• PharmaTutor
    15 April 2013

    MICROBIAL TREATMENT OF OFFSET PRINTING INDUSTRY EFFLUENT

    ABOUT AUTHORS:
    Archana G. Kulkarni, R.S. Awasthi
    Dept. of Microbiology, Shivaji Mahavidyalaya,
    Renapur (M.S.)
    *agnk.77@gmail.com

  • 14 April 2013
    DEVELOPMENT OF DOMPERIDONE NASAL GEL USING NATURAL MUCOADHESIVE AGENT OBTAINED FROM THE FRUITS OF DELLINIA INDICA. L.

    About Authors:
    Dharmendra Kumar*, BhanuPriya, S.K Gupta
    *Department of Pharmaceutical Technology,
    Meerut Institute of Engineering and Technology,
    Meerut, Uttar Pradesh, India, 250005
    *rvnimiet@gmail.com

    Abstract.
    The aim of this research work was replaced the tablet or injection of Domperidone by using domperidone nasal gel forrmulations. In research, day to day newer novel drug delivery comes for various drugs nasal gel drug delivery system one of them. Purpose of this study is formulating a nasal gel of Domperidone by using natural mucoadhesive agent extract from Dellinia Indica. In vitro drug release study carried out by using Franz-diffusion cell and excised bovine nasal membrane,characterisation was also found to be better in comparison to the HPMC and carbapolsynthetic polymers. Dellinia indica has valuable properties as a mucoadhesive agent because it is considered to be biocompatible, biodegradable and non-toxic. In future nasal gel formulations replace tablet/injection of Domperidone.

  • 14 April 2013
    DESIGN AND DEVELOPMENT OF COLON DRUG DELIVERY SYSTEM OF DICLOFENAC SODIUM

    ABOUT AUTHORS:
    A.Anil kumar, K.Surekha, M.Sujatha Kumari
    Department of Pharmaceutics
    Vikas college of pharmacy, Vissannapeta, 521215
    *anilkumar.adi@gmail.com

    ABSTRACT:
    The objective of the present study of Diclofenac sodium was to treat inflammatory bowel disease in colon.   Treatment for IBD is a long term therapy the colon drug delivery system of Diclofenac sodium to the colon provides the following benefits. Avoidance of first pass metabolism, to target local site. The tablet formulation of Diclofenac sodium provides time controlled release to treat the nocturnal symptoms of pain in colon.  The formulation is administered in the night at 10 pm the action will be start early morning 3’0 clock Symptoms that are experienced in early morning hours should be avoided to maintain the lag period of drug release 5hrs. To maintain lag time the best method is pulsein cap drug delivery system and it is high expensive, poor in vivo correlation. Due to cost effectiveness and poor in vivo correlation we preferred to target colon as tablet dosage form. In the present study, the polymer selected as Guargum. Granules were prepared by wet granulation technique using Guargum in different ratios (drug: polymer) FG1 (1:0.25), FG2(1:0.5), FG3(1:0.75), FG4(1:1), FG5(1:1.25). To perform the interaction studies by IR spectra studies. To study the influence of polymer concentration on the Diclofenac sodium release from tablets. The prepared tablets were evaluated for different physical parameters and dissolutions studies were performed in 3 dissolution mediums like 0.1N hydrochloric acid for 2hr, pH 7.4 for 3hr, pH 6.8 up to 24hrs. Among all these formulations FG4 formula (1:1) showed 98% up to 24 hrs drug release. The release mechanisms of all formulations are diffusion controlled conformed from higuchis plot, thus the present study concluded that drug and guar gum (1:1) ratio for fulfill to target local site for colon drug delivery system.

