Articles

About Author:
Kambham Venkateswarlu
Graduate Student
Sri Lakshmi Narasimha College of Pharmacy,
Palluru, Chittoor District, Andhra Pradesh-517132, India.
k.v.reddy9441701016@gmail.com

ABSTRACT:
Many different types of laboratory fermentors and bioreactors are used worldwide. The selection of a good quality bioreactor is not easy. Some advantageous parameters found in one product are cancelled out by other draw backs in the same system. Good high quality bioreactors are very expensive. Even then ease of use is not assured. The question arises, whether it is possible to construct a bioreactor, which would satisfy most requirements. The most important are high quality and easy to use, perfect sterility, precise measurement, control and recording of all important culture parameters and lasts but not lasts, and the bioreactor shouldn’t expensive!

About Authors:
Bhupender Kumar*, Assit. Prof. Prasant Beniwal, Monish Sharma, Ramchandra
Seth G.L. Bihani S.D. College of Technical Education
(Institute Of Pharmaceutical Sciences And Drug Research),
Sri Ganganagar, Rajasthan
*bhupendra.nimiwal@gmail.com

Abstract:
Thermoanalytical methods essentially techniques that are based entirely on the concept of heating a sample followed by well-defined modified procedures, such as : gravimetric analysis, differential thermal analysis (DTA) and differential scanning calorimetry (DSC). Thermogravimetric analysis measured weight change, differential scanning calorimetry measured heats and temperature of transitions and reactions, differential thermal analysis (DTA) measured temperatures of transitions and reactions.

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About Author:
Ravindra Singh Tomar
M.Pharm (Medicinal & Pharmaceutical Chemistry),
B R Nahta College of Pharmacy, Mandsaur (M.P)
ravindratomar16@gmail.com

ABSTRACT-
Here a scheme has been designed for synthesis of 2-chloropyridine-5-trifluoromethyl derivatives. The probability of being antiamnesic agent has been checked by pass prediction. All compound shows antiamnesic activity as result of pass prediction. By Lipinski rule of five all compounds shows drug like activity. Also a method for pharmacological evaluation & Biochemical evaluation is described under. All synthetic procedure has been designed & described under-

About Author:
Aarti Narkhede
Mahakal Institute of Pharmaceutical Studies,
Ujjain, MP
narkhede_aarti@rediffmail.com

ABSTRACT
The use of natural product has increased tremendously in a western world as well as in developing countries or in all over part of world. via this artical therapeutic potential and future prospect of Psidium guajava L. are described. Psidium guajava L. belonging to family, myrtaceae. It is a commen tree and easily found in a tropical countries or area. Traditionally it is a very popular and used from long time in a various system of medicine like, unani, Siddha, homeopathy and Ayurveda. It is used for treatment of many ailments like diarrhea, dysentery, wounds, rheumatism, lungs problems, ulcers, skin infections, vaginal discharge, epilepsy, menstrual pain, sore throat, mouth swelling, cold and cough, toothache and etc. In present time study on antipoliferitive or anticancer activities are undertaken and it is found that anticancer activity of P.Guajava has a four time greater than vincristine.

About Authors:
Awan Bharti^*1, Sweta Gautam^2
1Department of Pharmacognosy,
Shri Rawatpura Sarkar Institute of Pharmacy, Datia, M.P.
²Department of Pharmacognosy, RKDF College of Pharmacy, Bhopal
*bhartiawan@gmail.com, shwetagautam85@rediffmail

ABSTRACT
Interest in alternative medicine and plant-derived medications that affect the "mind" is growing. Anxiety affects one-eighth of the total population of the world and has become a very important area of research interest in psychopharmacology during this decade. Anxiety, a state of excessive fear, is characterized by motor tension, sympathetic hyperactivity, and apprehension and vigilance syndromes. Benzodiazepines are the major class of compounds used in anxiety and they have remained the most commonly prescribed treatment for anxiety, despite the important unwanted side effects that they produce such as sedation, muscle relaxation, ataxia, amnesia, ethanol and barbiturate potentiation and tolerance. Various types of herbal medicines have been used as anxiolytic drugs in different parts of the world. Folk medicines have particular values, for example, plants that "calm down", tranquilize, and raise mood, such as Passiflora coerulea, Valeriana officinalis, Matricaria recutita, Jatropa cilliata, Salvia guaranitica, Tilia tormentosa, and Tilia europeae. Plants have long been used to treat central nervous system (CNS) disorders.

