Articles

ABOUT AUTHORS:
Lohithasu Duppala*, Santhosh naidu Matsa, Manikumar Kothakota,
GITAM Institute of Pharmacy, GITAM University, visakhapatnam, Andhra Pradesh, India-530045.
lohithasu@gmail.com, +91-9491894432

ABSTRACT:
Generally, almost all communication in higher plants was thought to be mediated by the five classes of classical plant hormones  i.e. auxins, cytokinins,  gibberellins, abscisic acid and ethylene. The plant hormone action thus appeared to be basically different from that in animals. This article discusses the general role for new generation of plant hormones includes Brassinosteriods, Salicylic acid. Peptides,Polyaminesand Jasmonates.

About Author:
Dr. Vishwas B. Chavan
Ph.D. (Biochemistry)
Andheri (East), Mumbai – 400069
vishwaschavan2003@yahoo.co.in

Abstract:
The word “Cancer” is still synonymous with death for common people and the “stage IV cancer”, which is typically known as “last stage cancer”, is loss of hope even for medical community.
Many times patient presents to clinic, when cancer had already crossed II^{nd or} III^rd stage. This is mostly due to the reason that cancer may not have any symptoms at initial stages. Even if there are any symptoms, they can be mild and vague. Further rising cost of healthcare forced many patients, particularly women, to delay approach to physician. Therefore it is not uncommon for cancer patients to hear sentences like, “You are too late”, “You should have come earlier” etc. which is more depressing. This is a humble attempt to give the these patients some ray of hope.
So, in this 21^st Century, is it necessary, that cancer should be equal to death all the times, even when it has reached stage IV? To get answer of this question, we need to first know what stage IV cancer is and what its effects on human body are.
As most people know, cancer or malignancy means uncontrolled growth of any cell of the body. The mechanism which controls the growth of cells is lost in malignant cells. Cancer can occur in any cell of body and hence any organ can be affected by cancer, though cancers of some organs are more prevalent in some populations.

About Author:
Kapil Tomer
Assistant Professor of Law
IMIRC College of Law
Garh Mukteswar, Panchshell Nagar (Ghaziabad)
kpltomer75@gmail.com

ABSTRACT
In the modern age, we are now living with increasing stress owing to various factors. In the times to come, the stresses and strains will be further cared out, thereby making mental health a very significant issue. According to NIMHANS (National Institute of Mental Health and Neuro Sciences), there are over two crore persons in our country who are in need of treatment for serious mental disorder and about five crore people who are affected by common mental disorder.

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About Authors:
Lohithasu Duppala* , Manikumar Kothakota
GITAM Institute of Pharmacy,
GITAM University, visakhapatnam, Andhra Pradesh, India-530045.
* lohithasu@gmail.com, +919491894432

INTRODUCTION:
Cell Theory:
· All organisms consist of one  or more cells.
· Cell is the smallest unit of life.
· All cells come from pre-existing cells.

Cell cycle:
The dividing and non –dividing stages in the life of a cell are described by a series of events called the cell-cycle. The cell cycle  is the sequence of events by which a cell duplicates its genome and divides into daughter cells.Some cells, like skin cells ,divide continuously throught the life of the organism.Cardiac muscle cells are arrested in G2 phase.

About Authors:
Sharma Monish*, Kumar Bhupender
Seth G.L Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research.
Sri Ganganagar, Rajasthan (INDIA)
*monish28sharma@gmail.com

Introduction :
The name “Allium sativum” is derived from the Celtic word “all”, meaning burning or stinging, and the Latin “sativum” meaning planted or cultivated. The English word, garlic, is derived from the Anglo-Saxon “gar-leac” or spear plant, referring to its flowering stalk.(Kemper J Kathi.2000)
Garlic (Allium sativum), a member of the Liliaceae family, is a common food for flavour and spice  and it is one of the herbs most commonly used in modernfolkloric medicine. Garlic was an important medicine to theancient Egyptians as listed in the medical text Codex Ebers(ca.1550 BC) especially for the working class involved in heavy labour because it was an effective remedy for many aliments such as heart problems, headache, bites, worms and tumours. In 1858, Pasteur noted garlic’s antibacterial activity, and it was used as an antiseptic to prevent gangrene during World War I and World War II. (Thomson Martha.et.al.2007, Tattelman Ellen.2005)

ABOUT AUTHORS:
P.PRATHYUSHA*
Department of Pharmaceutics,
Raghavendra Institute of Pharmaceutical and Educational Research,
Anantapur, A.P, India.
* prathyusha2012@gmail.com

ABSTRACT
In the present investigation, an attempt was made to formulate the Oral Controlled Release Matrix Tablets of Glibenclamide in order to improve efficacy, reduce the frequency of administration, reduce dose related side effects and better patient compliance. Four formulations were prepared by wet granulation method using Ethyl cellulose and as a polymer in the ratio of 1:1, 1:2 and 1:4 and Conventional Tablets by using  Starch mucilage as a granulating agent. The formulated granules showed satisfactory flow properties. All the tablets formulation showed acceptable pharmaco technical properties and complied with pharmacopoeial standards. The tablets were evaluated for weight variation, hardness, friability, drug content and invitro dissolution studies. In- vitro release studies were carried out at pH1.2 for first 2 hrs followed by phosphate buffer at pH7.4 over a period of 12hrs using USP dissolution apparatus. F3 shows good initial release of 25.2% in 1 hr and may extend release of 96.8% in 12 hrs. Different release models like zero order, first order, higuchi, Hixson-Crowell and krosmeyer-peppas were applied to invitro drug release data in order to evaluate the drug release mechanisms and kinetics. Formulated matrix tablets were compared with conventional and marketed (diaonil 5mg) formulations. Matrix tablets with optimum concentration of Ethyl cellulose were successfully developed and evaluated.