ANTIDIABETIC ACTIVITY OF SEED EXTRACTS OF Gynocardia Odorata ROXB. IN EXPERIMENTAL ANIMALS
About Author:
Urmila Moyal
NIMS Institute of Pharmacy, NIMS University,
Shobha Nagar, Jaipur (Rajasthan)
urmilamoyal@gmail.com
Abstract:
The study was designed to evaluate antidiabetic activity of ethanolic and aqueous seed extracts of Gynocardia Odorata roxb.in streptozotocin induced diabetes in 2 days old pups models. The seeds were collected, authenticated and shade dried. Shade dried seeds were then grinded into coarse powder and processed for further studies. Ethanolic and aqueous extracts were prepared and the phytochemical screening was performed. Ethanolic and aqueous both extracts were evaluated for the antidiabetic activity by using the streptozotocin induced diabetes in 2 days old pups model. After 3 months of streptozotocin administration pups become diabetic then different treatment were given to animals. After 3 weeks treatment estimation of biological parameters like serum glucose, cholesterol and triglyceride were performed and body weight, water intake and food intake were also recorded. Histopathological study was performed to study the structure of islets of pancreas in different group of animals. After 3 weeks treatment of ethanolic and aqueous extracts, when the biological parameters i.e. serum glucose, cholesterol and triglyceride were estimated and compared with diabetic untreated group there was a significant decrease were observed. Treatment also reversed the loss of body weight and increased demand of food intake and water intake when compared with diabetic untreated group. From the above study we concluded that both ethanolic and aqueous, seed extracts of Gynocardia Odorata roxb.have antidiabetic activity, but the aqueous extract of Gynocardia Odorata roxb.showed more significance then ethanolic extract.
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