Articles

ABOUT AUTHORS:
Hiral H. Patel*, Paresh U. Patel,
Department of Pharmaceutical Analysis, Center for Health and Science Studies,
Ganpat University, Ganpat Vidyanagar – 384012,
Mehsana, Gujarat, India.
*patel.hiral2210@gmail.com

ABSTRACT
This method describes simple, sensitive, rapid, accurate, precise and economical derivative spectroscopic methodfor the simultaneous determination of tolperisone hydrochloride (TOL) and diclofenac sodium (DIC) in bulk and synthetic mixture. In this study, dual wavelength spectroscopic method was used for simultaneous determination of tolperisone hydrochloride and diclofenac sodium using the absorbance difference at two wavelengths. The absorbance differences of 257 nm and 306.20 nm were selected for the estimation of TOL and the absorbance differences of 243.40 nm and 265.40 nm were selected for estimation of DIC. The method was found to be linear (r2>0.999) in the range of 2- 18 μg/ml for tolperisone hydrochloride. The linear correlation was obtained (r2>0.997) in the range of 2- 18 μg/ml for diclofenac sodium. The limit of determination was 0.66 and 0.27 μg/ml for tolperisone hydrochloride and diclofenac sodium respectively. The limit of quantification was 2.00 and 0.83 μg/ml. The method was successfully applied for simultaneous determination of tolperisone hydrochloride and diclofenac sodium in binary mixture.

ABOUT AUTHORS:
Mohit kumar*, Vishal Sachdeva,
Seth G. L. Bihani S. D. College of Technical Education,
Sri Ganganagar (RAJASTHAN) 335001, INDIA
*mohigarg30@gmail.com

ABSTRACT
A well drafted application decides the fate of an invention. Drafting plays a vital role in the success of an invention during its prosecution, management and maintenance during its tenure and turning it into cash. Drafting a patent application is one of the most important and at the same time one of the most difficult process. The applicant or his agent should so draft a patent application that it is granted with an adequate scope or ambit so as to fully serve the business purpose(s) for which the patent is meant to be used. It is here that the importance of drafting the claims in a patent must be fully appreciated, as the drafting of claims must always be done with a clear focus on the exact business needs that are sought to be served by it. That is, a business strategy perspective must inform the thinking of the one who takes up the task of drafting the patent claims. The ultimate purpose of every business strategy is to ensure that a business makes the desired amount of profit to justify the risks taken in making the investments of resources and time. Similarly, the purpose of drafting claims should be to fully serve the business strategy at hand. Even so, only a small number of well drafted patents are actually used by businesses to help them to make or safeguard their profits. (Swarbrick James, 2007).

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ABOUT AUTHORS:
Jalaram H Thakkar^*, Ashiyana A Mansuri, Chirag Patel, Girish K Jani,
SSR College of Pharmacy,
Silvassa.
^*jay_143143@yahoo.com
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ABSTRACT:
The term Angiogenesis was coined by DR. John Hunter, a British surgeon in 1787. Later professor Judah Folkman gave the idea that growth of tumor depends on their blood supply and a new began research in this new field of therapeutics called ANGIOGENESIS.  Then, the identification of angiogenic growth factors, Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor (FGF) fueled interest in using these factors in inducing therapeutic angiogenesis.^[1] Initially angiogenesis was implicated only in few diseases like cancer, psoriases and arthritis. But, in recent years, it has been evident through a deep research that even excessive, insufficient and abnormal angiogenesis contribute to the pathogenesis of many disorders. Angiogenesis is regulated by a balance between pro- and anti- angiogenic factors. Research shows that angiogenesis and anti angiogenesis has given promising results in treatment of diseases like AIDS, atherosclerosis, ischemic heart disease and Alzheimer’s. In twenty first century, application of angiogenesis in therapeutics may have an impact on disorders similar to that which the discovery of antibiotics had in twentieth century.

About Author:
Amitava Sinha Ray,
Department of Pharmacy, Bengal School of Technology
West Bengal University of Technology,
West Bengal
^*a.amitava.s@gmail.com

INTRODUCTION:-
Diabetes is a chronic disease, which occurs when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces. This leads to an increased concentration of glucose in the blood (hyperglycaemia).
The body is unable to produce or unable to properly use and store glucose (a form of sugar). Glucose backs up in the bloodstream and blood glucose or "sugar" to rise too high.

ABOUT AUTHORS:
Lohithasu Duppala*, Santhosh naidu Matsa, Manikumar Kothakota,
GITAM Institute of Pharmacy, GITAM University, visakhapatnam, Andhra Pradesh, India-530045.
lohithasu@gmail.com, +91-9491894432

ABSTRACT:
Generally, almost all communication in higher plants was thought to be mediated by the five classes of classical plant hormones  i.e. auxins, cytokinins,  gibberellins, abscisic acid and ethylene. The plant hormone action thus appeared to be basically different from that in animals. This article discusses the general role for new generation of plant hormones includes Brassinosteriods, Salicylic acid. Peptides,Polyaminesand Jasmonates.

About Author:
Dr. Vishwas B. Chavan
Ph.D. (Biochemistry)
Andheri (East), Mumbai – 400069
vishwaschavan2003@yahoo.co.in

Abstract:
The word “Cancer” is still synonymous with death for common people and the “stage IV cancer”, which is typically known as “last stage cancer”, is loss of hope even for medical community.
Many times patient presents to clinic, when cancer had already crossed II^{nd or} III^rd stage. This is mostly due to the reason that cancer may not have any symptoms at initial stages. Even if there are any symptoms, they can be mild and vague. Further rising cost of healthcare forced many patients, particularly women, to delay approach to physician. Therefore it is not uncommon for cancer patients to hear sentences like, “You are too late”, “You should have come earlier” etc. which is more depressing. This is a humble attempt to give the these patients some ray of hope.
So, in this 21^st Century, is it necessary, that cancer should be equal to death all the times, even when it has reached stage IV? To get answer of this question, we need to first know what stage IV cancer is and what its effects on human body are.
As most people know, cancer or malignancy means uncontrolled growth of any cell of the body. The mechanism which controls the growth of cells is lost in malignant cells. Cancer can occur in any cell of body and hence any organ can be affected by cancer, though cancers of some organs are more prevalent in some populations.