Mehsana

Lupin Limited is an innovation led transnational pharmaceutical company producing a wide range of quality, affordable generic and branded formulations and APIs for the developed and developing markets of the world. The Company today has significant market share in key markets in the Cardiovascular, Diabctology, Asthma, Pediatrics, CNS, GI, Anti-Infectives and NSAIDs therapy segments, not to mention global leadership positions in the Anti-TB and Cephalosporins segments.

About Authors:
Kalpesh N. Patel¹*, Jayvadan K. Patel^2
1 Research Scholar, Jodhpur National University, Jodhpur,
Rajshathan, India
² Department of Pharmaceutical Technology,
Nootan Pharmacy College,
Visnagar (GUJARAT), India.

Abstract
Two simple spectrophotometric methods have been developed for simultaneous estimation of pyrimethamine and sulphadoxine from tablet dosage form. Method-I simultaneous equation method involves the measurement of absorbances at two wavelengths 215 nm (λmax of pyrimethamine) and 254 nm (λmax of sulphadoxine) in methanol and Method-II first order derivative spectroscopic method involves the measurement of absorbances at two wavelengths 250 nm (λmax of pyrimethamine) and 220.5 nm (λmax of sulphadoxine); The linearity lies between 5-30 µg/ml for both pyrimethamine and sulphadoxine for all the two methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All method were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of pyrimethamine and sulphadoxine in bulk and combined dosage form.

About Authors:
RAVIKUMAR R. PATEL¹, Dr. JAYVADAN K. PATEL^2
1 Research Scholar, Jodhpur National University, Jodhpur
² Principal and Professor, Nootan Pharmacy College, Visnagar, Mehsana, Gujarat.

AIM OF PRESENT INVESTIGATION
Now a day most of the pharmaceutical scientists are involved in developing an ideal drug delivery system with an objective of not only curing the disease but also to achieve patient compliance. Approximately 50 % of the drug delivery system available in market is oral drug delivery system. Conventional oral dosage forms provide a specific drug concentration in systemic circulation without offering any control over drug delivery. Over the past three decades, the pursuit and exploration of devices designed to be retained in the upper part of gastrointestinal tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems.

The college "Saraswati School of Pharmacy" is located at- Ranela, Mahesana. This college runs B. Pharm course in the college campus. The college is run by Shree B. M. Patel Education Trust. This is one of the largest educational campus running professional institutions in the University, to which it is affiliated with. It offers educational course.

About Author:
D. J. Kalena^*, C. N. Patel
Department of Quality Assurance,
Shri Sarvajanik Pharmacy College,
Near arvind baug, Mehsana - 384 001, Gujarat, India

A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and validated for the simultaneous estimation of atorvastatin calcium and olmesartan medoxomil in combined dosage forms. The stationary phase used was TLC aluminium plate precoated with silica gel 60F₂₅₄. The mobile phase used was a mixture of acetonitrile: chloroform: methanol: 10% glacial acetic acid (7: 2: 1.5: 0.1 v/v/v/v). The system was found to give compact spot for both atorvastatin and olmesartan (R_f value 0.5±0.01 and 0.76±0.02 respectively). The densitometric analysis of spot was carried out in reflectance mode at 253 nm. The method was validated in terms of linearity, specificity, precision, robustness and accuracy. The calibration curve was found to be linear in the range of 200 to 800 ng/spot for atorvastatin and 400 to 1600 ng/spot for olmesartan. The limit of detection and the limit of quantification for the atorvastatin were found to be 178.239 and 540.11 ng/spot and for olmesartan 40.10 and 121.51 ng/spot, respectively. The proposed method can be successfully used to determine the drug content of marketed tablet formulation.

Glenmark Pharmaceuticals today announced the settlement of litigation with Daiichi Sankyo and Genzyme Corporation regarding Glenmark's Abbreviated New Drug Application (ANDA) tiled with the US Food and Drug Administration (FDA) for Colesevelam Hydrochloride, a drug used in treatment of type-2 diabetes.

Comed was in 1986, when a team of experienced and energetic Pharma professionals decided to go big and to do something different and better than routine. A seed was sown: a beginning was made. These young, dynamic and experienced future leaders chose Baroda (Now called Vadodara), the Educational and Pharma capital of Gujarat (Western India) as their base, a choice which itself proved to be big contributing factor for growth.

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Panacea Biotec is a leading research based Health Management Company, with an annual turnover of approx. Rs. 830 Crores. We are engaged in research, development, manufacture & marketing of Vaccines, Bio-Pharmaceuticals and Pharmaceuticals (Rx & OTC) of international quality and Health Services. All Panacea Biotec plants are accredited by international agencies and they follow current Good Manufacturing Practices, as per WHO guidelines.We offer stimulating work environment & a career that spells growth.