  • 12 April 2013
    FORMULATION AND EVALUATION OF ATAZANAVIR SULPHATE FLOATING MATRIX TABLETS

    ABOUT AUTHOR:
    Swetha Kotla
    Malla Reddy Institute Of Pharmaceutical Sciences
    Hyderabad, AP, India
    swetha.pharma12@gmail.com

    ABSTRACT
    The study was aimed at formulation and evaluation of Fast Disintegrating Tablets (FDTs). Using a taste masking polymer Eudragit E100, to mask the taste of a delivered drug i.e., Quetiapine Fumarate (QTF). Taste masking was done by solvent evaporation technique in absolute Ethanol as solvent system.  Fast Disintegrating Tablets of QTF were prepared by using different techniques like Superdisintegrants addition method (Croscarmellose sodium (CCS), Sodium starch glycolate (SSG) and crospovidone (CP)), sublimation method (Camphor) and Effervescent formulation approach (sodiumbicarbonate+citrcacid). All the formulations were evaluated for flow properties, hardness, friability, content uniformity, wetting time, in vivo disintegration time (DT), release profiles. All the formulations showed satisfactory mechanical strength and other formulation parameters within the range. Dissolution parameters such as, Initial Dissolution Rate (IDR), Dissolution Efficiency (DE), Mean Dissolution Time (MDT) and Relative Dissolution Rate (RDR) were calculated. The optimized formula D5 prepared by using 10 % CP as a superdisintegrant and 12 % Camphor as subliming agent, which showed shortest DT (17 Sec) ( Q10= 88%, WT= 37Sec). The drug polymer complex was subjected to FTIR studies to understand the degree of interaction between drug and polymer. The dissolution parameters such as IDR, DE, RDR for the optimized formulation exhibited 1.8 fold increase when compared to marketed product. It can be concluded that the orally fast disintegrating tablets of QTF with better biopharmaceutical properties than conventional marketed tablet obtained using formula D5.

  • 11 April 2013
    PREPARATION AND EVALUATION OF RIVASTIGMINE NANOPARTICLES FOR TREATMENT OF DEMENTIA ASSOCIATED WITH ALZHEIMER’S DISEASE

    About Authors:
    Bajaj L.*, Chopra D.1
    *PCTE Institute of Pharmacy, Jhandey, Ludhiana-142021, Punjab, India.
    1Department of Pharmaceutical Sciences and Drug Reasearch,
    Punjabi University. Patiala.
    *lotika.bajaj@gmail.com / lotika@pcte.edu.in

  • 11 April 2013
    A REVIEW ON RECENT TRENDS IN ORAL DRUG DELIVERY- MOUTH DISSOLVING FORMULATION

    ABOUT AUTHORS:
    Manish Goswami, U.K.Singh, Rajat Kumar
    Kharvel subharti college of pharmacy (swami Vivekanandsubharti University) Subhartipuram,
    N.H-58, Meerut By Pass Road,
    Meerut, uttarpradesh- 250001, India.
    *manish.revosys88@gmail.com

    ABSTRACT:
    The desire of improved palatability in orally administered products has prompted thedevelopment of numerous formulations with improved performance and acceptability. Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last fewdecades, and the field has become a rapidly growing area in the pharmaceutical industry. Theunique property of mouth dissolving tablet is that they are rapidly disintegrating and/ordissolving and release the drug as soon as they come in contact with saliva, thus obviate therequirement of water during administration. this review also provides the detailed concept of some unique patents; technologiesdeveloped and marketed formulations of Mouth Dissolving Tablets(MDTs).The present investigation was undertaken with a view to develop mouth-dissolving tablets which offer a new range of product having desired characteristics and intended benefits. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The basic approach used in development of MDT is the use of super disintegrants like Crosslinked carboxymethyl cellulose (Croscarmellose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. whichprovide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva.

