• PharmaTutor
    19 September 2012

    DIFFERENT METHODS OF ENHANCEMENT OF SOLUBILIZATION AND BIOAVAILABILITY OF POORLY SOLUBLE DRUGS: A RECENT REVIEW

    About Authors:
    Patel Chirag J*, Asija Rajesh, Asija Sangeeta
    Maharishi Arvind Institute of Pharmacy, Department of Pharmaceutics,
    Jaipur, Rajasthan.
    *chirag.bangalore@gmail.com

    ABSTRACT
    Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is one of the important parameters to achieve desired concentration of drug in systemic circulation for desired pharmacological response. Low aqueous solubility is the major problem encountered with formulation development of new chemical entities as well as for the generic development. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. This review discusses BCS classification, carriers for solubility enhancement and different techniques for solubility enhancement.Various techniques are used for the enhancement of the solubility of poorly soluble drugs which include micronization, nanonization, sonocrystallization, supercritical fluid method, spray freezing into liquid and lyophilization, evaporative precipitation into aqueous solution, use of surfactant, use of co-solvent, hydrotropy method, use of salt forms, solvent deposition, solubilizing agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in carriers.Selection of solubility improving method depends on drug property, site of absorption, and required dosage form characteristics.With the advent of combinatorial chemistry and a high throughput screening, the number of poorly water soluble compounds has increased solubility. A success of formulation depends on how efficiently it makes the drug available at the site of action.The purpose of this review article is to describe the techniques of solubilization for the attainment of effective absorption with improved bioavailability.

  • 14 September 2012
    METHOD DEVELOPMENT AND ITS VALIDATION FOR ESTIMATION OF DEFLAZACORT IN TABLET DOSAGE FORM BY UV SPECTROPHOTOMETRY

    About Authors:
    Kapil Sharma*1, Subhash Gupta2, Priyanka Sharma1
    1Yaresun Pharmaceutical Pvt. Ltd.,India.
    2Oasis test house ltd.
    jaipur-302006,rajasthan,india.
    *pharma_kapil@rediffmail.com

    ABSTRACT
    This paper describe a simple, precise and economical spectrophotometric method for the quantitative determination of Deflazacort(DFCT) in tablet dosage form. Method is based on the estimation of DFCT in aqueous acetonitrileat 246 nm. Beer’s law was obeyed in the concentration range of 4-14 µg/ml. The accuracy of the method was assessed by recovery studies and was found to be 99.38±0.15 for DFCT. Results of the analysis were validated statistically so that it can be used for routine analysis of DFCT in tablet dosage form.

  • 11 September 2012
    Vertigo Management – Mapping prevalence and treatment. Understanding once a day preparation usage and place in therapy.

    About Authors:
    Indraneel sinha*, Mr. Sanjay sahai, Mr. Sunil jajoo, Mr. Abhijeet bhatkar
    Post graduate diploma in pharmaceutical management,
    Indian institute of health management research,
    jaipur
    *indraneel.sinha.999@gmail.com

    COMPANY PROFILE
    Sun Pharmaceuticals was set up in 1983 and the company started off with only 5 products to cure psychiatric illness.  Sun Pharma is best known worldwide as the manufacture of specialty Active Pharmaceuticals Ingredients (API) and formulations.

    However, the company is also concerned with chronic treatments such as cardiology, psychiatry, neurology, gastroenterology, diabetology and   respiratory ailments. Active Pharmaceuticals Ingredients (API) includes peptides, steroids, hormones, and anti?cancer drugs and their quality is internationally approved. Mr. Dilip S. Shanghvi is the Executive Chairman and Managing Director of Sun Pharma and Mr. Kamalesh H. Shah is the secretary.

  • 10 September 2012
    SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND AMLODIPINE IN RAW MATERIAL AND IN COMBINED TABLET DOSAGE FORM BY RP-HPLC

    About Authors:
    Kapil Sharma*1, Subhash Gupta 2
    1 Yaresun Pharmaceutical Pvt. Ltd.,India.
    2 Oasis test house ltd. Jaipur-302006, Rajasthan, India.
    *pharma_kapil@rediffmail.com

    ABSTRACT
    A method for simultaneous estimation of Atorvastatin (ATVS) and Amlodipine (AMLD) in raw material and in combined tablet dosage form has been developed. The method employs the application of RP-HPLC. Chromatgraphy was carried out on a nucleosil C-18,250 x 4.6 mm column using a mixture of phosphate buffer and methanol  (50:50 v/v)  as the mobile phase at a flow rate of 1.3 ml/min.  Run time was 15 min.  Detection was done at 245 nm and retention time of ATVS was 6.97 min and 3.96 min of AMLD.3  This method produced linear responses in the concentration range 20-140 µg/ml and 10-70 µg/ml for ATVS and AMLD respectively. The accuracy of the method was assessed by recovery studies and was found to be 100.54± 0.19 and 100.08±0.80 for ATVS and AMLD respectively.The procedure was successfully applied for the simultaneous determination of both drugs in laboratory prepared mixture of raw material and in market available tablet dosage form. Results of the analysis were validated statistically so that it can be used for routine analysis of ATVS and AMLD in combined tablet dosage form.4-6

  • 29 August 2012
    DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR ESTIMATION OF TADALAFIL AND DAPOXETINE HCL IN SOLID DOSAGE FORM

