Articles

11 April 2013

PREPARATION AND EVALUATION OF RIVASTIGMINE NANOPARTICLES FOR TREATMENT OF DEMENTIA ASSOCIATED WITH ALZHEIMER’S DISEASE

About Authors:
Bajaj L.*, Chopra D.¹
*PCTE Institute of Pharmacy, Jhandey, Ludhiana-142021, Punjab, India.
¹Department of Pharmaceutical Sciences and Drug Reasearch,
Punjabi University. Patiala.
*lotika.bajaj@gmail.com / lotika@pcte.edu.in
11 April 2013

A REVIEW ON RECENT TRENDS IN ORAL DRUG DELIVERY- MOUTH DISSOLVING FORMULATION

ABOUT AUTHORS:
Manish Goswami, U.K.Singh, Rajat Kumar
Kharvel subharti college of pharmacy (swami Vivekanandsubharti University) Subhartipuram,
N.H-58, Meerut By Pass Road,
Meerut, uttarpradesh- 250001, India.
*manish.revosys88@gmail.com

ABSTRACT:
The desire of improved palatability in orally administered products has prompted thedevelopment of numerous formulations with improved performance and acceptability. Mouth dissolving tablets (MDTs) have received ever-increasing demand during the last fewdecades, and the field has become a rapidly growing area in the pharmaceutical industry. Theunique property of mouth dissolving tablet is that they are rapidly disintegrating and/ordissolving and release the drug as soon as they come in contact with saliva, thus obviate therequirement of water during administration. this review also provides the detailed concept of some unique patents; technologiesdeveloped and marketed formulations of Mouth Dissolving Tablets(MDTs).The present investigation was undertaken with a view to develop mouth-dissolving tablets which offer a new range of product having desired characteristics and intended benefits. Mouth dissolving tablets are advantageous particularly for pediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. The basic approach used in development of MDT is the use of super disintegrants like Crosslinked carboxymethyl cellulose (Croscarmellose), Sodium starch glycolate (Primogel, Explotab). Polyvinylpyrrolidone (Polyplasdone) etc. whichprovide instantaneous disintegration of tablet after putting on tongue, thereby releasing the drug in saliva.
10 April 2013

AN OVERVIEW: ON SUPERDISINTEGRANTS

ABOUT AUTHORS:
Rahul Tiwari*¹, R.C. Jat¹, Narendra Sharma¹, Arvind Singh Rathore¹
¹Shri Ram College Of Pharmacy,
¹Banmore, Morena, India -476444
*rt30022@gmail.com, arvindsingh.rathore21@gmail.com

ABSTRACT
Disintegrants are substances or mixture of substances added to the drug formulation that facilitates the breakup or disintegration of tablet or capsule content into smaller particles that dissolve more rapidly than in the absence of disintegrants. In dosage forms, solid orals gain maximum popularities, about 85%, because of many advantages over others. The therapeutic activity of these formulations is obtained through a typical manner like disintegration followed by dissolution. Hence disintegration has major role for facilitating drug activity and thus gain popularity among other dosage forms. Superdisintegrants are generally used at a low level in the solid dosage form, typically 1- 10 % by weight relative to the total weight of the dosage unit. The present study comprises the various kinds of superdisintegrants which are being used in the formulation to provide the safer, effective drug delivery with patient's compliance. In this review article, more emphasis is given on application and usage of various superdisintegrants comparing with other disintegrants in reference to available scientific studies. The various sources of superdisintegrants and their modification to improve disintegration property are also high-lighted.

