Articles

ABOUT AUTHOR:
Sunitha Manthena
Nalla Narsimha Reddy School of Pharmacy,
Narapally, Hyderabad
Affiliated to JNTU(H);
sunithatgk@gmail.com

INTRODUCTION
The expenses for developing new drugs are exorbitant. Thus in the present scenario, more emphasis is laid  to develop newer drug delivery technologies, which would ensure better patient compliance, drug efficacy and extends the term of patents of the existing molecules. In the present era, the pharmaceutical industry is facing several challenges due to worldwide competition and growing demand for better products.¹

ABOUT AUTHOR:
Abhijeet Welankiwar.
Govt. College of pharmacy
kathora naka Amravati (Maharashtra) 444604.
abhi123welankiwar@gmail.com

ABSTRACT:
The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. With many drugs the basic Goal of therapy is to achieve a steady-state blood or tissue level that is therapeutically effective and nontoxic for an extended period of time. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications so as to achieve a measure of control on therapeutic effect in the face of uncertain fluctuations in the in vivo environment in which drug release takes place. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release formulations of the same drug, over which it provides a prolong release of the drug over extended period of time there by giving the better patient compliance and enhanced bioavailability and resulting blood concentration-time profiles of drugs that otherwise suffer from few limitations.

About Authors:
Dharmendra Kumar^*, Bhanu Priya, Sumedha Bansal,
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
Meerut, Uttar Pradesh, India, 250005
* rvnimiet@gmail.com

Abstract
A new Nasal drug delivery system of Domperidone has been developed as decent drug delivery by using natural mucoadhesive agent extract from Tamarindus indica L. The mucoadhesive strength, pH, viscosity and gelling property of this natural mucoadhesive agent was found to be higher in comparison to synthetic polymers, hydroxy propyl methyl cellulose (HPMC) and carbopol which are conventionally used for similar purpose. In vitro drug release characteristic through franz-diffusion cell using excised bovine nasal membrane was also found to be better in comparison to the above synthetic polymers. Now patient friendly, needle free dosage form may replace the Domperidone injections/ tablets in future.

ABOUT AUTHORS:
Rinku B Patel^*1, Paresh U Patel², Bharat G Patel³, Anil C Patel^2
1Department of Pharmaceutical Analysis, Centre For Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
²Department of Quality Assurance, Centre For Health Science Studies, Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
³Aspee college of Home Science and Nutrition, S.D.Agricultural University, S.K.Nagar-385506, Banaskantha, Gujarat, India.
*rinkupatel5890@gmail.com

ABSTRACT
Simple, accurate, precise, and sensitive ratio spectra derivative spectrophotometric method for simultaneous estimation of Eperisone hydrochloride (EPE) and Diclofenac sodium(DIC) in synthetic mixture have been developed and validated. The ratio derivative spectroscopic method involves measurement of first derivative amplitude of ratio spectra at 247 nm for EPE and 218.4 nm for DIC as two wavelengths for estimation. Beer's law is obeyed in the concentration range of 2-18 μg/ml for both EPE and DIC. LOD values for EPE and DIC are found to be 0.0634 μg/ml and 0.5386 μg/ml, respectively. LOQ values for EPE and DIC are found to be 0.1921 μg/ml and 1.6321 μg/ml, respectively. The method was validated statistically and recovery studies were carried out. It was found to be accurate, precise and reproducible. The method was applied to the assay of the drugs in synthetic mixture, which were found in the range of 98.0% to 102.0% of the labeled value for both Eperisone hydrochloride and Diclofenac sodium. Hence, the method herein described can be successfully applied in quality control of synthetic mixture.

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ABOUT AUTHORS
Anil C. Patel*, Dr Paresh U. Patel , Rinku B. Patel
Department of Quality Assurance, S. K. Patel College of Pharmaceutical Education and Research,
Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
*anilpatel002@gmail.com

ABSTRACT
A novel, precise, accurate and rapid isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method was developed, optimized and validated for  simultaneous determination of Ibuprofen and Chlorzoxazone. The method showed adequate separation for Ibuprofen and Chlorzoxazone and best resolution was achieved with ACE 5 C18 column (150 mm × 4.6 mm i.d, 5 μm particle size) using Acetonitrile-Phosphate buffer pH 3.5 - Methenol (20:20:60, v/v; pH adjusted to 3.5 with O-phosphoric acid and TEA(Tetra ethyl amine) as a mobile phase at a flow rate of 0.7 ml/min and wavelength of 221 nm. The calibration curves were linear over the concentration ranges of 2-30 μg/ml for Ibuprofen and Chlorzoxazone. The limit of detection (LOD) and limit of quantification (LOQ) for Ibuprofen were 0.96 and 2.92 μg/ml while for Chlorzoxazone were 0.69 and 2.09 μg/ml, respectively. All the analytes were separated in less than 6.0 min. The proposed method could be applied for routinelaboratory analysis of Ibuprofen and Chlorzoxazone in pharmaceutical dosage form. Methods were validated statistically and recovery studies were carried out. The proposed methods have been applied successfully to the analysis of cited drug either in pure form or in synthetic mixture of both drugs with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

ABOUT AUTHORS
Junaid Niazi^1*, Yogita Bansal², Narinderpal Kaur^3
1 Asst.Prof., Bahra Institute of Pharmacy, Patiala, India
² Assoc. Prof., Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India
³ Asst. Prof., Baddi University of Emerging Sciences and Technology, Baddi, India
* niazi.junaid@yahoo.co.in

ABSTRACT
Aegle marmelos Corr., a deciduous aromatic tree has been recognized in traditional medicine for the treatment of different diseases and ailments of humans like dysentery, fever, diabetes, asthma, heart problems, ophthalmia, haemorrhoids urinary problems etc.  The plant has been reported to contain several phytoconstituents belonging to category of coumarins (like marmenol), alkaloids (like aegeline), glycosides, triterpenoids, anthraquinones, sterols and volatile oils. Several modern scientific studies have authenticated its anti diarrhoeal and gastro protective, anti diabetic, antibacterial, analgesic, anti-inflammatory, antioxidant, anti thyroid, anti histaminic, anti prolifertive and anti fertility activity. Clinical trials of a formulation Diarex (containing A. marmelos has shown positive results patients suffering from diarrhoea and dysentery. This review gives a bird’s eye view mainly on folkloric uses, phytochemistry and pharmacological actions of the plant.

About Authors:
Virag A. Shah^1*, Tarashankar Basuri¹, Vishal S. Modi¹, Rohit R. Shah², Dhananjay S. Ghodke^2
1 SSR College of pharmacy, Silvassa, U.T of Dadra & Nagar Haveli-396230
² Appasaheb Birnale College of Pharmacy, Sangli, Dist: Sangli, Maharashtra- 416416
*viragshah687@gmail.com

Abstract:
Cyclodextrins (CDs) due to their inclusion formation ability finds wider applicability in Novel Drug Delivery Systems as well as in Pharma industries. This review highlights and focuses on history of CD molecules, their chemistry, need for derivatizations of CDs, production method, CDs inclusion complexes and various methods used for complexation. The article also focuses on various effects of CDs on drug solubility and dissolution, bioavailability, stability, and safety. Some important drug delivery systems which utilize CDs are also summarized with a brief overview on recent advances in CDs.