Manav Bharti University

2nd NATIONAL CONFERENCE ON BREAKING NEW GROUNDS IN PHARMACEUTICAL RESEARCH 28th - 29th March 2014 at Manav Bharti University

Manav Bharti University established in 2009 under the H.P. Private University (Establishment and regulation) Act, is owned by Manav Bharti Charitable Trust with the aim to advance and disseminate the knowledge and maintain highest standard of learning through teaching, research, extension education programme and conceptual aspects relevant to the need of the state.

A REVIEW OF MEDICINAL PLANTS WITH HEPATOPROTECTIVE ACTIVITY

ABOUT AUTHORS:
Shristi Badhani*, Shivani Sharma, Amrita Kainth, Bharat Parashar
Department of Pharmacy,
Manav Bharti University, Solan, H.P.
*shristibadhani0104@gmail.com

ABSTRACT:
Hepatic diseases are a major worldwide health problem, with frequently found in developing countries. They are mainly caused by uses of high doses of chemicals and some drugs. There is no effective drug available that stimulates liver function, offer protection to the liver from damage or help to regenerate hepatic cells. Therefore there is urgent need, for effective drugs to replace/add those in current use. Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytoconstituents from some medicinal herbs and those medicinal herbs have proven hepatotprotective potential.A number of herbal preparations are available in the market. The present review is aimed at compiling data on promising phytochemicals from medicinal plants that have been tested in hepatotoxicity models using modern scientific system. In this century clinicalresearch has confirmed the efficacy of  some herbs in the treatment of liver related disease. Hence, this review article contributes to the knowledge of reported indigenous plants, which are prevalent for prevention and treatment ofliver disorders.

INCIDENCE AND PREVENTION OF POSTOPERATIVE ADHESIONS

About Authors:
1Robin Sharma*, 1Ajay Kumar, 2Dr. Bharat Prashar
1M.Pharm (Pharmacology)
2Head of Pharmacy Department
Manav Bharti University, Solan.
*sharmarobin@hotmail.com

ABSTRACT
Postoperative adhesions are a significant health problem with major implications on quality of life, health care and expenses on treatment. The purpose of this review was to investigate the incidence of post operative adhesions and the treatment measures such as efficacy of preventative techniques and adhesion barriers. The National Library of Medicine, Medline and A-Z databases were used to identify articles related to postoperative adhesions. Ileal pouch–anal anastomosis, open colectomy, and open gynecologic procedures are associated with the highest risk of adhesive small-bowel obstruction (class I evidence). Based on expert opinion (class III evidence) intraoperative preventative principles, such as meticulous haemostasis, avoiding excessive tissue dissection and ischemia, and reducing remaining surgical material such as powdered gloves have been published. Laparoscopic techniques, result in fewer adhesions than laparotomy techniques (class I evidence). Available bioabsorbable barriers, such as hyaluronic acid/carboxymethylcellulose, have been shown to reduce adhesions (class I evidence). Postoperative adhesions are a significant health problem after the surgery. General intraoperative preventative techniques, laparoscopic techniques, and the use of bioabsorbable mechanical barriers in the appropriate cases reduce the incidence and severity of peritoneal adhesions and post operative adhesions.

A REVIEW ARICLE ON SYNTHESIS AND BIOLOGICAL PROPERTY OF SOME NOVEL BUTENOLIDE DERIVATIVES

About Authors:
Rajender Kumar1*,Dr.Sukhbir L.Khokara2,
1Department of Pharmacy, Manav Bharti University, Solan (H.P.) 173229
2Institute of pharmaceutical sciences, Kurukshetra University,
Kurukshetra, Harayana-136119
*rajkaushal13@gmail.com

ABSTRACT
Butenolides (furanones) consist of unsaturated γ- lactone which occur in plants as glycosides. There is a group of steroids which contain α,β unsaturated butenolide ring in the side chain such steroids are known as cardenolides. The  presence of γ - lactone ring contain natural products like Goniobutenolides A & B ,Digitoxigenin and  lignans. These compound have biological properties like antibiotic, antitumor, anticonvulsant, antimicrobial and medicinal uses like fungicides, bactericides and allergic inhibitor.

1st National Conference of Emerging Trend in Pharmaceuticals Sciences at Manav Bharti University | 29-30th sep 2012

Manav Bharti University established in 2009 under the H.P. Private University (Establishment & Regulation) Act, is owned by Manav Bharti Charitable Trust with the aim to advance and disseminate the knowledge and maintain highest standard of learning through teaching, research, extension education programme and conceptual aspects relevant to the need of the state. It is located in the rural backdrop of Himachal Pradesh and is equidistant (65 Km) from both Chandigarh and Shimla, 35 Km away from Kalka Railway Station, 6 Km away from NH 22 on Kumarhatti-Sultanpur Road (State Highway 6) at Laddo in District Solan. Serene and lush green picturesque surrounding makes the campus truly environment friendly, eloquent hustle free knowledge center.