    About Authors:
    CHIRAG S. RAJPARA*1, JAWED AKHTAR1, AMIT KHANDHAR2
    1. Department of Quality Assurance, School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-302025, Rajasthan, India.
    2. Zydus cadila pharma, moraiya,ahmedabad.
    *chiragrajpara2601@gmail.com

    ABSTRACT
    * A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for simultaneous estimation of Tadalafil and Dapoxetine HCL, Water Symmetry C-18 (150 x 4.6 mm),5 µ and a mobile phase composed of Buffer : Acetonitrile (65:35)

    * The retention time of Tadalafil and Dapoxetine HCL were found to be10.08 and 4.45 min respectively. Linearity was established for Tadalafil and Dapoxetine HCL in the range of 8.0-60 μg/ml and 24.0-180.0 μg/ml respectively. The percentage recovery of Tadalafil and Dapoxetine HCL were found to be in the range of 99.7-100.6% and 98.07-99.09% respectively. The drug was subjected to acid and alkali hydrolysis, oxidation, dry heat and photolytic degradation. The degradation studies indicated, Tadalafil showed degradation in acid and alkali while it was found stable in H2O2, photolytic and in presence of dry heat and Dapoxetine showed degradation in thermal and peroxide while it was found stable in rest of parameters . The degradation products of Tadalafil and Dapoxetine HCL in acidic, alkaline conditions were well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for the quantitative analysis of Tadalafil and Dapoxetine HCL in bulk drugs and formulations.

  • 28 August 2012
    RISK OF HYPERTENSION IN DIABETES PATIENT AS COMPARED TO NON DIABETIC

    About Authors:
    Gupta S*, Singal A
    Apex Institute Of Pharmaceutical Sciences,
    Jaipur, Raj., India
    *somesh.gupta88@gmail.com

    Abstract
    The aim of the present study was to correlate the occurrence of hypertension in the diabetics’ patient by the survey report on hypertension associated with diabetics’ patient. The effect of this study is symbolize that 70% patient have diabetes with hypertension and 30% patient with hypertension only so we can say that in this survey as the BGL increased leads to increased in B.P. And it was also found to be that aged patients have more risk of diabetes. Over 60- 70 year age group patient have 40% risk to get diabetes.

  • 7 August 2012
    LIPOSOMES: NOVEL DRUG DELIVERY CARRIER

    About Author:
    Patel Chirag J*, Asija Rajesh, Asija Sangeeta, Mangukia Dhruv
    Maharishi Arvind Institute of Pharmacy,
    Department of pharmaceutics, Jaipur,
    Rajasthan, India.
    *chirag.bangalore@gmail.com

    ABSTRACT
    Amongst the various carriers, few drug carriers reached the stages of clinical trials where liposome shows strong potential for effective drug delivery to the site of action. Liposomes are vesicles having concentric phospholipid bilayers. Molecules from low molecular weight to high molecular weight have been incorporated in liposomes. The water soluble compounds/drugs are present in aqueous compartments while lipid soluble compounds/drugs and amphiphilic compounds/drugs insert themselves in phospholipid bilayers. Drug encapsulated in liposomes include doxorubin, cisplatin, vincristin, melphalan, sarcolycin, daunorubicin, etoposide, etc. The liposomes containing drugs can be administrated by many routes (intravenous, oral inhalation, local application, ocular) and these can be used for the treatment of various diseases. Their predominance in drug delivery and targeting has enabled them to be used as therapeutics tool in fields like tumour targeting, gene and antisense therapy etc. This review discusses the advantages, disadvantages, mechanism, classification, method of preparation, characterization and application of liposomes.

  • 1 August 2012
    Job as Group Product Manager, Product Specialist, Area Sales Manager & Medical Representives Synokem Pharmaceuticals

    Synokem Pharmaceuticals, founded in 1982 is an emerging pharmaceutical company with proven capabilities in the areas of manufacturing and marketing. It’s among the fast growing pharmaceutical company in India, which has grown from strength to strength and diversified its activities.
    Synokem Pharmaceuticals Ltd., a 100 crore, progressive, 28 years old organization with all India operations requires for its different

  • 31 July 2012
    REVIEW ARTICLE : ANTIAGING COSMETICS

    About Authors:
    Joshi B.*, Agarwal P., Sahu D., Dashora A.
    Geetanjali Institute of Pharmacy,
    Udaipur Rajasthan, India
    *bhavesh.joshi8@gmail.com

    Abstract:
    Antiaging is emerging class of cosmetics which combine the benefit of anti aging ingredients with the elegance skin feel and delivery system of cosmetics antioxidants, anti cellulites and anti microbial have been use in maintaining and enhancing human beauty. Anti aging ingredients also help to reduce the fine lines, increasing the moisture level and reduces wrinkles and puffness to keep the skin in good condition. New delivery system is a more effective solution for the skin aging resulting from photoaging. New vehicle like liposome and nanoparticles is a new generation for antioxidants with enhanced bioavailability and very stable activity. Our objective is to review present state of the art knowledge pertaining to mechanisms involved in skin aging, factor responsible for aging and various new ingredients use to treat aging defect.

  • 24 July 2012
    Juggat Pharma invites for various positions in all major cities of Gujarat, Rajasthan & Madhya Pradesh

    Juggat Pharma, Pharmaceutical Division of Jagdale Industries Limited is one of the fastest growing and high performing pharmaceutical marketing company with a global presence based at Bangalore, Karnataka. We provide an ideal environment for highly qualified and committed professionals to pursue their career Under the expansion plan, we are looking for 'Marketing Professionals' in Gujarat/Rajasthan/Madhya Pradesh.

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