  • 10 April 2013
    AN OVERVIEW: ON SUPERDISINTEGRANTS

    ABOUT AUTHORS:
    Rahul Tiwari*1, R.C. Jat1, Narendra Sharma1, Arvind Singh Rathore1
    1Shri Ram College Of Pharmacy,
    1Banmore, Morena, India -476444
    *rt30022@gmail.com, arvindsingh.rathore21@gmail.com

    ABSTRACT
    Disintegrants are substances or mixture of substances added to the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. In dosage forms, solid orals gain maximum popularities, about 85%, because of many advantages over others. The therapeutic activity of these formulations is obtained through a typical manner like disintegration followed by dissolution. Hence disintegration has major role for facilitating drug activity and thus gain popularity among other dosage forms. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1-  10 % by weight relative to the total weight of the dosage unit. The present study comprises the various kinds of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance. In this review article, more emphasis is given on application and usage of various superdisintegrants comparing with other disintegrants in reference to available scientific studies. The various sources of superdisintegrants and their modification to improve disintegration property are also high-lighted.

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  • 10 April 2013
    miRNAs A NOVEL TARGET FOR ANTICANCER THERAPY

    ABOUT AUTHORS:
    Ketan M. Parmar*, Ritesh N. Sharma
    S.K.Patel College of Pharmaceutical Education & research,
    Department of Pharmaceutical chemistry, GANPAT UNIVERSITY.
    *brave_student_90@yahoo.com

    ABSTRACT
    With the development of technologies to look at the expression levels of hundreds of miRNAs at a time and the clear role of miRNAs in cancers, groups began looking at miRNAs profiles of different cancers,especially the circulating miRNAs. We intended to make sure whether circulating miRNAs could be a promising biomarker of human cancers. Method: We comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to Nov 2009 for the following terms: (“miRNA” or “microRNA”) and (“tumor” or “carcinoma”) and (“plasma” or “serum” or “circulating”). Detailed information was extracted from studies that met the inclusion criteria: blood-based miRNAs in human cancers and studies published in the English literature. Results: The current review show that different researches use different measurement methods which might impact the results;Cancers treatment might have an effect on circulating miRNAs; some miRNAs are multi-faceted RNA; small sample size might produce selection bias. Furthermore, because of the lack of randomized controlled trials and the heterogeneous nature of the available data, no attempt was made to perform quantitativemeta-analyses.
    In this review, based on those researches, circulating miRNAs are promising and difficulties for their future application for diagnosing human cancers.

  • 9 April 2013
    A SHORT REVIEW ON FAST DISSOLVING TABLETS - A NOVEL DRUG DELIVERY SYSTEM

    ABOUT AUTHORS:
    Yedale A.D.*, Waghmare P.V, Kulkarni S.D., Bhusnure O.G., Bhalekar M.S.
    Master of pharmacy, Department of Quality Assurance
    Maharashtra College of Pharmacy, Nilanga, dist. Latur (MS) 413521, India
    *ajayyedale03@gmail.com

  • 8 April 2013
    BEATING CANCER WITH NATURAL PLANT SOURCES

    ABOUT AUTHORS:
    Mohd. Yaqub khan*, Poonam gupta, Vikaskumar verma, Ashish pathak
    Saroj Institute of Technology & Management,
    Ahimamau, P.O. Arjunganj, Sultanpur Road, Lucknow-226002,
    Uttar Pradesh, India
    *khanishaan16@yahoo.com

    ABSTRACT
    Medicinal plants continue to play a central role in the healthcare system of large proportions of the world’s population. This is particularly true in developing countries, where herbal medicine has a long and uninterrupted history of use. Continuous usage of herbal medicine by a large proportion of the population in the developing countries is largely due to the high cost of Western pharmaceuticals and healthcare. Every year, millions of people are diagnosed with cancer, leading to death in a majority of the cases. Specific part of it is formulated into suitable preparations compressed as tablets or made into pills, used to make infusions, extracts, tinctures, etc., or mixed with excipients to make lotions, ointments, creams, etc. Few herbal drugs are subject to legislative control. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide, S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin, 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears), silymarin (milk thistle), anethol, catechins, eugenol, indole-3-carbinol, limonene, beta carotene, and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents.

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