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10 April 2013

miRNAs A NOVEL TARGET FOR ANTICANCER THERAPY

ABOUT AUTHORS:
Ketan M. Parmar*, Ritesh N. Sharma
S.K.Patel College of Pharmaceutical Education & research,
Department of Pharmaceutical chemistry, GANPAT UNIVERSITY.
*brave_student_90@yahoo.com

ABSTRACT
With the development of technologies to look at the expression levels of hundreds of miRNAs at a time and the clear role of miRNAs in cancers, groups began looking at miRNAs profiles of different cancers,especially the circulating miRNAs. We intended to make sure whether circulating miRNAs could be a promising biomarker of human cancers. Method: We comprehensively searched the Cochrane Library, Medline and EMbase from 1966 to Nov 2009 for the following terms: (“miRNA” or “microRNA”) and (“tumor” or “carcinoma”) and (“plasma” or “serum” or “circulating”). Detailed information was extracted from studies that met the inclusion criteria: blood-based miRNAs in human cancers and studies published in the English literature. Results: The current review show that different researches use different measurement methods which might impact the results;Cancers treatment might have an effect on circulating miRNAs; some miRNAs are multi-faceted RNA; small sample size might produce selection bias. Furthermore, because of the lack of randomized controlled trials and the heterogeneous nature of the available data, no attempt was made to perform quantitativemeta-analyses.
In this review, based on those researches, circulating miRNAs are promising and difficulties for their future application for diagnosing human cancers.
9 April 2013

A SHORT REVIEW ON FAST DISSOLVING TABLETS - A NOVEL DRUG DELIVERY SYSTEM

ABOUT AUTHORS:
Yedale A.D.*, Waghmare P.V, Kulkarni S.D., Bhusnure O.G., Bhalekar M.S.
Master of pharmacy, Department of Quality Assurance
Maharashtra College of Pharmacy, Nilanga, dist. Latur (MS) 413521, India
*ajayyedale03@gmail.com
8 April 2013

BEATING CANCER WITH NATURAL PLANT SOURCES

ABOUT AUTHORS:
Mohd. Yaqub khan*, Poonam gupta, Vikaskumar verma, Ashish pathak
Saroj Institute of Technology & Management,
Ahimamau, P.O. Arjunganj, Sultanpur Road, Lucknow-226002,
Uttar Pradesh, India
*khanishaan16@yahoo.com

ABSTRACT
Medicinal plants continue to play a central role in the healthcare system of large proportions of the world’s population. This is particularly true in developing countries, where herbal medicine has a long and uninterrupted history of use. Continuous usage of herbal medicine by a large proportion of the population in the developing countries is largely due to the high cost of Western pharmaceuticals and healthcare. Every year, millions of people are diagnosed with cancer, leading to death in a majority of the cases. Specific part of it is formulated into suitable preparations compressed as tablets or made into pills, used to make infusions, extracts, tinctures, etc., or mixed with excipients to make lotions, ointments, creams, etc. Few herbal drugs are subject to legislative control. The plant based drug discovery resulted mainly in the development of anticancer agents including plants (vincristine, vinblastine, etoposide, paclitaxel, camptothecin, topotecan and irinotecan). Beside this there is numerous agents identified from fruits and vegetables can used in anticancer therapy. The agents include curcumin (turmeric), resveratrol (red grapes, peanuts and berries), genistein (soybean), diallyl sulfide, S-allyl cysteine (allium), allicin (garlic), lycopene (tomato), capsaicin (red chilli), diosgenin, 6-gingerol (ginger), ellagic acid (pomegranate), ursolic acid (apple, pears), silymarin (milk thistle), anethol, catechins, eugenol, indole-3-carbinol, limonene, beta carotene, and dietary fiber. In this review active principle derived from natural products are offering a great opportunity to evaluate not only totally new chemical classes of anticancer agents.
8 April 2013

RP-HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND DESLORATADINE IN COMBINED DOSAGE FORM

ABOUT AUTHORS:
Rima M. Bankar*, Dipti B. Patel
Department of Pharmaceutical Analysis,
Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University,
Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
*rima.banker@yahoo.com