About Authors:
Sailesh Narayan*, Ankit Diwan
Sagar institute of Pharmacy and Technology,
Gandhi Nagar, Bhopal
*saileshcology@yahoo.co.in

INTRODUCTION
A tablet is a pharmaceutical dosage form. It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from  a powder into a solid dose. The excipients can include diluents, binders or granulating agents, glidants and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive. A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment or to enhance the tablet's appearance. These are compressed tablets. formulated to deliver an accurate dosage to a specific site; it is usually taken orally, but can be administered sublingually, buccally, rectally or intravaginally. Medicinal tablets were originally made in the shape of a disk of whatever color their components determined, but are now made in many shapes and colors to help distinguish different medicines. Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified.

About Authors:
Nareshkumar. G¹*, A.Eashwar rao², Ch.Ganga prasad³.
¹*Center for Pharmaceutical Sciences, IST, JNTU Hyderabad, India,
²Talla Padmavathi College of Pharmacy, Warangal, India,
³National College of Pharmacy, Shimoga, Karnataka, India.
*nareshkumar62@gmail.com

ABSTRACT:
Liquisolid technique is a new and propitious method that can change the dissolution rate of poorly water soluble drugs. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable non-volatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit enhanced release profiles. In this case, even though the drug is in a solid dosage form, it is held within the powder substrate in solution or, in a solubilized, almost molecularly dispersed state, which contributes to the enhanced drug dissolution properties. Successful liquisolid tablet is a determination of optimal flowable liquid retention.

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About Authors:
Sharda roy*, vikas chandra roy, dr. R. C. Roy
Address Faculty of Pharmaceutical Sciences. Global College of Pharmacy.
Kahnpur Khui. Punjab.
*roysharda08@gmail.com

Abstract:
Mitragyna parvifolia is a medium to large size tree belonging to the family Rubiaceae. It is popularly known as Kaim and is found growing gregariously throughout the drier parts of India, Pakistan and Srilanka. The aerial parts, stem-bark and roots of the tree contain various indolic (tetrahydroalstonine, akkuamigine, hirsuteine etc) and oxindolic (mitraphylline, isomitraphylline, pteropodine, isopteropodine etc) alkaloids. Important variations in the nature and quantity of alkaloids present in different parts of the plant are visible with change in geographical locations. In addition, various parts of the tree such as fruit juice, leaves and stem bark have been used in the traditional system of medicine by the natives and tribal since times immemorial. Mitragyna parvifolia has also got diverse medicinal and therapeutic properties such as analgesic, antipyretic, anti-inflammatory, antiarthritic, anthelmentic, antioxidant etc which have been validated scientifically. In this study we have critically reviewed the pharmacognostic and chemical profile, the traditional and the scientifically validated bioactivities of the plant.

About Authors:
Dharmendra Kumar^*1, Sumedha Bansal^1
1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
Meerut, Uttar Pardesh, India, 250005
*rvnimiet@gmail.com

Abstract:
In present era, nasal drug delivery system has been considered as potential and favourable route of drug delivery because it provides patient compliance, easy to administration, bypass first pass metabolism, excellent penetration, low dose required, rapid absorption and gives desirable effects. So many times nasal drug delivery has been considered as alternative of parenteral route. The purpose of this review, to provide a complete information about nasal drug delivery system such as advantage, limitations, anatomy of nose, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, novel drug formulations, types of nasal drug delivery system with uses of nasal drug delivery in various disease. So we have expectation, that researches and others cited person get benefitted from this review.