MONOCLONAL ANTIBODIES : A REVIEW

About authors:
1.Shashi Kant*, Satinder Kumar,
Research scholar department of pharmacy.
2. Dr. Bharat Prashar
HOD & Associate professor 
Department of Pharmaceutical Sciences,
Manav Bharti University, Solan (H.P)

shashi_ranaute@yahoo.in

ABSTRACT :
In this review article we discussed about are monospecific identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular the non-proprietary drug name ends in mabs,in this we discussed type of monoclonal antibodies,preparation,targeting of monoclonal antibodies as well as advantages and disadvantages of monoclonal antibodies. antibodies that are biology and medicine.

A General Overview On: Dentifrices

About Authors:
1Shashi Kant*, Satinder Kumar,
Research Scholar Department of Pharmacy.
2Dr. Bharat Prashar
HOD & Associate professor,
Department of Pharmaceutical Sciences,
Manav Bharti University, Solan (H.P)

* shashi_ranaute@yahoo.in

Abstract:
In this general overview, we discussed about dentifrices, types of dentifrices, formulation, evaluation and its recent trends. There have been many dentifrices produced over the years, many focusing on marketing strategies to sell products, such as offering whitening capabilities. The most essential dentifrice recommended by dentists is toothpaste which is used in conjunction with a toothbrush to help remove food debris and dental plaque.

A REVIEW ON: BIOAVAILABILITY AND BIOEQUILANCE

ABOUT AUTHORS:
1 Shashi Kant*,Satinder Kumar, Rajender Kumar,
Research scholar department of pharmacy.
2 Dr. Bharat Prashar
HOD & Associate professor  Department of Pharmaceutical Sciences, Manav Bharti University, Solan (H.P)

* shashi_ranaute@yahoo.in

ABSTRACT:-
In this review article, we discussed about Bioavailability and bioequilance study, bioavailability means rate and extent to which active ingredients absorbed from a drug product and become available at site of action. This article provides the information about important aspect involved in bioequivalence and regulatory requirement for bioequivalence study. The rate or rapidity at which drug is absorbed is important consideration in treatment of acute conditions such as asthma attack in pain. Extent of absorption is of special significance in treatment of chronic conditions like hypertension, epilepsy. In this review we discussed all the factors affecting bioavailability from its dosage form, objective/purpose of bioavailability study, design and evaluation of bioequilance study, methods of assessing of bioavailability and bioequilance etc.

CHEMISTRY AND COMMON SYNTHETIC ROUTE OF 1, 3, 4-OXADIAZOLE: AN IMPORTANT HETEROCYCLIC MOIETY IN MEDICINAL CHEMISTRY

About Authors:
Sukhbir L.Khokara1*, Naveen2, Jitendra2, Balram2, Dhirender2, Rajender Kumar1

1Department of Pharmacy, Manav Bharti University, Solan (H.P.) 173229
2Institute of pharmaceutical sciences, Kurukshetra University, Kurukshetra, Harayana-136119

rajkaushal13@gmail.com

ABSTRACT
These heterocyclic moiety are prepared by different method and  have different biological and physiological properties. The widespread use of 1,3, 4 –oxadiazole as a scaffold in medicinal chemistry establishes this moiety as an important bioactive class of heterocyclic compounds. These compound have biological properties like anticonvulsant, analgesic, antipyretic, antimitotic,antitubercular and antimicrobial etc.

A COMPLETE REVIEW ON: EFFLUENT TESTING AND TREATMENT IN PHARMACEUTICAL INDUSTRY

About Authors:
Shashi Kant*,  Dr. Bharat Prashar
Department of Pharmaceutical Sciences,
Manav Bharti University,
Solan (H.P)

*shashi_ranaute@yahoo.in

ABSTRACT:
In this review article, we discussed abouteffluent testing and treatment in pharmaceutical industry,Biological treatment of wastewater is frequently the most beneficial method for selecting various toxic compounds from the environment. Most of the organic compounds in industrial wastewaters are of natural origin and can be degraded by common bacteria in aerobic or anaerobic processes. The composition of these wastewaters is very variable. A great variety of organic chemicals can be determined among the principal components of these types of wastewaters. Antibiotics are the major group of pharmaceuticals. Among all the other pharmaceutical drugs and substances, antibiotics are important compounds due to its serious irreversible increase the release to the environment[1][2][3][4][5]

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