A team of Russian researchers has discovered a mechanism of DNA repair that will help prevent and treat diseases in the future. The article was published in the journal Science Advances.
The DNA molecule is chemically unstable, giving rise to DNA lesions of different nature. The damage of the DNA, if not repaired, leads to accumulation of mutations, cell death and to the development of various diseases, including Alzheimer's. In higher organisms, DNA is bound with proteins in complexes called the nucleosome. The mechanism of DNA repair opens up new perspectives for the treatment and prevention of neurodegenerative diseases.
"We have shown, not yet in the cell but in vitro, that the repair of breaks in the other DNA chain, which is "hidden" in the nucleosome, is still possible," said Vasily M Studitsky, professor at Lomonosov Moscow State University.
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