Articles

About Author:
Kunal Jain
Indo Soviet Friendship College of Pharmacy,
Moga, Punjab
jainkunal87@gmail.com

ABOUT AUTHORS:
Mrs.R.Deepa
Assistant professor, Department of biochemistry
Madha dental college and hospital, kundrathur
Chennai, Tamil Nadu.
deepanish1981@gmail.com

ABOUT AUTHORS:
Pankaj Sharma*, Bhupendra Vyas, Yuvraj Singh Sarangdevot, Abhishek Sharma, Bhuvanesh Sharma
Department of Quality Assurance,
Bhupal Nobles’ College of Pharmacy,
Udaipur- 313002, Rajasthan, India
*pankajs.medicolite@gmail.com

About Authors:
Sunil Roshan¹, Prabhakar Sharma*¹, Ramchandra Gupta¹, Sudhakar Sharma^2
1Department of Pharmacognosy, GRKIST (Pharmacy)
²Takshashila Institute Of Science And Technology
Jabalpur, M.P.
*prabhakar.sharma071026@gmail.com

Abstract
The traditional systems of medicine together with homoeopathy and folklore medicine continue to play a significant role largely in the health care system of the population. Butea monosperma(palas) belonging to the family leguminosae grown wildly in many parts of India. The plant is highly uses by the rural and tribal people in curing various disorders. Flowers are used as drug in many ailments like eye disease, chronic fever, enlargement of spleen, leucorrhoea, epilepsy, leprosy, antifungal activity, anti-inflammatory activity, liver disorders antifertility activity and gout etc. The plant parts are used in the form of extract, juice, infusion, powder and gum. The present paper enumerates various pharmacognostic and pharmacological aspects of the plant. This review also summaries the therapeutic potential of this plant.This is a moderate sized deciduous tree which is widely distributed throughout India, Burma and Ceylon, popularly known as 'dhak' or 'palas', commonly known as ‘flame of forest’. In this review an attempt has been done to highlight the work on Butea monosperma having pharmacological potential.

ABOUT AUTHORS:
Madhuri tadiparthi
Chalapathi institute of pharmaceutical sciences,
guntur, a.p, india.
tadiparthimadhuri@gmail.com

ABSTRACT:
Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker (dihydropyridine (DHP) class) used as an anti-hypertensive and in the treatment of angina. Indapamide is a thiazide diuretic used in the treatment of hypertension, as well as decompensated cardiac failure. Six new, simple, accurate and precise methods have been developed and validated according to ICH guidelines for the simultaneous estimation of Amlodipine and Indapamide in their combined dosage form (four UV-Spectrophotometric, one colorimetric and one RP-HPLC methods).
First method is based on simultaneous estimation using two wavelengths, 365 nm (λ_maxof AMLO) and 279 nm (λ_maxof INDA) by simultaneous equation method. The second method involves the use of first order derivative technique, here 293 nm, the zero crossing point of AMLO, 279 nm, the zero crossing point of INDA were used for the estimation. The third method is based on Q-absorption Ratio method using two wavelengths 365 nm (λ_maxof AMLO) and 312 nm (Isoabsorptive point). In the dual wavelength method two wave lengths 270 nm and 288 nm were selected as λ₁ and λ₂ for the estimation of AMLO, INDA shows the same absorbance at these wavelengths. Similarly, wavelengths 350 nm and 378 nm were selected as λ₁ and λ₂ for the estimation of INDA, AMLO shows the same absorbance at these wavelengths.Colorimetry:  The method is based on use of MBTH reagent for simultaneous estimation of AMLO and INDA using two wavelengths, 626 nm (λ_maxof AMLO) and 600 nm (λ_maxof INDA).

ABOUT AUTHOR:
Swetha Kotla
Malla Reddy Institute Of Pharmaceutical Sciences
Hyderabad, AP, India
swetha.pharma12@gmail.com

ABSTRACT
The study was aimed at formulation and evaluation of Fast Disintegrating Tablets (FDTs). Using a taste masking polymer Eudragit E100, to mask the taste of a delivered drug i.e., Quetiapine Fumarate (QTF). Taste masking was done by solvent evaporation technique in absolute Ethanol as solvent system.  Fast Disintegrating Tablets of QTF were prepared by using different techniques like Superdisintegrants addition method (Croscarmellose sodium (CCS), Sodium starch glycolate (SSG) and crospovidone (CP)), sublimation method (Camphor) and Effervescent formulation approach (sodiumbicarbonate+citrcacid). All the formulations were evaluated for flow properties, hardness, friability, content uniformity, wetting time, in vivo disintegration time (DT), release profiles. All the formulations showed satisfactory mechanical strength and other formulation parameters within the range. Dissolution parameters such as, Initial Dissolution Rate (IDR), Dissolution Efficiency (DE), Mean Dissolution Time (MDT) and Relative Dissolution Rate (RDR) were calculated. The optimized formula D5 prepared by using 10 % CP as a superdisintegrant and 12 % Camphor as subliming agent, which showed shortest DT (17 Sec) ( Q10= 88%, WT= 37Sec). The drug polymer complex was subjected to FTIR studies to understand the degree of interaction between drug and polymer. The dissolution parameters such as IDR, DE, RDR for the optimized formulation exhibited 1.8 fold increase when compared to marketed product. It can be concluded that the orally fast disintegrating tablets of QTF with better biopharmaceutical properties than conventional marketed tablet obtained using formula D5.