Pharmacognosy Articles

CUCURBITACINS A VIBRANT TRITERPENOID: A REVIEW ON ITS ANTICANCER PROPERTY

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ABOUT AUTHORS
Mir Sahidul Ali*1, Souvik Mukherjee2, Subhajit Makar2, Gargi Pal3
*1Department of Chemical and Polymer Engineering,
Tripura University, Suryamaninagar, Tripura, India
2Centre for Pharmaceutical Sciences &
Natural Products, School of Basic and Applied Sciences,
Central University of Punjab, Bathinda, Punjab, India
3Department of Pharmaceutical Sciences and Technology,
NSHM Knowledge Campus, Kolkata, India.

ABSTRACT:
Cucurbitacins which are structurally unlike triterpenes found in the members of Cucurbitaceae and several other plant families possess immense pharmacological activity. This diverse group of compounds may substantiate to be important lead molecules for the treatment of cancer. Research focused on these unattended medicinal compound can prove the significance and explore the hidden potential to cure various diseases. These compounds shows their proposed mode of action, probable molecular targets and have future aspects of their use as a medicinal agent. This review is aimed to provide the chemical nature and medicinal property of cucurbitacins.

PHARMACOGNOSTICAL, PRELIMINARY PHYTOCHEMICAL SCREENING AND ANTIBACTERIAL ACTIVITY OF METHANOL EXTRACT OF MURRAYA KOENIGII

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ABOUT AUTHORS
Patil N.B.*, Patil K.B., Wagh M.N., Patil A.A,
Department of Pharmacy, Ahinsa Institute of Pharmacy,
Dondaicha, Maharashtra, India

ABSTRACT
The methanol extract of murraya koenigii (leaf) were investigated for their antibacterial activity against staphylococcus aureus using cup plate agar diffusion method and methanol extract produces best results. various investigation like physiochemical standard ,preliminary phytochemical screening of the plant was carried out and parameter were reported. The present paper deals with investigation of various phytochemical present in methanol extract and in vitro antibacterial activity against the s.aureus .the literature survey does not exist anti bacerial activity of murraya koenigii (leaf) in methanol extract against s.aureus.it is concluded that the plant studied may source of antibacterial plant.

A REPORT ON MEDICINAL PLANTS USED IN ETHNO VETERINARY PRACTICES OF VILLAGE PEOPLES IN SATPUDA HILLS IN SHIRPUR TALUKA (DIST-DHULE ,MAHARASHTRA)

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ABOUT AUTHOR
Patil N.B.
Department of Pharmacy, Ahinsa Institute of Pharmacy,
Dondaicha, Maharashtra

ABSTRACT
This study reports the surveyed of medicinal plants used by village peoples of satpuda hills in shirpur taluka in ethno veterinary practices during this study ,information about ethno veterinary plants was obtained from villages peoples of personal meet them and collect the information .the ethno veterinary plants were collected and preserved as herbarium specimens by follows the standard methods.the identification of plants on botany department of R.C.Patel shirpur,Maharashtra.during the survey it was noted that 12 plants were traditionally used by treat various veterinary diseases such as  Inflammation, wound healing, Indigestion , Dysentry, Diarrhoea, Infertility, Afra disease, Infection of uterus, antimicrobial.

The information provided in this study would bring new medicine development of ecofriendly, effective medicines to control veterinary disease in the future prospective.this study may be useful to protect and conserve the endemic flora species of satpuda hills of shirpur taluka (Dist-Dhule,Maharashtra).

A REVIEW ON: PHYTOCHEMICAL AND PHARMACOLOGICAL STUDY OF ANNONA SQUAMOSA

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ABOUT AUTHORS
Diksha A. Narwade*, Dr. A. N. Aher
Department of Pharmacognosy,
MVP samaj college of pharmacy,
Gangapur road Nashik, Maharastra, India

ABSTRACT
This paper gives the information about the Annona squamosa Linn. (Family: Annonaceae). Phytochemical and pharmacological studies of medicinal plant were performed. The plant is highly used traditionally for curing diverse diseases and disorders. It is locally known as “Sitaphal'' in Hindi. Macroscopical & microscopical studies of leaves have been studied. The phytochemical studies showed the presence of amino acids, terpenes, lipids, steroids, flavonoids, ascorbic acid, tannins, vitamins and alkaloids. The plant has various pharmacological actions such as insecticidal, purgative, laxatives, astringent, anti-inflammatory, antidiabetic, anti-ulcer, anti-oxidant, antimalarial and antibacterial. The reveiw specifically deals with the phytochemical and folkloric medicinal importance of plant.