ABSTRACT
A novel, precise, accurate and rapid isocratic reversed-phase high performance liquid chromatographic/ultraviolet (RP-HPLC/UV) method was developed, optimized and validated for simultaneous determination of Montelukast Sodium and Desloratadine. The method showed adequate separation for Montelukast Sodium and Desloratadine and best resolution was achieved with ACE 5 C18 column (150 mm × 4.6 mm i.d, 5 μm particle size) using Acetonitrile-Methanol-Water (15:80:5, v/v) as a mobile phase at a flow rate of 1.0 ml/min and wavelength of 283 nm. The calibration curves were linear over the concentration ranges of 5-50 μg/ml for Montelukast Sodium and Desloratadine. The limit of detection (LOD) and limit of quantification (LOQ) for Montelukast Sodium were 0.33 and 1.01 μg/ml while for Desloratadine were 0.10 and 0.31 μg/ml, respectively. All the analytes were separated in less than 6.0 min. The proposed method could be applied for routinelaboratory analysis of Montelukast Sodium and Desloratadine in pharmaceutical dosage form. Methods were validated statistically and recovery studies were carried out. The proposed methods have been applied successfully to the analysis of cited drug either in pure form or in synthetic mixture of both drugs with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.

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7 April 2013

COLON TARGETED DRUG DELIVERY SYSTEM

ABOUT AUTHOR:
Sunitha Manthena
Nalla Narsimha Reddy School of Pharmacy,
Narapally, Hyderabad
Affiliated to JNTU(H);
sunithatgk@gmail.com

INTRODUCTION
The expenses for developing new drugs are exorbitant. Thus in the present scenario, more emphasis is laid to develop newer drug delivery technologies, which would ensure better patient compliance, drug efficacy and extends the term of patents of the existing molecules. In the present era, the pharmaceutical industry is facing several challenges due to worldwide competition and growing demand for better products.¹
7 April 2013

REVIEW: SUSTAINED RELEASE DOSAGE FORMS

ABOUT AUTHOR:
Abhijeet Welankiwar.
Govt. College of pharmacy
kathora naka Amravati (Maharashtra) 444604.
abhi123welankiwar@gmail.com

ABSTRACT:
The oral route of drug delivery is typically considered the preferred and most patient-convenient means of drug administration. With many drugs the basic Goal of therapy is to achieve a steady-state blood or tissue level that is therapeutically effective and nontoxic for an extended period of time. Sustain release system are considered a wiser approach for the drugs with short half-lives and which require repeated dosing, they are easy to formulate and are irrespective of absorption process from gastrointestinal tract after oral administration. The basic objective of these dosage forms is to optimize the delivery of medications so as to achieve a measure of control on therapeutic effect in the face of uncertain fluctuations in the in vivo environment in which drug release takes place. The advances in the formulation technology of modified release dosage form with sustained release oral dosage form has been widely accepted approach as compared to conventional immediate release formulations of the same drug, over which it provides a prolong release of the drug over extended period of time there by giving the better patient compliance and enhanced bioavailability and resulting blood concentration-time profiles of drugs that otherwise suffer from few limitations.
5 April 2013

REVIEW: TABLET COATING PROCESS

ABOUT AUTHOR
Abhijeet Welankiwar
Govt. College of pharmacy, kathora naka,
Amravati (Maharashtra) 444604
abhi123welankiwar@gmail.com

ABSTRACT:
Tablet coating is the key step involved in the manufacturing of tablets having controlled release, delayed release profiles. The tablet coating have number of advantages like masking odor, taste, color of the drug, providing physical and chemical protection to drug, Protecting drug from the gastric environment. 3 primary components of tablet coating are tablet properties, coating process and coating composition. Tablets are usually coated in horizontal rotating pan with coating solution is either directly poured or sprayed on to them. The amount of coating on the surface of a tablet is critical to the effectiveness of the oral dosage form. Recent trends in tablet coating focuses on overcoming disadvantage of solvent based coating. This article concerns with the coating process, equipments involved, coated tablets evaluation and specialized coating techniques.