plant seeds of Mucuna prurience.The extracts were prepared by continues hot soxhlet extraction using petroleum ether and water. Three different formulations were prepared for the study. The study reveals that the polyherbal formulations of plants leaves of Gymnema sylvestre, Ginkgo biloba and plant seeds of Mucuna prurience have antidiabetic activity and theactionmay be due to the restoration or regeneration of β-cells of pancreas.

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About Authors:
Habibur Rahman¹, M.C Eswaraiah^2
1Department of Pharmacology,
²Dept. of Pharmacognosy,
Anurag Pharmacy College,
Ananthagiri (V), Kodad (M),
Nalgonda (Dt.), A.P-508206, India

ABSTRACT
Brain neurotransmitters like Dopamine, serotonin, Adrenaline, Glutamate and enzymes like Acetyl cholinesterase (AchE), Mono amino-oxidase (MAO-A & MAO-B) levels and antioxidant enzymes like Superoxide dismutase, catalase, peroxidase etc play important roles in different complex neurological disorders like Alzheimer’s disease(AD), Parkinsonism, depression etc. But biochemical estimation of these parameters is very difficult to conduct in simple laboratory. This review is a collection of simple spectroscopic methods to determine the common brain neurotransmitters and antioxidant enzymes.

About Authors:
Dr. Amit Gangwal,
Smriti College of Pharmaceutical Education,
Indore

Abstract
For running any business or organization their products or services should be of utmost quality keeping other things aside. These products or services are known in commerce by their names. These names are called brand names and these are assigned by the owner or innovator or researcher or sponsor of that product or service depending on the type of produce and various parameters. Though company introduces the brand in commerce but after its (brand’s) establishment, brand becomes the identity of company. Brand names are most important attribute of a product after its quality and packing from end user’s (customer) point of view. Successful brand names never escape from the memory of consumer. Few such brand names are Bislery, Maggi, Vicks, Surf Excel, Coca-Cola, Google etc. Few reputed and well known pharmaceutical brands are Corex, Lipitor, Gleevac, Viagra etc. In present article various process to name a drug and a pharmaceutical formulations’ name (brand name) have been described. Article throws light on generic, chemical and brand names of a drug or formulations besides few case studies and guidelines.

ABOUT AUTHORS:
G. JYOTHI REDDY*¹, A. SRILAKSHMI¹, S.SINDHUJA², N.K. SREE¹, SK.AFSAR¹, B.PRIYANKA¹, R.E.AMRUTHA^1
1 Department of Pharmacology, P. Rami Reddy Memorial College of Pharmacy, Kadapa, Andhra Pradesh, India.
² Sri Padmavathi School Of Pharmacy, Tiruchanoor, Tirupathi, Andhra Pradesh, India

ABSTRACT
The ethanolic leaf extract of Allophylus serratus shown significant (p<0.05) antidiarrheal activity on gastrointestinal motility with  castor oil- induced diarrheal model in rats. The results obtained revealed that the leaf extract possess pharmacological activity against diarrhoea and may possibly explain the use of the plant in traditional medicine. The extract tested at 200 and 400 mg/kg like the standard drug, loperamide significantly inhibited the frequency of defecation droppings compared to untreated control rats. This result is in support of previous claims in respect of antidiarrhoeal herbs.