THE PHYTOCONSTITUENTS AND PHARMACOLOGICAL ACTIONS OF FICUS RACEMOSA LINN. FAMILY: MORACEAE AN UPDATED REVIEW

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ABOUT AUTHORS
Kajal V. Kosankar*, Dr. A.N. Aher
MVP samaj college of pharmacy, Gangapur road Nashik, Maharashtra, India

ABSTRACT
Ficus racemosa it belongs to family Moraceae syn. Ficus glomerata Roxb. is the major group of angiosperm (flowering plant). They are widely distributed throughout Asia, Africa, America, Australia, Himalayan ranges, Punjab, Khasia Mountain, Bihar, Orissa, Rajasthan, Deccan, China, Indonesia and Malaysia. Udumber is used from ancient time for treating the many diseases. This tree is used traditionally for public health. It is also called yajnodumbara and grows all over the India at different areas. The common name is ‘Audumbar’ and ‘Umbar’ and used in Unani, Ayurveda and Homeopathy. The leaves tender are used in kalasha prokshana it is sprinkle water to different places from a scared copper mug and the bark is used in Homa. In review macroscopically studies, microscopically studies and chemical constituents are studied on different parts of the plant. Traditional uses and pharmacological uses are described, the extraction of leaves, fruit, stem, bark and latex are done due to this the important constituents are isolated in respective solvent like ethanol, methanol, acetone, petroleum ether, ethyl acetate and water. The more information is described below and the people are moving towards ayurvedic preparations.

ASPARAGUS RACEMOSUS, A CLIMBING AYURVEDIC MEDICINAL PLANT: REVIEW ON ITS CULTIVATION, MORPHOLOGY AND MEDICINAL SIGNIFICANCE

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ABOUT AUTHORS
Mir Sahidul Ali1, Souvik Mukherjee2, Debayan Roy2, Gargi Pal3, Subhajit Makar*2
1Department of Chemical & Polymer Engineering, Tripura University (A Central   University), Suryamaninagar, Tripura 799022, India.
2School of Basic & Applied Sciences, Central University of Punjab,Bathinda-155110, Punjab, India.
3 Department of Pharmaceutical Sciences and Technology, NSHM Knowledge Campus, Kolkata- 700053, India.

ABSTRACT: Asparagus racemosus (A. racemosus) is a well-known medicinal plant due its various application in Ayurveda. It contains various type of secondary metabolite active natural products (or ingredients) such as steroids, alkaloids, flavonoids, furan derivatives and essential oils. In the present scenario due to growing catastrophic effect of diseases in human life, researchers are trying to stop synthetic drugs by replacing with herbal drugs. Herbal drug treatments are in general used to provide first-line and public health provider, both to persons abode in faraway areas the place it is the only on hand wellness service, and to people residing in bad areas the place it offers the one cheap relief. In this point of view A. racemosus can show a new path of herbal treatment.

SOME NATURAL ISOLATED COMPOUNDS AS ANTICANCER AGENTS

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ABOUT AUTHORS
R. Mishra1, P. Barad1, N. Patel2, N. Patel3*
1Department of Pharmacy,

Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat

2Department of Pharmacognosy,

Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat

3Department of Pharmacology,
Shree S.K. Patel College of  Pharmaceutical  Education & Research
Ganpat University, Kherva, Mehasana Gujarat

ABSTRACT
Worldwide cancer is the major cause of death. Almost 8.8 million people died due to different types of cancer such as lung cancer, liver cancer, breast cancer, stomach cancer, blood cancer etc. in 2015. Government of various countries and some private organizations are spending trillions dollars for the research in cancer.  According to report of WHO treatment cost of cancer is approximately US$ 1.16 trillion per year and this amount is increasing per year. Despite of huge work the exact cause of genesis is still unknown. Couples of therapies like chemotherapy, radiation, surgery and targeted therapy are available with some detrimental effect. Now scientists are seeking lead molecule from naturally occurring substances due to high safety margin as compared to current approaches. Natural phytochemicals are prominent strategy for prevention, treating, and curing cancer. There are many phytochemicals from herbs having potent anticancer property. Generally these phytochemicals treat cancer by different mechanisms like augmenting apoptosis, cell cycle arrest, targeting to some specific cancer inducing proteins, increasing cytotoxicity etc. This is our little attempt to gather information of phytochemicals having anticancer property such as Etoposide, Curcumin, Vincristine, etc. with postulated mechanism. Etoposide is effective in lung cancer, ovarian cancer by inhibiting type II Topoisomerase. Various research revealed that Curcumin is effective in different types of cancers by increasing apoptosis and targeting specific gene such as MDM2 oncogene is inhibited through the ETS2 transcription factor by modulation of signaling pathway PI3K/mTOR in breast cancer. Vincristine shows anticancer property by oncogenic EWS-FLI1 fusion protein inhibition which cause G2-M phase cell cycle arrest & reduce tumor. This review depicts few phytochemicals having anticancer property such as Etoposide, Curcumin, vincristine, etc. with possible mechanism.

PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF THE STEM OF ZIZIPHUS XYLOPYRUS (RETZ) WILLD

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ABOUT AUTHORS
Upendra B. Gandagule1, B. Duraiswamy2, Lokesh Gupta2, Mayur R. Bhurat1, Sanjay A. Nagdev3*

1Department of Pharmacognosy,
K.Y.D.S.C.T’s college of Pharmacy,
Sakegaon-Bhusawal, Maharashtra, India
2Department of Pharmacognosy,
JSS College of pharmacy,
Ooty, Karnataka, India
3Department of Quality assurance,
K.Y.D.S.C.T’s college of Pharmacy,
Sakegaon-Bhusawal,
Maharashtra, India

ABSTRACT
The present study deals with detailed pharmacognostic profile of stem of Z. xylopyrus, family Rhamnaceae an important plant in the Indian system of medicine. Stem samples of Z. xylopyrus were studied by morphological, microscopical, physicochemical, phytochemical and powder characters of the plant and other methods for standardization recommended by WHO. Macro and microscopical studies indicated the presence of stem reddish brown in colour externally and internally whitish in colour, odourless and having pungent taste with smooth, irregular fracture. Xylem fibers arranged in radial rows, xylem parenchyma, vessel or xylem vessels, medullary rays were uni to tetraserate and pith. Powder microscopy revealed the presence of sclerenchyma, sclerenchymatous fibre and wood elements. Phytochemical evaluation have been performed which clearly reveals the occurrence of alkaloids, carbohydrates, steroids and sterol, glycosides, saponins, flavonoids, phenolic compounds, triterpenoids. Physicochemical parameters such as ash value extractive values were also determined and results showed that water soluble extractive value was higher than alcohol soluble extractive value. The results of the study can serve as a valuable source of information and provide suitable standards for identification of this plant material in future investigation and application.

INVITRO STUDIES ON THE EFFECT OF TERMINALIA ARJUNA IN ADIPOCYTE 3T3 - L1 CELL LINES

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ABOUT AUTHORS
Ranjitha B1, Dinesh Bhaskar1, Balasubramanian Sathyamurthy2
1 Department of Biochemistry,
Reva Institute of Science and Management, Bangalore, Karnataka, India
2 Department of Biochemistry,
Ramaiah College of Arts, Science and Commerce, Bangalore,
Karnataka, India

ABSTRACT: 
The leaves of Terminalia Arjuna are commonly known as Arjuna. It is used as traditional medicinal plant distributed throughout the greater part of the Indian Peninsula along rivers and found in Sub-Himalayan tract, Chota Nagpur, Orissa, West Bengal, Punjab, Deccan and Konkan it has many medicinal properties like anti bacteria, anti inflammatory and used for the treatment of Asthama, Bronchities. These leaf extracts are found to have antioxidant, anticancer and antidiabetic activities. Out of many constituents arjunolic acid is the active principle which is responsible for antidiabetic effects. The present work was aimed to study the effect of Terminalia arjuna. Methanolic extracts on adipocyte 3T3-L1cell line and found the phytochemical compounds of Terminalia arjunaleaves have more inhibitory scavenging and more antidiabetic activities

ANTI-ANEMIC ACTIVITY OF HYDRO-ALCOHOLIC EXTRACT SEEDS OF FOENICULUM VULGARE IN PHENYLHYDRAZINE INDUCED ANEMIC RATS

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ABOUT AUTHORS
CHANDRAKANTA KUSHWAH 1*, DEEPANSHU GUPTA 1, ANKUR JOSHI 1, SAPNA MALVIYA 1 & ANIL KHARIA 1
1 Department of pharmacy Modern institute of Pharmaceutical Sciences,
Indore (M.P.), India
chandakushwah0@gmail.com

ABSTRACT
The main objective of this research was to evaluate the anti-anemic activity in hydro-alcoholic extract of seeds of Foeniculum vulgare in phenylhydrazine induced anemic rats. Phenylhydrazine (60mg/kg) was given intraperitoneally in rats for two days to induce anemia. The animal were divided into 5 groups of 6 animal each. Group 1 was known as normal control group, Group 2 was known as anemic control group, Group 3 was known as standard reference control group given with Vit. B12, Group 4 was known as test control-I given with 100mg/kg of hydro-alcoholic extract of seeds of Foeniculum vulgare, Group 5 was known as test control-II given with 200mg/kg of hydro-alcoholic extract of seeds of Foeniculum vulgare. All the test drugs were given for 28 days through oral route once in a day. On 29th day blood was taken out through tail puncture and was subjected to the determination of RBC, Hb and percentage Haematocrit. Both the hydro-alcoholic seeds extract of Foeniculum vulgare and Vit. B12 significantly increase the HB, RBC & percentage Haematocrit level which shows that Foeniculum vulgare seeds exhibits the anti-anemic activity

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